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世界胃肠病学杂志:英文版 2023年第33期29卷 5014-5019页

作者： Carmen Mota Reyes Henriette Klein Fabian Stögbauer henrik einwächter Melanie Boxberg Moritz Schirren Seyer Safi Hans Hoffmann Department of Surgery Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Division of Thoracic Surgery Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Technical University of MunichMunich 81675Germany Department of Internal Medicine II Technical University of MunichMunich 81675Germany

BACKGROUND Pulmonary carcinoids are rare,low-grade malignant tumors characterized by neuroendocrine differentiation and relatively indolent clinical *** cases present as a slow-growing polypoidal mass in the major bronchi leading to hemoptysis and pulmonary infection due to blockage of the distal *** syndrome is a paraneoplastic syndrome caused by the systemic release of vasoactive substances that presents in 5%of patients with neuroendocrine *** to such nonspecific presentation,most patients are misdiagnosed or diagnosed late and may receive several courses of antibiotics to treat recurrent pneumonia before the tumor is *** SUMMARY We report the case of a 48-year-old male who presented with cough,dyspnea,a history of recurrent pneumonitis,and therapy-refractory ulcerative colitis that completely subsided after the resection of a pulmonary *** We report and emphasize pulmonary carcinoid as a differential diagnosis in patients with nonresponding inflammatory bowel diseases and recurrent pneumonia.

关键词： Carcinoid syndrome Paraneoplastic syndrome Pulmonary carcinoid Neuroendocrine tumor Ulcerative colitis Case report

Amino acid and mineral digestibility,bone ash,and plasma inositol is increased by including microbial phytase in diets for growing pigs

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Journal of Animal Science and Biotechnology 2024年第2期15卷 699-712页

作者： Liz Vanessa Lagos Mike Richard Bedford Hans henrik Stein Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA AB Vista Marlborough SN84ANUK

Background The effect of microbial phytase on amino acid and energy digestibility is not consistent in pigs,which may be related to the phytase dosage or the adaptation length to the ***,an experiment was conducted to test the hypotheses that increasing dietary phytase after an 18-day adaptation period:1)increases nutrient and energy digestibility;2)increases plasma P,plasma inositol,and bone ash of young pigs;and 3)demonstrates that maximum phytate degradation requires more phytase than maximum P *** Data indicated that increasing inclusion of phytase[0,250,500,1,000,2,000,and 4,000 phytase units(FTU)/kg feed]in corn-soybean meal-based diets increased apparent ileal digestibility(AID)of Trp(quadratic;P<0.05),and of Lys and Thr(linear;P<0.05),and tended to increase AID of Met(linear;P<0.10).Increasing dietary phytase also increased AID and apparent total tract digestibility(ATTD)of Ca and P(quadratic;P<0.05)and increased ATTD of K and Na(linear;P<0.05),but phytase did not influence the ATTD of Mg or gross *** of plasma P and bone ash increased(quadratic;P<0.05),and plasma inositol also increased(linear;P<0.05)with increasing inclusion of *** concentrations of inositol phosphate(IP)6 and IP5(quadratic;P<0.05),reduced IP4 and IP3(linear;P<0.05),but increased inositol concentrations(linear;P<0.05)were observed in ileal digesta as dietary phytase *** ATTD of P was maximized if at least 1,200 FTU/kg were used,whereas more than 4,000 FTU/kg were needed to maximize inositol *** Increasing dietary levels of phytase after an 18-day adaptation period increased phytate and IP ester degradation and inositol release in the small ***,increasing dietary phytase resulted in improved digestibility of Ca,P,K,Na,and the first 4 limiting amino acids,and in increased concentrations of bone ash and plasma P and *** a corn-soybean meal diet,maximum inositol release requires appr

关键词： Bone ash Inositol Nutrient digestibility Phytase Phytate degradation Pigs

The synergies of SMAP enhanced and MODIS products in a random forest regression for estimating 1 km soil moisture over Africa using Google Earth Engine

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Big Earth Data 2024年第1期8卷 33-57页

作者： Farzane Mohseni Amirhossein Ahrari Jan-henrik Haunert Carsten Montzka Institute of Geodesy and Geoinformation University of BonnBonnGermany Water Energy and Environmental Engineering Research UnitUniversity of OuluOuluFinland Institute of Bio-and Geosciences:Agrosphere(IBG-3) Forschungszentrum Jülich GmbHJülichGermany

