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Journal of Green Building 2006年第4期1卷 3-10页

作者： Bruno Nielsen henrik sørensen Rasmus Pedersen Frans Drewniak Esbensen Consulting Vesterbrogade 124 BDK-1620 Copenhagen VDenmark Henning Larsens Tegnestue Vesterbrogade 76DK-1620 Copenhagen VDenmark

INTRODUCTION The theme for the renovation of Albertslund Library has been to create a markedly bright library that is open to its surroundings and *** overall objective is to satisfy the needs of the staff at the library and users in all age groups and from all social ***,the goal is to have a building which is optimized in terms of indoor daylight and thermal conditions,use of natural ventilation for saving energy in terms of cooling,and electricity for fan assistance and artificial light.

关键词： satisfy stratum library

Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark

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World Journal of Gastroenterology 2013年第4期19卷 503-510页

作者： Evan s Dellon Rune Erichsen Lars Pedersen Nicholas J shaheen John A Baron henrik T sφrensen Mogens Vyberg Center for Esophageal Diseases and swallowing and Center for Gastrointestinal Biology and DiseaseDivision of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Center for Gastrointestinal Biology and Disease Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Department of Clinical Epidemiology Aarhus University Hospital8000 AarhusDanmark Institute of Pathology Aalborg HospitalAarhus University Hospital8000 AarhusDanmark

AIM:To develop and validate a case definition of eosinophilic esophagitis(EoE) in the linked Danish health ***:For case definition development,we queried the Danish medical registries from 2006-2007 to identify candidate cases of EoE in Northern *** International Classification of Diseases-10(ICD-10) and prescription codes were obtained,and archived pathology slides were obtained and re-reviewed to determine case *** used an iterative process to select inclusion/exclusion codes,refine the case definition,and optimize sensitivity and *** then re-queried the registries from 2008-2009 to yield a validation *** case definition algorithm was applied,and sensitivity and specificity were ***:Of the 51 and 49 candidate cases identified in both the development and validation sets,21 and 24 had EoE,*** of EoE cases in the development set [mean age 35 years;76% male;86% dysphagia;103 eosinophils per high-power field(eos/hpf)] were similar to those in the validation set(mean age 42 years;83% male;67% dysphagia;77 eos/hpf).Re-review of archived slides confirmed that the pathology coding for esophageal eosinophilia was correct in greater than 90% of *** registrybased case algorithms based on pathology,ICD-10,and pharmacy codes were successfully generated in the development set,one that was sensitive(90%) and one that was specific(97%).When these algorithms were applied to the validation set,they remained sensitive(88%) and specific(96%).CONCLUsION:Two registry-based definitions,one highly sensitive and one highly specific,were developed and validated for the linked Danish national health databases,making future population-based studies feasible.

关键词： Eosinophilic esophagitis Denmark Epidemiology Case definition sensitivity specificity

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang henrik Biverstål Nicolas GBazan shuai Tan Nailin Li Makiko Ohshima Marianne schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Prof. henrik Petrowsky: complex hepatobiliary and pancreatic surgery

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Hepatobiliary surgery and Nutrition 2020年第1期9卷 124-125页

作者：无 henrik Petrowsky HBsN the Department of surgery and Transplantation at the University of Zürich Switzerland

Expert’s introduction *** Petrowsky(Figure 1)is a Professor of surgery and Vice-Chair of the Department of surgery and Transplantation at the University of Zürich,*** serves as Program Director of the HPB surgery and Liver Transplant Fellowship at the swiss HPB and Transplant Center *** is heading the Liver and Pancreas Tumor Center,which is embedded in the Comprehensive Cancer Center Zurich at the University Hospital *** current practice consists of liver transplantation and HPB *** research interests have mirrored his clinical work mainly focusing on translational and outcome research in liver transplantation and hepatobiliary surgery.

