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Nano Research 2023年第5期16卷 6584-6592页

作者： Dongdong wang Yue Liu Lili Liu Dongfang shan Guixin Shen shanlong Peng heng Zhang Xindong wang State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China Energy Storage Science and Engineering School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China

The design and preparation of cost-effective and durable catalysts for electrochemical water splitting are significant for the development and application of hydrogen ***,inspired by the underwater superaerophobicity of fish scales,a three-dimensional multilevel nanoarray electrode with superaerophobicity was designed and fabricated by the hydrothermal method to solve the bubble shielding effect in electrochemical *** from the high specific surface area,superaerophobic properties,Al doping,the Al-CoS_(2)nanosheets(NSs)/nickel foam(NF)-30 exhibits outstanding electrocatalytic activity and superior durability for electrochemical water splitting in 1 M ***,the Al-CoS_(2)NSs/NF-30 only required extremely low overpotential of 176 mV for oxygen evolution reaction(OER)to reach a current density of 10 mA·cm^(-2).Al-CoS_(2)NSs/NF-30 was employed as bifunctional electrode for electrochemical water splitting with a cell voltage of 1.58 V at 10 mA·cm^(-2).Meanwhile,Al-CoS_(2) NSs/NF-30 exhibited excellent durability(250 h@10 mA·cm^(-2)and 50 h@100 mA·cm^(-2)).The cobalt-based catalyst(Al-CoS_(2) NSs/NF-30)with superaerophobicity exhibits excellent performance in activity and durability,therefore is a promising electrochemical water splitting catalyst.

关键词： oxygen evolution reaction biomimetic structure superaerophobicity hydrogen evolution reaction

Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun wang Yongjian wang Dingge Liu Zhihua Zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Chemical constituents from the aerial parts of Plumbago zeylanica L.

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Journal of Chinese Pharmaceutical Sciences 2008年第2期17卷 144-147页

作者：黄小燕谭明雄吴强陈勇王恒山广西师范大学化学化工学院药用资源化学与药物分子工程重点实验室广西桂林541004

To investigate the chemical constituents from the aerial parts of Plumbago zeylanica L. The chemical constituents were isolated by various column chromatographic methods and the structures were elucidated by various spectroscopic methods, especially 2D- NMR spectra. A new tfiterpenoid, 1β,3β,1 1α-trihydroxy-urs-12-ene （1）, together with six known compounds, androsta-l,4-diene-3,17- dione （2）, isoshinznolone （3）, neoechinulin A （4）, harman （5）, ergostadiene-3β,5α,6β-triol （6） and N-（N＇-benzoyl-S-phenylalaninyl）-S- phenylalaninol （7） were isolated from the aerial parts ofP. zeylanica. Compound 1 was a new compound, and compounds 2, 4-7 were obtained from this genus for the first time.

关键词： Plumbago Plumbago zeylanica L. Chemical constituents

Novel analysis and improvement of Yahalom protocol

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 80-83页

作者： CHEN Chun-ling YU Han LU heng-shan wang Ru-chuan College of Software Nanjing University of Posts and Telecommunications Nanjing 210003 China Department of Mathematics College of Art and Science University of Wyoming Laramie Wyoming 82072 USA College of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 China

The modified version of Yahalom protocol improved by Burrows, Abradi, and Needham （BAN） still has security drawbacks. This study analyzed such flaws in a detailed way from the point of strand spaces, which is a novel method of analyzing protoeol＇s security. First, a mathematical model of BAN-Yahalom protocol is constructed. Second, penetrators＇ abilities are restricted with a rigorous and formalized definition. Moreover, to increase the security of this protocol against potential attackers in practice, a further improvement is made to the protocol. Future application of this re-improved protocol is also discussed.

关键词： strand spaces BAN-Yahalom protocol ideal minimal element

Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China

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Biomedical and Environmental Sciences 2021年第8期34卷 667-671页

作者： GU heng wang Yong Xia DU Meng Xuan XU shan shan ZHOU Bing Yi LI Ming Zhen NHC Key Laboratory of Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvineeGuangzhou 510000GuangdongChina Department of Public Health and Preventive Medicine Jinan UniversityGuangzhou 510000GuangdongChina

Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many *** forβ-thalassemia carriers is crucial for controlling this *** investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019.

