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Vitamin D and Secondary Hyperparathyroidism in HIV Infected Patients Taking Antiretroviral Therapy

World Journal of AIDS 2014年第4期4卷 430-437页

作者： Huylmer Lucena Chaves henrique pires moreira Hayato Augusto Hossoe Correa William Browne de Oliveira Machado Rian Brito Teles Lucigleyson Ribeiro do Nascimento Janedson Baima Bezerra Filho Camilla Camuza Coelho Rabelo Queiroz Danilo Goncalves Nobrega Ana Carolina Vasconcelos moreira Maria Carolina Nunes Albano de Meneses Fabricio de Maicy Bezerra Melissa Soares Medeiros Medicine School UNICHRISTUSFortalezaBrazil Fortaleza General Hospital FortalezaBrazil Sso Jose Hospital of Infectious Diseases FortalezaBrazil

Objective: Due to the lack of studies assessing hypovitaminosis D and secondary hyperparathyroidism in Brazilian HIV-infected population, especially in the northeastern population, this study aimed to determine the profile of these conditions in patients infected with HIV and its correlation with immuno-virological, sociodemographic data and associated comorbidities. Methods: Comparison studies were obtained from routine clinical samples of HIV infected patients submitted for 25-OH Vitamin D, PTH and alkaline phosphatase determination. Results: A total of 78 patients were included, 42 (53.8%) males, mean age 45.7 years. Antiretroviral regimens most used in this study were Zidovudine/Lamivudine/Efavirenz 17.9%, Tenofovir/Lamivudine/Efavirenz 17.9%,Tenofovir/Lamivudine/Atazanavir-r 15.4%. The mean value CD4 count was 592.1 ± 247.2 cells/mm3, CD8 cell count was 1026.5 ± 467.3 cells/mm3, mean detectable viral load was 2220 ± 15703 copies and CD4/CD8 ratio was 0.63 ± 0.33. A total of 34 vitamin D dosages were collected with 41.2% representing sufficient amount and 58.8% insufficient. Alkaline Phosphatase (ALP) dosage was elevated in 49.3% (N=35) of the patients. Parathormone (PTH) was elevated in 18% (N = 11). Among patients with elevated PTH levels, 81.9% had elevated levels of ALP (p = 0.01). In the group of patients with high levels of ALP, 45.7% had a CD4 count 3 (p = 0.02). There was no significant difference in vitamin D related to gender (p = 0.21), age (p = 0.23), CD4 count (p = 0.26), suppressed viral load (p = 0.44) or blood glucose (p = 0.45). Conclusions: This study evidenced a high prevalence of Vitamin D insufficiency in Northeast Brazil, which suggests HIV infection correlation. A high prevalence of Hyperparathyroidism was detected and related with inflammatory condition persistence and low CD4 count. We suggest improve vitamin D follow up and measurements in this population with better CD4 count control to avoid future osteoarticular complications of HIV

关键词： HIV Hyperparathyroidism Vitamin D Antiretroviral Therapy

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Improving sexual and reproductive health knowledge and practice in Mozambican families with media campaign and volunteer family health champions

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Family Medicine and Community Health 2019年第4期7卷 18-23页

作者： Paulo henrique pires Ronald Siemens Martins Mupueleque Health Sciences Faculty Lúrio University Lúrio UniversityNampulaMozambique University of Saskatchewan College of Medicine SaskatoonSaskatchewanCanada Universidade Mussa bin Bique NampulaNampulaMozambique

Objective To increase knowledge,attitudes and practice of sexual and reproductive health and family planning and to reduce maternal and neonatal mortality rates in *** An implementation research project’s intermediate evaluation,applying two cross-sectional *** surveys were planned for 316 subjects before and after *** Research performed in Natikiri district of Nampula province in northern Mozambique,targeting a suburban and rural populations in their *** 452 people were surveyed(91 before,361 after),all belonging to the Macua ethnic *** A media campaign(2 weekly radio spots,bimonthly theatre performances)was performed for 8 months(2017 to 2018)and family health champions’teachings(monthly home visits)performed for 3 months,on sexual and reproductive health and family *** measures planned and measured were adolescent’s and adult’s knowledge,attitudes and practice about *** were analysed by gender,age group and frequencies,using a CI of 95%(p<0.5 statistically significant).results Radio spots,community theatre and volunteer champions increased population’s knowledge about sexual and reproductive health and led to a more positive attitude toward family *** attitude,results show differences between adults’proportions before and after:(1)did you hear about sexual and reproductive health(p=0.0425);(2)knows project key messages(p<0.001);(3)knows prenatal visits importance(p=0.0301);(4)access to contraceptives was easy(p<0.001).Adolescents showed statistically significant differences before and after:(1)knows project key messages(p<0.001);(2)access to contraceptives was easy(p=0.0361).Family planning practice did not increase in both *** A health education intervention,using a media campaign and local volunteers,is useful to promote mother and child *** is an unmet need for family planning and the use of modern contraception is below desired pra

