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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao chenghao Guo Yunxi liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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Metal-free synthesis of pyridyl conjugated microporous polymers with tunable bandgaps for efficient visible-light-driven hydrogen evolution

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Chinese Chemical Letters 2023年第4期34卷 271-274页

作者： Zhonghua cheng Yan He Chen Yang Nan Meng Yaozu liao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Conjugated microporous polymers(CMPs) with tunable bandgaps have attracted increasing attention for photocatalytic hydrogen evolution. However, the synthesis of CMPs usually needs expensive metal-based catalysts. Herein, we report a metal-free synthetic route to fabricate pyridyl conjugated microporous polymers(PCMPs) via a condensed polymerization between aldehyde and aryl ketone monomers. The PCMPs show widely tunable specific surface areas(347–418 m^(2)/g), which were controlled via changing the used monomers. The PCMPs synthesized using monomers of dialdehyde and diacetylbenzene(diacetylpyridine) in the presence of pyridine exhibited the highest visible-light driven hydrogen evolution rate(9.56 μmol/h). These novel designed PCMPs provide wide adaptability to current materials designed for high-performance photocatalysts in different applications.

关键词： Pyridyl conjugated microporous polymers Metal-free synthesis Tunable bandgaps Photocatalysts Hydrogen evolution reaction

Altered metabolic state impedes limb regeneration in salamanders

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Zoological Research 2021年第6期42卷 772-782页

作者： Zhe-Lun Peng Bin-Xu Yin Rui-Min Ren Yin-Long liao Hao Cai heng Wang College of Animal Sciences and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhenGuangdong 518120China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China

Salamanders are unique among tetrapods in their ability to regenerate the limbs throughout *** other poikilothermic amphibians,salamanders also show a remarkable capacity to survive long periods of *** the physiological reserves necessary for tissue regeneration are preserved or sacrificed in starved salamanders is *** the current study,we maintained Iberian ribbed newts(Pleurodeles waltl)under extreme physiological stress to assess the extent of regeneration and identify the molecular and cellular changes that may occur under such *** 19 months of complete food deprivation,the animals exhibited extensive morphological and physiological adaptations but remained behaviorally active and *** was elevated in different tissues and the transformed gut microbiota indicated remodeling of the intestinal tract related to *** limb amputation in animals starved for 21 months,regeneration proceeded with progenitor cell proliferation and migration,leading to limb blastema ***,limb outgrowth and patterning were substantially *** of autophagy inhibited cell proliferation and blastema formation in starved animals,but not in fed ***,tissue autophagy and the regenerative response were tightly coupled only when animals were under *** results demonstrate that under adverse conditions,salamanders can exploit alternative strategies to secure blastema formation for limb regeneration.

关键词： Starvation Stress Autophagy Regeneration Salamander

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美国儿童阅读推广机制调研及其对我国的启示

大学图书情报学刊 2025年第1期43卷 137-144页

作者：廖颖深圳市南山区图书馆 518000

儿童阅读推广服务不仅是图书馆服务的重点领域,也是其发展的关键环节。文章采用网络调研与文献分析法,系统梳理和分析了美国公共图书馆在儿童阅读推广方面的策略和实践。研究重点包括美国公共图书馆儿童服务的政策框架、实施策略、社会... 详细信息

儿童阅读推广服务不仅是图书馆服务的重点领域,也是其发展的关键环节。文章采用网络调研与文献分析法,系统梳理和分析了美国公共图书馆在儿童阅读推广方面的策略和实践。研究重点包括美国公共图书馆儿童服务的政策框架、实施策略、社会参与、数字化融合、分级阅读推广情况与方式。研究表明,美国通过政策支持、多元化服务模式、紧密的社区与家庭合作、积极适应数字化转型以及注重儿童分级阅读推广等措施,有效满足了儿童的多元化阅读需求,进而提出构建全面的政策框架、深化社区及家庭参与、积极实施分级阅读策略、拥抱数字化转型等建议,以期推动我国儿童阅读推广高质量可持续性发展。

关键词：数字化转型儿童阅读推广实施策略多元化阅读政策框架可持续性发展家庭参与图书馆服务

Asymmetric and Single-Side Splitting of Dissipative Solitons in Complex Ginzburg–Landau Equations with an Asymmetric Wedge-Shaped Potential

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Chinese Physics Letters 2019年第1期36卷 24-27页

作者： Yun-cheng liao Bin Liu Juan Liu Jia Chen National Engineering Laboratory for Destructive Testing and Optoelectronic Sensing Technology and Application Nanchang HangKong University Nanchang Institute of Science and Technology

We report some novel dynamical phenomena of dissipative solitons supported by introducing an asymmetric wedge-shaped potential(just as a sharp ‘razor') into the complex Ginzburg–Landau equation with the cubicquintic nonlinearity. The potentials corresponding to a local refractive index modulation with breaking symmetry can be realized in an active optical medium with respective expanding antiwaveguiding structures. Using the razor potential acting on a central dissipative soliton, possible outcomes of asymmetric and single-side splitting of dissipative solitons are achieved with setting different strengths and steepness of the potentials. The results can potentially be used to design a multi-route splitter for light beams.

