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First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico

Advances in Microbiology 2016年第7期6卷 489-494页

作者： Marco Torres-Castro henry noh-pech Edwin Gutiérrez-Ruiz Julián García-Rejón Carlos Machain-Williams Jorge Zavala-Castro Fernando I. Puerto Centro de Investigaciones Regionales “Dr. Hideyo Noguchi” Universidad Autónoma de Yucatán Mérida México Campus de Ciencias Biológicas y Agropecuarias Universidad Autónoma de Yucatán Mérida México

Borna Disease Virus (BDV) causes a progressive non-suppurative meningoencephalitis that sometimes occurs in mortality;this disease has been reported for over two centuries ago in horses, sheep and cats in Central Europe and some regions of Asia. Currently, it is known that it causes neurological symptoms in various species of vertebrates including human beings. In Yucatan, Mexico, there is a single serological report about the circulation of BDV in schizophrenia patients;however, nothing is known about the circulation in animals. We obtained serum samples of 100 horses without apparent clinical signs caused by BDV infection, from various sites in the region. Antibodies against BDV were detected by electrochemiluminescence immunoassay (ECLIA) method with three recombinant proteins: BDV p24, BDV p40 and BDV p10 as antigens;obtaining a high seroprevalence of 44% (44/100). This study generates the first report of the probable activity of the BDV in healthy horses in Mexico and has expanded the infiltration area of BDV in the world. Nevertheless, several molecular investigations are required to detect BDV-RNA circulating and find sequences for clarification of the origin of BDV in Mexican horses.

关键词： Borna Disease Virus Electrochemiluminescence Immunoassay Healthy Horses Yucatan Mexico

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Validation of the trauma mortality prediction scores from a Malaysian population

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Burns & Trauma 2017年第4期5卷 254-259页

作者： Jih Huei Tan henry Chor Lip Tan Nur Azlin Md noh Yuzaidi Mohamad Rizal Imran Alwi General Surgery Department Hospital Sultanah Aminah Johor Bahru Malaysia Pusat Perubatan Universiti Kebangsaan Malaysia Cheras Malaysia Clinical Research Centre Hospital Sultan Ismail Johor Bahru Malaysia General Surgery Department Hospital Sultanah Aminah Johor Bahru Malaysia

Background:Well-known trauma mortality prediction scores such as New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) have been externally validated from high-income countries with established trauma databases. However, these scores were never used in Malaysian population. In this current study, we attempted to validate these scoring systems using our regional trauma surgery database. Methods:A retrospective analysis of the regional Malaysian Trauma Surgery Database was performed over a period of 3 years from May 2011 to April 2014. NISS, RTS, Major Trauma Outcome Study (MTOS)-TRISS, and National Trauma Database (NTrD)-TRISS scores were recorded and calculated. Individual scoring system's performance in predicting trauma mortality was compared by calculating the area under the receiver operating characteristic (AUC) curve. Youden index and associated optimal cutoff values for each scoring system was calculated to predict mortality. The corresponding positive predictive value, negative predictive value, and accuracy of the cutoff values were calculated. Results:A total of 2208 trauma patients (2004 blunt and 204 penetrating injuries) with mean age of 36 (SD=16) years were included. There were 239 deaths with a corresponding mortality rate of 10.8%. The AUC calculated for the NISS, RTS, MTOS-TRISS, and NTrD-TRISS were 0.878, 0.802, 0.812, and 0.848, respectively. The NISS score with a cutoff value of 24, sensitivity of 86.6%and specificity of 74.3%, outperformed the rest (p<0.001). Mortality was predicted by NISS with an overall accuracy of 75.6%;its positive predictive value was at 29.02%and negative predictive value at 97.86%. Conclusion:Amongst the four scores, the NISS score is the best trauma mortality prediction model suited for a local Malaysian trauma population. Further validation with multicentre data in the country may require to ascertain the finding.

关键词： Trauma scoring system Prediction model Injury grading Southeast Asia New Injury Severity Score Revised Trauma Score Trauma and Injury Severity Score

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