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Role of endovascular embolisation for curative treatment of intracranial non- Galenic pial arteriovenous fistula

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Stroke & Vascular Neurology 2021年第2期6卷 260-266页

作者： hengwei jin Xiangyu Meng Jiale Quan Yi Lu Youxiang Li Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Interventional Neuroradiology department Beijing Neurosurgical InstituteBeijingChina Pediatric department Dongming People’s HospitalBeijingChina Department of Interventional Neuroradiology Beijing Neurosurgical InstituteBeijingChina

Background and purpose The safety and effectiveness of endovascular treatment for non-Galenic pial arteriovenous fistula(NGPAVF)is inadequately *** aim of this study is to explore the role of endovascular embolisation for curative treatment of *** and methods Patients with NGPAVF underwent endovascular treatment from January 2011 to November 2019 in our institution were retrospectively ***,clinical information,treatment details and clinical outcomes were *** associated with clinical outcomes were statistically *** Twenty patients were included,with a total of 22(2 patients have 2 fistulas)lesions.A total of 25 procedures were performed and 5 patients underwent 2 ***-up ranged from 3 to 84 months(mean=34.5 months).Thirteen(59.1%)lesions in 12(60.0%)patients acquired immediate occlusion after initial treatment(immediately occluded group)and follow-up confirmed the complete obliteration.A total of 17(77.3%)lesions in 15(75.0%)patients were cured at last *** maximal diameter of feeding arteries(p=0.04)and the maximal diameter of the varix(p=0.01)in immediately occluded group was smaller than non-immediately occluded *** number of feeding artery(p=0.004)and the maximal diameter of the varix(p<0.001)were much smaller in curative group than non-curative *** patients suffered procedure-related *** patients had an increased Modified Rankin Scale(mRS)and all patients had favourable clinical outcome(mRS≥2)at last *** Endovascular therapy plays an important role in curative treatment of *** with less feeding arteries and small varix may be easier to be cured by endovascular embolisation.

关键词： curative fistula treatment

Cell-free microRNA-21: biomarker for intracranial aneurysm rupture

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Chinese Neurosurgical Journal 2020年第3期6卷 141-151页

作者： hengwei jin Yuhua Jiang Xinke Liu Xiangyu Meng Youxiang Li Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityNo.119South 4th Ring West RoadFengtai DistrictBeijing 100070China

Background:Deregulation of miRNA-21 expression has been reported to be associated with vascular smooth muscle behavior and cytoskeletal *** study is aimed to investigate the density of serum miRNA-21 in patients with different phases of intracranial aneurysms(IAs)and explore its warning function for IA ***:A total of 16 in 200 IA patients were selected and categorized into 4 groups based on the phase of *** study was carried out using serum miRNA and differentially expressed miRNAs were *** 24 samples from a cohort of 360 patients were added and real-time polymerase chain reaction(RT-PCR)was performed on expanded sample size(n=40)for miRNA-21 *** gene targets of miRNA-21 were screened out from Gene Ontology(GO)database and ***:Microarray study identified 77 miRNAs with significantly different expression levels between experimental groups and the control ***-PCR assays validated significant downregulation of miRNA-21 in experimental groups,among which miRNA-21 expression level of daughter aneurysm group decreased the *** analyses revealed that several target genes related with miRNA-21 may be involved in IA formation and ***:This study suggested that miRNA-21 had a protective effect for intracranial vascular wall against remodeling and warning function for intracranial aneurysm *** suppression of serum miRNA-21 in IA patients may provide diagnostic clues for aneurysm rupture and guide clinical intervention.

