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World Journal of Clinical Oncology 2021年第8期12卷 702-711页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Jhajaira M Araujo Heberth Daniel Vallejos henry Guerra henry l Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Escuela de Medicina Humana Universidad Privada San Juan BautistaLima 15067Peru Department of Medical Oncology Russian Scientific Center of Radiology and RadiotherapyKonkovo 117485MoscowRussia Department of Pathology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru

BACKGROUND Currently,the detection of PIK3CA mutations is of special interest in personalized medicine because it is frequently found in triple-negative breast cancer(TNBC).The PI3KCA mutation is an independent negative prognostic factor for survival in metastatic breast cancer,and its prognostic value in liquid biopsy as a biomarker of treatment and early relapse is under investigation,both for metastatic disease and neoadjuvant scenario with curative *** SUMMARY A 54-year-old female patient with TNBC clinical stage IIIA,who,after receiving neoadjuvant chemotherapy(based on anthracyclines and taxanes),surgery,radiotherapy,and adjuvant capecitabine,was detected with a PI3KCA mutation in tissue and peripheral blood(ctDNA in liquid biopsy).After 10 mo,the patient had disease relapse of left cervical node *** The detection of PIK3CA mutation in TNBC after neoadjuvant treatment might be associated with early relapse or rapid disease progression.

关键词： Triple-negative breast cancer PIK3CA mutation liquid biopsy Early relapse Biomarker Case report

Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy

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World Journal of Clinical Oncology 2016年第5期7卷 387-394页

作者： Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-lopez Julio Abugattas Gabriela Calderon Miguel De la Cruz Manuel Cotrina Jorge Dunstan henry l Gomez Tatiana Vidaurre Department of Research Instituto Nacional de Enfermedades Neoplasicas Department of Medical Oncology Instituto Nacional de Enfermedades Neoplasicas Department of Surgical Oncology the University of Texas MD Anderson Cancer Center Department of Pathology Instituto Nacional de Enfermedades Neoplasicas Department of Pathology Division of Pathology the University of Texas MD Anderson Cancer Center Department of Breast Cancer Surgery Instituto Nacional de Enfermedades Neoplasicas

AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIl) intriple-negative-breast-cancer(TNBC).METHODS TIls were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value lly significant. RESUlTS Higher TIl evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIl evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIl in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIl levels than those without pCR(P = 0.6331). NAC produced a TIl decrease in full-face sections(P l subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with *** TIl in pre-NAC full-face sections in TNBC are correlated to longer survival. TIl in full-face differ from TMA sections, absolute count and percentage analysis of TIl subpopulation closely related.

关键词： Triple-negative breast cancer Survival Tumor-infiltrating lymphocytes Neoadjuvant therapy

Advanced brain organoids for neuroinflammation disease modeling

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Neural Regeneration Research 2024年第1期19卷 154-155页

作者： Sonia Sabate-Soler henry Kurniawan Jens Christian Schwamborn luxembourg Centre for Systems Biomedicine University of LuxembourgEsch-sur-AlzetteLuxembourg

Brain organoids mimic closely the embryonic human brain:Over the last decade,the development of human organoid systems has evolved *** tissues have been modeled with organoids,such as the gut,lung,liver,kidney retina and *** systems have a high cellular heterogeneity,with many cell types integrated into the same ***'cellular populations interact between and amongst each other in a cellular and molecular level,which represents an advantage with respects to monolayer 2D cell culture systems.

