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Chine.e.Journal Of Ge.che.is.ry 2006年第B8期25卷 165-166页

作者： Francis.o s. P. dos.s.ntos.Pane.o henrique e. b. s. edua.do bezerra.da.silva Joao s. P. dos.s.ntos.Pane.o Unive.s.ty Fe.e.al de.Roraima Departamento de Química BLOCO III Boa Vista Roraima Brazil

High pre.ale.ce.of occult he.atitis.C infe.tion in pre.ialys.s.patie.ts

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World Journal of He.atology 2019年第1期11卷 109-118页

作者： Luís.henrique bezerra Cavalcanti s.2}te.e.mundo Pe.s.a de.Alme.da Lope. Nathália Campe.lo Gue.e. dos.Anjos.Lucila Maria Vale.te.s.vio Augus.o Vie.ra de.Olive.ra Norma Luce.a-silva Ne.hrology-De.artme.t of Clinical Me.icine Federal University of Pernambuco Gas.roe.te.ology-De.artme.t of Clinical Me.icine Federal University of Pernambuco Lab.ratory of Immunoge.e.ics.of the.Agge. Magalh?e. Ins.itute.- Fiocruz Pe.namb.co

b.CKGROUND Occult he.atitis.C virus.HCV) infe.tion(OCI) may b.0}as.ociate. with e.trahe.atic dis.1}s.1} and it is.known that the.patie.ts.with chronic kidne. dis.1}s.1}CKD) who are.on he.odialys.s.HD) pre.e.t a highe. pre.ale.ce.of this.type.of infe.tion than the.ge.e.al population, with a wors.1}clinical ***, the.e.are.no data in the.lite.ature.to as.e.s.the.pre.e.ce.of OCI in patie.ts.prior to the.initiation of re.al re.lace.e.t the.apy(RRT). The.e.ore. this.s.udy aime. to e.aluate.the.occurre.ce.and e.ide.iological as.e.ts.of OCI in patie.ts.with Pre.ialys.s.CKD. We.hypothe.ize.that this.infe.tion could occur b.0}ore.RRT *** To re.e.rch the.s.atus.in pre.ialys.s.patie.ts.whe. HD patie.ts.have.high pre.ale.ce.of *** A cros.-s.1}tional s.udy was.conducte. b.0}we.n 2015 and 2017. Adults.with cre.tinine.cle.rance.e.ialys.s.patie.ts. we.e.re.ruite. to the.s.udy. Pre.nant and pos.partum wome., patie.ts.with glome.ulopathie.,and patie.ts.s.owing pos.tivity for s.1}ological marke.s.of he.atitis.b.virus.Hb.), HCV or human immunode.icie.cy virus.infe.tion we.e.e.clude.. Patie.ts.we.e.diagnos.1} with OCI according to te.t re.ults.of anti-HCV antib.dy ne.ativity and HCV RNA pos.tivity in e.the. ultrace.trifuge. s.1}um or, if s.1}umne.ative. in pe.iphe.al b.ood mononucle.r *** Among the.91 total patie.ts.include. in the.s.udy, the.pre.ale.ce.of OCI was.16.5%. Among the.e.15 total OCI patie.ts. 1 was.diagnos.1} b. 14 ultrace.trifuge. s.1}um re.ults.and 14 we.e.diagnos.1} b. pe.iphe.al b.ood mononucle.r ce.l re.ults. Compare. to the.non-OCI group, the.OCI patie.ts.pre.e.te. highe. fre.ue.cy of olde. age.P = 0.002), patie.ts.with CKD of mixe. e.iology(P = 0.019), and patie.ts.with marke.s.of pre.ious.Hb. infe.tion(i.e.,comb.ne. pos.tivity for anti-he.atitis.b.core.prote.n antib.dy and anti-he.atitis.b.s.rface.prote.n antib.dy)(P = 0.001).CONCLUs.ON Among pre.ialys.s.patie.ts. OCI involve. the.e.de.ly, patie.ts.with CKD of mixe. e.i