关键词： knowledge media campaign

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Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

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Journal of Animal Science and Biotechnology 2018年第1期9卷 228-232页

作者： Lúcio Flávio Macedo Mota Cristina moreira Bonafé Pamela Almeida Alexandre Miguel henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu Departmento de Zootecnia Universidade Federal dos Vales do Jequitinhonha e MucuriDiamantinaMG 39100 000Brazil Faculdade de Ciencias Agrarias e Veterinarias Universidade Estadual Paulista JaboticabalSP 14884 900Brazil Departamento de Medicina Veterinaria Faculdade de Zootecnia e Encjenharia de AlimentosUniversidade de Sao PauloAM.Duque de Caxias Norte n225Pirassununcja 13635 900SPBrazil Departmento de Zootecnia e Desenvolvimento Acjrossocioambiental Sustentavel Faculdade de VeterinariaUniversidade Federal FluminenseNiteroiRJ 24230 340Brazil Departamento de Zootecnia Faculdade de Zootecnia e Engenharia de AlimentosUniversidade de Sao PauloPirassununga 13635-900SPBrazil

Background： Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the *** this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake（DMI） and average daily gain（ADG） of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake（RFI） and select 20 animals for the high feed efficient（LRFI） and 20 for the low feed efficient（HRFI） groups. Blood samples were collected on d 56 and at slaughter（80 d） to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression ***： DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter（P = 0.0049）. Gene expression of leptin were greater in LRFI animals（P = 0.0022） in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene ***： These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake.

关键词： Beef cattle Energy homeostasis Fat depositon Residual feed intake

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Diagnosis of Boron Deficiency in Green Dwarf Coconut Palm

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Agricultural Sciences 2015年第1期6卷 164-174页

作者： Leandro Glaydson da Rocha Pinho Pedro henrique Monnerat Andre Assis pires Marta Simone Mendonca Freitas Claudio Roberto Marciano Instituto Federal do Espirito Santo Campus ItapinaColatinaBrazil Universidade Estadual do Norte Fluminense Campos dos GoytacazesBrazil

The diagnosis of boron deficiency in coconut palms has been hampered by lack of information about its distribution in the plant. Two experiments were conducted, one in a greenhouse to induce boron deficiency in dwarf green coconut palms, and other in the field, in which the plants received doses of boric acid, B(OH)3. The objective was to verify symptoms of boron deficiency and boron content variation in canopy, leaves and folioles (or leaflets). Boron deficient plants led leaves and folioles to become deformed. The deficient and sufficient contents of boron varied significantly in the canopy, but did not vary in leaves. The boron content increased significantly from bottom to the apex of the folioles in both treatments. To survey the level of boron in the coconut palm, the ideal is, using samples taken from the youngest leaf, to calculate the relation between the boron content in the apex of the foliole and the content in the center or in the folioles bottom, with minimum values 2.2 or 2.7, respectively.

关键词： Symptoms Leaf Analysis Deficiency Induction Boric Acid Samples Cocos nucifera

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Floristic and Structural Analysis of Urban Tree Canopy: From Its Ecology to Its Social Issues

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Journal of Geoscience and Environment Protection 2024年第11期12卷 1-28页

作者： Richieri Antonio Sartori Ana Paula Balderi Camila Conti Anna Thereza Carcamo henrique Rajão Jakeline Prata de Assis pires Department of Biology Pontifical Catholic University of Rio de Janeiro Rio de Janeiro Brazil Copaba Environmental Association Socorro Brazil Institute of Biology Unicamp Campinas Brazil

