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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Prof. henrik Petrowsky: complex hepatobiliary and pancreatic surgery

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 124-125页

作者：无 henrik Petrowsky HBSN the Department of Surgery and Transplantation at the University of Zürich Switzerland

Expert’s introduction *** Petrowsky(Figure 1)is a Professor of Surgery and Vice-Chair of the Department of Surgery and Transplantation at the University of Zürich,*** serves as Program Director of the HPB Surgery and Liver Transplant Fellowship at the Swiss HPB and Transplant Center *** is heading the Liver and Pancreas Tumor Center,which is embedded in the Comprehensive Cancer Center Zurich at the University Hospital *** current practice consists of liver transplantation and HPB *** research interests have mirrored his clinical work mainly focusing on translational and outcome research in liver transplantation and hepatobiliary surgery.

关键词： Surgery surgery hepato

Fundamental influences of particles on stirred and unstirred venting processes of foaming systems

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 141-148页

作者： henrik LEIMEISTER Jorg STEINBACH Department of Process Engineering Technische Universitat Berlin Strage des 17. Juni 135 10623 Berlin Germany

Venting is the common safety measure to protect plant equipment against excessive overpressure. So far, scenarios in which particles were part of the system and should have been accounted for did ignore their presence; the scenarios were treated like a two-phase system. Current research shows that particles can have a major influence on the venting behaviour. Experimental results indicate that particles affect level swell and relief flow especially of foamy systems. Based on those results four different layers of influence of the particle have been identified and are presented in a first model. Based on this model recommendations for the development of new and more complex models are given.

关键词： venting multi-phase

The tensor embedding for a Grothendieck cosmos

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Science China Mathematics 2023年第11期66卷 2471-2494页

作者： henrik Holm Sinem Odabasi Department of Mathematical Sciences University of CopenhagenCopenhagen 02100Denmark Instituto de Ciencias Físicas y Matemáticas Universidad Austral de ChileValdivia 5090000Chile

While the Yoneda embedding and its generalizations have been studied extensively in the literature,the so-called tensor embedding has only received a little *** this paper,we study the tensor embedding for closed symmetric monoidal categories and show how it is connected to the notion of geometrically purity,which has recently been investigated in the works of Enochs et al.(2016)and Estrada et al.(2017).More precisely,for a Grothendieck cosmos,i.e.,a bicomplete Grothendieck category V with a closed symmetric monoidal structure,we prove that the geometrically pure exact category(V,ε■)has enough relative injectives;in fact,every object has a geometrically pure injective *** also show that for some regular cardinalλ,the tensor embedding yields an exact equivalence between(V,ε■)and the category ofλ-cocontinuous V-functors from Presλ(V)to V,where the former is the full V-subcategory ofλ-presentable objects in *** many cases of interest,λcan be chosen to be■0 and the tensor embedding identifies the geometrically pure injective objects in V with the(categorically)injective objects in the abelian category of V-functors from fp(V)to *** we explain,the developed theory applies,e.g.,to the category Ch(R)of chain complexes of modules over a commutative ring R and to the category Qcoh(X)of quasi-coherent sheaves over a(suitably nice)scheme X.

关键词： enriched functor exact category (pre)envelope (pure)injective object purity symmetric monoidal category tensor embedding Yoneda embedding

Harmonic Analysis for Real Spherical Spaces

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Acta Mathematica Sinica,English Series 2018年第3期34卷 341-370页

作者： Bernhard KROTZ henrik SCHLICHTKRULL Universitat Paderborn Institut fiir MathematikWarburger Strafle 10033098 PaderbornGermany University of Copenhagen Department of MathematicsUniversitetsparken 5DK-2100 Copenhagen ODenmark

We give an introduction to basic harmonic analysis and representation theory for homogeneous spaces Z = G/H attached to a real reductive Lie group G. A special emphasis is made to the case where Z is real spherical.