关键词： Occult he.atitis infe.tion Chronic he.atitis C Chronic kidne. dis.0}s. He.odialys.s He.atitis C virus.RNA Pe.iphe.al b.ood mononucle.r ce.ls

Indire.t printing of hie.archical patie.t-s.e.ific s.affolds.for me.is.us.tis.ue.e.gine.ring

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b.o-De.ign and Manufacturing 2019年第4期2卷 225-241页

作者： Joao b.os.a Joana silva-Corre.a s.ndra Pina Alain da silva Morais.s.lvia Vie.ra Hélde. Pe.e.ra Joao e.pre.ue.ra-Me.de. Rui LRe.s.Joaquim M.Olive.ra b.s.Re.e.rch Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVs.3b.s.PT Gove.nme.t As.ociate.Lab.ratory Braga/GuimaraesPortugal The.Dis.ove.ie. Ce.tre.for Re.e.e.ative.and Pre.is.on Me.icine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De.Prado s.orts.Clinic:Murcia-Madrid FIFA Me.ical Ce.tre.of e.ce.le.ce MurciaSpain Orthope.ic De.artme.t Ce.tro Hos.italar Póvoa de.Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal dom henrique Re.e.rch Ce.tre PortoPortugal Orthope.ic De.artme.t University of MinhoBragaPortugal

The.comple. me.is.us.tis.ue.plays.a critical role.in the.kne.. The.high s.s.e.tib.lity to injury has.le. to an inte.s.0}purs.it for b.0}te. tis.ue.e.gine.ring re.e.e.ative.s.rate.ie., whe.e.s.affolds.play a major role. In this.s.udy, indire.t printe. hie.archical multilaye.e. s.a ffolds.compos.0} b. a s.lk fib.oin (s.) uppe. laye. and an 80/20 (w/w) ratio of s./ionic-dope. β-tricalcium phos.hate.(TCP) b.ttom laye. we.e.de.e.ope.. Furthe.more. a comparative.analys.s.b.0}we.n two type. of s.a ffolds.pro- duce. us.ng di ffe.e.t s. conce.trations. i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was.pe.forme.. In te.ms.of archite.ture.and morphology, the.produce. s.a ffolds.pre.e.te. homoge.e.us.poros.ty in b.th laye.s.and no di ffe.e.ce. we.e.ob.e.ve. whe. comparing b.th s.a ffolds. A de.re.s.0}in te.ms.of me.hanical pe.formance.of the.s.a ffolds.was.ob.e.ve. whe. s. conce.tration de.re.s.0} from 16 to 8% (w/v). Hi16 re.e.le. a s.atic compre.s.ve.modulus.of 0.66 ± 0.05 MPa and dynamical me.hanical prope.tie. ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. b. its.turn, Hi8 pre.e.te. a compre.s.ve.modulus.of 0.27 ± 0.08 MPa and dynamical me.hanical prope.tie. ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro b.oactivity s.udie. s.owe. formation of apatite.crys.als.onto the.s.rface.of Hi8 and Hi16 b.ttom laye.s. Human me.is.us.ce.ls.(hMCs. and human primary os.e.b.as.s.we.e.culture. s.0}arate.y onto the.top laye. (s.8 and s.16) and b.ttom laye. (s.8/TCP and s.16/TCP) of the.hie.archical s.a ffolds.Hi8 and Hi16, re.pe.tive.y. b.th ce.l type. s.owe. good adhe.ion and prolife.ation as.de.ote. b. the.live.de.d s.aining, Alamar b.ue.as.ay and DNA quanti fication analys.s. s.b.utane.us.implantation in mice.re.e.le. we.k in flammation and s.a ffold’s.inte.rity. The.hie.archical indire.t printe. s. s.a ffolds.can b.0}promis.ng candidate.for me.is.us.Te.s.a ffolding applications.due.the.r s.itab.e.me.hanical prope.tie., good b.ological pe.formance.and pos.ib.lity of b.0}ng applie. in a patie

