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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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HEY YOU,mr.Q

汽车测试报告 2014年第1期 68-73页

作者：陈欢 l.m(图)

容我邪恶地抄了遍蔡依林的歌词做引言，不过这曲子真是把Q50的特质概括得挺好了，请让我给你慢慢解释。

关键词：轿车车型品牌安全性能

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal.michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curricul.m,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal.mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to suppl.ment mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curricul.m may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

EFFECT OF mICROSTRUCTURE ON HYDROGEN DAmAGE OFJBK-75 PRECIPITATE-STRENGTHENED AUSTENITIC STEEl

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Acta metallurgica Sinica(English letters) 1997年第3期10卷 206-211,112页

作者： l.m ma G.J. liang CG. Fan and Y Y li(Institute of metal Research, Chinese Academy of Sciences, Shenyang 110015, China) Inst of metal Research Chinese Acad of Sciences Shengyang China

Effects of γ， η precipitates and grain size on hydrogen damage (HD) of JBK-75 precipitate-strengthened austenitic steel were examined using the method of high-pressure thermal hydrogen charging and tensile tests. The hydrogen content in the charged specimens was 25.2 wppm. At the condition of η phase-free precipitating, the HD of the steel increased with increasing γ size, fine spherical γ dispersively dis-tributed was beneficial to improve the hydrogen-resistant property. η-phae precipitated at grain boundary increased HD tendency, while intragranular cellular η had less effect on it. Fine austenitic gruin Aize was beneficial to decrease the HD. At the condition of η phase-free precipitating, both hydrogen changed and uncharyed specimens of the steel fractured in ductile transgranular mode, whilst hydrogen promoted the intergranular fracture when obvious η precipitates were found.

关键词： hydrogen damage microstructure precipitate-strengthened austenitic steel

modeling of ultrafast X-ray induced magnetization dynamics in magnetic multilayer systems

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npj Computational.materials 2022年第1期8卷 2044-2052页

作者： K.J.Kapcia V.Tkachenko F.Capotondi A.lichtenstein S.molodtsov l.müller A.Philippi-Kobs P.Piekarz B.Ziaja Center for Free-Electron laser Science CFEl Deutsches Elektronen-Synchrotron DESYNotkestr.8522607HamburgGermany Institute of Spintronics and Quantum Information Faculty of PhysicsAdam Mickiewicz University in PoznańPoznańPoland Institute of Nuclear Physics Polish Academy of SciencesKrakówPoland European XFEl GmbH SchenefeldGermany Elettra-Sincrotrone Trieste S.C.p.A TriesteBasovizzaItaly University of Hamburg HamburgGermany Deutsches Elektronen-Synchrotron DESY Notkestr.8522607HamburgGermany

In this work,we report on modeling results obtained with our recently developed simulation tool enabling nanoscopic description of electronic processes in X-ray irradiated ferromagnetic *** this tool,we have studied the response of Co/Pt multilayer system irradiated by an ultrafast extreme ultraviolet pulse at the m-edge of Co(photon energy~60 eV).It was previously investigated experimentally at the FERmI free-electron-laser facility,using the magnetic small-angle X-ray scattering *** simulations show that the magnetic scattering signal from cobalt decreases on femtosecond timescales due to electronic excitation,relaxation,and transport processes both in the cobalt and in the platinum layers,following the trend observed in the experimental *** confirmation of the predominant role of electronic processes for X-ray induced demagnetization in the regime below the structural damage threshold is a step toward quantitative control and manipulation of X-ray induced magnetic processes on femtosecond timescales.

关键词： magnetization multilayer cobalt

Therapeutic potential of alpha 5 subunit containing GABA_(A) receptors in Alzheimer's disease

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Neural Regeneration Research 2021年第8期16卷 1550-1551页

作者： Andrea Kwakowsky henry J.Waldvogel Richard l.m.Faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alheimer's disease(AD) is a common neurodegenerative disorder and the leading cause of dementia. It has been estimated that over 50 million people worldwide were affected by dementia in 2019, and the prevalence of dementia is expected to double approximately once every 20 years(Govindpani et al., 2017). most people who die with AD require high levels of care for long periods of time.