Currently, urban areas are the largest segment of the world’s population, and they can reach up to 80% of it in some countries. Understanding green areas is of paramount importance to also understand the population’s mental health and well-being, as well as to achieve ecological understanding and its impact on urban infrastructure. Thus, the aim of the present study is to carry out a survey on both urban afforestation structure and on its social impact on a Brazilian municipality. It also sought to understand the damages caused by these species to urban infrastructure in comparison to data collected in 2009, to assess forest coverage in this municipality and tree planting underutilized capacity. Accordingly, all the streets in this municipality’s urban area, the botanical data of each tree and its damage to the city’s infrastructure and phytosanitary conditions were surveyed (from 1 to 5). Data were compared to those from the 2009 census, and social issues were analyzed. In total, 5044 individuals belonging to 189 species were recorded. The most often found species were Lagerstroemia indica and Murraya paniculata. Out of the total number of trees, 458 trees scored at least one score “5” in one of the criteria, and this number represents 8.9% of the total of the trees. L. indica was the species accounting for the highest rates of phytosanitary and infrastructure issues. Data comparison evidenced that urban tree canopy lost 25% of its vegetation between the two measurements taken herein, but the number of species has increased. When it comes to damages, many trees started showing phytosanitary issues or damage to urban infrastructure.

关键词： Urban Ecology Urban Tree Canopy Impact on Urban Infrastructure Socorro-SP Green Coverage

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Climate Justice Dimensions:Approaching Loss and Damage and Adaptation towards a Just City

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Journal of Geographical Research 2023年第4期6卷 26-44页

作者： Pedro henrique Campello Torres Gabriel pires de Araújo Marcos Tavares de Arruda Filho Isabela Carmo Cavaco Beatriz Dunder Institute of Energy and Environment University of São PauloSão Paulo05508-900Brazil

The escalating occurrence of severe climatic events over the past decade,with a projection for further intensification due to the climate emergency,underscores the critical role of urban and regional planning in climate action towards just *** and regions are both significant contributors to CO_(2)emissions and are vulnerable to the adverse impacts of climate *** paper contends that urban and regional planning must undergo a paradigm shift to address this *** justice,encompassing dimensions of inequality and environmental equity,is a pivotal dialogue in these *** a comprehensive review,this study contributes to the evolving landscape of climate justice planning and policy,offering insights that could resonate across the Global South and *** an illustrative case,the authors delve into Brazil’s climate challenges,discussing adaptation planning and post-disaster response,and emphasizing the need for localized and community-driven *** article delves into the interplay between Loss and Damage,adaptation,and just cities,with a focus on the Global *** authors scrutinize the emerging discourse on Loss and Damage,its associations with climate impacts,and the quest for a just and equitable *** work advances the understanding of the distinction between adaptation and Loss and Damage actions,highlighting the significance of a dedicated fund for addressing Loss and Damage in vulnerable countries.

关键词： Climate justice Loss and Damage Global South Just adaptation Brazil

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Chia Seeds Storage in Different Environmental Conditions and Packages

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American Journal of Plant Sciences 2018年第1期9卷 74-82页

作者： Claudia Kely pires de Mattos Sorana Fernanda Brito Cardoso Carlos henrique Queiroz Rego Ana Carina da Silva Candido Charline Zaratin Alves Federal University of Mato Grosso do Sul UFMS Chapadao do Sul Mato Grosso do Sul Brazil

In general, seeds are not used immediately after harvesting. For this reason, they have to be stored for future use, which requires the maintenance of their viability during the storage time by applying the appropriate conservation technology for each species. This study aimed to evaluate whether package and environmental conditions interfere with the physiological quality of chia seeds (Salvia hispanica L.) stored for 12 months. The experiment consisted of a completely randomized design in a 3?× 3 × 4 factorial scheme, with four replications, using three packages, three storage environments, and four storage times. After each storage time, seeds were subject to germination and vigor tests (emergence and electrical conductivity). Chia seeds can be stored in a cold or dry chamber, in plastic, glass, or paper containers, for 12 months, without hindering seeds physiological quality.

关键词： Conservation Storage Physiological Quality Salvia hispanica

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Enteroparasitoses in Patients with Rheumatoid Arthritis

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Advances in Infectious Diseases 2017年第4期7卷 143-152页

作者： Ana Paula Monteiro Gomides Alex Luiz de Oliveira pires Cleandro pires Albuquerque Talita Yokoy de Souza Luciana Muniz Caliandra Maria Bezerra Luna Lima Leopoldo Luiz Santos-Neto Licia Maria henrique da Mota Universidade de Brasília (UnB) Brasília Brazil Universidade Federal da Paraíba Jo&#227 o Pessoa Brazil