Due to the coarse scale of soil moisture products retrieved from passive microwave observations(SMPMW),several downscaling methods have been developed to enable regional scale ***,it can be challenging for users to access final data products and algorithms,as well as managing different data sources and formats,various data processing methods,and the complexity of the workflows from raw data to information ***,the Google Earth Engine(GEE),which as of late offers SMPMW,is used to implement a workflow for retrieving 1 km SM at a depth of 0-5 cm using MODIS optical/thermal measurements,the SM_(PMW)coarse scale product,and a random forest *** proposed method was implemented on the African continent to estimate weekly SM *** results of this study were evaluated against in-situ measurements of three validation ***,in comparison to the original SM_(PMW)product,which was limited by a spatial resolution of only 9 km,this method is able to estimate SM at 1 km spatial resolution with acceptable accuracy(an average correlation coefficient of 0.64 and a ubRMSD of 0.069 m^(3)/m^(3)).The results show that the proposed method in GEE provides a precise estimation of SM with a higher spatial resolution across the entire continent.

关键词： Soil moisture SMAP Google Earth Engine random forest regression MODIS

New approach for particle size and shape analysis of iron-based oxygen carriers at multiple oxidation states

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Particuology 2024年第7期90卷 493-503页

作者： Victor Purnomo Marcelo Dal Belo Takehara Robin Faust Lidiya Abdisa Ejjeta henrik Leion Division of Energy and Materials Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucial issues in the chemical looping technology lies in its bed material:the oxygen *** size analysis of an oxygen carrier is important since in a fluidized bed the material can only work well within a specific size *** the favorable size ranges for oxygen carrier materials have already been reported,none of the published studies has analyzed the particle size and shape of oxygen carriers in ***,the effect of oxygen carriers'oxidation degree on such properties has not been considered *** study aimed to report the particle size and shape analysis of five iron-based oxygen carriers,one natural ore,one synthetic material,and three residue products,at different oxidation degrees using dynamic image analysis(DIA).The oxygen carriers were prepared at different mass conversion degrees in a fluidized bed batch *** size distribution,sphericity,and aspect ratio of the oxygen carrier particles were examined experimentally using a Camsizer *** results show that the DIA method was successfully able to analyze the particle size and shape of our oxygen carriers with satisfying accuracy for *** oxidation state of the investigated materials seems to only affect the particle size and shape of oxygen carriers to a minor ***,exposures to redox cycles in a fluidized bed reactor may alter the particle size and shape of most oxygen carriers.

关键词： Oxygen carrier Size and shape analysis Dynamic image analysis Oxidation state Fluidized bed Chemical looping

Development and evaluation of a vision driven sensor for estimating fuel feeding rates in combustion and gasification processes

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Energy and AI 2024年第1期15卷 44-54页

作者： YngveÖren Alexey Sepman Ehsan Fooladgar Fredrik Weiland henrik Wiinikka RISE AB Box 726 SE-94128PiteåSweden Energy Engineering Division of Energy ScienceLuleåUniversity of TechnologySE 97187LuleåSweden

A machine vision driven sensor for estimating the instantaneous feeding rate of pelletized fuels was developed and tested experimentally in combustion and gasification *** feeding rate was determined from images of the pellets sliding on a transfer chute into the *** the images the apparent area and velocity of the pellets were *** was determined by a segmentation model created using a machine learning framework and velocities by image registration of two subsequent *** measured weight of the pelletized fuel passed through the feeding system was in good agreement with the weight estimated by the *** observed variations in the fuel feeding correlated with the variations in the gaseous species concentrations measured in the reactor core and in the *** the developed sensor measures the ingoing fuel feeding rate prior to the reactor,its signal could therefore help improve process control.

关键词： Fuel feeding Process monitoring Image processing Neural network Combustion Gasification

CFD investigation of structural effects of internal gas intake on powder conveying performance in fuel supply systems for aerospace engines

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Particuology 2024年第9期92卷 140-154页

作者： Guanlong Ren Haijun Sun Fangjun Chen Wen Shen Yunzhen Cai Yihua Xu henrik Ström Bilainu Oboirien Qingang Xiong School of Aircraft Engineering Nanchang Hangkong UniversityNanchang330063China Engineering Research Center of Aero-engine Technology for General Aviation Ministry of EducationNanchang330063China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou510640China Department of Mechanics and Maritime Sciences Chalmers University of TechnologyGöteborg41296Sweden Department of Chemical Engineering University of JohannesburgJohannesburg17011South Africa

