AIM:To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase(PRKAA1)and the risk of gastric ***:The study subjects consisted of 477 ageand sex-matched case-control **...
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AIM:To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase(PRKAA1)and the risk of gastric ***:The study subjects consisted of 477 ageand sex-matched case-control *** was performed for 5 tag single nucleotide polymorphisms(SNPs):rs13361707,rs154268,rs3805486,rs6882903,and *** between gastric cancer and putative risk factors(including the SNPs)were analyzed with multivariate conditional logistic regression models,after adjusting for potential confounding *** testing corrections were implemented following methodology for controlling the false discovery ***-based association tests were performed by using the versatile gene-based association study(VEGAS)***:In the dominant model,SNPs rs13361707[odds ratio(OR)=1.51,95%CI:1.07-2.11)],rs154268(OR=1.65,95%CI:1.22-2.22),rs6882903(OR=1.48,95%CI:1.09-2.00),and rs10074991(OR=1.53,95%CI:1.09-2.16)were significantly associated with an increased risk of gastric *** the recessive model,SNPs rs154268(OR=1.66,95%CI:1.22-2.26),rs3805486(OR=0.63,95%CI:0.46-0.85),and rs10074991(OR=1.47,95%CI:1.15-1.88)were significant risk or protective factors for gastric *** the codominant model,the ORs of each of the5 SNPs were statistically *** SNPs in the model showed a dose-response relationship between the minor allele frequency and the risk of gastric *** notably,subjects with a homozygous minor allele in SNP rs10074991 showed 2.15 times the risk of gastric cancer as subjects without a minor *** PRKAA1 gene showed a significant gene-based association with gastric cancer in the VEGAS ***:All 5 tested tag SNPs of the PRKAA1gene(rs13361707,rs154268,rs3805486,rs6882903,and rs10074991)were significantly associated with gastric cancer.
Erratum to:*** Univ.(2014)21:3811-3820DOI:10.1007/s11771-014-2366-9The original version of this article unfortunately contained three *** mistakes are corrected as follows:1)The spelling of third author is *** correct...
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Erratum to:*** Univ.(2014)21:3811-3820DOI:10.1007/s11771-014-2366-9The original version of this article unfortunately contained three *** mistakes are corrected as follows:1)The spelling of third author is *** correct name is Jae-Young PYUN.2)The information of corresponding author is *** correct information should be Goo-Rak KWON,Professor,PhD;Tel/Fax:+98-711-7264102;E-mail:grkwon@***.
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