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Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal:A nationwide,multicenter study

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Chinese Medical Journal 2024年第15期137卷 1802-1810页

作者： Changyang Xing Xiujing Xie Yu Wu Lei Xu Xiangping Guan Fan Li Xiaojun Zhan hengli yang Jinsong Li Qi Zhou Yuming Mu Qing Zhou Yunchuan Ding Yingli Wang Xiangzhu Wang Yu Zheng Xiaofeng Sun Hua Li Chaoxue Zhang Cheng Zhao Shaodong Qiu Guozhen Yan Hong yang Yinjuan Mao Weiwei Zhan Chunyan Ma Ying Gu Wu Chen Mingxing Xie Tianan Jiang Lijun Yuan Department of Ultrasound Medicine Tangdu HospitalAir Force Medical UniversityXi’anShaanxi 710038China Department of Ultrasound Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Ultrasound Xi’an Hospital of Traditional Chinese MedicineXi’anShaanxi 710021China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s HospitalXi’anShaanxi 710068China Department of Ultrasound Hospital of Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Ultrasound Xi’an No.1 HospitalThe First Affiliated Hospital of Northwest UniversityXi’anShaanxi 710002China Department of Ultrasound Diagnosis The Second Affiliated HospitalXi’an Medical CollegeXi’anShaanxi 710038China Department of Ultrasound Xi’an Gem Flower ChangQing HospitalXi’anShaanxi 710201China Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong UniversityChinaXi’anShaanxi 710004China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Ultrasound Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Ultrasound Yan’an HospitalThe Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650051China Department of Ultrasound Yan’an University Xianyang HospitalXianyangShaanxi 712000China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Ultrasound Xi’an Central HospitalXi’anShaanxi 710004China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound CenterFirst Hospital of Jilin UniversityChangchunJilin 130000China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical UniversityUrumqiXinjiang 830002China Department of Ultrasound First Affiliated

Background:Carotid intima-media thickness(IMT)and diameter,stiffness,and wave reflections,are independent and important clinical biomarkers and risk predictors for cardiovascular *** purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***:A total of 3053 healthy Han Chinese adults(1922 women)aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July *** real-time tracking of common carotid artery walls was achieved by the radio frequency(RF)ultrasound *** IMT,diameter,compliance coefficient,βstiffness,local pulse wave velocity(PWV),local systolic blood pressure,augmented pressure(AP),and augmentation index(AIx)were then automatically measured and *** were stratified by age groups and *** relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear *** major clinical determinants of carotid properties were identified by Pearson’s correlation,multiple linear regression,and analyses of ***:All the parameters of carotid properties demonstrated significantly age-related *** showed thinner IMT,smaller carotid diameter,larger AP,and AIx than ***βstiffness and PWV were significantly higher in men than women before forties,but the differences reversed after *** increase rate of carotid IMT(5.5µm/year in women and 5.8µm/year in men)and diameter(0.03 mm/year in both men and women)were similar between men and *** the stiffness and wave reflections,women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes(all P for age by sex interaction<0.05).The blood pressures,body mass index(BMI),and triglyceride levels were identified as major clinical determinants of carotid properties with adjustment of age and ***

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

高效氯氟氰菊酯与烯啶虫胺增效混配剂的筛选及其对小麦蚜虫的田间防治效果

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植物保护 2024年第2期50卷 332-337页

作者：杨恒力李红宝董文阳王翠翠史雪岩梁沛中国农业大学植物保护学院北京100193

为了延缓麦蚜抗药性和降低杀虫剂使用量,本研究筛选了具有增效作用的高效氯氟氰菊酯和烯啶虫胺的复配比例,并研究了增效复配剂对麦蚜的田间防治效果。浸叶法测定结果表明,高效氯氟氰菊酯对麦蚜的LC_(50)为25.01 mg/L,烯啶虫胺对麦蚜的LC... 详细信息

