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Chinese Journal of Polymer Science 2018年第12期36卷 1312-1320页

作者： Teng Wu Min Tan heng-ye gong Yong Wang Xin-Tao shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-Sen University Guangzhou 510275 China Center of Biomedical Engineering Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China

Chronic inflammatory responses induced by macrophages play a pivotal role in the progression of atherosclerosis. In the present study, a multifunctional nanocarrier based on poly（ethylene glycol）-block-poly（L-aspartic acid） grafted with diethylenetriamine, lysine and cholic acid （PEG-PAsp（DETA）-Lys-CA2） polymer was synthesized for co-delivery of andrographolide and siRNA targeting Notchl gene to alleviate the inflammatory response in macrophages. The nanocarrier exerted low cytotoxicity as well as high performance in drug/siRNA co-delivery. In vitro studies demonstrated the co-delivery of andrographolide and Notchl siRNA not only significantly inhibited lipopolysaccharide （LPS）-activated interleukin-6 （IL-6） and monocytes chemotactic protein 1 （MCP-1） expression as well as blocked nuclear factor-rd3 （NF-rd3） signal activation, but also interfered the Notchl gene expression and increased anti-inflammatory cytokines such as interleukin-10 （IL-10） and arginase-1 expression obviously in macrophages. These results suggested that the combination therapy based on Notchl siRNA and andrographolide co-delivered nanocarrier, i.e. suppressing the expression of proinflammatory cytokines while simultaneously increasing anti-inflammatory factors expression, be a feasible strategy for atherosclerosis treatment.

关键词： Macrophages Anti-inflamatory Andrographolide Notchl siRNA

Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

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Chinese Journal of Polymer Science 2019年第12期37卷 1224-1233,I0006页

作者： heng-ye gong Yan-Gui Chen Xing-Su Yu Hong Xiao Jin-Peng Xiao Yong Wang Xin-Tao Shuai PCFM Lab of Ministry of Education School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou 510275China HEC Pharma Co. Ltd.Dongguan 523871China Reproductive Center Guangdong Women’s Health Care CenterGuangzhou 511400China

Drug-resistance and drastic side effects are two major issues of traditional chemotherapy which may result in trail failure even ***-mediated multidrug combination treatment has been proven to be a feasible strategy to overcome these *** the present study,amphipathic block polymer of methoxyl poly(ethylene glycol)-poly(aspartyl(dibutylethylenediamine)-co-phenylalanine)(m PEG-P(Asp(DBA)-co-Phe))was synthesized and self-assembled into p H-responsive polymeric *** vesicle was utilized to co-deliver cancer-associated epidermal growth factor(EGFR)inhibitor of afatinib and DNA-damaging chemotherapeutic doxorubicin hydrochloride(DOX)for enhanced non-small-cell lung cancer(NSCLC)*** evaluated in vitro,the p H-responsive design of nanovesicle resulted in a rapid release of encapsulated drugs into tumor cells and caused enhanced cell *** addition,in vivo therapeutic studies were conducted and the results evidenced that the co-delevery of DOX and afatinib using p H-sensitive nanovector was a promising strategy for NSCLC treatment.

关键词： Nanovesicle Polymeric vector Combination therapy pH-responsive

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多解产量预测模型求解与参数优选

特种油气藏 2003年第2期10卷 58-60页

作者：柴安庆孙业恒马功联中石化胜利油田股份有限公司山东东营257000

在油田的生产规划和对外合作中 ,产量预测是一个重要技术支持 ,目前双曲递减模型翁氏模型得到了广泛应用 ,但其中的传统手工试差法不仅繁杂 ,且难以得到最满意解。文章通过区间试差编程技术。

关键词：多解模型产量预测求解参数优选油田

Neighborhood co-occurrence modeling in 3D point cloud segmentation

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Computational Visual Media 2022年第2期8卷 303-315页

作者： Jingyu gong Zhou ye Lizhuang Ma Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai CLS Fintech Co. LTDShanghai 200030China MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong UniversityShanghai 200240China

