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Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice

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Asian Journal of Andrology 2020年第6期22卷 590-601页

作者： Chen Chu Lu Yu Joelle henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian zhang State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Genetics Reproduction and Development Laboratory CNRS UMR 6293-INSERM U1103-Universite Clermont AuvergneClermont-Ferrand 63001France Institute of Neuroscience State Key Laboratory of NeuroscieneeShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Agricultural Animal Genetics Breedingand Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of AgricultureHuazhong Agricultural UniversityWuhan 430070China Department of Cellular and Molecular Medicine University of CaliforniaSan DiegoLa JollaCA 92093-0651USA Department of Anatomy Histology and EmbryologyShanghai Jiao long University School of MedicineShanghai Key Laboratory of Reproductive MedicineShanghai 200025China department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Priority Research Centre for Reproductive Sciences School of Environmental and Life SciencesThe University of NewcastleCallaghanNSW 2308Australia.

The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various *** foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic *** mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal ***,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 *** explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m *** analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-*** agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and *** absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-***,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses.

关键词： epididymis GPX5 oxidative stress piRNA PIWI-interacting RNA small noncoding RNA

Effect of Hypertriglyceridemia on Beta-Cell Mass and Function in ApoC3 Transgenic Mice

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Effect of Hypertriglyceridemia on Beta-Cell Mass and Functio...

A new tetrahydrophenanthrene from Chloranthus henryi

中国神经科学学会第十二届全国学术会议

作者： Yun-Zi Liu Xiaoyun Cheng Ting zhang Sojin Lee Jun Yamauchi Xiangwei Xiao George Gittes Shen Qu Chun-Lei Jiang H.henry Dong Division of Pediatric Endocrinology Department of Pediatrics Children's Hospital of Pittsburgh of UPMC University of Pittsburgh School of Medicine Laboratory of Stress Medicine Faculty of Psychology and Mental HealthSecond Military Medical University Department of Endocrinology & Metabolism Shanghai 10th People's Hospital Tongji University School of Medicine Division of Pediatric Surgery Department of Surgery Children’s Hospital of Pittsburgh of UPMC University of Pittsburgh School of Medicine

Objective Hypertriglyceridemia results from increased production and decreased clearance of triglyceride-rich very low-density lipoproteins, a pathological condition that accounts for heightened risk of ischemic vascular diseases in obesity and type 2 diabetes. Despite its intimate association with insulin resistance, whether hypertriglyceridemia constitutes an independent risk for beta-cell dysfunction in diabetes is unknown. Answering to this fundamental question is stymied by the fact that hypertriglyceridemia is intertwined with hyperglycemia and insulin resistance in obese and diabetic subjects. Methods and Results To circumvent this limitation, we took the advantage of apolipoprotein C3（ApoC3） transgenic mice, a model with genetic predisposition to hypertriglyceridemia. We showed that ApoC3-transgenic mice, as opposed to age/sex-matched wild-type littermates, develop hypertriglyceridemia with concomitant elevations in plasma cholesterol and non-esterified fatty acid levels. Antiinsulin and anti-glucagon dual immunohistochemistry in combination with morphometric analysis revealed that ApoC3-transgenic and wild-type littermates had similar beta-cell and alpha-cell masses as well as islet size and architecture. These effects correlated with similar amplitudes of glucose-stimulated insulin secretion and similar degrees of postprandial glucose excursion in ApoC3-transgenic vs. wild-type littermates. Oil red O histology did not visualize lipid infiltration into islets, correlating with the lack of ectopic triglyceride and cholesterol depositions in the pancreata of ApoC3-transgenic vs. wildtype littermates. Conclusion ApoC3-transgenic mice, in spite of persistent hypertriglyceridemia, maintained euglycemia under both fed and fasting conditions without manifestation of insulin resistance and fasting hyperinsulinemia. Thus, hypertriglyceridemia per se is not an independent risk factor for beta-cell dysfunction in ApoC3 transgenic mice.