为了延缓麦蚜抗药性和降低杀虫剂使用量,本研究筛选了具有增效作用的高效氯氟氰菊酯和烯啶虫胺的复配比例,并研究了增效复配剂对麦蚜的田间防治效果。浸叶法测定结果表明,高效氯氟氰菊酯对麦蚜的LC_(50)为25.01 mg/L,烯啶虫胺对麦蚜的LC_(50)为28.21 mg/L。通过最佳增效配比的筛选,发现高效氯氟氰菊酯和烯啶虫胺的有效成分比为1.3∶1、1∶1.1、1∶1.7、1∶10.2时,对麦蚜的毒效比分别为1.28、1.49、1.64、1.50,表现为增效作用。深入研究发现高效氯氟氰菊酯和烯啶虫胺的有效成分为1∶4.5、1∶7.5和1∶10.2的混配组合的共毒系数均显示了显著增效作用,其中,当高效氯氟氰菊酯与烯啶虫胺有效成分比为1∶7.5时,混配剂的LC_(50)为5.22 mg/L,共毒系数达到532.61。按有效成分比1∶7.5,将10%高效氯氟氰菊酯水乳剂与20%烯啶虫胺可溶液剂混用后,进行田间试验,结果表明,在药后1、3 d和7 d,混配剂的防效与高效氯氟氰菊酯单剂的防效无显著性差异,在药后1 d,混配剂的防效高于烯啶虫胺单剂的防效,在药后3 d及7 d,混剂与烯啶虫胺单剂的防效没有显著差异。混配剂的防效在药后7 d内不断上升,其中药后7 d防效达到92.98%。混配剂的使用可以达到对高效氯氟氰菊酯减量的目的,同时保证了对麦蚜的防效。

关键词：高效氯氟氰菊酯烯啶虫胺混配麦蚜防治效果

Pre-reduction of WO_(3)-Co_(3)O_(4)by H_(2)-C_(2)H_4 in a fluidized bed

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Chinese Journal of Chemical Engineering 2024年第2期66卷 273-284页

作者： Huijun Shang hengli Li Weijun Li Feng Pan Zhan Du State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences(CAS)Beijing 100190China College of Chemical Engineering Nanjing Technology UniversityNanjing 211816China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China College of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Chinalco Environmental Protection and Energy Conservation Group Co. Ltd.Xiong’an 071700China

In order to avoid the formation ofηphase(W_(6)Co_(6)C or W_(3)Co_(3)C)that adversely affects the sintering process and its products in the preparation process of ultra-fine WC-Co powder,a technical route of prereduction of WO_(3)-Co_(3)O_(4)to WO_(2)-Co and then deep reduction carbonization to WC-Co powder has been *** study mainly investigates the influence of gas partial pressure on the pre-reduction process of WO_(3)-Co_(3)O_(4)under a mixed atmosphere of H_(2)-C_(2)H_(4)-Ar at 600℃and establishes the kinetic equations of pre-reduction and carbon *** results indicate that increasing the partial pressure of hydrogen is conducive to the rapid and complete conversion of WO_(3) to WO_(2).High carbon content can be generated by the deposition of C_(2)H_(4),and it hinders the diffusion of the reducing gas;WO_(3)still cannot be completely reduced to WO_(2)as the partial pressure of C_(2)H_(4) increases to 60%.For the carbon evolution of C_(2)H_(4),the carbon amount is positively related to the H_(2)partial pressure,but it shows the highest amount and evolution rate when the ethylene partial pressure is 20%.Based on the reduction rate curves of WO_(3) and carbon evolution rate curves of C_(2)H_(4),the rate equations of pre-reduction and carbon evolution of WO_(3)-Co_(3)O_(4)system at 600℃are *** pre-reduction reaction belongs to the first-order reaction,and its equation is expressed as follows:r=-(dw_(WO_(3)))/dt=(9±0.15)×10^(-2)×P_(H_(2))^(0.44)P_(C_(2)H_(4))&(0.57)The carbon deposition rate equation of C_(2)H_(4) can be expressed as follows:r=-(dc_C)/dt=r_f-r_b≌7.35×10^(-2)×P_(C_(2)H_(4))^(0.31)

