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Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng Yanyi Jiang hengxing chen Yongqiang Wang Qiusheng Lan Shuiqin chen Zhanwang Huang Jingyuan Zhang Duanqing Tian Yuntan Qiu Diankui Cai Jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AJUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AJUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AJUBA through the KRAS *** of both EHF and its coactivator AJUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

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基于强化学习的自动驾驶联合训练方法

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机电工程技术 2024年第3期53卷 131-135页

作者：陈恒星刘一鸣澳门科技大学商学院中国澳门999078 中山大学管理学院广州510006

自动驾驶控制算法对自动驾驶至关重要,为了设计适应多种环境更高效的自动驾驶控制算法,提出了基于强化学习的联合训练方法。自动驾驶控制算法应该在各种道路环境、各种天气环境、各种场景下都可以稳定的运行,因此通过人工智能的方法设... 详细信息

自动驾驶控制算法对自动驾驶至关重要,为了设计适应多种环境更高效的自动驾驶控制算法,提出了基于强化学习的联合训练方法。自动驾驶控制算法应该在各种道路环境、各种天气环境、各种场景下都可以稳定的运行,因此通过人工智能的方法设计自动驾驶算法时必须要考虑到各种场景。基于TORCS仿真软件设计了基于强化学习的联合训练方法,包括使用神经网络拟合动作、状态空间,设置训练策略、奖励函数等机制。同时通过在不同环境下设置多个智能体进行强化学习训练,并设计了联合训练的算法,实现多个智能体在不同环境下进行联合训练,不同智能体共享相互学习到的经验,提高了模型的泛化性。所设计的联合训练方法实现了多个强化学习智能体的联合训练,并通过了实验验证,达到了高效、稳定的训练策略。

关键词：强化学习自动驾驶人工智能

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论我国商业数据产权制度之构建

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山东科技大学学报（社会科学版） 2023年第3期25卷 21-29页

作者：来小鹏陈恒星中国政法大学民商经济法学院北京100088

商业数据产权制度是数据要素市场的基础制度。当下商业数据产权制度体系构建面临着规范对象边界不明、确权授权属性不清以及对产业实践回应不足等现实困境。考虑到商业数据客体的特殊性、所涉法律关系的利益多元性以及数据竞争、数据交... 详细信息

商业数据产权制度是数据要素市场的基础制度。当下商业数据产权制度体系构建面临着规范对象边界不明、确权授权属性不清以及对产业实践回应不足等现实困境。考虑到商业数据客体的特殊性、所涉法律关系的利益多元性以及数据竞争、数据交易等不同领域的差异性,为解决商业数据产权制度供给难以满足实践需求的困境,应当从基于关系进路理解权利、克服单一制度模式选择两个方面调整商业数据产权制度构建的理论依据。在竞争制度外,专门构建商业数据的有限排他权,为其配置相对受限的禁止权能以及较低门槛的许可权能,并对商业数据进行科学分类分级,统筹协调商业数据与公共数据的关系,以保障商业数据交易流通和有效利用。

关键词：商业数据数据权益数据竞争数据交易产权制度

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HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing Jie Wang chen Xu Ziming Liu Qingze chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-Peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth Sciences Guilin University of TechnologyGuilin 541004China Department of Physics Anhui Normal UniversityWuhu 241002China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 19 beams were only slightly(~5%)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1 and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1)is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

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干湿循环作用下石窟砂岩的抗拉强度劣化机理及破坏模式

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地球科学 2024年第2期49卷 612-624页

作者：陈钊兰恒星刘世杰都奎建长安大学地质工程与测绘学院陕西西安710054 中国科学院地理科学与资源研究所北京100101

干湿循环作用对石窟砂岩影响严重,造成了大量石窟砂岩的悬臂拉裂式破坏.通过室内干湿循环试验、巴西劈裂试验以及应变场分析等方法,分析了不同干湿循环次数下试样的内摩擦角φ、粘聚力c、微观结构、以及应变场特征的变化规律.研究发现... 详细信息

干湿循环作用对石窟砂岩影响严重,造成了大量石窟砂岩的悬臂拉裂式破坏.通过室内干湿循环试验、巴西劈裂试验以及应变场分析等方法,分析了不同干湿循环次数下试样的内摩擦角φ、粘聚力c、微观结构、以及应变场特征的变化规律.研究发现随着干湿循环次数的增加,粘土矿物逐渐流失,结构变得松散,矿物颗粒间的胶结作用减弱,导致了砂岩粘聚力c的减小.同时由于砂岩内部颗粒形状以及孔隙结构的变化改变了颗粒间的接触关系,导致了内摩擦角φ的减小,最终造成了其拉裂力学性质的劣化.最后结合试样的破坏过程及裂纹展布总结出了不同干湿循环作用下石窟砂岩的两种破坏模式.