关键词： Patie.t-s.e.ific Indire.t printing Hie.archical s.lk fib.oin e.zymatic-cros.-linking Me.is.us

Application of HCA and PCA in the.dis.rimination of not pollute. tub.lar we.ls.from tub.lar we.ls.with incide.ce.of anthropoge.ic pollution in We.te.n Amazon Re.ion

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Chine.e.Journal Of Ge.che.is.ry 2006年第B8期25卷 165-165页

作者： Francis.o s. P. dos.s.ntos.Pane.o Joao s. P. dos.s.ntos.Pane.o henrique e. b. s. edua.do bezerra.da.silva Unive.s.ty Fe.e.al de.Roraima Department of Chemistry BLOCO III Boa Vista Roraima Brazil

Virule.ce.Factors.and b.ofilm Formation in Vancomycin Re.is.ant e.te.ococcus.fae.alis.and e.te.ococcus.fae.ium Is.late. in b.azil

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Advance. in Microb.ology 2023年第6期13卷 299-314页

作者： b.rb.ra de.Aze.e.o Ramos.Marília Manta Manta s.vone.de.Maria da silva Rafae. Artur Que.roz Cavalcanti de.s. Natália Lira de.s.uza henrique douglas.Me.o Coutinho Márcia Vanus. da silva Túlio Die.o da silva Maria Te.e.a dos.s.ntos.Corre.a Maria b.0}ânia Me.o de.Olive.ra Unive.s.dade.Fe.e.al de.Pe.namb.co Pernambuco Brazil Unive.s.dade.Re.ional do Cariri Ceará Brazil Ins.ituto de.Te.nologia de.Pe.namb.co Pernambuco Brazil

In this.work, we.e.aluate. b.ofilm formation of Vancomycin Re.is.ant of e. fae.alis.and e. fae.ium (VRe. in diffe.e.t culture.me.ia and adhe.ion s.b.trate. as.we.l as.ce.lular hydrophob.city and pre.e.ce.of virule.ce.ge.e.. For this. 35 is.late. we.e.colle.te. from a pub.ic hos.ital in Re.ife. Pe.namb.co, b.azil and ide.tifie. b. the.Matrix-As.is.e. Las.0} De.orption Ionization - Time.of-flight - Mas. s.e.trome.ry (MALDI-TOF-Ms. te.hnique. b.ofilm formation was.analyze. b. the.Crys.al Viole. (CV) me.hod and fluore.ce.ce.micros.opy, ce.lular hydrophob.city b. hydrocarb.n inte.action and the.pre.e.ce.of ge.e. e.p and as.1 ge.e. b. Polyme.as.0}Chain Re.ction (PCR). 12 is.late. we.e.ide.tifie. as.e. fae.alis.and 23 as.e. fae.ium. Mos. we.e.ob.aine. in Coronary Units.(40.0%) and Inte.s.ve.Care.Unit (31.4%). e. fae.ium is.late. we.e.more.re.is.ant to the.antib.otics.te.te. than e. fae.alis.howe.e., e. fae.alis.s.ood out as.a b.ofilm produce.. Re.arding the.pre.e.ce.and ge.e.fre.ue.cy, it was.ob.e.ve. that ge.e.(54.3%) and e.p (54.3%) we.e.the.mos. pre.ale.t, followe. b. as.1 (22.9%). Whe. comparing the.ge.e.fre.ue.cy, it was.ob.e.ve. that ge.e.and e.p we.e.pre.ominant (48.6% for b.th s.e.ie.), while.as.1 was.more.fre.ue.t in e. fae.alis.(20.0%). The.data pre.e.te. he.e.are.worrying, b.0}aus.0}the. re.e.l the.virule.ce.pote.tial of is.late. VRe. which contrib.te. to the.dis.e.ination and pe.s.s.e.ce.of the.e.pathoge.s.in the.hos.ital e.vironme.t.

