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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang heng-chang yao Liang-Xin Peng Bao-Jia yao Zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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Long-duration aqueous Zn-ion batteries achieved by dual-salt highly-concentrated electrolyte with low water activity

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Journal of Energy Chemistry 2025年第2期101卷 778-785页

作者： Lvzhang Jiang Lingbo yao Gege Wang chang Liu Xiaowei Chi Yu Liu Shanghai Institute of Ceramics Chinese Academy of Sciences University of Chinese Academy of Sciences

Aqueous Zn-ion batteries have attracted much attention due to their unique high safety and low-cost ***,their practical applications are at a slow pace due to their short cycle life,which fundamentally results from the instability of the positive/negative electrode interface in the traditional dilute aqueous electrolytes with high water *** highly concentrated electrolyte（HCE）has been considered as an effective *** previous studies of single salt-based HCE（SSHCE）,herein,a new dual-salt HCE（15 m ZnCl2+10 m NH4NH2SO3DS-HCE） was proposed for the first ***-HCE was proven to simultaneously possess higher conductivity than traditional dilute electrolytes and ultralow water activity of SS-HCE by the regulation of dual high-concentration salts on the solvation structure,which renders the Zn‖Zn symmetric cell the record-long cycling life of 2200 h compared with those with SS-HCE（30 m ZnCl2,300 h） and other reported ***,the Zn‖NH4V4O10full cell with DS-HCE demonstrated impressed rate capability within a wide-range current densities from 0.1 to 10 A ***,at the high current density of 5 A g-1,the full cell shows almost100% capacity retention after 4000 cycles,which indicates the promising future of the DS-HCE system for long-duration aqueous Zn-ion batteries.

关键词： Ammonium vanadate Aqueous zinc battery Cycling stability Electrolyte

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Pressure-Dependent Thermal Network Model for Press-Pack Power Modules with Prognostics of Mechanical Status

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 424-439页

作者： yao chang Yu Zhou Ankang Zhu Haoze Luo Wuhua Li Chushan Li Francesco Iannuzzo Xiangning He College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang University–University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining314400China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark

The press-pack power module with multi-chip layout has drawn increasing attention from industry and academia with its thermal analysis becoming an essential ***,the pressure-dependent thermal variables,such as thermal contact resistance and thermal coupling resistance,are often *** this paper,a pressure-dependent thermal network model is developed to characterize the thermal performance and mechanical status of press-pack power *** including the thermal contact resistance and thermal coupling resistance as the function of pressure,the proposed model ensures a more precise thermo-mechanical evaluation inside the press-pack power *** influence of pressure on self-heating effects and thermal coupling effects of power modules is studied using the knowledge of elastic mechanics.A press-pack prototype with variable pressure loads is ***,thermal experiments under different pressures on chips are conducted and the pressure-variable temperature responses of the thermal network are ***,the feasibility of the proposed thermal network model is validated.A cost-effective prognostic method on the mechanical status of press-pack power module is also achieved.

关键词： Mechanical status press-pack power module pressure-dependent model thermal network.

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Hybrid conductive-lithophilic-fluoride triple protection interface engineering:Dendrite-free reverse lithium deposition for high-performance lithium metal batteries

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Journal of Energy Chemistry 2025年第2期101卷 416-428页

作者： Huiying Li chang Hong Runming Tao Xiaolang Liu Jianxing Wang Jianyu Chen Shuhao yao Jiazhi Geng Guang Zheng Jiyuan Liang Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education School of Optoelectronic Materials & Technology Jianghan University Applied Materials Division Argonne National Laboratory State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications

Lithium metal batteries（LMBs） with high energy density are impeded by the instability of solid electrolyte interface（SEI） and the uncontrolled growth of lithium（Li） *** mitigate these challenges,optimizing the SEI structure and Li deposition behavior is the key to stable *** study novelty proposes a facile synthesis of MgF2/carbon（C） nanocomposite through the mechanochemical reaction between metallic Mg and polytetrafluoroethylene（PTFE） powders,and its modified polypropylene（PP）separator enhances LMB *** in-situ formed highly conductive fluorine-doped C species play a crucial role in facilitating ion/electron transport,thereby accelerating electrochemical kinetics and altering Li deposition *** cycling,the in-situ reaction between MgF2and Li leads to the formation of LiMg alloy,along with a LiF-rich SEI layer,which reduces the nucleation overpotential and reinforces the interphase strength,leading to homogeneous Li deposition with dendrite-free *** from these merits,the Li metal is densely and uniformly deposited on the MgF2/C@PP separator side rather than on the current collector ***,the symmetric cell with MgF2/C@PP exhibits superb Li plating/stripping performance over 2800 h at 1 mA cm-2and 2 mA h *** importantly,the assembled Li@MgF2/C@PPILiFePO4full cell with a low negative/positive ratio of 3.6delivers an impressive cyclability with 82.7% capacity retention over 1400 cycles at 1 C.

关键词： Lithium metal batteries Mechanochemical reaction MgF2 Reverse deposition Separator modification

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A breakthrough of printable mesoscopic perovskite solar cells

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Science China Materials 2025年第1期68卷 307-308页

作者： Zhiyi yao Zhijun Ning School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

High-performance solar cells based on low-cost wet coating methods are the much-anticipated technology for the next generation of photovoltaics. Perovskite solar cells (PSCs) provide a fascinating choice because their... 详细信息

关键词： perovskite breakthrough absorber

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New results on finite-time stability and instability theorems for stochastic nonlinear time-varying systems

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Science China(Information Sciences) 2025年第2期68卷 186-199页

作者： Weihai ZHANG Liqiang yao College of Electrical Engineering and Automation Shandong University of Science and Technology School of Mathematics and Information Science Yantai University

This paper studies finite-time stability and instability theorems in the probability sense for stochastic nonlinear timevarying systems. Firstly, a new sufficient condition is proposed to guarantee that the considered system has a global ***, we propose new finite-time stability and instability criteria that relax the constraints on LV(the infinitesimal operator of Lyapunov function V) by the uniformly asymptotically stable function. On the one hand, these obtained results make up for the shortcomings of the existing results. On the other hand, the new finite-time stability theorems can be viewed as natural extensions of the existing results and also allow LV to be indefinite(negative or positive) rather than just only allow LV < ***, some simulation examples verify the validity of the theoretical results.

关键词： stochastic nonlinear systems finite-time stability finite-timeinstability uniformly asymptotically stable function

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Velogenic Newcastle disease virus invades chicken brain by infecting brain microvascular endothelial cells to increase blood-brain barrier permeability

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Journal of Integrative Agriculture 2025年第2期24卷 712-723页

作者： Jie Zhao Sa Xiao Wei yao Xudong chang Xinglong Wang Zengqi Yang Wenbin Wang Poultry Institute Shandong Academy of Agricultural Sciences College of Veterinary Medicine Northwest A&F University People's Government of Guangpu Town

The blood-brain barrier(BBB) keeps poisons and infections out of the brain. Some viruses can pass through this barrier and replicate in the central nervous system(CNS). Velogenic Newcastle disease virus(VNDV) is a neurotropic virus that causes avian nonsuppurative encephalitis. VNDV often develops into a chronic infection that seriously affects poultry health in partially immune birds. The routes by which the virus enters the chicken brain are poorly understood. In this study, we discovered that VNDV increased BBB permeability in vivo and in vitro by breaking the tight junction protein zona occludens-1(ZO-1) continuity of chicken brain microvascular endothelial cells(chBMECs). By investigating the susceptibility of chBMECs to NDV infection, we found that VNDV but not lentogenic NDV was detected in the basolateral compartment in transwell assays after apical infection, suggesting that efficient replication and transcellular transport of the virus across the BBB in vitro. Furthermore, viral replication and BBB permeability were reduced during the early stage of infection by using the dynamin inhibitor dynasore. Our data demonstrate that VNDV invades the chicken brain by infecting and damaging the tight junction of chBMECs directly to increase BBB permeability. VNDV could infect chBMECs via endocytosis. As a result, our findings provide compelling evidence for VNDV entrance into the brain via the BBB, paving the way for the development of medications for NDV prevention and therapy.

关键词： velogenic Newcastle disease virus blood-brain barrier permeability chicken brain microvascular endothelial cells

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Neural Network Based on Inter-layer Perturbation Strategy for Text Classification

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Machine Intelligence Research 2025年第1期22卷 176-188页

作者： Nai Zhou Nianmin yao Qibin Li School of Computer Science and Technology Dalian University of TechnologyDalian116024China

Recently,many researches have created adversarial samples to enrich the diversity of training data for improving the text classification performance via reducing the loss incurred in the neural network ***,existing studies have focused solely on adding perturbations to the input,such as text sentences and embedded representations,resulting in adversarial samples that are very similar to the original *** adversarial samples can not significantly improve the diversity of training data,which restricts the potential for improved classification *** alleviate the problem,in this paper,we extend the diversity of generated adversarial samples based on the fact that adding different disturbances between different layers of neural network has different *** propose a novel neural network with perturbation strategy(PTNet),which generates adversarial samples by adding perturbation to the intrinsic representation of each hidden layer of the neural ***,we design two different perturbation ways to perturb each hidden layer:1)directly adding a certain threshold perturbation;2)adding the perturbation in the way of adversarial *** above settings,we can get more perturbed intrinsic representations of hidden layers and use them as new adversarial samples,thus improving the diversity of the augmented training *** validate the effectiveness of our approach on six text classification datasets and demonstrate that it improves the classification ability of the *** particular,the classification accuracy on the sentiment analysis task improved by an average of 1.79%and on question classification task improved by 3.2%compared to the BERT baseline,respectively.

关键词： Perturbation strategy adversarial training machine learning text classification adversarial samples

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Impulsive thrust strategy for orbital pursuit-evasion games based on impulse-like constraint

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Chinese Journal of Aeronautics 2025年第1期38卷 520-536页

作者： Hongbo WANG yao ZHANG Hao LIU Kunpeng ZHANG School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Space Intelligent Control Beijing Institute of Control EngineeringBeijing 100094China

This paper proposes a novel impulsive thrust strategy guided by optimal continuous thrust strategy to address two-player orbital pursuit-evasion game under impulsive thrust *** strategy seeks to enhance the interpretability of impulsive thrust strategy by integrating it within the framework of differential game in traditional continuous ***,this paper introduces an impulse-like constraint,with periodical changes in thrust amplitude,to characterize the impulsive thrust ***,the game with the impulse-like constraint is converted into the two-point boundary value problem,which is solved by the combined shooting and deep learning method proposed in this *** learning and numerical optimization are employed to obtain the guesses for unknown terminal adjoint variables and the game terminal ***,the accurate values are solved by the shooting method to yield the optimal continuous thrust strategy with the impulse-like ***,the shooting method is iteratively employed at each impulse decision moment to derive the impulsive thrust strategy guided by the optimal continuous thrust *** examples demonstrate the convergence of the combined shooting and deep learning method,even if the strongly nonlinear impulse-like constraint is *** effect of the impulsive thrust strategy guided by the optimal continuous thrust strategy is also discussed.

关键词： Orbital pursuit-evasion game Differential game Impulsive thrust Deep learning Shooting method

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Dynamic Event-Triggered Active Disturbance Rejection Formation Control for Constrained Underactuated AUVs

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 460-462页

作者： Zhiguang Feng Sibo yao IEEE the College of Intelligent Systems Science and Engineering Harbin Engineering University

Dear Editor,This letter addresses the formation control problem for constrained underactuated autonomous underwater vehicles (AUVs). The feasibility condition of the virtual control law is eliminated by introducing a nonlinear state dependence function (NSDF) that transforms the state of each AUV in the formation.

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