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芳香化酶抑制剂阿纳托唑阴道给药治疗直肠阴道子宫内膜异位症的初步研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 37-38页

作者： hefler L.A. Grimm C. Van Trotsenburg M. Nagele F. F. Nagele 李跃萍 Dr. Department of Obstetrics and Gynecology Medical University of Vienna Waehringer Guertel 18-20 A-1090 Vienna Austria

In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometriosis. In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and dyspareunia, improved during therapy.

关键词：阿纳托唑子宫内膜异位症芳香化酶抑制剂阴道给药慢性盆腔痛痛经症状性交困难社会功能组织学

血清中鳞状上皮细胞癌抗原水平对早期外阴癌的预测价值

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 40-40页

作者： hefler L.A. Sliutz G. Leodolter S 李跃萍 Department of Obstetrics and Gynecology Medical University of Vienna Waehringer Guertel 18- 20 A- 1090 Vienna Austria

Objective. To determine whether SCC- Ag serum levels can be used as a prognostic parameter in surgically treated early stage vulvar cancer. Methods. SCC- Ag serum levels were measured preoperatively in 61 surgically staged patients with squamous cell vulvar cancer (UICC pT1 and pT2). Results were correlated to clinical data. Results. Mean (standard deviation) SCC- Ag serum levels in patients with vulvar cancer were 1.5 (1.99) ng/mL. SCC- Ag serum levels were significantly higher in patients with pT2 vulvar cancer (2.2 [2.6] ng/mL) compared with patients with pT1 vulvar cancer (1.0 [1.2] ng/mL, P = 0.034). SCC- Ag serum levels were not associated with lymph node involvement (P = 0.1), tumor grade (P = 0.6), and patients’ age (P = 0.5). Multivariate Cox regression models considering tumor stage, lymph node involvement, patients’ age, and SCC- Ag serum levels as covariates showed that lymph node involvement (P = 0.04 and P = 0.01) and tumor stage (P = 0.006 and P = 0.009), but not SCC- Ag serum levels (P = 0.8 and P = 0.6), and patients’ age (P = 0.08 and P = 0.22) are prognostic factors for disease-free and overall survival, respectively. Conclusion. SCC- Ag serum levels cannot be used as an additional prognostic parameter in patients with surgically treated early stage vulvar cancer.

关键词：鳞状上皮细胞预测价值肿瘤分期受累程度鳞癌存活期围手术期预测参数肿瘤分级协变量

高加索子宫平滑肌瘤女性患者α雌激素受体、儿茶酚胺-O-甲基转移酶和细胞色素P450 17基因多态性的基因型分布

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 23-23页

作者： Denschlag D. Bentz E.-K. hefler L. 马超 Dept.of Obstetrics and Gynecology Royal Victoria Hospital McGill UniversityMontreal Que. CanadaDr.

Objective: To evaluate the association between the presence of uterine leiomyomas and three functional single nucleotide polymorphisms (SNPs) of the estrogen receptor alpha (ESR1), catechol- O- methyltransferase (COMT), and cytochrom P450 17 (CYP17A) genes, which have been described to modify the estrogen metabolism. Design: Prospective case control study. Setting: Academic research institution. Patient(s): One hundred thirty women with clinically and surgically diagnosed uterine leiomyomas and 139 population controls. Intervention(s): Peripheral venous puncture. Main Outcome Measure(s): Polymerase chain reaction and pyrosequencing were performed to genotype women with respect to the ESR1 IVS1- 397 T/C (PvuII), COMT G158A, and the CYP17A 34T→ C SNPs. Result(s): Comparing women with uterine leiomyomas and controls, no statistically significant differences with respect to allele frequency and genotype distribution were ascertained for ESR1 IVS 1- 397 T/C (PvuII) (P=0.9 and P=0.6, respectively), COMT G158A (P=0.3 and P=0.6, respectively), and CYP17A 34T→ C (P=0.1 and P=0.5, respectively). When all two- way interactions of investigated SNPs were ascertained, no significant interactions were observed. In a multivariate model, no SNP was significantly associated with leiomyomas. Conclusion(s): Carriage of the ESR1 IVS1- 397 T/C (PvuII), COMT G158A, and the CYP17A 34T→ C SNPs is not associated with the susceptibility to uterine leiomyoma in a Caucasian population.

关键词：子宫平滑肌瘤 α雌激素受体基因型分布甲基转移酶女性患者细胞色素儿茶酚胺基因多态性高加索病例对照研究

Nos3基因多态性与妊娠晚期不明原因胎死宫内的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 15-15页

作者： Huber A. Grimm C. jirecek S. L. hefler 张剑萍 Department of Obstetrics and Gynecology Medical University of Vienna Waehringer Guertel 18-20 A-1090 Vienna Austria

Objective: Genetic polymorphisms associated with vascular diseases have been proposed to be involved in the pathogenesis of late unexplained intrauterine fetal death (IUFD). The Nos3 gene is known to regulate vascular tone via the endothelial nitric oxide synthase/nitric oxide pathway. Study design: In a multicenter case-control study, we evaluated two Nos3 polymorphisms (exon 7 Glu298Asp and a 27 bp-repeat in intron 4) in 92 women with IUFD and 92 healthy control women. Results: The investigated Nos3 polymorphisms were not associated with the occurrence of IUFD. In the subgroup of pregnancies affected by IUFD, women with at least one mutant allele of the Nos3 intron 4 polymorphism were diagnosed with IUFD at a significantly earlier gestational age (31.8 [standard deviation (SD) = 4.9] weeks versus 34.6 [SD=4.8] weeks, p=0.02) and showed a significantly reduced birth weight (2113 g [SD = 1028] versus 1571 g [SD = 568], p = 0.03). Conclusion: We are the first to report on Nos3 polymorphisms and IUFD. While not being associated with the incidence of IUFD overall, the intron 4 Nos3 polymorphism might modulate the timing of IUFD in affected pregnancies.

关键词：妊娠晚期胎死宫内 Nos3 基因多态性正常妊娠妇女胎儿出生体重血管紧张度血管病重复序列