关键词： Hypertriglyceridemia Apolipoprotein C3 Beta-cell function lucosestimulated insulin secretion Mice

来源： cnki会议评论

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Chinese Chemical Letters 2010年第2期21卷 206-208页

作者： Fu, Hui Zheng Luo, Yong Ming Liu, Hua zhang, Dong Ming Ji, Teng Fei Jiangxi Univ Tradit Chinese Med Nanchang 330004 Peoples R China Chinese Acad Med Sci Inst Mat Med Key Lab Bioact Substances & Resources Utilizat Ch Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

A new tetrahydrophenanthrene named henryin A(1) was isolated from the leaves of Chloranthus *** structure was determined to be(S)-4,6,9-trimethyl-5,6,7,8-tetrahydrophenanthrene-1,2-diol on the basis of IR,MS,1D and 2D... 详细信息

关键词： Chloranthus henryi Tetrahydrophenanthrene (S)-4 6 9-Trimethyl-5 7 8-tetrahydrophenanthrene-1 2-diol

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一个忙碌的证券经纪人的罗曼史(节选)

海外英语 2006年第3期 40-41页

作者：张英欧·亨利山东科技大学　

　　今天又是哈维·麦克斯维尔的大日子.自动收录器开始吐出证券行情,桌上的电话开始响个不停.人们开始涌入交易所,隔着栏杆对他大喊大叫,有人言词激烈,有人怀有恶意,有人兴奋不已.信童拿着信件和电报跑进跑出.职员们在交易所里忙碌地... 详细信息

　　今天又是哈维·麦克斯维尔的大日子.自动收录器开始吐出证券行情,桌上的电话开始响个不停.人们开始涌入交易所,隔着栏杆对他大喊大叫,有人言词激烈,有人怀有恶意,有人兴奋不已.信童拿着信件和电报跑进跑出.职员们在交易所里忙碌地跳来跳去,就像遇上暴风雨的海员.就连皮彻的脸上也呈现出一幅充满精神和活力的表情.……

关键词：证券经纪人罗曼交易所证券行情暴风雨职员信件收录栏杆海员电话电报

Multiple SiGe/Si layers epitaxy and SiGe selective etching for vertically stacked DRAM

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Journal of Semiconductors 2023年第12期44卷 133-140页

作者： Zhenzhen Kong Hongxiao Lin Hailing Wang Yanpeng Song Junjie Li Xiaomeng Liu Anyan Du Yuanhao Miao Yiwen zhang Yuhui Ren Chen Li Jiahan Yu Jinbiao Liu Jingxiong Liu Qinzhu zhang Jianfeng Gao Huihui Li Xiangsheng Wang Junfeng Li henry HRadamson Chao Zhao Tianchun Ye Guilei Wang Key Laboratory of Microelectronics Devices&Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Research and Development Center of Optoelectronic Hybrid IC Guangdong Greater Bay Area Institute of Integrated Circuit and SystemGuangzhou 510535China Microelectronics Institute University of Chinese Academy of SciencesBeijing 100049China Hefei National Laboratory Hefei 230088China

Fifteen periods of Si/Si_(0.7)Ge_(0.3)multilayers(MLs)with various Si Ge thicknesses are grown on a 200 mm Si substrate using reduced pressure chemical vapor deposition(RPCVD).Several methods were utilized to characterize and analyze the ML *** high resolution transmission electron microscopy(HRTEM)results show that the ML structure with 20 nm Si_(0.7)Ge_(0.3)features the best crystal quality and no defects are *** Si_(0.7)Ge_(0.3)ML structures etched by three different methods were carried out and compared,and the results show that they have different selectivities and *** this work,the fabrication process influences on Si/Si Ge MLs are studied and there are no significant effects on the Si layers,which are the channels in lateral gate all around field effect transistor(L-GAAFET)*** vertically-stacked dynamic random access memory(VS-DRAM),it is necessary to consider the dislocation caused by strain accumulation and stress release after the number of stacked layers exceeds the critical *** results pave the way for the manufacture of high-performance multivertical-stacked Si nanowires,nanosheet L-GAAFETs,and DRAM devices.

