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Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches

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Oncology Research 2024年第2期32卷 297-308页

作者： heng zhang WENJING Cheng HAIBO ZHAO WEIDONG chen QIUJIE zhang QING-QING YU Department of Laboratory Shandong Daizhuang HospitalJining272051China Jining No.1 People’s Hospital Shandong First Medical UniversityJining272000China

Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in humans.Recently,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically CRC.However,the regulatory FAM pathways in CRC require comprehensive elucidation.Methods:The clinical and gene expression data of 175 fatty acid metabolic genes(FAMGs)linked with colon adenocarcinoma(COAD)and normal cornerstone genes were gathered through The Cancer Genome Atlas(TCGA)-COAD corroborating with the Molecular Signature Database v7.2(MSigDB).Initially,crucial prognostic genes were selected by uni-and multi-variate Cox proportional regression analyses;then,depending upon these identified signature genes and clinical variables,a nomogram was generated.Lastly,to assess tumor immune characteristics,concomitant evaluation of tumor immune evasion/risk scoring were elucidated.Results:A 8-gene signature,including ACBD4,ACOX1,CD36,CPT2,ELOVL3,ELOVL6,ENO3,and SUCLG2,was generated,and depending upon this,CRC patients were categorized within high-risk(H-R)and low-risk(L-R)cohorts.Furthermore,risk and age-based nomograms indicated moderate discrimination and good calibration.The data confirmed that the 8-gene model efficiently predicted CRC patients’prognosis.Moreover,according to the conjoint analysis of tumor immune evasion and the risk scorings,the H-R cohort had an immunosuppressive tumor microenvironment,which caused a substandard prognosis.Conclusion:This investigation established a FAMGs-based prognostic model with substantially high predictive value,providing the possibility for improved individualized treatment for CRC individuals.

关键词： Fatty acid metabolism Colorectal cancer Gene signatures Machine learning

One-step hydrothermal synthesis of Cit-NaYbF_(4):Er^(3+)nanocrystals with enhanced red upconversion emission for in vivo fluorescence molecular tomography

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Journal of Rare Earths 2024年第1期42卷 36-45,I0002页

作者： Xiaoli Luo Qichen chen Hongbo Guo heng zhang Xiaowei He Wu Zhao School of Mathematics and Computer Science Ningxia Normal UniversityGuyuan756099China School of Information Science and Technology Northwest UniversityXi'an710127China

Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical studies.In this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modifiedα-NaYbF_(4):2%Er^(3+)nanocrystals was proposed.The introduction of various doping ions into NaYbF_(4):2%Er^(3+)and the different valence states of the same ions affect both the crystal size and upconversion luminesce nce.There fore,we investigated the upconversion luminesce nce enha ncement of NaYbF_(4):2%Er^(3+)by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol%Fe^(2+)ions shows the greatest enhancement,especially for red emission at654 nm.Furthermore,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detectio n.Confocal laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF_(4):2%Er/5%Fe^(2+)leads to a clear outline and improves visualization of the cell morphology.In addition,the CA coated NaYbF_(4):2%Er^(3+)/5%Fe^(2+)nanoparticles and NaYbF_(4):2%Er^(3+)/5%Fe^(2+)show low cytotoxicity in HeLa cells.Organ imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and spleen.Together,these results indicate that the Cit-NaYbF_(4):2%Er^(3+)/5%Fe^(2+)UCNPs are efficient nanoprobes for fluorescence molecular to mography.

关键词： Hydrothermal method Fe^(2+)ion doping Tuning size Nanoprobes Fluorescence imaging Rare earths

Construction of Naphthalenediimide Lanthanide(Ⅲ)-MOFs and Composites Incorporated Electron-Rich Pyrene Derivative as Multifunctional Fluorescence Sensing for Nitro Aromatic Compounds and Aldehydes

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Chinese Journal of Chemistry 2024年第3期42卷 283-293页

作者： Rong Huo Ting zhang Guang Zeng chen Wang Yong heng Xing Feng Ying Bai College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalianLiaoning116029 China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

The development of host-guest MOF luminescent composites has attracted considerable attention. However,it is still a challenge to reasonably design large scale conjugated polycarboxylic acids metal-organic framework (MOF) and modulate donor-acceptor interaction. Herein,a series of isostructural 3D porous lanthanide MOF [Ln_(2)(BINDI)0.5(NO_(3))(DMA)(H_(2)O)]∙DMA∙2.5H_(2)O (Ln = La (1),Ce (2),Pr (3) and Nd (4);H_(4)BINDI (N,N’-bis(5-isophthalic acid)-1,4,5,8-naphthalenediimide) were synthesized. Considering the electron-deficient performances of Ln-BINDI MOFs,D-A type composites Ln-MOFs (1—4@H_(4)TBAPy) were prepared via the incorporation of electron-rich H_(4)TBAPy (1,3,6,8-tetrakis(p-benzoic acid) pyrene),which more improved the luminescence performance of complexes 1—4 and can be used as fluorescence sensors for the detection of nitro compounds and aldehydes. High sensitivity of 1@H_(4)TBAPy towards pNBA,pNA PNP,DNP,and TNP could be achieved through hydrogen bond interactions between MOF and analytes,as well as the π-π interaction between H_(4)TBAPy and the naphthalene ring of BINDI,thus the fluorescence quenching efficiency of 1@H_(4)TBAPy was better than that of the complex 1. In addition,it is found that 1@H_(4)TBAPy has high selectivity and sensitivity to aromatic aldehyde SA,5-Mesal and HMBA. Such strategy to enhance the emission of NDI based Ln-BINDI MOFs,will open up an avenue to obtain more fluorescent MOFs for sensing.

关键词： Ln-MOF Pyrene molecule NACs Aldehydes Fluorescence sensing Carboxylate ligands Charge transfer Donor-acceptor systems

Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengyu zhang Zhiyang zhang heng Sun Jie Li Yi chen Jiang Wang Chuanlang Zhan Key Laboratory of Advanced Materials Chemistry and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent years, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have exceeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of OSCs.The ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency OSCs.In this review, a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.

关键词： Organic solar cell Ternary/quaternary strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

Optimized Auxiliary Frequency Control of Wind Farm Based on Piecewise Reduced-order Frequency Response Model

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 791-802页

作者： Xu zhang chen Zhao Junchao Ma Long zhang Dan Sun chenxu Wang Yan Peng heng Nian the School of Electrical Engineering Zhejiang University Electric Power Research Institute of State Grid Zhejiang Electric Power Corporation

With the increasing wind power penetration in the power system, the auxiliary frequency control(AFC) of wind farm(WF) has been widely used. The traditional system frequency response(SFR) model is not suitable for the wind power generation system due to its poor accuracy and applicability. In this paper, a piecewise reduced-order frequency response(PROFR) model is proposed, and an optimized auxiliary frequency control(O-AFC) scheme of WF based on the P-ROFR model is proposed. Firstly, a full-order frequency response model considering the change in operating point of wind turbine is established to improve the applicability. In order to simplify the fullorder model, a P-ROFR model with second-order structure and high accuracy at each frequency response stage is proposed. Based on the proposed P-ROFR model, the relationship between the frequency response indexes and the auxiliary frequency controller coefficients is expressed explicitly. Then, an OAFC scheme with the derived explicit expression as the optimization objective is proposed in order to improve the frequency support capability on the premise of ensuring the full release of the rotor kinetic energy and the full use of the effect of time delay on frequency regulation. Finally, the effectiveness of the proposed P-ROFR model and the performance of the proposed OAFC scheme are verified by simulation studies.

关键词： Frequency control Frequency response Rotors Analytical models Indexes Optimization Delay effects

Structural properties of residual carbon in coal gasification fine slag and their influence on flotation separation and resource utilization:A review

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 217-230页

作者： Rui Han Anning Zhou Ningning zhang Kaiqiang Guo Mengyan Cheng heng chen Cuicui Li College of Chemistry and Chemical Engineering Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Natural Resources of ChinaXi’an 710021China

Coal gasification fine slag(FS)is a typical solid waste generated in coal gasification.Its current disposal methods of stockpil-ing and landfilling have caused serious soil and ecological hazards.Separation recovery and the high-value utilization of residual carbon(RC)in FS are the keys to realizing the win-win situation of the coal chemical industry in terms of economic and environmental benefits.The structural properties,such as pore,surface functional group,and microcrystalline structures,of RC in FS(FS-RC)not only affect the flotation recovery efficiency of FS-RC but also form the basis for the high-value utilization of FS-RC.In this paper,the characteristics of FS-RC in terms of pore structure,surface functional groups,and microcrystalline structure are sorted out in accordance with gasification type and FS particle size.The reasons for the formation of the special structural properties of FS-RC are analyzed,and their influence on the flotation separation and high-value utilization of FS-RC is summarized.Separation methods based on the pore structural characterist-ics of FS-RC,such as ultrasonic pretreatment-pore-blocking flotation and pore breaking-flocculation flotation,are proposed to be the key development technologies for improving FS-RC recovery in the future.The design of low-cost,low-dose collectors containing polar bonds based on the surface and microcrystalline structures of FS-RC is proposed to be an important breakthrough point for strengthening the flotation efficiency of FS-RC in the future.The high-value utilization of FS should be based on the physicochemical structural proper-ties of FS-RC and should focus on the environmental impact of hazardous elements and the recyclability of chemical waste liquid to es-tablish an environmentally friendly utilization method.This review is of great theoretical importance for the comprehensive understand-ing of the unique structural properties of FS-RC,the breakthrough of the technological bottleneck in the efficient flotation separation of FS,and the expa

关键词： coal gasification fine slag residual carbon pore structure surface functional groups microcrystalline structure flotation sep-aration resource utilization

Value iteration algorithm for continuous-time linear quadratic stochastic optimal control problems

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Science China(Information Sciences) 2024年第2期67卷 170-180页

作者： Guangchen WANG heng zhang School of Control Science and Engineering Shandong University

In this study, we investigate a continuous-time infinite-horizon linear quadratic stochastic optimal control problem with multiplicative noise in control and state variables. Using the techniques of stochastic stability, exact observability, and stochastic approximation, a value iteration algorithm is developed to solve the corresponding generalized algebraic Riccati equation. Unlike the existing policy iteration algorithm, this algorithm does not rely on an initial stabilizing control. Further, this algorithm can also be used to compute policy evaluation steps that arise in the policy iteration algorithm. Herein, a simulation example is provided to validate the obtained results.

关键词： stochastic systems optimal control linear quadratic stochastic problem generalized algebraic Riccati equation value iteration algorithm

Thermodynamic and Economic Analysis of a Conceptual System Combining Sludge Gasification,SOFC,Supercritical CO2 Cycle,and Organic Rankine Cycle

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Journal of Thermal Science 2024年第4期33卷 1491-1508页

作者： LV Jiayang WANG Chizhong chen heng PAN Peiyuan XU Gang zhang Guoqiang School of Energy Power and Mechanical EngineeringNorth China Electric Power University

In order to reduce the environmental impact of conventional sludge treatment methods and to utilize the energy in sludge more effectively,a coupled system based on sewage sludge gasifier（SSG）,solid oxide fuel cells（SOFC）,supercritical CO2cycle（S-CO2）,and organic Rankine cycle（ORC） is proposed.The clean syngas obtained from sludge gasification is mixed with CH4 and then first utilized by the fuel cell.The exhaust gas from the fuel cell is fully combusted in the afterburning chamber and then enters the bottom cycle system consisting of S-CO2& ORC to generate electricity.To understand the performance of the system,thermodynamic and economic analyses were conducted to examine the project's performance.The thermodynamics as well as the economics of the coupled system were analyzed to arrive at the following conclusions,the power production of the system is 37.34 MW;the exergy efficiency is 55.62%,and the net electrical efficiency is 61.48%.The main exergy destruction is the gasifier and SOFC,accounting for 62.45% of the total exergy destruction.It takes only6.13 years to repay the construction investment in the novel system,and the project obtains a NPV of 17 723 820USD during 20 years lifetime.The above findings indicate that the new coupled system has a better performance in terms of energy utilization and economy.

关键词： sewage sludge gasifier SOFC supercritical CO 2 cycle organic Rankine cycle multi-system coupling

Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

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中华医学杂志(英文版) 2024年第10期137卷 1151-1159页

作者： zhang Chunlan Qin Yun Wu Yu Xu heng Shu Yang Department of Hematology West China Hospital Sichuan University Chengdu Sichuan China Department of Radiology West China Hospital Sichuan University Chengdu Sichuan China Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China Department of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan China Institute of General Surgery West China Hospital Sichuan University Chengdu Sichuan China Department of General Surgery Gastric Cancer Center and Laboratory of Gastric Cancer West China Hospital Sichuan University Chengdu Sichuan China

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome in solid cancers. Recently, a series of studies has highlighted its potential role in hematological malignancies in terms of these events. Similar to solid cancers,MALAT1 can regulate various target genes via sponging and epigenetic mechanisms, but the miRNAs sponged byMALAT1 differ from those identified in solid cancers. In this review, we systematically describe the role and underlying mechanisms ofMALAT1 in multiple types of hematological malignancies, including regulation of cell proliferation, metastasis, stress response, and glycolysis. Clinically,MALAT1 expression is related to poor treatment outcome and drug resistance, therefore exhibiting potential prognostic value in multiple myeloma, lymphoma, and leukemia. Finally, we discuss the evaluation ofMALAT1 as a novel therapeutic target against cancer in preclinical studies.

关键词： Long non-coding RNA MALAT1 Hematological malignancies Tumorigenesis Metastasis Drug resistance Prognostic biomarker