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Cancer Communications 2023年第6期43卷 720-725页

作者： Mikkel G.Terp Martina Tuttolomondo Neil Portman Sidse Ehmsen Lene E.johansen Martin Bak Elgene Lim henrik j.ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark Garvan Institute of Medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of Geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3Ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed MCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(MPF-R and TPFR)or combined PI3Ki alpelisib and fulvestrant(MAF-R and TAF-R),respectively(Supplementary Materials and Methods).Drug-sensitive isogenic cells(M-S and T-S)grown in parallel with MPF-R and TPF-R cells and the original MCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

Particle size and packing characterization by diffuse light transmission

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Particuology 2012年第5期10卷 619-627页

作者： henrik Ehlers jyrki Heinmki jouko Yliruusi Division of Pharmaceutical Technology Faculty of Pharmacy P.O. Box 56 (Viikinkaari 5 E) FI-00014 University of Helsinki Finland Pharmaceutical Sciences Laboratory Department of Biosciences bo Akademi University BioCity Artillerigatan 6 20520 Turku Finland Department of Pharmacy Faculty of Medicine University of Tartu Nooruse 1 50411 Tartu Estonia

Particle size, packing density and blend composition of glass ballotini, microcrystalline cellulose pellets and theophylline granules were studied by diffuse light transmission. Diffuse visible light was directed to the sample and the intensity of the light transmitted to the opposite side of the sample was measured through a diffusing lens using a phototransistor, Light transmission was found to decrease with decreasing particle size and with increasing packing density, There was a correlation, though somewhat irregular, between light transmission and particle size for glass ballotini and microcrystalline cellulose pellets, and a strong near-linear correlation between light transmission and particle size for theophylline granules, The effect of packing density on light transmission was significant, Differentiating the composition of binary blends of microcrystalline cellulose pellets and glass ballotini and blends of theophylline granules was found possible on the basis of light transmission, The method proposed showed potential as a rapid, simple and inexpensive analytical tool for basic process diagnostics,

关键词： Light transmissionParticle sizePacking densityConvectionSegregation

Infrared spectroscopic probing of dimethylamine clusters in an Ar matrix

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journal of Environmental Sciences 2016年第2期28卷 51-59页

作者： Siyang Li henrik G.Kjaergaard Lin Du Environment Research Institute Shandong University Shanda South Road 27 Shandong 250100 China Department of Chemistry University of Copenhagen Universitetsparken 5 DK-2100 Copenhagen φ Denmark

Amines have many atmospheric sources and their clusters play an important role in aerosol nucleation processes. Clusters of a typical amine, dimethylamine（DMA）, of different sizes were measured with matrix isolation IR（infrared） and NIR（near infrared）spectroscopy. The NIR vibrations are more separated and therefore it is easier to distinguish different sizes of clusters in this region. The DMA clusters, up to DMA tetramer, have been optimized using density functional methods, and the geometries, binding energies and thermodynamic properties of DMA clusters were obtained. The computed frequencies and intensities of NH-stretching vibrations in the DMA clusters were used to interpret the experimental spectra. We have identified the fundamental transitions of the bonded NH-stretching vibration and the first overtone transitions of the bonded and free NH-stretching vibration in the DMA clusters. Based on the changes in vibrational intensities during the annealing processes, the growth of clusters was clearly observed. The results of annealing processes indicate that DMA molecules tend to form larger clusters with lower energies under matrix temperatures, which is also supported by the calculated reaction energies of cluster formation.

关键词： Matrix isolation Infrared(IR) spectroscopy Dimethylamine clusters Aerosol nucleation

ICT and E-learning, the Road to Hell or Paradise? The Need for a Strategic Thinking on Sustainable Digital Environment for E-learning

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开放教育研究 2005年第3期11卷 58-61页

作者： henrik Hansson Institute of International Education Stockholms University Sweden

The paper mainly discusses the negative sides of technology in education that have arisen from the the rapid development of technology.

关键词：建构主义在线学习现代教育技术学习环境自主学习利弊分析

The synergies of SMAP enhanced and MODIS products in a random forest regression for estimating 1 km soil moisture over Africa using Google Earth Engine

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Big Earth Data 2024年第1期8卷 33-57页

作者： Farzane Mohseni Amirhossein Ahrari jan-henrik Haunert Carsten Montzka Institute of Geodesy and Geoinformation University of BonnBonnGermany Water Energy and Environmental Engineering Research UnitUniversity of OuluOuluFinland Institute of Bio-and Geosciences:Agrosphere(IBG-3) Forschungszentrum Jülich GmbHJülichGermany

Due to the coarse scale of soil moisture products retrieved from passive microwave observations(SMPMW),several downscaling methods have been developed to enable regional scale ***,it can be challenging for users to access final data products and algorithms,as well as managing different data sources and formats,various data processing methods,and the complexity of the workflows from raw data to information ***,the Google Earth Engine(GEE),which as of late offers SMPMW,is used to implement a workflow for retrieving 1 km SM at a depth of 0-5 cm using MODIS optical/thermal measurements,the SM_(PMW)coarse scale product,and a random forest *** proposed method was implemented on the African continent to estimate weekly SM *** results of this study were evaluated against in-situ measurements of three validation ***,in comparison to the original SM_(PMW)product,which was limited by a spatial resolution of only 9 km,this method is able to estimate SM at 1 km spatial resolution with acceptable accuracy(an average correlation coefficient of 0.64 and a ubRMSD of 0.069 m^(3)/m^(3)).The results show that the proposed method in GEE provides a precise estimation of SM with a higher spatial resolution across the entire continent.

关键词： Soil moisture SMAP Google Earth Engine random forest regression MODIS

Severe steroid refractory gastritis induced by Nivolumab: A case report

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World journal of Gastroenterology 2020年第16期26卷 1971-1978页

作者： Helene Hjorth Vindum jØrgen S Agnholt Anders Winther Moelby Nielsen Mette Bak Nielsen henrik Schmidt Department of Oncology Aarhus University HospitalAarhus 8200Denmark Department of Gastroenterology Aarhus University HospitalAarhus 8200Denmark Department of Pathology Aarhus University HospitalAarhus 8200Denmark

BACKGROUND Immune checkpoint inhibitors are widely used for treatment of many advanced *** gastrointestinal(GI)side effects,such as diarrhea and colitis,are common,but upper GI side effects are rarely ***,the correct treatment of upper GI adverse events has been less frequently *** SUMMARY We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using *** patient developed severe gastritis after six series of Nivolumab with weight loss,nausea,and *** was no effect of intravenous steroids,but the patient′s condition resolved after administration of *** This case report supports the same treatment for gastritis as for colitis,which is in line with current guidelines.

关键词： Gastritis Immune checkpoint inhibitors Nivolumab Case report Immune-related adverse events Infliximab

Structural and chemical changes in pyrogenic organic matter aged in a boreal forest soil

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Pedosphere 2023年第3期33卷 436-447页

作者： jari HYVÄLUOMA Arttu MIETTINEN Riikka KESKINEN Kimmo RASA henrik LINDBERG Häme University of Applied Sciences Mustialantie 105Mustiala FI-31310(Finland) Department of Physics University of JyväskyläP.O.Box 35JyväskyläFI-40014(Finland) Natural Resources Institute Finland Tietotie 4Jokioinen FI-31600(Finland) Häme University of Applied Sciences Visamäentie 35 AP.O.Box 230Hämeenlinna FI-13101(Finland)

Pyrogenic organic matter(PyOM)is formed during wildfires and prescribed burnings or produced intentionally in the form of biochar for soil amendment *** is attracting a growing scientific and practical interest due to its important role in the global carbon cycle and agronomic applications as a soil *** of the studies on the physicochemical properties of PyOM have been conducted using fresh biochars even though the characteristics of PyOM are expected to alter due to aging processes in soil *** this paper,we report the results of a study that utilized X-ray microtomography and elemental analysis to investigate the chemical and structural changes in the PyOM formed during prescribed burning events and aged thereafter for 1–71 years in a boreal forest *** results indicate that changes in elemental composition occurred at decadal timescales,and an apparent steady state was reached ca.30 years after PyOM formation and exposure to the *** such timescales,PyOM was able to retain its porous structure originating from the cellular structure of the initial wood ***,structural analysis revealed several effects of aging on the pore structure,such as the formation of surface coating layers,pore fillings,and *** changes may alter pore size distribution and accessibility of the pores and further alter the influence of PyOM on soil functions,such as the transfer and retention of water and nutrients in PyOM pores.