关键词： RPCVD epitaxy SiGe/Si multilayers L-GAAFETs VS-DRAM

Tailoring Pore Structure and Morphologies in Covalent Organic Frameworks for Xe/Kr Capture and Separation

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Chemical Research in Chinese Universities 2021年第3期37卷 679-685页

作者： YUAN Mengjia WANG Xia CHEN Long zhang Mingxing HE Linwei MA Fuyin LIU Wei WANG Shuao State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123P.R.China School of Environment and Material Engineering Yantai UniversityYantai264005P.R.China

As a rising star among porous solid materials,covalent organic frameworks(COFs)with excellent properties including but not limit to facilely controllable structure,high porosity,and multi-chemical functionality represent significant potential for efficient 127Xe/85Kr capture and *** this study,through tuning the length of the organic ligands,two-dimensional(2D)COF materials with identical connection group but different pore properties,denoted as ATFG-COF and TpPa-COF with AA-stacking model and TpBD-COF with AB-stacking model were synthesized and tested for Kr and Xe adsorption for the first *** measurements indicate that the narrower pore apertures and higher porosity are conducive for COF materials to capture Xe and ***,the henry’s constant,isosteric heat of adsorption(Q_(st)),and ideal adsorbed solution theory(IAST)selectivity of ATFG-COF,the pore size of which is closest to the kinetic diameter of the Xe atom(0.41 nm)among 2D COF materials,were carried out based on the single component sorption *** results illustrate that the high isosteric heat values of Xe/Kr adsorption on ATFG-COF are 25 and 16 kJ/mol at room temperature,***’s law predicts that the selectivity factor of Xe to Kr is 6.07,consistent with the adsorption selectivity(ca.6)calculated based on the IAST.

关键词： Covalent organic framework Kr/Xe capture Kr/Xe separation Pore size Pore volume

下刚果—刚果扇浊积水道沉积演化与成藏主控因素——以A油田下中新统X砂组为例

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地质论评 2024年第S1期70卷 287-288页

作者：刘丽军周瑞胡俊峰程学峰任朝波方建明张红霖中国石化集团国际石油勘探开发有限公司北京100029

下刚果—刚果扇盆地为深水浊积岩油气勘探成功的典型含油气盆地。盆内广泛发育的浊积水道为重要储层类型,蕴含丰富的油气资源。前人从构造和沉积等角度对深水水道沉积模式及控制因素进行了大量研究,取得了长足进展(henry et al.,2019;... 详细信息

下刚果—刚果扇盆地为深水浊积岩油气勘探成功的典型含油气盆地。盆内广泛发育的浊积水道为重要储层类型,蕴含丰富的油气资源。前人从构造和沉积等角度对深水水道沉积模式及控制因素进行了大量研究,取得了长足进展(henry et al.,2019;陈华等,2021)。然而也有大量实钻资料表明水道体系内部砂体期次的沉积发育和叠置关系非常复杂,储层非均质性很强(张文彪等,2017)。

关键词：浊积水道沉积演化油气成藏主控因素下中新统下刚果—刚果扇盆地

延安治沟造地小流域水库氨氮对降雨变化的响应

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第四纪研究 2017年第6期37卷 1204-1218页

作者：余云龙林杭生金钊褚光琛张晶中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 中国科学院大学北京100049 Department of Ecosystem Science and Management The Pennsylvania State University University Park PA 16802 USA

地球关键带是以小流域为单元的近地表开放系统。流域内坝库体系作为小流域物质迁移的重要汇集区，将坝库水体作为研究对象，监测其物质浓度变化，并与气候变化和人类活动等因素进行关联性分析，对于理解和预测小流域物质迁移过程、规律... 详细信息