关键词： Serum miRNA-21 Intracranial aneurysm Daughter aneurysm Vascular wall remodeling

Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience

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Stroke & Vascular Neurology 2021年第1期6卷 65-73页

作者： Yu Chen Ruinan Li Li Ma Xiangyu Meng Debin Yan Hao Wang Xun Ye hengwei jin Youxiang Li Dezhi Gao Shibin Sun Ali Liu Shuo Wang Xiaolin Chen Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Stroke Center Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Gamma-Knife Center Beijing Tiantan HospitalBeijingChina

Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations(AVMs)after different management *** The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and *** rupture risk was represented by annualised haemorrhagic *** were divided into five groups:conservation,microsurgery,embolisation,stereotactic radiosurgery(SRS)and embolisation+*** outcomes were evaluated by the modified Rankin Scale(mRS).Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured *** All of 61 brainstem AVMs(12 unruptured and 49 ruptured)were followed up for an average of 4.5 *** natural annualised rupture risk was 7.3%,and the natural annualised reruptured risk in the ruptured cohort was 8.9%.13 cases were conservative managed and 48 cases underwent intervention(including 6 microsurgery,12 embolisation,21 SRS and 9 embolisation+SRS).In the selection of interventional indication,diffuse nidus were often suggested conservative management(p=0.004)and nidus involving the midbrain were more likely to be recommended for intervention(p=0.034).The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management(p<0.001,p=0.036,respectively).In the subgroup analysis,the follow-up mRS scores of different management modalities were similar whether in the rupture cohort(p=0.064)or the unruptured cohort(p=0.391),as well as the haemorrhage-free survival(p=0.145).In the adjusted Bonferroni correction analysis of the ruptured cohort,microsurgery and SRS could significantly improve the obliteration rate compared with conservation(p<0.001,p=0.001,respectively)and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation(p=0.003,p=0.003,respectively).Conclusio

关键词： brainstem modalities conservative

Pipeline versus Tubridge in the treatment of unruptured posterior circulation aneurysms

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Chinese Neurosurgical Journal 2023年第4期9卷 251-257页

作者： hengwei jin Jian Lv Xiangyu Meng Xinke Liu Hongwei He Youxiang Li Department of Neurosurgery Beijing Tiantan Hospital and Beijing Neurosurgical InstituteCapital Medical UniversityNo.119South 4Th Ring West RoadFengtai DistrictBeijing 100070China Neurosurgery Department The First Hospital of Hebei Medical UniversityDonggang Road 89ShijiazhuangHebei ProvinceChina

Background To compare the safety and efficacy of pipeline embolization device(PED)and Tubridge flow diverter(TFD)for unruptured posterior circulation *** Posterior aneurysm patients treated with PED or TFD between January,2019,and December,2021,were retrospectively ***’demographics,aneurysm characteristics,treatment details,complications,and follow-up information were *** procedural-related complications and angiographic and clinical outcome were *** A total of 107 patients were involved;PED was applied for 55 patients and TFD for 52 patients.A total of 9(8.4%)procedural-related complications occurred,including 4(7.3%)in PED group and 5(9.6%)in TFD *** a mean of 10.3-month angiographic follow-up for 81 patients,complete occlusion was achieved in 35(85.4%)patients in PED group and 30(75.0%)in TFD *** occlusion rate of PED group is slightly higher than that of TFD group.A mean of 25.0-month clinical follow-up for 107 patients showed that favorable clinical outcome was achieved in 53(96.4%)patients in PED group and 50(96.2%)patients in TFD group,*** statistical difference was found in terms of procedural-related complications(p=0.737),occlusion rate(p=0.241),and favorable clinical outcome(0.954)between *** The current study found no difference in complication,occlusion,and clinical outcome between PED and TFD for unruptured PCAs.