关键词： Dissipative Solitons Complex Ginzburg-Landau Equations Asymmetric Wedge-Shaped Potential

A six-variable quasi-3D isogeometric approach for free vibration of functionally graded graphene origami-enabled auxetic metamaterial plates submerged in a fluid medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期 157-176页

作者： Wei CHEN Zhihong TANG Yufen liao Linxin PENG College of Civil Engineering University of South China College of Civil Engineering and Architecture Guangxi University Key Laboratory of Disaster Prevention and Structural Safety of Ministry of Education Guangxi University

This paper presents, for the first time, an effective numerical approach based on the isogeometric analysis(IGA) and the six-variable quasi-three dimensional(3D)higher-order shear deformation theory(HSDT) to study the free vibration characteristics of functionally-graded(FG) graphene origami(GOri)-enabled auxetic metamaterial(GOEAM) plates submerged in a fluid medium. The plate theory incorporates the thickness stretching and the effects of transverse shear deformation without using any shear correction factors. The velocity potential function and Bernoulli's equation are used to derive the hydrodynamic pressure acting on the plate surface. Both horizontally and vertically immersed plate configurations are considered here in the form of inertia *** plates are composed of multilayer GOEAMs, with the GOri content varying through the plate's thickness in a layer-wise manner. This design results in graded auxetic *** material properties are evaluated by mixing rules and a genetic programming(GP)-assisted micromechanical model. The governing equations of motion for the FG-GOEAM plates immersed in a fluid medium are derived by Hamilton's principle. After validating the convergence and accuracy of the present model, a comprehensive parametric study is carried out to examine the effects of the GOri content, GOri distribution pattern, GOri folding degree, fluid level, immersed depth, and geometric parameter on the natural frequencies of the FG-GOEAM plates. The results show that the natural frequencies for the four GOri distribution patterns increase with the increase in the layer number when the lay number is fewer than 10, and then stabilize after the layer number reaches ***, in general, the natural frequency of the FG-GOEAM plate in a vacuum or fluid increases when the GOri content increases, while decreases when the GOri folding degree increases. Some additional findings related to the numerical results are presented in the conclusions. It is belie

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On the Development of a Model for the Prediction of Liquid Loading in Gas Wells with an Inclined Section

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Fluid Dynamics & Materials Processing 2019年第5期15卷 527-544页

作者： Mengna liao Ruiquan liao Jie Liu Shuangquan Liu Li Li Xiuwu Wang Yang cheng School of Petroleum Engineering Yangtze UniversityWuhan430100China Laboratory of Multiphase Pipe Flow of Gas Lift Innovation Center CNPC(Yangtze University)Wuhan430100China Oil and Gas Technology Research Institute of Changqing Oilfield Company Xi’an710000China

The ability to predict liquid loading in horizontal gas wells is of great importance for determining the time of drainage and optimizing the related production *** the present work,we describe the outcomes of experiments conducted using air-water mixtures in a horizontal *** results show that the configuration with an inclined section is the most susceptible to liquid *** experiments in an inclined pipe were also conducted to analyze the variation of the critical gas flow rate under different angles,pressure and liquid volume(taking the equal liquid volume at inlet and outlet as the criterion for judging on the critical state).According to these results,the related angle of the inclined section ranges from 45°to 60°.Finally,a modified approach based on the Belfroid model has been used to predict the critical gas flow rate for the inclined *** comparison with field data,this modified model shows an accuracy of 96%,indicating that it has better performances with respect to other models used in the past to predict liquid loading.

关键词： Horizontal gas well inclined section liquid loading critical gas flow rate air-water flow

Developer Role Evolution in Open Source Software Ecosystem： An Explanatory Study on GNOME

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Journal of Computer Science & Technology 2017年第2期32卷 396-414页

作者： Can cheng Bing Li Zeng-Yang Li Yu-Qi Zhao Feng-Ling liao International School of Software Wuhan University Wuhan 430072 China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China Complex Networks Research Center Wuhan University Wuhan 430072 China

An open source software （OSS） ecosystem refers to an OSS development community composed of many software projects and developers contributing to these projects. The projects and developers co-evolve in an ecosystem. To keep healthy evolution of such OSS ecosystems, there is a need of attracting and retaining developers, particularly project leaders and core developers who have major impact on the project and the whole team. Therefore, it is important to figure out the factors that influence developers＇ chance to evolve into project leaders and core developers. To identify such factors, we conducted a case study on the GNOME ecosystem. First, we collected indicators reflecting developers＇ subjective willingness to contribute to the project and the project environment that they stay in. Second, we calculated such indicators based on the GNOME dataset. Then, we fitted logistic regression models by taking as independent variables the resulting indicators after eliminating the most collinear ones, and taking as a dependent variable the future developer role （the core developer or project leader）. The results showed that part of such indicators （e.g., the total number of projects that a developer joined） of subjective willingness and project environment significantly influenced the developers＇ chance to evolve into core developers and project leaders. With different validation methods, our obtained model performs well on predicting developmental core developers, resulting in stable prediction performance （0.770, F-value）.

关键词： developer role evolution open source software ecosystem project environment subjective willingness

No Evidence for Significant Effect of Body Size and Age on Male Mating Success in the Spot-legged Treefrog

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Asian Herpetological Research 2016年第1期7卷 41-45页

作者： Jianping YU cheng CHEN Long JIN Li ZHAO Wenbo liao Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal University

In anurans, body size and age of individuals generally affect male mating success. To test whether body size and age have effects on male mating success in the foam-nesting treefrog Polypedates megacephalus, a species widely distributed in China, we analyzed differences in body size and age between mated and unmated males for three populations using a Generalized Linear Mixed Model（GLMM）. The results showed that mated males did not exhibit larger body size and older age than unmated males, suggesting that large and/or old male individuals did not have greater mating success than small and/or young males. Moreover, we also found a non-significant size-assortative mating pattern for all populations. Our findings suggest that body size and age of the foam-nesting treefrog do not affect male mating success.

关键词： age body size male mating success Polypedates megacephalus size-assortative