关键词： Real spherical spaces harmonic analysis homogeneous spaces representation theory

Three-Dimensional Mode Coupling around a Conical Seamount and the Use of Random Discretization

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Chinese Physics Letters 2010年第11期27卷 137-140页

作者：骆文于 SCHMIDT henrik State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences Beijing 100190 Department of Mechanical Engineering Massachusetts Institute of Technology Massachusetts 02139 USA

Three-dimensional mode coupling around a conical seamount in an ocean waveguide is studied. It is shown that strong mode coupling occurs at the edge of a conical seamount for the incident normal modes with significant amplitudes below the top of the seamount. Therefore, mode coupling is critical for the investigation of the acoustic field around a seamount. In addition, we suggest the use of random discretization for representing smoothly varying bathymetry. For the use of uniform discretization, when the horizontal step size is greater than half of the wavelength, artificial diffraction lobes appear due to coherent backscatter. However, by using the random discretization scheme instead, such artificial diffraction lobes are diffused, resulting in a faster convergence rate.

关键词： Environmental and Earth science

A Spectral Coupled-Mode Formulation for Sound Propagation around Axisymmetric Seamounts

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Chinese Physics Letters 2010年第9期27卷 131-134页

A spectral coupled-mode solution of the three-dimensional （319） acoustic field generated by a point source in the presence o[ an axisymmetric seamount is developed. Based on the same theoretical foundation as the for- mulation presented by Taroudakis [3. Comput. Acoust. 4 （1996） 101], the present approach combines a spectral decomposition in azimuth with a coupled-mode theory for two-way range-dependent propagation. However, the earlier formulations are severely limited in terms of frequency, size and geometry o[ the seamount, the seabed composition, and the distance between the source and the seamount, and are there/ore severely limited in regard to realistic seamount problems. Without changing the fundamental theoretical foundation, the present approach applies a number of modifications to the formulation, leading to orders of magnitude improvement in numerical efficiency for realistic problems. Therefore, realistic propagation and scattering scenarios can be modeled, including effects of seamount roughness and realistic sedimentary structure.

关键词： COUPLED mode theory (Wave-motion) SEAMOUNTS SPECTRUM analysis AZIMUTH DECOMPOSITION method (Mathematics) SURFACE roughness

Geometric Counting on Wavefront Real Spherical Spaces

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Acta Mathematica Sinica,English Series 2018年第3期34卷 488-531页

作者： Bernhard KROTZ Eitan SAYAG henrik SCHLICHTKRULL Universitat Paderborn Institut Jur MathematikWarburger Strafle 10033098 PaderbornDeutschland Department of Mathematics Ben Gurion University of the NegevP.O.B.653Be'er Sheva 84105Israel Department of Mathematics University of CopenhagenUniversitetsparken 5DK-2100 Copenhagen ODenmark

We provide L^p-versus L~∞-bounds for eigenfunctions on a real spherical space Z of wavefront type. It is shown that these bounds imply a non-trivial error term estimate for lattice counting on Z. The paper also serve... 详细信息

关键词： Homogeneous spaces real spherical spaces lattice counting error term wavefront lemma spectral analysis norm comparison of eigenfunctions

Circadian enhancer profiling in diet-induced obese mice reveals a critical time window for lipid-lowering therapies

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 280-282页

作者： henrik Oster Institute of Neurobiology University of LübeckLübeckGermany

The 24-hour rhythms in physiology and behavior are controlled by endogenous cellular clocks found in all cells and tissue of the *** the molecular level,these clocks are based on interlocked transcriptional-translational feedback loops comprised of a set of clock genes and proteins(1).While the nature of the core clockwork is conserved across all tissues,the output from these clocks is highly cell type-specific and believed to be specified by tissue-specific cistromes including enhancer sites,where transcription factor binding leads to regulation of gene transcription over large genomic *** normal metabolic conditions,5–10%of active transcripts oscillate in a circadian fashion within a *** the mouse,up to 50%of genes are clock-controlled in at least on tissue of the body(2).

关键词： endogenous specified critical