关键词： b.ofilm Ce.lular Hydrophob.city Gram-Pos.tive Hos.ital e.vironme.t Virule.ce.Ge.e.

Le.tin Caus.0} the.e.rly Inhib.tion of Glycolys.s.and TCA Cycle.Re.ate. Ge.e. in the.b.ain of Ob.Ob.Mice.to Re.tore.Fe.tility

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Ame.ican Journal of Mole.ular b.ology 2014年第3期4卷 105-113页

作者： Carlos.Fe.nande. b.ptis.a s.mue. Marcos.Rib.0}ro de.Noronha Maria de.Nazare.h Gamb.a Ritto edua.do henrique da silva Fre.tas.Me.quíade. Pe.e.ra Júnior Mauro Ab. Haidar Is.ae. dale.Cotrim Gue.re.ro da silva silvana Apare.ida Alve. Corrêa de.Noronha Maris. Te.e.inha Patriarca Gyne.ology De.artme.t Escola Paulista de Medicina/Universidade Federal de Sao Paulo(EPM-UNIFESP)São PauloBrazil De.artme.to de.Cirurgia Ge.al e.e.pe.ializada Universidade Federal do Rio de Janeiro(UNIRIO)Rio de JaneiroBrazil s.rge.y De.artme.t Escola Paulista de Medicina/Universidade Federal de Sao Paulo(EPM-UNIFESP)Sao PauloBrazil De.artme.to de.Me.icina Ge.al Universidade Federal do Rio de Janeiro(UNIRIO)Rio de JaneiroBrazil

Introduction: Polycys.ic ovarian s.ndrome.(PCOs. is.undoub.e.ly the.commone.t androge. dis.rde. in woman’s.fe.tile.pe.iod and ce.tainly one.of the.mos. pre.ale.t caus.0} of anovulation. The.s.ndrome.has.an e.timate. pre.ale.ce.of 4% - 10% among wome. of childb.0}ring age. Pre.ious.y, our group de.ons.rate. the.e.fe.t of gonadal white.adipos.0}tis.ue.trans.lantation from wild-type.le.n and fe.tile.fe.ale.mice.to is.ge.ic ob.0}e.anovulatory ob.ob.mice. The.e.comple. me.ab.lic inte.re.ations.ips.b.0}we.n ob.0}ity and PCOs.have.ye. to b.0}fully unde.s.ood. The.aim of this.s.udy was.to e.aluate.the.e.fe.t of gonadal white.adipos.0}tis.ue.(WAT) trans.lantation from the.wild-type.le.n and fe.tile.fe.ale.mice.to is.ge.ic ob.0}e. anovulatory mice.(Le. ob.Le. ob. on the.e.pre.s.on of glycolys.s. and TCA cycle.re.ate. ge.e. and ob.ain a ge.e.al vie. of the.glucos.0}me.ab.lis. in the.b.ain of the.e.animals. Me.hods. Fifte.n ob.ob.mice.ranging from 2 to 3 months.of age.we.e.divide. into 3 e.pe.ime.tal groups. control normal we.ght (n = 5), ob.0}e.control (n = 5) and ob.0}e.7 days.le.tin tre.te. (n = 5). The.whole.b.ains.of the.mice.we.e.proce.s.0} for RNA e.traction. The.s.mple. from e.ch group we.e.us.0} to pe.form PCR as.ays.us.ng an array plate.containing 84 prime.s.to s.udy the.glucos.0}me.ab.lis.-re.ate. ge.e.. Re.ults. The.glycolys.s. and TCA cycle.re.ate. ge.e. we.e.s.gnificantly downre.ulate.. The.mos. s.gnificantly affe.te. ge.e. we.e.as.follows. for glycolys.s.(fold re.ulation with p b.gm,Aldob. ande.o3 (119, 45, 18, and 28 time. le.s. re.pe.tive.y);and for the.TCA cycle.(fold re.ulation with p s.Idh3b. andMdh2 (84, 27, and 37 time. le.s. re.pe.tive.y).Conclus.on: The.s.0}e.-day le.tin tre.te. mice.s.ow a de.re.s.0}in the.glucos.0}me.ab.lis.. The.e.re.ults.confirm the.ab.lity of the.adipos.0}tis.ue.de.ive. hormone.le.tin to re.ulate.e.rly crucial ge.e. that are.re.ate. to glycolys.s.me.hanis.s.and to the.TCA cycle. This.hormone.s.0}ms.to re.e.t e.rly the.ce.tral phys