关键词： Fluidization WO_(3)-Co_(3)O_(4) Reduction Carbon deposition Rate equation

Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 1092-1097页

作者： Qian Zhang Yao Jing Qiuyuan Gong Lin Cai Ren Wang Dianxu yang Liping Wang Meijie Qu Hao Chen Yaohui Tang hengli Tian Jun Ding Zhiming Xu Department of Gerontology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong UniversityShanghaiChina Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Endorepellin plays a key role in the regulation of angiogenesis,but its effects on angiogenesis after traumatic brain injury are *** study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in *** were randomly divided into four groups:sham,controlled cortical impact only,adeno-associated virus(AAV)-green fluorescent protein,and AAV-shEndorepellin-green fluorescent protein *** the controlled cortical impact model,the transduction of AAV-shEndorepellin-green fluorescent protein downregulated endorepellin while increasing the number of CD31+/Ki-67+proliferating endothelial cells and the functional microvessel density in mouse *** changes resulted in improved neurological function compared with controlled cortical impact *** blotting revealed increased expression of vascular endothelial growth factor and angiopoietin-1 in mice treated with AAV-shEndorepellin-green fluorescent *** radiation angiography showed that endorepellin downregulation promoted angiogenesis and increased cortical neovascularization,which may further improve neurobehavioral ***,an in vitro study showed that downregulation of endorepellin increased tube formation by human umbilical vein endothelial cells compared with a *** analysis found that endorepellin downregulation may mediate angiogenesis by activating vascular endothelial growth factor-and angiopoietin-1-related signaling pathways.

关键词： angiogenesis controlled cortical impact endorepellin neurological function traumatic brain injury

Realization of an Adaptive Radiative Cooler with a Multilayer-Filter VO_(2)-Based Fabry-Pérot Cavity

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Chinese Physics Letters 2024年第4期41卷 38-44页

作者：谢恒立殷怀远范春珍 School of Physics and Laboratory of Zhongyuan Light Zhengzhou UniversityZhengzhou 450001China

A high-performance adaptive radiative cooler comprising a multilayer-filter VO_(2)-based Fabry-Pérot(FP)cavity is *** bottom FP cavity has four layers,VO_(2)/NaCl/PVC/*** on the phase transition of VO_(2),the average emissivity in the transparent window can be switched from 3.7%to 96.3%.Additionally,the average emissivity can also be adjusted with external strain to the PVC layer,providing another way to attain the desired cooling *** upper filter is included to block most of the solar radiation and provide a transmittance of 96.7% in the atmospheric *** high temperature,the adaptive emitter automatically activates radiative *** net cooling power is up to 156.4 W·m^(-2)at an ambient temperature of 303 *** adaptive emitter still exhibits stable selective emissivity at different incident angles and heat transfer *** low temperature,the radiative cooling automatically deactivates,and the average emissivity decreases to only 3.8%.Therefore,our work not only provides new insights into the design of high-performance adaptive radiative coolers but also advances the development of intelligent thermal management.

关键词： emissivity cavity switched

Classical spin liquid state in a rhombic lattice metal-organic framework

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Nano Research 2024年第4期17卷 3407-3412页

作者： Sihua Feng Chao Wang Jiyin Zhao Xuguang Liu Chaocheng Liu Zeming Qi Lei Chen Huijuan Wang Minghui Fan hengli Duan Wensheng Yan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Discovering more and new geometrically frustrated systems remains an active point of inquiry in fundamental physics for the existence of unusual states of ***,we report spin-liquid-like behavior in a two-dimensional(2D)rhombic lattice Fe-metal-organic framework(Fe-MOF)with frustrated *** Fe-MOF exhibits a high frustration factor f=|θCW|/TN≥315,and its long-range magnetic order is suppressed down to 180 *** theoretical calculations demonstrate strong antiferromagnetic coupling between adjacent Fe3+ions,indicating the potential of a classical spin-liquid-like ***,a T-linear heat capacity parameter,γ,originating from electronic contributions and with magnetic field independence up to 8 T,can be observed in the specific heat capacity measurements at low-temperature,providing further proof for the spin-liquid-like *** work highlights the potential of MOF materials in geometrically frustrated systems,and will promote the research of exotic quantum physics phenomena.