Optimal design of gas intake in powder fuel supply systems is crucial for performance of aerospace *** is little research on the impact of intake structure on powder conveying *** novel internal intakes were proposed,which are spherical,cube-shaped,and *** validation,CFD simulations demonstrate that fluctuation of mass flow rate of powders in the dome-shaped intake is reduced by about 73.3%compared with the annular external *** trends of phase velocities are similar for the spherical and cube-shaped intakes,while those are similar for the annular external and dome-shaped internal *** of area of gas zone for the annular external and spherical internal intakes is larger than that for the cube-shaped and dome-shaped internal *** and relative pressure drop in the fluidization chamber have a stable stage,and fluctuation of relative pressure drop is small when dome-shaped internal intake is used.

关键词： Powder supply system Intake structure Dense gas-solid flow Two-fluid model Powder fluidization Pressure drop

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Extracellular Vesicles from Mesenchymal Stromal Cells (imEVs) Improve Cold Preservation of Isolated Mitochondria

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Journal of Biosciences and Medicines 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesch-Andersen Catherine C. Baucom Karl-henrik Grinnemo Brent Segal Elliott Mitochondrial Center Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgical Sciences Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (ALS). However, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°C - 6°C for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.

关键词： Mitochondria Extracellular Vesicles Mitochondrial Preservation MOT imEVs

Mapping and Floristic Diversity of the Nakpadjouak Community Forest, Tami Canton, Togo (West Africa)

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Natural Resources 2024年第4期15卷 83-105页

作者： Senyo Kossi Ehlui Christian Anthony-Krueger Edinam Kola Wouyo Atakpama Alagie Bah henrik von Wehrden Tchaa Boukpessi West Africa Science Service Center on Climate Change and Adapted Land Use WASCAL University of the Gambia Banjul Gambia Laboratoire de Recherche sur la Dynamique des Milieux et des Socié t&#233s Department of Geography University of Lom&#233 Lome Togo Department of Science Education University of Cape Coast Cape Coast Ghana Laboratoire de Botanique et É cologie V&#233g&#233tale D&#233partement botanique Facult&#233 des sciences Universit&#233 de Lom&#233 Lome Togo West Africa Plant Red List Authority (WAPRLA) IUCN Species Survival Commission Gland Switzerland Center for International Forestry Research and World Agroforestry (CIFOR-ICRAF) Nairobi Kenya Faculty of Sustainability Center of Methods Leuphana University of L&#252neburg L&#252neburg Germany Laboratoire de Recherches Biogé ographiques et d&#8217Etudes Environnementales Department of Geography University of Lome Lome Togo

Since 2015, community forests have been promoted in Togo as an alternative to protect areas from degradation and as a means of contributing to forest landscape restoration. The study focuses on the Nakpadjouak Community Forest (NCF) in Tami (Togo, West Africa) which contributes to community forests sustainable management. It aims in (i) mapping forest ecosystems and analysing their dynamic and (ii) characterizing the floristic diversity of the NCF. The ecosystems were mapped and their dynamic was evaluated based on Google Earth images of 2014 and 2020. Floristic and forestry inventories were carried out using the transect technique in a sample of 20 plots of 50 m × 20 m. The NCF was made up mainly by wooded/shrub savannahs (95.37%) and croplands/fallow (4.63%) in 2014. These two land use types undergone changes over the 6 years prior to 2020. By 2020, the NCF had 3 land use types: wooded/shrub savannahs (77.59%), open forest/wooded savannahs (22.23%), and croplands/fallows (0.18%). A total of 89 plant species belonging to 70 genera and 28 families were recorded within the NCF. The dominant species are: Heteropogon contortus (L.) ***. and Combretum collinum Fresen. followed by Pteleopsissuberosa Engl. & Diels, Annona senegalensis Pers. The most common species are: Lannea acida ***. s.l., A. senegalensis, Vitellaria paradoxa *** subsp. paradoxa, C. collinum and Acacia dudgeonii Craib ex Holland. Due to its small area of just 40 hectares and its diverse plant life, this community forest of Savannahs Region is a significant biodiversity hotspot and warrants conservation efforts.

关键词： Community Forest Floristic Diversity Land Use Change Biodiversity Hotspot Tami Savannah Region Togo

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela henrik J.Persson Magnus Ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele Papucci Patrik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference