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Endoscopic ultrasound features of rectal melanoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第16期12卷 2862-2868页

作者： Zhang-E Xiong Xin-xiang Wei Li Wang Chen xia Zi-Yin Li Chan Long bo Peng Ting Wang Department of Gastroenterology Wuhan Third HospitalWuhan 430060Hubei ProvinceChina Department of Pharmacy Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina Department of Pathology Wuhan Third HospitalWuhan 430060Hubei ProvinceChina

BACKGROUND Rectal mucosal melanoma is a rare and highly aggressive *** symptoms include anal pain,an anal mass,or *** such,the disease is usually detected on rectal examination of patients with other suspected anorectal ***,due to its rarity and nonspecific symptoms,melanoma of the rectal mucosa is easily *** SUMMARY This report describes the case of a 58-year-old female patient who presented with a history of blood in her stool for the prior one or two months,without any identifiable *** colonoscopy,a bulge of approximately 2.2 cm×2.0 cm was ***,the patient underwent endoscopic ultrasound(EUS)to characterize the depth of invasion of the *** suggested a hypoechoic mucosal mass with involvement of the submucosal layer and heterogeneity of the internal *** surgical intervention,the excised tissue samples were examined and confirmed to be rectal malignant *** patient recovered well with no evidence of recurrence during *** This case shows that colonoscopy with EUS and pathological examination can accurately diagnose rare cases of rectal mucosal melanoma.

关键词： Endoscopic ultrasound Rectal mucosal melanoma Colonoscopy Treatment Case report

Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma

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TMR Modern Herbal Medicine 2024年第2期7卷 11-18页

作者： Zhi-Qiang Wang Zhen-Yu Mu bo Yang Tao Wang Zhi-Yong Su Shan-Chun Guo Jiang-xia Yin Department of Urology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Medical Insurance Office Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Intensive Care Unit Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Anal Surgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Neurosurgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China RCMI Cancer Research Center Xavier University of LouisianaLA 1870125USA Department of Medical Oncology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China

Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking ***:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their *** Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of *** assisted in constructing herb-compound-target(H-C-T)*** STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential *** of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 *** Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression *** Vina software validated the molecular docking regarding GQW components and pivotal ***:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects *** to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling ***1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to *** docking and molecular dynamics simulations showed that diosgenin has

关键词： Gualou Qumai Wan AKT1 PI3K-Akt signaling pathway network pharmacology diosgenin clear cell renal cell carcinoma

Astronomical data fusion tool based on PostgreSQL

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Research in Astronomy and Astrophysics 2016年第11期16卷 105-112页

作者： bo Han Yan-xia Zhang Shou-bo Zhong Yong-heng Zhao International School of Software Wuhan University Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences

With the application of advanced astronomical technologies, equipments and methods all over the world, astronomical observations cover the range from radio, infrared, visible light, ultraviolet, X-ray and gamma-ray bands, and enter into the era of full wavelength astronomy. How to effectively integrate data from different ground- and space-based observation equipments, different observers, different bands and different observation times, requires data fusion technology. In this paper we introduce a cross-match tool that is developed in the Python language, is based on the PostgreSQL database and uses Q3C as the core index, facilitating the cross-match work of massive astronomical data. It provides four different cross- match functions, namely：（I） cross-match of the custom error range; （II） cross-match of catalog errors; （III） cross-match based on the elliptic error range; （IV） cross-match of the nearest neighbor algorithm. The resulting cross-matched set provides a good foundation for subsequent data mining and statistics based on multiwavelength data. The most advantageous aspect of this tool is a user-oriented tool applied locally by users. By means of this tool, users can easily create their own databases, manage their own data and cross- match databases according to their requirements. In addition, this tool is also able to transfer data from one database into another database. More importantly, it is easy to get started with the tool and it can be used by astronomers without writing any code.

