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Particuology 2021年第6期19卷 2-15页

作者： Kimiaki Washino Ei l.chan Tetsushi Kaji Yoshiaki Matsuno Toshitsugu Tanaka Department of Mechanical Engineering Osaka UniversitySuitaOsaka 565-0871Japan

Particulate flows in a mixture of gas and liquid,***-liquid-solid three-phase flows,are frequently encountered both in nature and *** such flows,complex interactions between multiple phases,***-particle interactions,fluid-particle interactions and interfacial interactions(such as surface tension and particle wetting),play a crucial *** literature,simulations of three-phase flows are sometimes performed by incorporating interface capturing methods(*** method)into the CFD-DEM coupling ***,it is practically impossible to perform large(industrial)scale simulation because of the high computational *** of the strategies often employed to reduce the computational cost in CFD-DEM is to upscale particle size,which is applied mainly to particle single-phase and fluid-solid two-phase *** present work is focused on the scaled-up particle model for gas-liquid-solid three-phase *** interaction forces between multiple phases are scaled using the general criteria derived from the continuum assumption of particulate flow.A colour function based interface-capturing method with improved interface smoothness is developed,and the diffusion based coarse graining is employed to ensure sufficient space resolution in CFD even when particle size is *** is shown that the model developed is capable of predicting the both particles and fluid behaviour in the original system.

关键词： CFD-DEM Three-phase flow Scaled-up particle Surface tension and wetting

Deep ResNet Strategy for the Classification of Wind Shear Intensity Near Airport Runway

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1565-1584页

作者： Afaq Khattak Pak-wai chan Feng Chen Abdulrazak H.Almaliki Department of Civil Structural and Environmental EngineeringTrinity College DublinDublinD02 PN40Ireland Hong Kong Observatory 134A Nathan RoadKowloonHong Kong999077China College of Transportation Engineering Tongji UniversityShanghai201804China Department of Civil Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia

Intense wind shear(I-WS)near airport runways presents a critical challenge to aviation safety,necessi-tating accurate and timely classification to mitigate risks during takeoff and *** study proposes the application of advanced Residual Network(ResNet)architectures including ResNet34 and ResNet50 for classifying I-WS and Non-Intense Wind Shear(NI-WS)events using Doppler light Detection and Ranging(liDAR)data from Hong Kong International Airport(HKIA).Unlike conventional models such as feedforward neural networks(FNNs),convolutional neural networks(CNNs),and recurrent neural networks(RNNs),ResNet provides a distinct advantage in addressing key challenges such as capturing intricate WS dynamics,mitigating vanishing gradient issues in deep architectures,and effectively handling class imbalance when combined with Synthetic Minority Oversampling Technique(SMOTE).The analysis results revealed that ResNet34 outperforms other models with a Balanced Accuracy of 0.7106,Probability of Detection of 0.8271,False Alarm Rate of 0.328,F1-score of 0.7413,Matthews Correlation Coefficient of 0.433,and Geometric Mean of 0.701,demonstrating its effectiveness in classifying I-WS *** findings of this study not only establish ResNet as a valuable tool in the domain of WS classification but also provide a reliable framework for enhancing operational safety at airports.

关键词： Aviation safety wind shear deep residual network Doppler liDAR

一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF)与富马酸替诺福韦二吡呋酯(TDF)的3期研究:96周时疗效和安全性结果

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一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF...

What do oncologists need to know about biosimilar products?

第九届全国疑难及重症肝病大会

作者： Kosh Agarwal Scott Fung Wai Kay Seto Young Suk lim Ed Gane Harry l.Janssen Manoj Sharma Wan long Chuang Ho Bae Ki Tae Yoon John F.Flaherty Audrey lau Anuj Gaggar Vithika Suri Andrea Cathcart lanjia lin G Mani Subramanian Shalimar Norihiro Furusyo Maria Buti henry l.chan Kings College Hospital Department of Medicine University of Toronto Queen Mary Hospital Hong Kong Asan Medical Center Kaohsiung Medical University Hospital Pusan National University Yangsan Hospital All India Institute of Medical Sciences Kyushu Medical Center The Chinese University of Hong Kong

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的疗效并不劣于T...

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的疗效并不劣于TDF,且骨骼和肾脏影响改善。本文摘展示了96周治疗后的结果。

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Chinese Journal of Cancer 2016年第11期35卷 574-584页

作者： linda K.S.leung Kevin Mok Calvin liu Stephen l.chan 1 State Key laboratory in Oncology in South China Department of Clinical OncologySir YK Pao Center for CancerHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina. Faculty of Medicine The Chinese University of Hong KongHong KongChina.

Many biologic products have improved the outcomes of cancer patients,but the costs can substantially burden healthcare *** products can potentially reduce drug costs and increase patient access to beneficial *** of a biosimilar product relies on the demonstration of "comparability" or "no clinically meaningful differences" as compared to its reference biologic *** products for erythropoietin,granulocyte colonystimulating factor,trastuzumab,and rituximab are already available,and the regulatory processes in various countries are constantly *** is important that oncologists be familiar with the potential issues surrounding the clinical use of biosimilar *** this review article,we provide background information about biosimilar products and their regulatory approval processes,followed by a discussion of individual biosimilar drugs.

关键词： Biosimilar products Biologic products Regulation Oncology

Pulmonary cystic disease associated with integumentary and renal manifestations

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The Journal of Biomedical Research 2013年第6期27卷 515-519页

作者： Katherine S.Cayetano Timothy E.Albertson Andrew l.chan Department of Internal Medicine Division of Pulmonary Critical Care and Sleep Medicine University of CaliforniaDavis School of Medicine Veteran's Administration Northern California Health Care System

A 69-year-old man with multiple skin lesions on his face, neck and upper torso, which first appeared in the 3rd decade of his life, was admitted to our hospital. He had cystic changes in his lungs noted on chest computed to- mography （CT） scanning, as well as a left kidney mass. This patient exhibited a rare complex of renal, cutaneous and pulmonary manifestations, eponymously named Birt-Hogg-Dube syndrome, with characteristic skin features （fibrofolliculomas, trichodiscomas and acrochordons）. This syndrome is due to an autosomal dominant germ-line mutation of thefolliculin （FlCN） gene located at chromosome 17p11.2. Diagnosis and differentiation from other disease complexes including the skin, kidneys and lungs are important in prognostication and management of po- tentially life-threatening complications such as renal cell carcinoma and pneumothoraces.

关键词： pulmonary cystic disease Birt-Hogg-Dube syndrome folliculin mutation

Systemic treatment for inoperable pancreatic adenocarcinoma: review and update

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Chinese Journal of Cancer 2014年第6期33卷 267-276页

作者： Stephen l.chan Sin T.chan Eric H.chan Zhe-Xi He State Key laboratory in Oncology in South China Sir YK Pao Center for Cancer Department of Clinical Oncology and Hong Kong Cancer Institute and Prince of Wales Hospital The Chinese University of Hong Kong The Faculty of Medicine The Chinese University of Hong Kong

There have been many clinical trials conducted to evaluate novel systemic regimens for unresectable pancreatic cancer. However, most of the trial results were negative, and gemcitabine monotherapy has remained the standard systemic treatment for years. A number of molecular targeted agents, including those against epidermal growth factor receptor and vascular endothelial growth factor receptors, have also been tested. In recent years, there have been some breakthroughs in the deadlock: three regimens, namely gemcitabine-erlotinib, FOlFIRINOX, and gemcitabine-nab-paclitaxel, have been shown to prolong the overall survival of patients when compared with gemcitabine monotherapy. In addition, emerging data suggested that the membrane protein human equilibrative nucleotide transporter 1 is a potential biomarker with which to predict the efficacy of gemcitabine. Here we review the literature on the development of systemic agents for pancreatic cancer, discuss the current choices of treatment, and provide future directions on the development of novel agents.

关键词：全身治疗胰腺癌审查血管内皮生长因子受体表皮生长因子受体手术临床试验靶向药物

The impacts of suspended mariculture on coastal zones in China and the scope for Integrated Multi-Trophic Aquaculture

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Ecosystem Health and Sustainability 2017年第6期3卷 32-51页

作者： Reece Wartenberg limin Feng Jia Jun Wu Yim ling Mak leo l.chan Trevor C.Telfer Paul K.S.lamab.c State Key laboratory in Marine Pollution City University of Hong KongKowloonHong Kong SARChina Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine BiodiversityCity University of Hong Kong Shenzhen Research Institute BuildingShenzhenGuangdongChina Department of Biology and Chemistry City University of Hong KongKowloonHong Kong SARChina Department of Biomedical Sciences City University of Hong KongKowloonHong Kong SARChina Institute of Aquaculture University of StirlingStirlingUK

Introduction:China is responsible for more than 60%of global aquaculture *** the frontiers of food production have expanded,the cultivation of marine organisms in coastal zones and the open ocean has grown *** dominant mariculture industry in China is suspended mariculture,which uses net cages,ropes,or other structures suspended in the water column to cultivate aquatic *** systematic,quantitative review provides a clear and comprehensive account of research that has investigated the adverse impacts of suspended mariculture in China and reviews research that has applied Integrated Multi-Trophic Aquaculture(IMTA)systems for mitigating *** work builds on 218 peer reviewed papers that have been published in English-language ***:Eighteen impacts were identified,including chemical,ecological,physical,and socioeconomic *** measures for improving suspended mariculture were recommended consisting of government department,farm management,and ecological engineering *** was the most frequently recommended *** capabil-ities of IMTA for bioremediation and increased farm production were the most frequently studied *** other benefits have been explored but remain *** current challenges facing the expansion of commercial IMTA include limited use of new technology,limited skills development,decreasing production of low trophic-level species,biogeographic and temporal barriers,and negative system ***:Despite challenges,implementing commercial IMTA is a promising measure for reducing the impacts of sus pended mariculture because it presents a range of secondary benefits that can improve the overall sustainability of aquaculture in the coastal zone.

关键词： Aquaculture bioremediation China impacts Integrated Multi-Trophic Aquaculture pollution suspended mariculture

Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury

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Neural Regeneration Research 2014年第4期9卷 362-376页

作者： linda l.Phillips Julie l.chan Adele E.Doperalski Thomas M.Reeves Department of Anatomy and Neurobiology Virginia Commonwealth UniversityRichmondVAUSA

Over the past two decades, many investigators have reported how extracellular matrix molecules act to regulate neuroplasticity. The majority of these studies involve proteins which are targets of matrix metalloproteinases. Importantly, these enzyme/substrate interactions can regulate degenerative and regenerative phases of synaptic plasticity, directing axonal and dendritic reorganization after brain insult. The present review first summarizes literature support for the prominent role of matrix metalloproteinases during neuroregeneration, followed by a discussion of data contrasting adaptive and maladaptive neuroplasticity that reveals time-dependent metalloproteinase/substrate regulation of postinjury synaptic recovery. The potential for these enzymes to serve as therapeutic targets for enhanced neuroplasticity after brain injury is illustrated with experiments demonstrating that metalloproteinase inhibitors can alter adaptive and maladaptive outcome. Finally, the complexity of metalloproteinase role in reactive synaptogenesis is revealed in new studies showing how these enzymes interact with immune molecules to mediate cellular response in the local regenerative environment, and are regulated by novel binding partners in the brain extracellular matrix. Together, these different examples show the complexity with which metalloproteinases are integrated into the process of neuroregeneration, and point to a promising new angle for future studies exploring how to facilitate brain plasticity.

关键词： neuroregeneration reactive synaptogenesis matrix metalloproteinases brain injury adaptive and maladaptive neuroplasticity metalloproteinase inhibition osteopontin lipocalin 2

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试论“俄罗斯”一词之翻译

国外文学 2008年第3期28卷 64-67页

作者：陈炜舜台湾佛光大学文学系

宋元之际出现"俄罗斯"一词的汉译后,至今沿用。这种译法和俄语原来的发音有所差异,是由蒙、满语"Oros"转译。而蒙、满语的拼法,则是同化增音的结果。"俄罗斯"一词最初所指涉的乃是"罗斯"(Russ),而非后来的"Russia"。

关键词：俄罗斯罗斯蒙语满语同化增音