关键词： Pipeline embolization device Tubridge flow diverter Posterior circulation aneurysm

Embolization of feeding arteries and symptom alleviation of mixed dural-pial arteriovenous malformations

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Chinese Neurosurgical Journal 2018年第2期4卷 59-64页

作者： hengwei jin Hong Qiu Chang Chen Huijian Ge Youxiang Li Hongwei He Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityNo.6Tiantan XiliDongchengBeijing 100050China Neurosurgery Department Xintai Hospital of Traditional Chinese MedicineTai’anShandong 271200China Beijing Engineering Research Center for Interventional Neuroradiology No.6Tiantan XiliDongchengBeijing 100050China

Background: To examine whether embolization of dural or pial blood supply branch is more efficient for symptom alleviation for unruptured mixed dural-pial arteriovenous malformations (DPAVMs). Methods: We retrospectively reviewed 30 DPAVM patients from a database of 425 consecutive cerebral arteriovenous malformation (CAVM) patients who underwent endovascular embolization between January 2010 and December 2015 at our institution. Demographics, angioarchitectural characteristics, endovascular embolization details and patients clinical outcomes were recorded. The modified Rankin Scale (mRS), Engel‘s classification and Visual Analogue pain scale (VAS) were used to assess clinical outcomes. Results: The single center cohort data shows that the incidence of DPAVM is 7.1%. Among the 30 DPAVM patients, 9 (30.0%) are ruptured and 21 (70.0%) are unruptured. Four (19.0%) of the 21 unruptured DPAVM patients are failed to follow-up, leaving 17 to analysis the clinical outcomes. Clinical presentations of the 17 unruptured DPAVM patients are epilepsy (n=10), headache (n=5) and focal neurological dysfunction (n=2). Six patients have DPAVMs occluded via pial blood supply branches, 4 via dural branches and 7 via both pial and dural branches. Unruptured DPAVM patients with nidus occluded via dural blood supply branches, or both pial and dural branches have higher symptom alleviation rate than patients with nidus occluded via pial branches (100%/85.7% vs 66.7%). Conclusions: For DPAVM patients presented with epilepsy, headache and FND, embolization via dural blood supply branches may be more efficient for symptom alleviation. Large cohort study is needed to confirm the generalizability.

关键词： Mixed dural-pial arteriovenous malformations Endovascular treatment Clinical outcome

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“九一八”新史料与辽宁抗战研究

兰台世界 2016年第19期 143-145,148页

作者：金恒薇沈阳"九.一八"历史博物馆沈阳110044

以"九一八"事变为起点的辽宁抗战,不仅是中国抗日战争的重要组成部分,也是世界反法西斯战争的重要构成。对"九一八"新史料的深入研究,凸显了辽宁抗战所独具的典型性、完整性和国际性的特点,进一步弘扬了具有丰富内涵的辽宁抗战精神。"... 详细信息

以"九一八"事变为起点的辽宁抗战,不仅是中国抗日战争的重要组成部分,也是世界反法西斯战争的重要构成。对"九一八"新史料的深入研究,凸显了辽宁抗战所独具的典型性、完整性和国际性的特点,进一步弘扬了具有丰富内涵的辽宁抗战精神。"九一八"新史料为辽宁抗战研究提供理论论证的同时,也为建设新辽宁提供了强大的精神动力,极具现实意义与影响。

关键词： “九一八”事变新史料辽宁抗战研究

新中国政府成功处理战后问题的作用——以溥仪作证为例

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辽宁大学学报（哲学社会科学版） 2015年第6期43卷 158-161页

作者：金恒薇牟岱沈阳九一八历史博物馆辽宁沈阳110030 辽宁社会科学院辽宁沈阳110032

第二次世界大战结束后,战后问题的处理是否得当对反法西斯战争胜利成果的捍卫和法西斯势力的彻底消灭起着决定性的作用。对此,新中国政府在战犯改造和审判工作中因方法正确而独特,成为成功处理战后问题的典范。从溥仪在远东国际军事法... 详细信息

第二次世界大战结束后,战后问题的处理是否得当对反法西斯战争胜利成果的捍卫和法西斯势力的彻底消灭起着决定性的作用。对此,新中国政府在战犯改造和审判工作中因方法正确而独特,成为成功处理战后问题的典范。从溥仪在远东国际军事法庭和沈阳军事法庭两次出庭作证的表现来看,新中国政府改造战犯工作是成功的,对最终审判起到了良好的衔接作用,并为其奠定了坚实的基础。改造与审判工作的互相衔接与促进,对战后国际新秩序的形成和人类改造产生了良好的延续与深远的影响。