关键词： inflammation lung kidney

Handheld bedside ultrasound in the diagnosis of myocarditis

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World Journal of Emergency Medicine 2024年第1期15卷 73-74页

作者： Frank Wheeler Robin lahr James Espinosa Alan lucerna henry Schuitema Department of Emergency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emergency Medicine Residency Program Jeff erson HealthStratford 08084USA Department of Emergency Medicine and Associate Chief Medical Offi cer Stratford 08084USA

Myocarditis is a disease process that every emergency physician fears *** severity can be mild to life-threatening,and many cases are likely undetected because they are subclinical with nonspecifi c signs.[1]Subtle cardiac signs may be overshadowed by systemic symptoms of the underlying infectious ***,myalgias,lethargy,symptoms commonly associated with viral syndrome,can mask the life-threatening myocarditis that may be *** fact,in the United States Myocarditis Treatment Trial,almost 90%of patients reported symptoms consistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myocarditis had either reduced left ventricular ejection fraction,ventricular arrhythmias,or low cardiac ***,we present a case report,in which handheld point-of-care ultrasound was utilized at the bedside to aid in the critical diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary care facility in an expeditious manner and receive possible defi nitive treatment.

关键词： diagnosis myocarditis Fever

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美国持证康复注册护士认证制度和启示

中国康复医学杂志 2016年第9期31卷 1014-1017页

作者：汪冕孟宪梅廖维靖 henry l.lew 蔡毅罗丹陈晓莉武汉大学HOPE护理学院 430071 武汉大学中南医院康复医学科 University of Hawaii at Mānoa John A. Burns School of Medicine’s communication sciences and disorders department

世界卫生组织（World Health Organization，WHO）指出，康复是为病、伤、残者提供所需工具来帮助他们重获独立和自我决策能力，使他们达到和保持最高生理、感知、智能、心理和社会功能水平。

关键词：护士认证制度康复注册美国世界卫生组织决策能力功能水平

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生物固体的应用及其对重金属的影响研究

农业环境保护 1997年第5期16卷 227-231页

作者：杨林薛栋森 C.l.henry R.B.Harrison 美国华盛顿大学森林资源学院

本文介绍了近年来美国和欧洲对生物固体（废水处理的副产物）的研究情况。研究表明：生物固体施用于农田、林地等，可促进植物生长；生物固体的来源、性质及土壤、气候、植被等都会对施用地重金属的含量、吸收、移动及形态产生影响；植... 详细信息

本文介绍了近年来美国和欧洲对生物固体（废水处理的副产物）的研究情况。研究表明：生物固体施用于农田、林地等，可促进植物生长；生物固体的来源、性质及土壤、气候、植被等都会对施用地重金属的含量、吸收、移动及形态产生影响；植物吸收重金属受土壤有机质含量、阳离子交换量、ｐＨ、质地、铁和锰氧化物等的影响；生物固体中绝大部分重金属在施用土壤后就被有机质、碳酸盐结合为稳定的、难移动的形式，被固定的量与土壤ｐＨ、粘土矿物和有机化合物的性质有关。

关键词：生物固体重金属土壤植物废水处理

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生物固体对土壤氮循环和硝态氮淋洗的影响

农业环境保护 1997年第4期16卷 182-186页

作者：杨林薛栋森 C.l.henry R.B.Harison 华盛顿大学森林资源学院

根据近２０余年有关生物固体对土壤中氮循环及硝态氮淋洗的文献综述了有关的研究结果。从生物固体中氮的形态、矿化作用、氮被植物的摄取、氨的挥发、氮的固定与储存、硝化作用、反硝化作用及铵的淋洗介绍了氮的循环；从林地及农田的生... 详细信息

根据近２０余年有关生物固体对土壤中氮循环及硝态氮淋洗的文献综述了有关的研究结果。从生物固体中氮的形态、矿化作用、氮被植物的摄取、氨的挥发、氮的固定与储存、硝化作用、反硝化作用及铵的淋洗介绍了氮的循环；从林地及农田的生物固体施用量、植被、季节及土壤的特征介绍了硝酸盐的淋洗状况。这对于生物固体合理的土地利用，发挥其正效应，以及保护环境可供参考与研究。

关键词：生物固体氮循环硝态氮淋洗土壤

In memory of Professor David Alexander Yuen

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Earthquake Research Advances 2024年第2期4卷 1-6页

作者： Gabriele Morra henry M.Tufo Ⅲ Department of Physics University of louisiana at lafayette 104 E University AveLafayette70504LouisianaUSA Department of Computer Science University of Colorado at BoulderBoulderCO80309USA