关键词： astronomical databases: miscellaneous - catalogs - surveys

Effect of ultrasonic and mechanical vibration treatments on evolution of Mn-rich phases and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2393-2414页

作者： bo LIN xiang-xiang HE Song-chao xia Hua-qiang xiaO Yu-liang ZHAO Khashayar KHANLARI School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Centro Nacional de Investigaciones Metalúrgicas(CENIM) C.S.I.C.Avda.de Gregorio del Amo 8Madrid 28040Spain Department of Chemical&Biotechnological Engineering Universitéde SherbrookeQuébecQC J1K 2R1Canada

Effects of ultrasonic vibration(UV)and mechanical vibration(MV)on the Mn-rich phase modification and mechanical properties of Al−12Si−4Cu−1Ni−1Mg−2Mn piston alloys were *** results show that the UV and UV+MV treatments can significantly refine and fragmentize the *** addition,UV treatment can significantly passivate the primary Mn-rich Al15Mn3Si2 *** formation mechanisms of refinement and passivation of the grains and non-dendrite particles were *** with the gravity die-cast alloys,the UV and UV+MV treated alloys exhibit improved tensile and creep resistance at room and elevated *** results can be attributed to the refinement of theα(Al)grains and the secondary intermetallics,the increased proportion of refined heat-resistant precipitates,and the formation of nano-sized Si *** ultimate tensile strength of the UV treated alloys at 350℃ exceeds that of commercial piston *** indicates the high application potential of the developed piston alloys in density diesel engines.

关键词： Al−Si piston alloys Mn-rich phases mechanical properties ultrasonic vibration mechanical vibration

Screening antimicrobial peptides and probiotics using multiple deep learning and directed evolution strategies

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3476-3492页

作者： Yu Zhang Li-Hua Liu bo Xu Zhiqian Zhang Min Yang Yiyang He Jingjing Chen Yang Zhang Yucheng Hu Xipeng Chen Zitong Sun Qijun Ge Song Wu Wei Lei Kaizheng Li Hua Cui Gangzhu Yang Xuemei Zhao Man Wang Jiaqi xia Zhen Cao Ao Jiang Yi-Rui Wu Tidetron Bioworks Technology(Guangzhou)Co. Ltd.Guangzhou Qianxiang Bioworks Co.Ltd.Guangzhou 510000China Biology Department and Institute of Marine Sciences College of ScienceShantou UniversityShantou 515063China School of Basic Medical Sciences Hubei University of Science and TechnologyXianning 437100China School of Education Jianghan UniversityWuhan 430056China Yeasen Biotechnology(Shanghai)Co. Ltd.Shanghai 200000China School of Basic Medicine Jiamusi UniversityJiamusi 154000China

Owing to their limited accuracy and narrow applicability,current antimicrobial peptide(AMP)prediction models face obstacles in industrial *** address these limitations,we developed and improved an AMP prediction model using Comparing and Optimizing Multiple DEep Learning(COMDEL)algorithms,coupled with high-throughput AMP screening method,finally reaching an accuracy of 94.8%in test and 88%in experiment verification,surpassing other state-of-the-art *** conjunction with COMDEL,we employed the phage-assisted evolution method to screen Sortase in vivo and developed a cell-free AMP synthesis system in vitro,ultimately increasing AMPs yields to a range of 0.5-2.1 g/L within ***,by multi-omics analysis using COMDEL,we identified Lactobacillus plantarum as the most promising candidate for AMP generation among 35 edible *** this,we developed a microdroplet sorting approach and successfully screened three *** mutants,each showing a twofold increase in antimicrobial ability,underscoring their substantial industrial application values.

关键词： Antimicrobial peptide Deep learning Cell-free synthesis Probiotics L.plantarum

基于DEM-FDM耦合的顺层岩质边坡强震动力响应及破坏模式分析

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地球科学 2024年第8期49卷 2799-2812页

作者：刘毛毛石振明李博夏成志同济大学土木工程学院上海200092

基于DEM-FDM耦合,考虑结构面的三维延展情况,分区建立不同岩体结构的顺层岩质边坡数值模型,输入双向地震动,分析强震下不同岩体结构顺层岩质边坡的动力响应及破坏模式,得出了如下结论:(1)地震作用下,边坡加速度存在一定的高程放大效应,... 详细信息