关键词： spin-liquid-like state two-dimensional metal-organic framework(2D MOF) rhombic lattice ultralow temperature(ULT)measurements spin-frustrated

Investigating the interaction between umami peptides and umami receptor T1R1/T1R3-VFT: a computational approach

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Food Science and Human Wellness 2024年

作者： hengli Meng Zhiyong Cui Yingqiu Li Yanyang Yu Shui Jiang Yuan Liu Department of Food Science & Technology， School of Agriculture and Biology， Shanghai Shanghai Jiao Tong University Secondary College of Cereals and Tourism， Guangxi Vocational College of Technology and Business

The study of ligand-receptor interactions is of great significance in food flavor perception. In this study， a computer simulation method was used to investigate the mechanism of interaction between umami peptides and T1R1/T1R3-VFT receptor. The binding site， conformational changes， and binding free energy between umami peptides and T1R1/T1R3-VFT were analyzed through molecular modeling， molecular docking， and molecular dynamics simulations. The receptor model constructed using AlphaFold2 has the best rationality. The molecular docking results showed that umami peptides primarily bound to T1R1-VFT through hydrogen bonding， with key binding residues such as 149THR， 151ARG， and 108ASP. The binding of umami peptides led to a more stable complex system， and the positively charged amino acids contributed positively to the overall binding free energy. This study provides theoretical support for the development of a better understanding of the interaction between umami substances and the umami receptor.

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多功能纳米液滴超声造影剂对胰腺癌分子靶向诊疗的实验研究

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中华超声影像学杂志 2022年第10期31卷 893-899页

作者：杨恒丽赵萍李俏颖杨瑞静苏小佩段云友西安医学院第二附属医院超声科西安710038 空军军医大学第二附属医院超声科西安710038

目的探讨自制的诊疗一体化相变纳米液滴"IR780/叶酸-纳米液滴-多西紫杉醇(IR780/FA-Nds-DTX)"作为分子靶向超声造影剂,对胰腺癌荷瘤裸鼠的精准诊断和联合靶向治疗效果。方法体外培养胰腺癌细胞系,建立异位皮下移植胰腺癌荷瘤裸鼠模型50... 详细信息