关键词：岩石力学干湿循环石窟砂岩抗拉强度劣化机理

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： hengxing Zhou Yongfu Lou Lingxiao chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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高校校园足球文化建设困境及改革方向

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体育科技文献通报 2019年第11期27卷 31-31,43页

作者：陈恒兴云南大学体育学院

采用文献资料法对高校足球文化建设进行了全面的研究,详细阐述了高校园足球文化是由物质文化、精神文化、制度文化和行为文化构成的,分析了四者在高校校园足球文化建设中的作用。结果表明:高校校园足球文化建设存在着足球物质文化基础... 详细信息

采用文献资料法对高校足球文化建设进行了全面的研究,详细阐述了高校园足球文化是由物质文化、精神文化、制度文化和行为文化构成的,分析了四者在高校校园足球文化建设中的作用。结果表明:高校校园足球文化建设存在着足球物质文化基础建设不完善、足球精神文化氛围不浓厚和足球制度文化建设不健全等困境,并提出了完善足球物质文化建设、凸显教育功能,营造足球精神文化氛围和加强足球制度文化建设等改革方向。

关键词：高校院校足球文化建设困境改革方向

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体育旅游在滇西北地区的安全策略研究

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湖北体育科技 2013年第12期32卷 1041-1043页

作者：陈恒兴云南大学体育学院云南昆明650091

采用文献资料法、实地考察等研究方法对滇西北地区体育旅游的发展和救援现状进行分析和讨论,提出在滇西北地区旅游地建立适合的救援体系。

关键词：体育旅游救援体系滇西北地区

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HiFAST:An H?data calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期Mechanics & Astronomy) .卷 186-203页

作者： Yingjie Jing Jie Wang chen Xu Ziming Liu Qingze chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-Peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu School of Astronomy and Space Science University of Science and Technology of China Astrophysics Department of PhysicsUniversity of Oxford College of Earth Sciences Guilin University of Technology Department of Physics Anhui Normal University School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing University National Astronomical Observatories Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Astronomy and Space Science University of Chinese Academy of Sciences Guizhou Radio Astronomical Observatory Guizhou University Max Planck Institute for Extraterrestrial Physics Kavli Institute for Astronomy and Astrophysics Peking University Institute of Computational Cosmology Department of PhysicsUniversity of Durham CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of China

The Five-hundred-meter Aperture Spherical radio Telescope（FAST） has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas（H?） in the *** present HiFAST（https://***）,a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square（RMS） noises of the calibrated spectra from all 19 beams were only slightly（～5%） higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps（0,1 and 2） of M33 agree well with the results from the Arecibo Galaxy Environment Survey（AGES） with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA（ALFALFA） survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1) is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H? in the universe.

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过氧化氢预处理对褐煤物化性质及生物产气的影响

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微生物学报 2024年第6期64卷 1972-1991页

作者：魏雨萌任义何环赵晗任恒星陈林勇黄再兴中国矿业大学化工学院煤炭加工与清洁利用教育部重点实验室江苏徐州221116 晋能控股集团煤与煤层气共采全国重点实验室山西晋城048000 中国矿业大学炼焦煤资源绿色开发全国重点实验室江苏徐州221116 中国矿业大学国家煤加工与洁净化工程技术研究中心江苏徐州221116

【目的】研究过氧化氢预处理对褐煤物化性质及生物产气的影响。【方法】以胜利5号褐煤为研究对象,利用正交试验对过氧化氢预处理褐煤条件进行优化,在最优条件下处理褐煤得到处理后的残煤和处理液,通过X射线衍射分析(X-ray diffraction,X... 详细信息

【目的】研究过氧化氢预处理对褐煤物化性质及生物产气的影响。【方法】以胜利5号褐煤为研究对象,利用正交试验对过氧化氢预处理褐煤条件进行优化,在最优条件下处理褐煤得到处理后的残煤和处理液,通过X射线衍射分析(X-ray diffraction,XRD)、扫描电镜分析(scanning electron microscopy,SEM)、比表面积分析及孔隙分析(brunauer-emmett-teller,BET)、气相色谱-质谱分析(GC-MS)、高效液相色谱分析(HPLC)等方法对原煤、残煤和处理液的物化性质进行比较分析。【结果】经过氧化氢预处理,褐煤的最优条件为过氧化氢浓度5.0%、预处理时间20 d、液固比30:1,处理液中总有机碳含量为105 mg/L。在最优条件下,过氧化氢处理后残煤表面裂痕、凹陷增多,表面结构变得松散;煤的芳香面网间距增加,芳环结构更加疏松,晶核结构变小;孔隙度和比表面积均增大。处理后残煤中的固定碳、C元素和镜质组的相对含量降低,而灰分、挥发分、O和H元素及惰质组含量增加,残煤中O=C−O、C=C、C=O官能团含量增加,而N−H、C−H官能团含量则减少。生物产气结果表明反应液和残煤产气量均低于原煤,分别减少了39.13%和94.46%。过氧化氢预处理主要作用于煤中镜质组,使其有机碳溶解,煤中大分子结构的官能团发生变化,改变煤的芳环结构,在氧化作用下煤结构中的小分子溶解进入处理液。处理液中有机物以短链脂肪酸为主。经生物产气后,反应液中小分子酸以及有机物种类减少,被微生物利用产气。而各产气试验组中优势菌门及优势菌属的菌群丰度呈现出显著差异,古菌中原煤产气组盐杆菌门(Halobacteriota)为优势菌门,甲烷八叠球菌属(Methanosarcina)为优势菌属;反应液产气组热变形菌(Thermoprotei)为优势菌门,深古菌属(Bathyarchaeia)为优势菌属;细菌中原煤产气组放线菌门(Actinomycetota)为优势菌门,Gaiellales为优势菌属;反应液产气试验组假单胞菌门(Pseudomonadota)为优势菌门,代尔夫特菌属(Delftia)为优势菌属。【结论】煤溶解有机碳可以被微生物利用产气,但是煤中有机组分的过氧化脱除导致生物产气量减少。

关键词：褐煤生物产气化学预处理过氧化氢

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