基于DEM-FDM耦合,考虑结构面的三维延展情况,分区建立不同岩体结构的顺层岩质边坡数值模型,输入双向地震动,分析强震下不同岩体结构顺层岩质边坡的动力响应及破坏模式,得出了如下结论:(1)地震作用下,边坡加速度存在一定的高程放大效应,边坡底部水平向放大效应强于竖直向放大效应,顶部水平与竖向放大效应不相上下;(2)在32.5~42.5 m高程范围内,层面和节理等结构面的存在,对于地震波的传播有一定阻隔作用.坡肩相对于其他部位放大效应更强,且节理越发育,坡肩放大效应越强,相比倾向180°的节理,倾向90°的节理对放大效应影响更大;(3)具有不同岩体结构的4个模型分别呈现稳定、局部开裂、滑移—拉裂破坏及滑移—溃散破坏等不同的变形破坏特征,倾向90°的节理是顺层边坡稳定性的主控结构面.通过与以往研究结果对比可知,耦合方法能较好地揭示不同岩体结构顺层岩质边坡的动力响应及破坏模式,为强震区相关边坡工程提供了一定参考.

关键词： DEM-FDM耦合顺层岩质边坡强震动力响应破坏模式工程地质

热处理对选区激光熔化Co-Cr合金微观组织与力学性能的影响

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有色金属科学与工程 2024年第2期15卷 265-273页

作者：张波刘艺夏书标贵阳职业技术学院贵阳550081 曲靖师范学院化学与环境科学学院云南曲靖655011

热处理不仅可以消除激光增材制造材过程中的热应力,还可以调控材料组织结构和力学性能。本文研究了选区激光熔化Co-Cr合金微观组织在不同热处理条件下的变化及其相应的力学性能。研究发现,打印态下合金组织为γ奥氏体,基体中存在大量层... 详细信息

热处理不仅可以消除激光增材制造材过程中的热应力,还可以调控材料组织结构和力学性能。本文研究了选区激光熔化Co-Cr合金微观组织在不同热处理条件下的变化及其相应的力学性能。研究发现,打印态下合金组织为γ奥氏体,基体中存在大量层错和亚晶界组织,以及少量四方σ-CoCr沉淀相;在1150℃下保温1 h,发生γ-ε转变,ε马氏体含量为10.4%(V/V),同时沉淀相由四方σ相转变为六方Co_(3)W(Mo)_(2)Si相;再经过800℃处理2 h后,马氏体含量进一步增加至15.5%(V/V),同时沉淀相数量增加且尺寸增大。热处理后的沉淀相对力学性能影响显著,材料的硬度从31 HRC提高至38 HRC,屈服强度从848 MPa提高至1119 MPa。本研究可以为研究激光选区熔化Co基合金组织与性能调控提供参考。

关键词：选区激光熔化 Co-Cr合金热处理沉淀相力学性能

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Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

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World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： Yang Song Hao-Jun Zhang xia Song Jie Geng Hong-Yi Li Li-Zhong Zhang bo Yang Xue-Chun Lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone *** translocation,(t)(4;14),results in high-risk MM with limited treatment ***,there is an urgent need for identification and validation of potential treatments for this MM *** data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic *** To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive *** The transcriptional signature of t(4;14)MM was sourced from the Gene Expression *** datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,*** the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub ***,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** the STRING database and Cytoscape,protein–protein interaction networks and core targets were *** small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,*** In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were *** hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were *** drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)*** molecular docking,ivermectin showed strong binding affinity to all 10 ide

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

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铁路货车敞车下侧门折页自动组焊机的研究

哈尔滨铁道科技 2024年第2期 24-27页

作者：夏博中国铁路哈尔滨局集团有限公司齐齐哈尔车辆段黑龙江齐齐哈尔161000

在车辆段检修生产中,货车敞车车门检修是一个重要环节。为了解决传统的人工焊接方式效率低下,劳动强度大,且对作业环境造成污染等问题,研究一种铁路货车敞车下侧门折页自动组焊机,实现自动上料、车门折页自动定位、全自动完成下侧门折... 详细信息

在车辆段检修生产中,货车敞车车门检修是一个重要环节。为了解决传统的人工焊接方式效率低下,劳动强度大,且对作业环境造成污染等问题,研究一种铁路货车敞车下侧门折页自动组焊机,实现自动上料、车门折页自动定位、全自动完成下侧门折页焊接、成品自动出料码垛等功能。自动焊接设备的使用提高了铁路货车检修作业效率和焊接质量,能够减少废气、废水、噪音等工业污染,改善作业环境,符合环保要求,取得了良好的经济、社会和环保效益。

关键词：铁路货车敞车下侧门门折页自动组焊机 PLC