目的探讨自制的诊疗一体化相变纳米液滴"IR780/叶酸-纳米液滴-多西紫杉醇(IR780/FA-Nds-DTX)"作为分子靶向超声造影剂,对胰腺癌荷瘤裸鼠的精准诊断和联合靶向治疗效果。方法体外培养胰腺癌细胞系,建立异位皮下移植胰腺癌荷瘤裸鼠模型50只,双模态靶向成像分实验组(IR780/FA-Nds-DTX)和4个对照组[生理盐水、Nds(FITC)、FA-Nds(FITC)、IR-780]。小动物活体成像验证IR780/FA-Nds-DTX对肿瘤的体内高效靶向探测能力及近红外荧光成像,低强度聚焦超声诱导相变及进一步超声造影成像验证IR780/FA-Nds-DTX在肿瘤局部的高效聚集及对肿瘤轮廓的精准评估。治疗效果观察分实验组(IR780/FA-Nds-DTX)和4个对照组(FA-Nds-IR780、FA-Nds-DTX、FA-Nds和生理盐水)。低强度聚焦超声辐照30 s诱导各组相变后的微泡爆破后,808 nm光热治疗仪分组辐照肿瘤局部,治疗前及治疗后3 d、9 d、15 d分别用二维超声监测各组荷瘤裸鼠肿瘤体积变化并记录,对比各组肿瘤体积变化率及抑制率。结果IR780/FA-Nds-DTX在肿瘤局部靶向聚集的量最多,实验组肿瘤平均荧光强度明显高于对照组:IR780/FA-Nds-DTX组比Nds(FITC)组[(5.12±0.69)×10^(7)比(1.06±0.23)×10^(7),P<0.05],IR780/FA-Nds-DTX组比FA-Nds(FITC)组[(5.12±0.69)×10^(7)比(2.98±0.34)×10^(7),P<0.05],IR780/FA-Nds-DTX组比IR-780组[(5.12±0.69)×10^(7)比(1.54±0.42)×10^(7),P<0.05],生理盐水组肿瘤局部无荧光显示。进一步液滴相变后形成的超声增强显影能更精准定位肿瘤边界。光热消融联合化疗后第15 d,IR780/FA-Nds-DTX治疗组肿瘤体积增长率较各对照组明显减低:IR780/FA-Nds-DTX组比FA-Nds-IR780组[(0.105±0.075)比(0.405±0.175),P<0.05],IR780/FA-Nds-DTX组比FA-Nds-DTX组[(0.105±0.075)比(1.385±0.035),P<0.05],IR780/FA-Nds-DTX组比FA-Nds组[(0.105±0.075)比(2.255±0.105),P<0.05],IR780/FA-Nds-DTX组比生理盐水组[(0.105±0.075)比(2.185±0.155),P<0.05]。而肿瘤体积抑制率明显增高:IR780/FA-Nds-DTX组比FA-Nds-IR780组[(0.93±0.06)比(0.48±0.17),P<0.05],IR780/FA-Nds-DTX组比FA-Nds-DTX组[(0.93±0.06)比(-0.51±0.105),P<0.05],IR780/FA-Nds-DTX组比FA-Nds组[(0.93±0.06)比(-1.63±0.115),P<0.05],IR780/FA-Nds-DTX组比生理盐水组[(0.93±0.06)比(-1.35±0.245),P<0.05]。结论自制的诊疗一体化双模态相变纳米液滴超声造影剂IR780/FA-Nds-DTX在胰腺癌微小病灶甚至转移灶的精准靶向探测与联合靶向治疗中具有较好的潜在临床应用价值。

关键词：分子靶向多功能相变纳米液滴胰腺癌双模态成像联合靶向治疗

中国太阳能富集区居住建筑光储系统设计方法研究

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太阳能学报 2024年第7期45卷 101-110页

作者：许馨尹冯珩力杨柳刘衍西安建筑科技大学建筑学院西安710055 苏州科技大学电子与信息工程学院苏州215009 绿色建筑全国重点实验室西安710055

以太阳能富集区居住建筑光储系统为研究对象,提出该能源系统的多目标优化设计方法。首先建立系统各设备动态模型,并以系统年化费用和建筑自持化率为优化目标,以全年逐小时供-储-需能流平衡、设备性能为约束,光伏安装倾角、方位角、容量... 详细信息

以太阳能富集区居住建筑光储系统为研究对象,提出该能源系统的多目标优化设计方法。首先建立系统各设备动态模型,并以系统年化费用和建筑自持化率为优化目标,以全年逐小时供-储-需能流平衡、设备性能为约束,光伏安装倾角、方位角、容量以及储能电池容量为决策变量,并利用非支配排序遗传算法(NSGA-Ⅱ)结合TOPSIS方法评估不同情景下的系统最优方案,最后以拉萨单层居住建筑为案例分析验证所提方法的可行性。结果表明:该方法可得到建筑自持化率和经济性双重目标下的光储系统关键参数,且余电是否上网交易会对能源系统设计产生重要影响。

关键词：太阳能电池储能优化设计 NSGA-Ⅱ算法 TOPSIS