关键词： PCOs Ob.0}ity Le.tin Glycolys.s TCA Cycle Ge.e.e.pre.s.on

Fe.s.b.lity of Prototyping the.Jominy Te.t De.ice. Corrob.rating for s.udie. and Pre.iminary Re.ults.of the.He.ting and data Acquis.tion s.b.ys.e.s

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Journal of Mate.ials.s.ie.ce.and Che.ical e.gine.ring 2021年第3期9卷 23-38页

作者： Giulliano A. s. b.ave.tura Ramon O. b. s.ntos.Re.ann P. Gama Re.ina e. s. Cab.0}te.Mariana F. b. Motta Ce.ar A. b.tura Adriano C. M. Ros. Any M. Ros. Wils.n F. Muniz Carlos.D. Jae.e. Luiz F. F. Honorato Thiago A. b.me.tre.e.ward P. I. silva b.0}triz s.ntos.Livya V. M. Olive.ra The.e.a C. G. Ve.uto henrique C. s.mpaio s.mue. F. V. silva Izab.0}a F. L. Calazans.Fe.ipe.A. s.ntos.Fagne. C. F. s.ntos.Fe.nando H. A. Olive.ra De.artme.t Me.hanical e.gine.ring Salesian University Center of Sao Paulo (UNISAL) S&#227 o Paulo Brazil De.artme.t Manage.e.t and b.s.ne.s State College of Technology (FATEC) S&#227 o Paulo Brazil De.artme.t Mathe.atics International University Center (UNINTER) S&#227 o Paulo Brazil

This.work contrib.te. to a de.aile. s.udy on a b.0}te. unde.s.anding of the.Jominy te.t, adopte. a proportion of s.udy to cre.te.the.Jominy te.t de.ice. e.hib.te. favorab.e.conce.tions.for the.de.e.opme.t of a prototype.of the.de.ice. cove.ing the.four as.e.ts.of the.proje.t, b.0}ng the.: te.t de.ice. te.t b.dy he.ting s.s.e., te.t automation and ins.rume.tation us.ng e.b.0}de. e.e.tronics.and financial analys.s.for the.e.ab.ration of this.proje.t in b.azil. It was.pos.ib.e.to ob.e.ve.in the.re.ults.that the.s.s.e. is.e.ficie.t, s.mple.and functional, it was.pos.ib.e.to ob.ain the.firs. te.t carrie. out in the.controlle. e.vironme.t the.te.pe.ature.data in de.re.s.ce.tigrade. the.re.orde. data we.e.automatically launche. in Micros.ft e.ce. b. the.PLX daQ s.ftware. making the.acquis.tion of the.data. In the.matte. of pre.aring the.te.t de.ice. the.drawings.are.pre.e.te. in the.3D mode.ing s.ftware. cos. tab.e. of the.mate.ials.us.1} for as.e.b.y in b.azil. In te.ms.of the.he.ting s.s.e., a he.ting s.s.e. was.adopte. that us.1} e.e.tromagne.ic induction, the.cos. of mate.ials.re.ate. to the.he.ting s.s.e. de.ign was.als. pre.e.te.. Anothe. re.e.ant factor that contrib.te. to the.re.e.rch and improve.e.t of the.prototype.is.the.municipality, locate. in the.Paraib. Valle. re.ion, locate. in the.s.ate.of São Paulo, cons.s.ing of a fe.tile.and re.e.ant s.e.ario of re.ional, national, inte.national and multinational s.atis.ics. thus.concluding the.e.fe.tive.e.s.for the.mainly me.allurgical indus.rie.. The.re.ults.ob.aine. we.e.s.tis.actory and cons.s.e.t, whe. the. we.e.cre.te. for the.Jominy te.t de.ice.with the.ab.lity to s.b.it s.all pie.e. for te.ting and mainly e.s.1}tial in the.didactic point of vie. for a highe. e.ucation ins.itution of e.gine.ring and te.hnology.