地球关键带是以小流域为单元的近地表开放系统。流域内坝库体系作为小流域物质迁移的重要汇集区，将坝库水体作为研究对象，监测其物质浓度变化，并与气候变化和人类活动等因素进行关联性分析，对于理解和预测小流域物质迁移过程、规律和变化趋势具有基础理论意义和现实指导意义。当前，流域水文过程与氮迁移的耦合研究较多关注硝态氮，而对氨氮关注较少，导致了关键带过程中水文和氮循环耦合过程的部分环节缺失。本研究以延安顾屯治沟（填沟）造地小流域为对象，研究小流域水库氨氮浓度周时间尺度的动态变化及其与降雨的联系，揭示强烈人类活动影响下黄土小流域氨氮迁移特征和可能的内在机制。通过对上游至下游5座水库氨氮浓度连续1年（2016年6月至2017年5月）的每周监测，结果表明：5座水库氨氮浓度变化均滞后于降雨事件1～2周，而与月降雨量和降雨前流域湿润指数的变化趋势相比，则滞后1个月；不同季节之间，5座水库夏季和秋季氨氮浓度远高于冬季和春季。水库与地下水的氨氮浓度变化趋势一致，且存在显著线性关系（p〈0．001），表明降雨可能通过影响地下水氨氮浓度从而影响水库氨氮浓度。降雨入渗的影响因素，如降雨量、降雨强度、降雨持续时间和降雨前流域湿润程度，控制着水库氨氮浓度上升的幅度。从空间分布来看，小流域上游至下游水库氨氮浓度呈显著正相关（p〈0.001），且相邻2座水库氨氮相关系数大于不相邻水库。降雨量较大的夏季、秋季和春季水库间氨氮浓度变化的相关性均大于降雨量较小的冬季。这些现象表明，降雨是延安治沟造地小流域水库氨氮的重要控制因素，其中水分在雨水-地下水-水库系统和上游水库-下游水库系统的迁移过程起到关键性作用。

关键词：黄土高原坝库小流域地球关键带氨氮降雨周时间尺度时空动态

Variability of SO_2 in an intensive fog in North China Plain:Evidence of high solubility of SO_2

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Particuology 2013年第1期11卷 41-47页

作者： Qiang zhang Xuexi Tie Weili Lin Junji Cao Jiannong Quan Liang Ran Wanyun Xu Beijing Weather Modification Office Key Laboratory of Aerosol SKLLQGInstitute of Earth EnvironmentChinese Academy of Sciences Center for Atmospheric Research BoulderCOUSA Chinese Academy of Meteorological Science Department of Atmospheric and Oceanic Sciences School of PhysicsPeking University

A field experiment was conducted in an intensive fog event between November 5 and November 8, 2009, in a heavily SO2-polluted area in North China Plain （NCP）, to measure SO2 and other air pollutants, liquid water content （LWC） of fog droplets, and other basic meteorological parameters. During the fog period, the concentrations of SO2 showed large variability, which was closely related to the LWC in the fog droplets. The averaged concentration of SO2 during non-fog periods was about 25 ppbv, while during the fog period, it rapidly reduced to about 4-7 ppbv. Such large reduction of SO2 suggested that a majority of SO2 （about 70%-80%） had reverted from gas to aqueous phase on account of the high solubility of SO2 in water in the fog droplets. However, the calculated gas to aqueous phase conversion was largely underestimated by merely using the henry＇s Law constant of SO2, thus suggesting that aqueous reaction of SO2 in fog droplets might play some important role in enhancing the solubility of SO2. To simplify the phenomenon, an ＂effective solubility coefficient＂ is proposed in this study. This variability of SO2 measurement during the extensive fog event provides direct evidence of oxidation of SO2 in fog droplets, thus providing important implications for better understanding of the acidity in clouds, precipitation, and fogs in NCP, now a central environmental focus in China due to its rapid economic development.

关键词： Solubility of SO2 Fogs in the North China Plain Aqueous phase reactions