David Alexander Yuen was born on June 14,1948,in Shanghai during the Chinese Civil *** family moved to Hong Kong the following *** to the help of Senator Mike Mansfield,a Democrat from Montana,who met Dave's father during World War II,the entire family of seven moved to New York City in *** showed much enthusiasm as a student,graduating from Xavier High School in lower Manhattan in 1965,along with other successful Americans such as Supreme Court Justice Antonin *** proceeded to Caltech to study chemical physics and then moved to the chemistry department at the University of California,Berkeley in 1969,where the beginning of the plate tectonics revolution inspired him to change his focus to geophysics.

关键词： Berkeley moved lower

A biomarker study in Peruvian males with breast cancer

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World Journal of Clinical Oncology 2021年第10期12卷 926-934页

作者： Carlos A Castaneda Miluska Castillo luis A Bernabe Joselyn Sanchez Ebert Torres Nancy Suarez Katherine Tello Hugo Fuentes Jorge Dunstan Miguel De la Cruz Jose Manuel Cotrina Julio Abugattas henry Guerra henry l Gomez Faculty of Health Sciences Universidad Cientifica del SurLima 15067Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Breast Cancer Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

BACKGROUND Breast cancer(BC)frequency in males is extremely low and tumor features vary from its female *** cancer clinical and pathological features differ by race in *** infiltrating lymphocyte(TIl)levels,mismatch repair(MMR)protein loss,androgen receptor(AR)expression,and PIK3CA gene mutations are predictive biomarkers of response to biological therapy in female *** is limited information about clinical and pathological features as well as predictive biomarkers in males of non-Caucasian races with *** To investigate clinicopathological features and biomarkers of BC tumors in males and their prognostic value in Peruvian *** This study looked at a single-institution series of 54 Peruvian males with invasive BC who were diagnosed from Jan 2004 to June *** pathological features,TIl levels,MMR proteins,AR immunohistochemistry staining,and PIK3CA gene mutations were prospectively evaluated in cases with available paraffin *** of AR and estrogen receptor(ER)positive cells was additionally calculated by software after slide *** analyses included association tests,intraclass correlation test and Kaplan Meier overall survival *** The median age was 63 years and most cases were ER-positive(85.7%),HER2 negative(87.2%),luminal-A phenotype(60%)and clinical stage II(41.5%)among our male breast *** TIl was 10%and higher levels tended to be associated with luminal-B phenotype and higher ***-positive was found in 85.3%and was correlated with ER(intraclass index of 0.835,Ploss of MMR proteins was found in 15.4%and PIK3CA mutation(H1047R)in 14.3%(belonged to the luminal-A phenotype).loss of MMR proteins was associated with AR-negative(P=0.018)but not with ER(P=0.43)or TIl(P=0.84).Early stages(Plower grade(P=0.006)were associated with longer overall *** status,phenotype,AR status,TIl level,MMR protein loss nor PIK3CA mutation was not associated

关键词： Male breast neoplasm Androgen receptor Tumor-infiltrating lymphocyte Mismatch repair protein PIK3CA mutation

Immunotherapy in triple-negative breast cancer:A literature review and new advances

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World Journal of Clinical Oncology 2022年第3期13卷 219-236页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Rossana Ruiz Hugo Fuentes Carlos A Castaneda Tatiana Vidaurre Silvia Neciosup henry l Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15036Peru

Triple-negative breast cancer(TNBC)is a highly complex,heterogeneous disease and historically has limited treatment *** has a high probability of disease recurrence and rapid disease progression despite adequate systemic *** has emerged as an important alternative in the management of this malignancy,showing an impact on progression-free survival and overall survival in selected *** this review we focused on immunotherapy and its current relevance in the management of TNBC,including various scenarios(metastatic and early-neoadjuvant,adjuvant-),new advances in this subtype and the research of potential predictive biomarkers of response to treatment.

关键词： Triple-negative breast cancer Early disease Immunotherapy Biomarkers Metastatic disease