Background: Patients with rheumatic diseases have profound alterations in the immune system as a result of underlying diseases and the treatments used, which increases the risk of occurrence and severity of infections, including enteroparasitosis. The current treatment for rheumatoid arthritis involves immunosuppressive therapies powerfully needed for screening infectious processes. The prevalence of parasitic infections in rheumatoid arthritis patients is not currently documented in literature. The objective of the current study was to determine the prevalence of parasitic diseases in a population with RA. Methods: We collected demographic and socioeconomic data from 67 patients at the Hospital Universitário de Brasília from July 2015 to April 2016. All patients underwent a parasitological examination of their stool and multiple variables were analyzed using Poisson regression method. Results: The mean age of patients was 53.9 years. They were predominantly in women (94%) and caucasian (47.8%). The mean disease duration was 9.2 years and most patients had the disease in remission or light activity. The prevalence of parasitic infections in these patients was 11.9%, all cases being that of protozoa of the following species: Endolimax nana, Entamoeba histolytica and Entamoeba coli. The final multivariate analysis indicated that the presence of disease had a significant statistical relationship between the presence of enteroparasitosis and rheumatoid arthritis with no fatigue by VAS (p = 0.0488) and best current health index by VAS (p = 0.0012). Conclusion: This study indicates that the prevalence of enteroparasitoses in a population with Rheumatoid Arthritis was 11.9% and all cases were found of protozoa.

关键词： Parasitic Infections Rheumatoid Arthritis Protozoosis Enteroparasitoses Intestinal Infection

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Porcine Circovirus 2:Immunopathogenesis and Recent Developments in Vaccines

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World Journal of Vaccines 2012年第2期2卷 96-104页

作者： Abelardo Silva Junior Otavio Valerio de Carvalho Luiz henrique Silva Bulos Juliana Lopes Rangel Fietto Mauro pires Moraes Marcia Rogeria de Almeida Animal Virology Laboratory Veterinary DepartmentFederal University of VicosaVicosaBrazil Molecular Animal Infectology Laboratory Applied Biotechnology Institute(BIOAGRO)Federal University of VicosaVicosaBrazil Plum Island Animal Dis-ease Center New YorkUSA

Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. This virus is frequently associated with postweaning multisystemic wasting syndrome (PMWS), and also with other clinical conditions such as porcine dermatitis and nephropathy syndrome (PDNS), late-term abortions, reproductive failure in sows, proliferative and necrotizing pneumonia and congenital tremors. The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are associated with PCV2 infection. The PCV2 was recognized as a pathogen in 1997, and many questions regarding its biology and pathogenesis remain unanswered. Currently, some studies have shown the production of new vaccine candidates and field efficacy testing of commercial vaccines. This review discusses some major points concerned with immunopathogenesis and vaccines for PCV2 infection.

关键词： Porcine circovirus 2 Vaccine Immunopathogenesis

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Antifungal Activity of Oleoresin and Fractions of Pinus elliottii Engelm and Pinus tropicalis against Phytopathogens

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American Journal of Plant Sciences 2014年第26期5卷 3898-3903页

作者： Gessica Andrade Fariza Abrao Patrick Silva Sergio Ricardo Ambrosio Rodrigo Cassio Sola Veneziani Wilson Roberto Cunha Regina Helena pires Carlos henrique G.Martins Laboratory of Research in Applied Microbiology University of FrancaFrancaBrazil Research Group on Natural Products University of FrancaFrancaBrazil

Microorganism resistance to the existing products is yet another difficulty that agriculturalists have to deal with. In this context, the search for new agricultural products that can fight phytopathogens has become increasingly important. Plants have played an important role in this process, because they can serve as a source of new compounds for drug discovery. Plants belonging to the genus Pinus produce an oleoresin that protects the plant against herbivores and pathogens. With a view to developing products that can combat fungal pathogens without harming the environment, this work aimed to evaluate the antifungal activity of the oleoresins and fractions of Pinus elliottii Engelm and Pinus tropicalis against phytopathogens. The methodology based on NCCLS M38-A standards aided antifungal activity assessment. The microdilution method helped to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). The oleoresins of P. elliottii and P. tropicalis afforded the most significant results—they displayed fungicidal activity against all the tested species. MIC values were promising, especially the MIC of the oleoresin of P. elliottii against S. rolfsii (1.95 μg·mL-1). The MIC values of the oleoresins of P. elliottii and P. tropicalis ranged from 1.95 to 1000 μg·mL-1 and from 31.25 to 250 μg·mL-1, respectively. Fraction PT2 of P. tropicalis furnished the best results among all the assayed fractions: MIC values lay between 125 and 500 μg·mL-11. In conclusion, the oleoresin of P. tropicalis is a promising source of new antifungal agents for application in the treatment of phytopathogenic infections.

关键词： Pinus elliottii Pinus tropicalis Phytopathogens Antifungal Activity Oleoresin

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