关键词： Guangdong Population thalassemia

Effects of the dust size distribution in one-dimensional quantum dusty plasma

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Frontiers of physics 2015年第5期10卷 69-74页

作者： Juan-Fang Han Dong-Ning Gao heng Zhang Xiao-Yun wang Wen-shan Duan College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China Department of Mathematics and Physics Lanzhou Jiao Tong University Lanzhou 730070 China

The effects of the dust size distribution in ultracold quantum dusty plasmas are investigated. The amplitude φm and width ω of quantum dust acoustic waves are studied with different dust size distributions in the system. The φm and ω of the quantum dust acoustic waves are found to increase as the total number density increases. The φm and ω are greater for unusual dusty plasmas than for typical dusty plasmas. Moreover, as the Fermi temperature of the dust grains increases, the φm of the wave decreases. The ω of quantum dust acoustic waves increases as the speed u0 of the wave increases

关键词： dusty plasma electrostatic waves

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke Jiang Zhi Chen Ji Yu Chen Zheng shan Huang Ming wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

Dehydration-triggered structural phase transition-associated ferroelectricity in a hybrid perovskite-type crystal

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Chinese Chemical Letters 2024年第10期35卷 461-464页

作者： Zhi-Yuan Yue Hua-Kai Li Na wang shan-shan Liu Le-Ping Miao heng-Yun Ye Chao Shi Chaotic Matter Science Research Center Jiangxi University of Science and TechnologyGanzhou 341000China

Since the appearance of Rochelle salt,ferroelectrics have received extensive attention from researchers due to they are playing an important role in sensors,memories,mechanical actuation,and so *** recent years,with the rapid development of molecular ferroelectrics,high-performance molecular ferroelectrics have become effective complement to inorganic ***,compared with inorganic ferroelectrics,the family of molecular ferroelectrics is relatively scarce,and exploring highperformance ferroelectric materials through new synthesis strategies has become the trend of molecular ***,we successfully transformed non-polar material 1(2-H_(2)PCA)_(2)(H_(2)O)CdCl_(6)(2-H_(2)PCA=2-picolylamine cation)into polar material 2(2-H_(2)PCA)2CdCl_(6)by single-crystal to single-crystal transformation(SCSCT).Meanwhile,2 exhibits clear ferroelectricity with a high-temperature Tc of 378 K,a Ps of 1.18μC/cm^(2)at 300 *** work not only realizes the purpose of synthesizing ferroelectrics by forming polar structures by SCSCT,but also realizes the reversibility of SCSCT,which provides ideas for the construction and exploration of new molecular ferroelectrics.

关键词： Hybrid perovskite Ferroelectric materials Single-crystal to single-crystal transformation Phase transition Stimulus-structure-response

Particle-in-cell simulation of ion-acoustic solitary waves in a bounded plasma

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Chinese Physics B 2021年第3期30卷 364-370页

作者： Lin Wei Bo Liu Fang-Ping wang heng Zhang Wen-shan Duan College of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China

We study some nonlinear waves in a viscous plasma which is confined in a finite *** averaging the physical quantities on the radial direction in some cases,we reduce this system to a simple one-dimensional *** seems that the effects of the bounded geometry(the radius of the cylinder in this case)can be included in the damping *** notice that the amplitudes of both Korteweg–de Vries(KdV)solitary waves and dark envelope solitary waves decrease exponentially as time increases from the particle-in-cell(PIC)*** dependence of damping coefficient on the cylinder radius and the viscosity coefficient is also obtained numerically and *** are in good *** using a definition,we give a condition whether a solitary wave exists in a bounded ***,some of potential applications in laboratory experiments are suggested.

关键词： ion-acoustic solitary waves particle-in-cell simulation bounded plasmas

危险预知训练模式结合密室逃脱教学在儿科急诊护士培训中的应用

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卫生职业教育 2025年第1期43卷 143-145页

作者：王珍朱杉华中科技大学同济医学院附属同济医院湖北武汉430030

目的探讨在儿科急诊护士培训中,危险预知训练模式结合密室逃脱教学的实践效果。方法选取湖北省武汉市某三甲医院2023年1—12月儿科急诊护士46人作为研究对象,随机分为对照组与研究组,分别实施常规培训模式、危险预知训练模式结合密室逃... 详细信息

目的探讨在儿科急诊护士培训中,危险预知训练模式结合密室逃脱教学的实践效果。方法选取湖北省武汉市某三甲医院2023年1—12月儿科急诊护士46人作为研究对象,随机分为对照组与研究组,分别实施常规培训模式、危险预知训练模式结合密室逃脱教学模式,对比两组考核成绩、应急能力、评判性思维能力与风险识别能力。结果研究组理论和急救技能考核成绩及应急能力、评判性思维能力、护理风险识别能力均优于对照组,差异有统计学意义(P<0.05)。结论危险预知训练模式结合密室逃脱教学应用于儿科急诊护士培训中效果较好,能有效提升护士的理论和急救技能水平及综合能力,值得推广。

关键词：危险预知训练模式密室逃脱教学模式儿科急诊护士