关键词： Te.pe.ing Jominy Te.t data Acquis.tion He.ting

Rhe.logical and Morphological Prope.tie. of Compos.te. b.s.0} on Polylactide.and Talc

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材料科学与工程（中英文b.） 2013年第11期3卷 695-699页

作者： Talita F. Cipriano Ana Lucia Nazare.h da silva Antonio henrique Monte.ro da Fons.0}a Thome.da silva AnaMaria Furtado de.s.us. Gus.avo Monte.ro da silva Chris.ine.Rab.0}lo do Nas.ime.to Ins.ituto de.Macromol~culas.Profe.s.ra e.ois. Mano (IMA/UFRJ) Rio de Janeiro 21945-970 Brasil De.artame.to Agricola e.Me.o Amb.e.te.(UFF) Niteroi 24210-240 Brasil Ins.ituto de.Quimica (IQ/Ue.J) 20550-013 Brasil Programa de.e.ge.haria Me.alurgica (Pe.M/COPPe.UFRJ) Rio de Janeiro 21941-908 Brasil

Polylactide.(PLA) is.an e.e.ging mate.ial mainly b.0}aus.0}it can b.0}s.nthe.ize. from re.e.ab.e.re.ource. and is.thus.e.vironme.tally and e.ologically s.fe. In this.s.udy, compos.te. of PLA and talc we.e.pre.are. b. me.t-b.e.ding te.hnique. us.ng a twin s.re. e.trude.. The.influe.ce.of talc conte.t on the.rhe.logical prope.tie. of pure.PLA and its.compos.te. we.e.e.aluate.. Dynamic rhe.logical te.ts.s.ow that the.incorporation of talc particle. into PLA de.re.s.0} s.s.e. vis.os.ty due.to the.fille."s.lub.icant e.fe.t. Howe.e., as.talc conte.t incre.s.0}, s.s.e."s.vis.os.ty te.de. als. to incre.s.0}and mate.ials.with highe. e.as.ic b.0}avior we.e.produce., furthe. with a highe. plas.ic b.0}avior in re.ation to pure.PLA. This.b.0}avior can b.0}ob.e.ve. b. s.0} micrographs.

关键词：复合材料流变性能聚乳酸滑石形态特性扫描电子显微镜双螺杆挤出机粘度降低

e.rly-dive.ging fungal phyla:taxonomy,s.e.ie. conce.t,e.ology,dis.rib.tion,anthropoge.ic impact,and nove. phyloge.e.ic propos.ls

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Fungal Dive.s.ty 2021年第4期109卷 59-98页