关键词： surgery surgery hepato

MicroRNA-126 and epidermal growth factor-like domain 7 predict recurrence in patients with colon cancer treated with neoadjuvant chemotherapy

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Cancer Drug Resistance 2019年第3期2卷 885-896页

作者： Torben Frøstrup Hansen Anting Liu Carlsen Julia Tanas Tanassi Ole Larsen Flemming Brandt sørensen Lars henrik Jensen Anders Jakobsen Danish Colorectal Cancer Center south Vejle HospitalInstitute of Regional Health ResearchUniversity of Southern DenmarkVejle 7100Denmark Department of Autoimmunology and Biomarkers Statens Serum InstitutCopenhagen 2300Denmark Department of Congenital Disorders Statens Serum InstitutCopenhagen 2300Denmark Department of Oncology Herlev HospitalHerlev 2730Denmark University Institute of Pathology Aarhus University Hospitaland department of Clinical MedicineUniversity of AarhusAarhus 8200Denmark

Aim:Neoadjuvant chemotherapy may represent a shift in the treatment of locally advanced colon *** angiogenic couple has-microRNA-126(miRNA-126)and epidermal growth factor-like domain 7(EGFL7)are transcribed from the same gene and regulates all aspects of angiogenesis and may influence the ability of tumor cells to *** aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant ***:This study included 71 patients from a phase II study all planned for three cycles of capecitabine and oxaliplatin before *** was sampled at baseline and right before and after the *** miRNA-126 was analysed by RT-qPCR and a quantitative immunoassay was used for the analyses of ***:The rates of 5-year disease-free survival(DFs)and overall survival(Os)were 80%and 85%,*** level of circulating miRNA-126 before the operation predicts recurrence,P=*** patients with values below and above the median the recurrence rate was 31%and 4%,*** results applied to EGFL7.A combined estimate identified a subgroup of patients(25 of 71)with no recurrence and a 5-year DFs and Os rate of 100%,***:MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy.

关键词： Chemotherapy colon cancer epidermal growth factor-like domain 7 microRNA-126

Oxidation controlled lift-off of 3D chiral plasmonic Au nano-hooks

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Nano Research 2019年第7期12卷 1635-1642页

作者： Gunnar Klos Amanda Andersen Matteo Miola henrik Birkedal Duncan s. sutherland Interdisciplinary Nanoscience Center (iNANO) Aarhus UniversityAarhus C 8000Denmark Department of Chemistry and iNANO Aarhus UniversityAarhus C 8000Denmark Carbon Dioxide Activation Center (CADIAC)- iNANO Aarhus UniversityAarhus C 8000Denmark

Colloidal suspensions of plasmonic nanoparticles (NPs) are a well-established tool for biomedical applications and enhanced spectroscopy because of their strong optical *** specific response is greatly dependent on the NP *** strong optical activity of chiral NPs has created special interest but fabrication of chiral NPs in solution remains ***,we present an approach whereby three-dimensional (3D) chiral Au nano-hooks,fabricated with the parallel hole-mask colloidal lithography (HMCL) method,can be lifted off from a glass substrate in a controllable manner by using a combined treatment with oxygen plasma oxidation and a reduction step in *** method has the advantage of being based on established techniques and not requiring strong acids or complex substrates as in etching based *** furthermore demonstrate the integration of the hook NPs into reversibly cross-linked hydrogels inspired by mussel catechol chemistry but containing an oxidation resistant catechol analogue grafted onto poly(allylamine) crosslinked by coordination of Al^3+ and how this facilitates the remote analysis of hydrogel microenvironment,*** water *** suspended particles are promising candidates for optically active surface-enhanced Raman spectroscopy (sERs),asymmetric photo catalysis or aggregation *** integration into hydrogels to produce functional hydrogels holds benefits for applications of metamaterials in optics,sensing or activation in environmental remediation or drug delivery.

关键词： chiral nanostructures circular dichroism plasmonic sensor hole-mask colloidal lithography

Fundamental influences of particles on stirred and unstirred venting processes of foaming systems

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Frontiers of Chemical science and Engineering 2014年第2期8卷 141-148页

作者： henrik LEIMEIsTER Jorg sTEINBACH Department of Process Engineering Technische Universitat Berlin Strage des 17. Juni 135 10623 Berlin Germany

Venting is the common safety measure to protect plant equipment against excessive overpressure. so far, scenarios in which particles were part of the system and should have been accounted for did ignore their presence; the scenarios were treated like a two-phase system. Current research shows that particles can have a major influence on the venting behaviour. Experimental results indicate that particles affect level swell and relief flow especially of foamy systems. Based on those results four different layers of influence of the particle have been identified and are presented in a first model. Based on this model recommendations for the development of new and more complex models are given.