关键词：战犯改造远东国际军事法庭审判沈阳军事法庭审判末代皇帝溥仪

房颤合并急性颅内大动脉闭塞患者的临床特点及机械取栓疗效分析

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中华医学杂志 2019年第39期99卷 3068-3072页

作者：张宝瑞刘爱华莫大鹏霍晓川刘鹏金恒伟缪中荣北京市神经外科研究所北京100070 首都医科大学附属北京天坛医院神经介入中心北京100070

目的探讨房颤合并急性颅内大动脉闭塞患者的临床特点及机械取栓疗效。方法纳入East(endovascular therapy for acute ischemic stroke trial)研究中房颤合并急性颅内大动脉闭塞患者58例,East研究是由北京天坛医院于2016年联合全国17家... 详细信息

目的探讨房颤合并急性颅内大动脉闭塞患者的临床特点及机械取栓疗效。方法纳入East(endovascular therapy for acute ischemic stroke trial)研究中房颤合并急性颅内大动脉闭塞患者58例,East研究是由北京天坛医院于2016年联合全国17家卒中中心同期开展的前瞻性、非随机对照研究。根据TOAST(trial of Org 10172 in acute stroke treatment)分型,将患者分为心源性栓塞组和动脉粥样硬化组(ICAS)。分析房颤合并急性颅内大动脉闭塞患者的临床特点、治疗方式及临床预后。结果本研究共纳入房颤合并急性颅内大动脉闭塞患者58例,其中栓塞组46例(79%),ICAS组12例(21%);ICAS组院前转运时间要长于心源性栓塞组(P<0.05)。房颤合并急性颅内大动脉闭塞患者取栓开通率为98.3%(57/58),90 d功能独立(改良RANKIN量表0~2分)患者比例为51.7%(30/58)。心源性栓塞组和ICAS组患者在90 d功能独立、死亡比例、颅内出血及症状性颅内出血方面差异无统计学意义。结论机械取栓治疗房颤伴发急性颅内大动脉闭塞是一项有效的治疗方法。

关键词：房颤颅内栓塞血栓切除术预后

微生物-肠-脑轴调控蛋鸡应激性异常行为的研究进展

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动物营养学报 2021年第4期33卷 1859-1868页

作者：邹昕羽 CHENG hengwei 金美兰江莎西南大学动物医学院动物健康与动物性食品安全国际合作联合实验室重庆400715 美国农业部农业研究所西拉斐特479072 西南大学医学研究院免疫学研究中心重庆402460

现代养禽业采用的高密度笼养体系、分阶段饲养、断喙等管理措施可引起禽的过度应激,使它们出现啄羽、攻击或同类相食等异常行为。肠道菌群被视为一种跨物种的虚拟内分泌器官,通过肠-脑轴的双向通讯整合来自代谢、免疫、内分泌和神经通... 详细信息

现代养禽业采用的高密度笼养体系、分阶段饲养、断喙等管理措施可引起禽的过度应激,使它们出现啄羽、攻击或同类相食等异常行为。肠道菌群被视为一种跨物种的虚拟内分泌器官,通过肠-脑轴的双向通讯整合来自代谢、免疫、内分泌和神经通路发出的信号,并通过肠神经和迷走神经等外周神经系统、5-羟色胺和短链脂肪酸等微生物代谢产物以及免疫系统等途径调控动物应激反应及相应异常行为。本文系统地总结了蛋鸡饲养管理措施所造成的禽过度应激行为,并对微生物-肠-脑轴对鸡应激及其相关行为调控的可能机制进行论述,旨在为益生菌在蛋鸡饲养管理的推广应用提供参考依据。

关键词：蛋鸡应激异常行为肠道菌群微生物-肠-脑轴