A significant performance boost has been achieved in point cloud semantic segmentation by utilization of the encoder-decoder architecture and novel convolution operations for point ***,co-occurrence relationships within a local region which can directly influence segmentation results are usually ignored by current *** this paper,we propose a neighborhood co-occurrence matrix(NCM)to model local co-occurrence relationships in a point *** generate target NCM and prediction NCM from semantic labels and a prediction map ***,Kullback-Leibler(KL)divergence is used to maximize the similarity between the target and prediction NCMs to learn the co-occurrence ***,for large scenes where the NCMs for a sampled point cloud and the whole scene differ greatly,we introduce a reverse form of KL divergence which can better handle the difference to supervise the prediction *** integrate our method into an existing backbone and conduct comprehensive experiments on three datasets:Semantic3D for outdoor space segmentation,and S3DIS and ScanNet v2 for indoor scene *** indicate that our method can significantly improve upon the backbone and outperform many leading competitors.

关键词： 3D vision point cloud co-occurrence relation modeling semantic segmentation

Analyzing Asymmetric City Connectivity by Toponym on Social Media in China

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Chinese Geographical Science 2021年第1期31卷 14-26页

作者： ye Xinyue gong Junfang LI Shengwen Department of Landscape Architecture and Urban Planning Texas A&M University College StationTX 77843 USA School of Geography and Information Engineering China University of GeosciencesWuhan 430074China Key Laboratory of Urban Land Resources Monitoring and Simulation Ministry of Natural ResourcesShenzhen 518034China

The connectedness between cities has become one of the most widely discussed topics in urban and regional research in the mobile and big data era. One problem identified is the asymmetric city connectivity, partially due to data availability. We present a data-driven approach based on location and toponym(place name) extracted from social media data, to assess the asymmetric connectivity between cities. The assumption is that a higher frequency of occurrences of the name of city i in posts located in city j would imply that the city i is more influential than other cities upon city j. In addition, we’ve developed a group of measurements such as the relatedness index, impact index, link strength index, dependence index, and structure similar index to characterize such interactions. This framework of connectivity measurements can also be used to support smart planning taking into account the evolving interplay among cities. The space-time structure of urban systems in China is examined as the case study.

关键词： asymmetric city connectivity social media urban system China

Graphene oxide-derived single-atom catalysts for electrochemical energy conversion

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Rare Metals 2022年第5期41卷 1703-1726页

作者： Jian-Bin Liu Hai-Sheng gong gong-Lan ye Hui-Long Fei State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Sustainable electrochemical energy conversion is considered as a promising solution to energy crises and environmental issues. Owing to their maximized utilization efficiency and excellent catalytic performance, single-atom catalysts(SACs) have obtained tremendous attention in the field of electrochemical energy conversion. In the last few years, graphene oxide(GO) has been considered to be a promising precursor for fabricating graphene-supported SACs due to its advantageous features such as large surface area, high density of intrinsic defects, and scalability. In this review, the recent advances in the preparation of graphene oxide-derived single-atom catalysts(GO-SACs) and their diverse electrochemical applications are ***, the synthetic strategies of GO-SACs are discussed with focuses on the advantages and shortages of each method. Subsequently, the electrochemical applications of GO-SACs in various energy conversion processes,including the oxygen reduction reaction(ORR), oxygen evolution reaction(OER), hydrogen evolution reaction(HER), nitrogen reduction reaction(NRR), and carbon dioxide reduction reaction(CO;RR), are discussed in detail. Finally, the remaining challenges and future prospects in the fabrication and application of GO-SACs are presented.

关键词： Single-atom catalysts Graphene oxide Electrocatalysis Energy conversion

Model of Collisional Sheath in Spherical and Cylindrical Geometries for Plasma Source Ion Implantation

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Chinese Physics Letters 1996年第2期13卷 117-120页

作者： WANG De-zhen YU Jiong gong ye The Key National Laboratory of Materials Modification by Three Beams and Department of PhysicsDalian University of TechnologyDalian 116024

A model is developed that describes the temporal evolution of the sheath during a pulse of high negative voltage applied to a spherical and cylindrical target in a plasma such as that present in plasma source ion implantation for the case in which the pressure of the neutraJ gas is large enough that the ion motion in the sheath can be assumed to be highly *** analytic expressions of the sheath expanding velocity are *** positions of the shea th edge as a function of time predicted by the model are in agreement with those obtained by Huid equations.