关键词： biochar charcoal chronosequence porosity prescribed burning soil amendment X-ray microtomography

New approach for particle size and shape analysis of iron-based oxygen carriers at multiple oxidation states

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Particuology 2024年第7期90卷 493-503页

作者： Victor Purnomo Marcelo Dal Belo Takehara Robin Faust Lidiya Abdisa Ejjeta henrik Leion Division of Energy and Materials Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucial issues in the chemical looping technology lies in its bed material:the oxygen *** size analysis of an oxygen carrier is important since in a fluidized bed the material can only work well within a specific size *** the favorable size ranges for oxygen carrier materials have already been reported,none of the published studies has analyzed the particle size and shape of oxygen carriers in ***,the effect of oxygen carriers'oxidation degree on such properties has not been considered *** study aimed to report the particle size and shape analysis of five iron-based oxygen carriers,one natural ore,one synthetic material,and three residue products,at different oxidation degrees using dynamic image analysis(DIA).The oxygen carriers were prepared at different mass conversion degrees in a fluidized bed batch *** size distribution,sphericity,and aspect ratio of the oxygen carrier particles were examined experimentally using a Camsizer *** results show that the DIA method was successfully able to analyze the particle size and shape of our oxygen carriers with satisfying accuracy for *** oxidation state of the investigated materials seems to only affect the particle size and shape of oxygen carriers to a minor ***,exposures to redox cycles in a fluidized bed reactor may alter the particle size and shape of most oxygen carriers.

关键词： Oxygen carrier Size and shape analysis Dynamic image analysis Oxidation state Fluidized bed Chemical looping

Identification of non-linear autoregressive models with exogenous inputs for room air temperature modelling

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Energy and AI 2022年第3期9卷 78-87页

作者： Christian Ankerstjerne Thilker Peder Bacher Davide Cali henrik Madsen Technical University of Denmark Department of Applied Mathematics and Computer ScienceAsmussens AlléBuilding 303BDK-2800 Kgs.LyngbyDenmark

This paper proposes non-linear autoregressive models with exogenous inputs to model the air temperature ineach room of a Danish school building connected to the local district heating network. To obtain satisfactorymodels, the authors find it necessary to estimate the solar radiation effect as a function of the time of the dayusing a B-spline basis expansion. Furthermore, this paper proposes a method for estimating the valve positionof the radiator thermostats in each room using modified Hermite polynomials to ensure monotonicity of theestimated curve. The non-linearities require a modification in the estimation procedure: Some parametersare estimated in an outer optimisation, while the usual regression parameters are estimated in an inneroptimisation. The models are able to simulate the temperature 24 h ahead with a root-mean-square-errorof the predictions between 0.25℃ and 0.6℃. The models seem to capture the solar radiation gain in away aligned with expectations. The estimated thermostatic valve functions also seem to capture the importantvariations of the individual room heat inputs.

关键词： Time series analysis Non-linear models District heating Smart energy systems

Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark

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World journal of Gastroenterology 2013年第4期19卷 503-510页

作者： Evan S Dellon Rune Erichsen Lars Pedersen Nicholas j Shaheen john A Baron henrik T Sφrensen Mogens Vyberg Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and DiseaseDivision of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Center for Gastrointestinal Biology and Disease Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Department of Clinical Epidemiology Aarhus University Hospital8000 AarhusDanmark Institute of Pathology Aalborg HospitalAarhus University Hospital8000 AarhusDanmark

AIM:To develop and validate a case definition of eosinophilic esophagitis(EoE) in the linked Danish health ***:For case definition development,we queried the Danish medical registries from 2006-2007 to identify candidate cases of EoE in Northern *** International Classification of Diseases-10(ICD-10) and prescription codes were obtained,and archived pathology slides were obtained and re-reviewed to determine case *** used an iterative process to select inclusion/exclusion codes,refine the case definition,and optimize sensitivity and *** then re-queried the registries from 2008-2009 to yield a validation *** case definition algorithm was applied,and sensitivity and specificity were ***:Of the 51 and 49 candidate cases identified in both the development and validation sets,21 and 24 had EoE,*** of EoE cases in the development set [mean age 35 years;76% male;86% dysphagia;103 eosinophils per high-power field(eos/hpf)] were similar to those in the validation set(mean age 42 years;83% male;67% dysphagia;77 eos/hpf).Re-review of archived slides confirmed that the pathology coding for esophageal eosinophilia was correct in greater than 90% of *** registrybased case algorithms based on pathology,ICD-10,and pharmacy codes were successfully generated in the development set,one that was sensitive(90%) and one that was specific(97%).When these algorithms were applied to the validation set,they remained sensitive(88%) and specific(96%).CONCLUSION:Two registry-based definitions,one highly sensitive and one highly specific,were developed and validated for the linked Danish national health databases,making future population-based studies feasible.

关键词： Eosinophilic esophagitis Denmark Epidemiology Case definition Sensitivity Specificity