关键词： venting multi-phase

The tensor embedding for a Grothendieck cosmos

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science China Mathematics 2023年第11期66卷 2471-2494页

作者： henrik Holm sinem Odabasi Department of Mathematical sciences University of CopenhagenCopenhagen 02100Denmark Instituto de Ciencias Físicas y Matemáticas Universidad Austral de ChileValdivia 5090000Chile

While the Yoneda embedding and its generalizations have been studied extensively in the literature,the so-called tensor embedding has only received a little *** this paper,we study the tensor embedding for closed symmetric monoidal categories and show how it is connected to the notion of geometrically purity,which has recently been investigated in the works of Enochs et al.(2016)and Estrada et al.(2017).More precisely,for a Grothendieck cosmos,i.e.,a bicomplete Grothendieck category V with a closed symmetric monoidal structure,we prove that the geometrically pure exact category(V,ε■)has enough relative injectives;in fact,every object has a geometrically pure injective *** also show that for some regular cardinalλ,the tensor embedding yields an exact equivalence between(V,ε■)and the category ofλ-cocontinuous V-functors from Presλ(V)to V,where the former is the full V-subcategory ofλ-presentable objects in *** many cases of interest,λcan be chosen to be■0 and the tensor embedding identifies the geometrically pure injective objects in V with the(categorically)injective objects in the abelian category of V-functors from fp(V)to *** we explain,the developed theory applies,e.g.,to the category Ch(R)of chain complexes of modules over a commutative ring R and to the category Qcoh(X)of quasi-coherent sheaves over a(suitably nice)scheme X.

关键词： enriched functor exact category (pre)envelope (pure)injective object purity symmetric monoidal category tensor embedding Yoneda embedding

Harmonic Analysis for Real spherical spaces

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Acta Mathematica sinica,English series 2018年第3期34卷 341-370页

作者： Bernhard KROTZ henrik sCHLICHTKRULL Universitat Paderborn Institut fiir MathematikWarburger Strafle 10033098 PaderbornGermany University of Copenhagen Department of MathematicsUniversitetsparken 5DK-2100 Copenhagen ODenmark

We give an introduction to basic harmonic analysis and representation theory for homogeneous spaces Z = G/H attached to a real reductive Lie group G. A special emphasis is made to the case where Z is real spherical.

关键词： Real spherical spaces harmonic analysis homogeneous spaces representation theory

Diversity patterns, environmental drivers and changes in vegetation composition in dry inter-Andean valleys

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Journal of Plant Ecology 2017年第3期10卷 461-475页

作者： Catalina Quintana Marco Girardello Anders s.Barfod henrik Balslev Department of Bioscience Ecoinformatics and Biodiversity GroupAarhus UniversityNy Munkegade 114DK-8000 Aarhus CDenmark Departamento de Ciencias Biológicas Pontificia Universidad Católica del EcuadorAv.12 de Octubre 1076Apartado postal 17012184QuitoEcuador

Aims We studied diversity,patterns of endemism and turnover of veg-etation composition in dry inter-Andean valleys(DIAVs)where lit-tle is known about the influence of the abiotic drivers controlling plant species composition and occurrences,and the life forms that contribute most toα-andβ-diversity,*** study was focused on DIAVs located in the highlands(800-2800 m)around the Equator(1°N-5°s).The following questions were addressed:(i)what differences exist between endemic and non-endemic species in terms of species number,frequency and abundance?(ii)are pat-terns ofα-andβ-diversity correlated with latitude?(iii)what are the major environmental drivers controlling spatial patterns in species composition and occurrence?Methods We established 63 transects of 5×100 m in areas with DIAV vegetation,impacted as little as possible by human *** each transect,all mature trees and shrubs were identified and counted to determine their *** coverage of terrestrial herbs was *** additive models were used to quantify the relationship betweenα-andβ-diversity with *** recordα-diversity,we used the exponential shannon *** sørensen index was used to measureβ-diversity or species *** used canonical correspondence analysis to deter-mine species composition and generalized linear mixed models to quantify simultaneously the determinants of species occur-rence across species and *** models were evaluated using the Akaike information *** analyses were run separately for trees,herbs and *** Findings Overall,we found that shrubs was the most diverse life form,constituting 43%(12%endemic)of the 313 species,followed by herbs(36%;11.5%endemic)and trees(20%;5%endemic).Trees comprise mostly species with low abundance(e.g.s ha^(−1)),which was also true for herbs,whereas shrubs showed a larger number of abundant species(>30 individuals ha^(−1)),includ-ing four endemic *** of the e

关键词： endemics α-diversity β-diversity life forms Ecuador