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Soluble membrane attack complex in ascites in patients with liver cirrhosis without infections

World Journal of Hepatology 2010年第6期2卷 221-225页

作者： Mette Bjerre Peter Holland-Fischer henning Grφnbk Jan Frystyk Troels K hansen Hendrik Vilstrup Allan Flyvbjerg The Medical Research Laboratories Clinical Institute and Department of Endocrinology and Internal Medicine Aarhus University Hospital Department of Medicine V (Hepatology and Gastroentology) Aarhus University Hospital

AIM: To study complement activation in 46 patients with alcoholic cirrhosis and ascites but no spontaneous bacterial peritonitis (SBP) and 10 healthy controls. METHODS: Complement activation was determined by the measurement of soluble membrane attack complex (sMAC) concentrations in ascites and plasma. In patients, metabolic liver function was determined by the galactose elimination capacity and the clinical status assessed by the Model of End-Stage Liver Disease and Child-Pugh scores. RESULTS: Ascites sMAC levels were markedly higherthan in the corresponding plasma sample (median (range): 596 (170 - 1519) vs 160 (77 - 848) μg/L; P < 0.01). Ascites sMAC levels correlated positively with liver status. There was no relationship between ascites sMAC and leukocyte count. No relationship between ascites sMAC and blood C-reactive protein, albumin or neutrophile count was found. Plasma sMAC concentrations were slightly higher in patients than in controls [130 μg/L (70 - 204); P = 0.04]. Neither sMAC in ascites nor plasma was related to mortality. CONCLUSION: The increased sMAC concentration in ascites and plasma indicate an activation of the complement system in cirrhosis even in the absence of SBP. This was particularly evident in the peritoneal fluid and most marked in patients with preserved liver status. The high ascites sMAC levels may reflect transudation of membrane attack complexes from the liver. Whether this complement activation has any clinical implications remains to be clarified.

关键词： Ascites Cirrhosis Complement sC5b-9 Soluble membrane attack complex

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NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.Jude Children’s Research Hospital MemphisTNUSA MD Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures

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斯堪的纳维亚高尔夫俱乐部

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中国建筑装饰装修 2011年第9期 74-81页

作者： Thorbjoern hansen henning Larsen事务所

该项目因其具有特色的外观和材料的合理利用获得了2009年哥本哈根木匠协会年度奖（Copenhagen Carpenters＇Guild）。外观的主角即俱乐部会所,它＂锋利＂的屋顶高低错落,材料也独具匠心,让人联想到日本的折纸艺术品.

关键词：高尔夫俱乐部斯堪的纳维亚哥本哈根合理利用艺术品材料外观屋顶

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丹麦多元节能住宅

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中国建筑装饰装修 2012年第7期 244-247页

作者： Thorbjoern hansen

该项目是henning Larsen建筑事务所与丹麦技术研究所和工程师Buro Happold共同合作完成的一个多样化的研发和实验性建筑,该项目于2009年在哥本哈根举行的联合国气候变化大

关键词：丹麦研究所北欧 test 技术室

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Pacemaker implantation in a patient with brugada and sick sinus syndrome

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World Journal of Cardiology 2013年第3期5卷 65-67页

作者： Bjarke Risgaard henning Bundgaard Reza Jabbari Stig HaunsФ Bo Gregers Winkel Jacob Tfelt-hansen The Danish National Research Foundation Centre for Cardiac Arrhythmia University of Copenhagen Laboratory of Molecular Cardiology Department of Cardiology The Heart Centre Copenhagen University Hospital Rigshospitalet

Brugada syndrome (BrS) is a rare and inherited primary arrhythmic syndrome characterized by ST-segment elevations in the right precordial leads (V1 -V3 ) with an increased risk of sudden cardiac death (SCD). Arrhythmias in BrS are often nocturne, and brady-arrhythmias are often seen in patients with loss-of-function mutations in SCN5A . In this case-report we present a 75-year old woman referred to our outpatient clinic for inherited cardiac diseases for a familial clinical work-up. Since childhood she had suffered from dizziness, absence seizures, and countless Syncope's. In 2004 sick sinus syndrome was suspected and she wastreated with implantation of a pacemaker (PM) at another institution. An inherited cardiac disease was one day suddenly suspected, as the patient had a 61-year old brother who was diagnosed with symptomatic BrS, and treated with an implantable cardioverter defibrillator (ICD) after aborted SCD. A mutation screening revealed a SCN5A [S231CfsX251 (c.692-693delCA )] loss-of-function mutation not previously reported, and as a part of the cascade screening in relatives she was therefore referred to our clinic. In the 7 year period after PM implantation she had experienced no cardiac symptoms, although her electrocardiogram changes now were consistent with a BrS type 1 pattern. A genetic test confirmed that she had the same mutation in SCN5A as her brother. In this case-report we present a loss-of function mutation in SCN5A not previously associated with BrS nor presented in healthy controls. Sinus node dysfunction has previously been documented in patients with symptomatic BrS, which suggests it is not a rare concomitant. The only accepted treatment of BrS is today implantation of an ICD. In the future studies should evaluate if PM in some cases of symptomatic BrS can be used instead of ICDs in patients with a loss-of-function SCN5A

关键词： Brugada syndrome Pacemaker Arrhythmias Sudden cardiac death

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自然的重塑

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建筑实践 2011年第11期 36-39页

作者：刘洋洋 Thorbjoern hansen henning Larsen Architects

宁静悠闲的生活方式和以人为本、自然和谐的价值观,造就了形式与功能统一的斯堪的纳维亚风格。现代北欧建筑师们始终继承和发展着这种传统工艺与现代设计思想相结合,广泛运用自然材料的建筑特点。斯堪的

关键词：高尔夫球场北欧欧洲屋面美术家建筑师斯堪的纳维亚玻璃幕墙

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