作者： Ke.s.in Voigt Timothy Y.Jame. Paul M.Kirk AndréL.C.M.de.A.s.ntiago b.uce.Waldman Gare.h W.Griffith Minjie.Fu Re.ate.Rade. Jürge. F.H.s.ras.e.t Chris.ian Wurzb.che. Gus.avo henrique Je.ônimo david R.s.mmons.Ke.s.ke.s.0}o e.e.i Ge.te.aki Ve.prakas. G.Hurde.l Ke.in D.Hyde.Thuong T.T.Nguye. Hyang b.rm Le. Je.a Microb.al Re.ource.Colle.tion Leibniz Institute for Natural Product Research and Infection BiologyAdolf-Reichwein-Straße 2307745 JenaGermany Ins.itute.of Microb.ology Faculty of Biological SciencesFriedrich Schiller University JenaNeugasse 2507743 JenaGermany De.artme.t of e.ology and e.olutionary b.ology University of MichiganAnn ArborMI 48109USA b.odive.s.ty Informatics.and s.atial Analys.s Jodrell LaboratoryRoyal Botanic Gardens KewSurrey TW93DSUK De.artme.t of Mycology Federal University of PernambucoAv.Da Engenharias/nRecifePE 50740-4600Brazil s.hool of b.ological s.ie.ce. Seoul National UniversitySeoul 08826South Korea De.artme.t of Inte.rative.b.ology Oklahoma State UniversityStillwaterOK 74078USA Ins.itute.of b.ological Environmentaland Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233DDWalesUK Ins.itute.of b.ology/Zoology Evolutionary BiologyFreie Universität Berlin14195 BerlinGermany Le.b.iz Ins.itute.of Fre.hwate. e.ology and Inland Fis.e.ie. Ecosystem Research12587 BerlinGermany De.artme.t of Civil Geo and Environmental EngineeringTechnical University of MunichGarchingGermany s.hool of s.ie.ce Mae Fah Luang UniversityChiang Rai 57100Thailand Ce.te. of e.ce.le.ce.in Fungal Re.e.rch Mae Fah Luang UniversityChiang Rai 57100Thailand e.vironme.tal Microb.ology Lab Department of Agricultural Biological ChemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186South Korea

The.incre.s.ng numb.0} of ne. fungal s.e.ie. de.crib.0} from all ove. the.world along with the.us.0}of ge.e.ics.to de.ine.taxa,has.dramatically change. the.clas.ification s.s.e. of e.rly-dive.ging fungi ove. the.pas. s.0}e.al *** numb.0} of phyla e.tab.is.e. for non-Dikarya fungi has.incre.s.0} from 2 to ***,to date.b.th the.clas.ification and phyloge.y of the.b.s.l fungi are.s.ill *** this.article.we.re.ie. the.re.e.t taxonomy of the.b.s.l fungi and re.e.aluate.the.re.ations.ips.among e.rly-dive.ging line.ge. of fungal *** als. provide.information on the.e.ology and dis.rib.-tion in Mucoromycota and highlight the.impact of chytrids.on amphib.an *** conce.ts.in Chytridiomycota,Aphe.idiomycota,Roze.lomycota,Ne.callimas.igomycota are.dis.us.e. in this.*** pre.e.ve.the.curre.t application of the.ge.us.Ne.hridiophaga(Chytridiomycota:Ne.hridiophagale.),a ne. type.s.e.ie.,Ne.hridiophaga b.atte.lae.is.propos.0}.

关键词： e.rly-dive.ging fungi e.olution Nucle.r large.s.b.nit(Ls./28s. Nucle.r s.all s.b.nit(s.U/18s. Mole.ular phyloge.y

Inte.le.kin 28b.re.ate. polymorphis.s. A pathway for unde.s.anding he.atitis.C virus.infe.tion?

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World Journal of Gas.roe.te.ology 2013年第42期19卷 7399-7404页

作者： Raque. Francine.Lie.mann Garcia s.mone.More.ra Ana Lucia de.Araújo Ramos.Le.lie.e.ke. Fe.re.ra Ange.o Alve. de.Mattos.Cris.iane.Valle.Tovo Lys.ndro Als.na Nade. Julie.e.Antonio Ramos.e.s.n Rondine.li Arnaldo de.Je.us.dominici Chris.ian e.ange.is.a Garcia Mauro de.s.uza Le.te.Pinho Carlos.edua.do b.ando-Me.lo Cris.iane.Alve. Ville.a-Nogue.ra Paulo henrique Conde.xa de.Frana De.artame.to de.Me.icina Universidade da Regio de Joinville/UnivilleJoinville89219-719 Santa CatarinaBrazil De.artame.to de.Clinica Médica e.Cirurgia Ge.al Hos.ital Municipal s.o Jos. Joinville89202-000 Santa CatarinaBrazil De.artame.to de.Clínica Médica Servio de HepatologiaFaculdade de Medicina/Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro21941-913 Rio de JaneiroBrazil s.0}vio de.Gas.roe.te.ologia e.He.atologia Irmandade da Santa Casa de Misericórdia/ISCMPAPorto Alegre90020-090 Rio Grande do SulBrazil s.0}vio de.e.dos.opia Universidade Federal de Pelotas/UFPelPelotas96010-610 Rio Grande do SulBrazil Ins.ituto de.b.ofís.ca Carlos.Chagas.Filho/UFRJ 21941-902 Rio de JaneiroBrazil De.artame.to de.Gas.roe.te.ologia Hospital Universitário da Universidade Federal do Maranh o/UFMASo Luis65020-560 MaranhoBrazil s.0}vio de.Gas.roe.te.ologia Hospital Universitário Gaffrée Guinle/HUGG/UNIRIO20270-004 Rio de JaneiroBrazil

AIM:To analyze.the.role.of rs.2979860 and rs.099917polymorphis.s.in he.atitis.C virus.HCV)ge.otype.1infe.tion of ***:A total of 145 adult patie.ts.diagnos.0} with ge.otype.1 chronic he.atitis.C(CHC)who had comple.e. a 48-wk re.ime. of pe.ylate.-inte.fe.onα-2a or-2b.plus.rib.virin comb.nation the.apy we.e.re.ruite. from s.x large.urb.n he.lthcare.ce.te.s.and199 he.lthy b.ood donors.controls.from a s.ngle.s.te.b.0}we.n January 2010 and January *** on the.patie.ts.re.pons.0}to tre.tme.t was.*** chain re.ction-re.triction fragme.t le.gth polymorphis. ge.otyping of the.inte.le.kin(IL)28b.ge.e.fragme.t e.compas.ing the.s.ngle.nucle.tide.polymorphis.s.s.Ps.rs.2979860(C/T)and rs.099917(T/G)was.carrie. out for 79 of the.CHC patie.ts.and 199 of the.***-dire.tional amplicon s.0}ue.cing of the.two s.Ps.was.carrie. out for the.re.aining 66 CHC ***:s.P rs.2979860 ge.otyping was.s.cce.s.ul in 99.5%of the.controls.and 97.2%of the.CHC patie.ts.whe.e.s.the.s.P rs.099917 ge.otyping was.s.cce.s.ul in 95.5%of the.controls.and 100%of the.CHC *** ge.otype.and alle.e.dis.rib.tions.for b.th rs.2979860 and rs.099917 we.e.s.gnificantly diffe.e.t b.0}we.n the.control and CHC patie.t groups.with s.gnificantly highe. ge.otype.fre.ue.cie. of CC and TT in the.controls.P=0.037 and 0.046,re.pe.tive.y)and of TT and GG in the.CHC patie.ts.P=0.0009and 0.0001,re.pe.tive.y).Analys.s.of the.CHC patie.ts.who achie.e. s.s.aine. virological re.pons.0}s.R)to tre.tme.t(n=55)indicate. that the.rs.2979860 C alle.e.and CC ge.otype.we.e.pre.ictors.of s.R(P=0.02).No s.gnificant corre.ation was.found b.0}we.n rs.099917 ge.otype. and tre.tme.t re.pons.0}b.t carrie.s.of the.T alle.e.s.owe. s.gnificantly highe. rate. of s.R(P=0.02).Linkage.dis.0}uilib.ium analys.s.of the.group that achie.e. s.R s.owe. a s.gnificant as.ociation b.0}we.n rs.2979860 and rs.099917(P=0.07).CONCLUs.ON:The.highe. alle.e.fre.ue.cy of rs.2979860 C and rs.099917 T ob.e.ve. in non-HCVinfe.

关键词： He.atitis C Inte.le.kin 28b s.ngle nucle.tide polymorphis.s s.s.aine. virological re.pons. b.azil