关键词： al. Alzheimer Therapeutic

Sequence assembly using next generation sequencing data —challenges and solutions

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Science China(life Sciences) 2014年第11期57卷 1140-1148页

作者： CHIN Francis Y.l. lEUNG henry C.m. YIU S.m. Department of Computer Science The University of Hong Kong

Sequence assembling is an important step for bioinformatics *** the help of next generation sequencing(NGS)technology,high throughput DNA fragment(reads)can be randomly sampled from DNA or RNA molecular ***,as the positions of reads being sampled are unknown,assembling process is required for combining overlapped reads to reconstruct the original DNA or RNA *** with traditional Sanger sequencing methods,although the throughput of NGS reads increases,the read length is shorter and the error rate is *** introduces several probl.ms in ***,paired-end reads instead of single-end reads can be sampled which contain more *** existing assemblers cannot fully utilize this information and fails to assemble longer *** this article,we will revisit the major probl.ms of assembling NGS reads on genomic,transcriptomic,metagenomic and metatranscriptomic *** will also describe our IDBA package for solving these *** package has adopted several novel ideas in assembling,including using multiple k,local assembling and progressive depth *** with existence assemblers,IDBA has better performance on many simulated and real sequencing datasets.

关键词： genomic assembling de Bruijn graph paired-end reads next generation sequencing

Stress reduction via neuro-emotional technique to achieve the simultaneous resolution of chronic low back pain with multiple infl.mmatory and biobehavioural indicators:A randomized,double-blinded,placebo-controlled trial

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Journal of Integrative medicine 2022年第2期20卷 135-144页

作者： Peter Bablis henry Pollard Anthony l.Rosner Universal Health New South Wales 2028Australia School of medical and Applied Sciences University of Central QueenslandBrisbaneNew South Wales 4000Australia medical Information Services MA 02479-4149United States

Background:Beginning with the concepts of stress developed by Selye,an approach to stress and pain management,known as neuro-emotional technique(NET),has been *** is a treatment approach based on the principle that the stressor effects of dormant and/or current unresolved issues or trauma are what determine one’s bodily *** responses are relatively personalized to the conditioned,experiential and emotional reality of the ***:To determine the effect of NET on patients with chronic low back pain(ClBP)over ***,setting,participants,and interventions:In a randomized,double-blinded,placebo-controlled study conducted in a single clinic,NET or control treatments were given twice weekly for 4 weeks in a population of 112 *** outcome measures:Outcome measures,including Oswestry Disability Index,Quadruple Visual Analogue Scale,the psychoneuroimmunology markers of blood serum levels of C-reactive protein,tumour necrosis factor-a,interleukin-1(Il-1),Il-6,and Il-10,and 10 dimensions of the Short Form Health Survey scale,were assessed at baseline and at 1,3 and 6 months following the intervention ***:Compared to placebo,NET produced clinical and statistical significance(Plines of virtually all physiological,pain and disability markers,accompanied by gains in quality-of-life indicators at 0(baseline),1,3 and 6 *** of the percentages of patients whose 5 biomarkers lay outside the normative range were achieved at 1,3 and 6 months by NET but not control ***:A randomized,controlled trial of ClBP patients indicated that 8 NET interventions,compared to placebo,produced clinically and statistically significant reductions in pain,disability and infl.mmatory biomarkers,and improvements in quality-of-life measures.

关键词： Neuro-emotional technique Biopsychosocial.model Emotion mind-body therapies Infl.mmation Biomarker

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计算数据库询问的一种实用算法

软件 1989年第11期10卷 897-907页

作者： Vet,l.m 刘蕊红