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Synthesis of 3- [ 1- (4-Ethoxyphenyl)-5-methyl-1,2,3-triazol-4-yl ]-6- substituted- s-triazolo [ 3,4- b ] -1,3,4-thiadiazoles

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有机化学 2003年第Z1期23卷 427-427页

作者： DONG heng-shan wang Bin National Laboratory of Applied Organic Chemistry Institute of Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Institute of Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000

　　Several 3- [ 1- (4-ethoxyphenyl)-5-methyl- 1,2, 3-triazol-4-yl ]-6-substituted-s-triazolo [ 3,4- b ]- 1,3,4-thiadia zoles have been synthesized and the structures of these compounds were established by MS, IR and ... 详细信息

关键词： spectral data

Cu（Ⅱ）-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

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Cu（Ⅱ）-catalyzed Mannich-type–cyclization–oxidation tand...

P2Y1 receptor in Alzheimer’s disease

第十七届全国金属有机化学学术讨论会

作者： Pei Liu Jin-heng Zhang Zheng-hong Li heng-shan wang Ying-ming Pan School of Chemistry and Chemical Engineering of Guangxi Normal University

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Synthesis of 3-[1-（4-Ethoxyphenyl）-5-methyl-1 ,2,3-triazol-4-yl]-6-substituted-s -triazolo [3,4-b ]-1,3,4-thiadiazoles

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Synthesis of 3-[1-（4-Ethoxyphenyl）-5-methyl-1 ,2,3-triazol...

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

第三届全国有机化学学术会议

作者： DONG, heng-shan wang, Bin (National Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry , College of Chemistry and Chemical Engineering , Lanzhou University, Lanzhou 730000 )

＜正＞ Several 3-[1-（4-ethoxyphenyl）-5-methyl-1, 2, 3-triazol-4-yl]-6-substituted-s-triazolo[3, 4-b]-1, 3, 4-thiadia-zoles have been synthesized and the structures of these compounds were established by MS, IR and 1...

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-shan wang Hong-Xia Yu shan-shan wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1–S4 bundle rather than a quiescent state

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Science Bulletin 2022年第10期67卷 1062-1076,M0004页

作者： Meng-Yang Sun Xue Zhang Peng-Cheng Yu Di Liu Yang Yang Wen-Wen Cui Xiao-Na Yang Yun-Tao Lei Xing-Hua Li Wen-Hui wang Peng Cao heng-shan wang Michael X.Zhu Chang-Zhu Li Rui wang Ying-Zhe Fan Ye Yu School of Life Sciences and Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha 410004China Department of Pharmacology and Chemical Biology Institute of Medical SciencesShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009China Putuo Hospital Shanghai University of Chinese Traditional MedicineShanghai 200062China College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha 410128China Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Department of Integrative Biology and Pharmacology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTX 77030USA

Transient receptor potential vanilloid 1(TRPV1)channel plays an important role in a wide range of physiological and pathological processes,and a comprehensive understanding of TRPV1 gating will create opportunities for therapeutic *** incredible advances in cryo-electron microscopy(cryo-EM)have yielded high-resolution structures of all TRPV subtypes(TRPV1-6)and all of them share highly conserved six transmembrane(TM)domains(S1-S6).As revealed by the open structures of TRPV1 in the presence of a bound vanilloid agonist(capsaicin or resiniferatoxin),TM helices S1 to S4 form a bundle that remains quiescent during channel activation,highlighting differences in the gating mechanism of TRPV1 and voltage-gated ion ***,however,we argue that the structural dynamics rather than quiescence of S1-S4 domains is necessary for capsaicin-mediated activation of *** fluorescent unnatural amino acid(flUAA)incorporation and voltage-clamp fluorometry(VCF)analysis,we directly observed allostery of the S1-S4 bundle upon capsaicin *** occupation of VCF-identified sites,single-channel recording,cell apoptosis analysis,and exploration of the role of PSFL828,a novel non-vanilloid agonist we identified,have collectively confirmed the essential role of this coordinated S1-S4 motility in capsaicin-mediated activation of *** study concludes that,in contrast to cryo-EM structural studies,vanilloid agonists are also required for S1-S4 movement during TRPV1 *** the gating process of vanilloid agonists and the discovery of new non-vanilloid agonists will allow the evaluation of new strategies aimed at the development of TRPV1 modulators.

关键词： Ligand-gated ion channels TRPV1 Allostery Voltage-clamp fluorometry Vanilloid agonist

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke Jiang Zhi Chen Ji Yu Chen Zheng shan Huang Ming wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

龟鹿二仙胶对地塞米松诱导骨髓间充质干细胞损伤的保护作用

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南京中医药大学学报 2017年第4期33卷 395-398页

作者：徐卫峰费逸明王建伟尹恒王善付葛卫红南京医科大学药学院江苏南京211166 南京中医药大学无锡附属医院江苏无锡214071 南京大学医学院附属鼓楼医院江苏南京210008

目的研究龟鹿二仙胶对地塞米松诱导骨髓间充质干细胞损伤的保护作用。方法体外培养SD大鼠骨髓间充质干细胞,传至第二代后分5组培养:正常组、地塞米松(10-8 mol/L)组、骨化三醇含药血清组、龟鹿二仙胶含药血清低剂量组、龟鹿二仙胶含药... 详细信息

目的研究龟鹿二仙胶对地塞米松诱导骨髓间充质干细胞损伤的保护作用。方法体外培养SD大鼠骨髓间充质干细胞,传至第二代后分5组培养:正常组、地塞米松(10-8 mol/L)组、骨化三醇含药血清组、龟鹿二仙胶含药血清低剂量组、龟鹿二仙胶含药血清高剂量组。MTT法检测骨髓间充质干细胞活力,检测细胞上清中的超氧化物歧化酶(SOD)、丙二醛(MDA)、炎症因子白介素-6(IL-6)、小鼠白介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)。采用Western blot检测Nrf-2/HO-1/NF-κB信号通路蛋白表达。结果龟鹿二仙胶能显著提高细胞活力,增加SOD水平、降低MDA水平、降低炎症因子水平,增加蛋白Nrf-2、HO-1蛋白表达水平,降低NF-κB信号蛋白表达。结论龟鹿二仙胶对地塞米松诱导骨髓间充质干细胞损伤有保护作用,且作用与调控Nrf-2/HO-1/NF-κB信号相关。

关键词：龟鹿二仙胶地塞米松骨髓间充质干细胞氧化应激炎症

Empirical Likelihood Inference for a Partially Linear Errors-in-variables Model with Covariate Data Missing at Random

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 305-318页

作者： shan-shan wang heng-jian CUI School of Economics and Management Beihang UniversityBeijing 100191China Beijing Key Laboratory of Emergency Support Simulation Technologies for City Operations Beijing 100191China School of Mathematical Sciences&:BCMIIS Capital Normal UniversityBeijing 100048China

The authors study the empirical likelihood method for partially linear errors-in-variables model with covariate data missing at random. Empirical likelihood ratios for the regression coeffidents and the baseline function are investigated, and the corresponding empirical log-likelihood ratios are proved to be asymptotically standard chi-squared, which can be used to construct confidence regions. The finite sample behavior of the proposed methods is evaluated by a simulation study which indicates that the proposed methods are comparable in terms of coverage probabilities and average length of confidence intervals. Finally, the Earthquake Magnitude dataset is used to illustrate our proposed method.

关键词： chi-square distribution confidence region coverage probability empirical likelihood partiallylinear model