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Effect of Monosodium Glutamate on Behavioral Phenotypes, Biomarkers of Oxidative Stress in Brain Tissues and Liver Enzymes in Mice

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World Journal of Neuroscience 2015年第5期5卷 339-349页

作者： Solomon Umukoro Gabriel Oluwafemi Oluwole henry egbewunmi olamijowon Adrian Itiviere Omogbiya Anthony Taghogho Eduviere Department of Pharmacology and Therapeutics College of Medicine University of Ibadan Ibadan Nigeria Department of Pharmacology and Therapeutics College of Health Sciences Delta State University Abraka Nigeria Department of Pharmacology and Therapeutics College of Medicine and Health SciencesAfe Babalola University Ado-Ekiti Nigeria

The effects of oral administration of low doses of monosodium glutamate (MSG) on behavioral phenotypes, biomarkers of oxidative stress in the brain and liver enzymes in mice were evaluated in this study. Mice were treated orally with MSG (100, 250 and 500 mg/kg) daily for 21 days before testing for behavioral phenotypes;memory, anxiety, spontaneous motor activity (SMA) and depression. Thereafter, the brain levels of malondialdehyde (MDA) and glutathione (GSH) as well as the activities of liver enzymes, aminotransferase (AST) and alanine aminotransferase (ALT) were determined spectrophotometrically. MSG did not produce significant (P?> 0.05) impairment of memory in the Y-maze test. It also failed to modify the behaviors of mice in the elevated plus maze and light/dark transition tests of animal models of anxiety. MSG had no significant effect on SMA but produced depressive-like symptoms in the forced swim test at a dose of 500 mg/kg. Moreover, it increased the levels of MDA and decreased GSH concentrations in brain tissues of mice. The activity of AST and ALT were elevated in the blood of MSG-treated mice suggesting liver injury. Taken together, these findings suggested that MSG induced oxidative stress in the brain and impaired liver functions but did not produce any behavioral abnormalities in mice at lower doses.

关键词： Monosodium Glutamate Depression Oxidative stress Liver Enzymes

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