关键词： assumed implantation cylindrical

Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 676-694页

作者： Dong-dong DENG Ying-lan gong Guo-fa SHOU Pei-feng JIAO heng-gui ZHANG Xue-song ye Ling XIA College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310027China Institute of Clinical Anatomy Southern Medical UniversityGuangzhou 510515China Biological Physics University of ManchesterManchester M139PLUK

In order to better understand biatrial conduction,investigate various conduction pathways,and compare the differences between isotropic and anisotropic conductions in human atria,we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial *** addition to known pathways:(1) Bachmann's bundle(BB),(2) limbus of fossa ovalis(LFO),and(3) coronary sinus(CS),we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis(CT),LFO,and *** simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental *** comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed,although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic *** conclusion,we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working *** study presents readers with new insights into human atrial conduction.

关键词： Cardiac electrophysiology Conduction Human atrial model Modeling

Soil Respiration in a Subtropical Mangrove Wetland in the Jiulong River Estuary, China

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Pedosphere 2013年第5期23卷 678-685页

作者： JIN Liang LU Chang-Yi ye Yong ye gong-Fu College of the Environment & Ecology Xiamen University Xiamen University Tan Kah Kee College Fujian Institute of Forestry Science

The diurnal and seasonal variations of soil respiration （SR） were studied at a subtropical mangrove wetland in the Jiulong River Estuary from May 2010 to April 2011. SR rates were measured continuously from 08：00 to 06：00 local time （24-h time system） on July 8-9 and October 3-4, 2010; and January 15-16 and April 11-12, 2011. Similar patterns in the diurnal variation of SR were observed on October 2-3 and April 11-12, with the maximum values at 14：00 and the minimum at 00：00. However, the diurnal dynamics of SR on July 8-9, 2010 and January 15-16, 2011 showed different patterns, with the maximum values at 08：00-10：00 on above sampling dates and the minimum at 22：00 on July 8 and at 04：00 on January 16. The daily mean values of SR approximated to the values measured at 08：00. SR fluctuated with distinct seasonal patterns. The seasonal variation was characterized by a mono-peak pattern, with the highest rate （6.18 ~mol CO2 m-2 s-1） in July and the lowest rate （0.36 ~tmol CO2 m-2 s-1） in December. The results showed that the variation of SR in mangrove wetland was mainly controlled by soil temperature, and there was no significant correlation between SR and soil water content. It also implied that the model of SR in mangrove wetland should not only consider the effect of soil temperature, but also incorporate other factors, such as water level, precipitation, microbial activity and photosynthesis, which also could affect SR.

关键词： controlling factors Kandelia candel microbial activity neap tide soil temperature

Aligned porous carbon film with ultralow loadings of Pt single atoms and clusters for high-current-density hydrogen generation

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Nano Research 2023年第1期16卷 256-263页

作者： Rui Liu Zhichao gong Minmin Yan gonglan ye Huilong Fei Advanced Catalytic Engineering Research Center of the Ministry of Education State Key Laboratory for Chemo/Biosensing and Chemometricsand College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

The development of electrocatalysts toward the hydrogen evolution reaction(HER)with high-current-density capability is critical for the practical application of water splitting for hydrogen *** Pt-based materials are regarded as the most efficient HER catalysts,they suffer from scarcity and high ***,it is of vital importance to lower the loading of Pt while maintaining high ***,we report the fabrication of a monolithic aligned porous carbon film electrode co-modified with Pt single atoms and Pt nanoclusters(Pt SA/NC-AF)containing ultralow Pt content(0.038 wt.%)via a facile electrochemical deposition *** from the aligned porous structure of the carbon film and the high exposure of the Pt species,the optimized Pt SA/NCAF electrode exhibits outstanding HER performance in 0.5 M H_(2)SO_(4)with exceptional intrinsic activity(turnover frequency(TOF)=904.9 s^(−1)atη=100 mV)and ultrahigh mass activity(888.6 A·mg_(Pt)^(−1)atη=100 mV).Further,it can deliver an industrially relevant current density of 1,000 mA·cm−2 at an overpotential as low as 139 *** work provides a feasible avenue for the rational design of metal single-atom and nanocluster catalysts and additionally promotes the application of ultralow-loading noble metal-based catalysts in high-rate hydrogen production.

关键词： monolithic electrodes single atoms clusters hydrogen evolution reaction high current density