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Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells

Journal of Pharmaceutical Analysis 2024年第6期14卷 889-901页

作者： Shaowei Huang Xueqian Xie bo Xu Zengfeng Pan Junjie Liang Meiling Zhang Simin Pan xiaojing Wang Meng Zhao Qing Wang Jinyan Chen Yanyang Li Lian Zhou xia Luo School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine510006China School of Basic Medicine Guangzhou University of Chinese Medicine510006China First Clinical Medical College Guangzhou University of Chinese Medicine510000China

Inhibiting the death receptor 3(DR3)signaling pathway in group 3 innate lymphoid cells(ILC3s)presents a promising approach for promoting mucosal repair in individuals with ulcerative colitis(UC).Paeoniflorin,a prominent component of Paeonia lactiflora Pall.,has demonstrated the ability to restore barrier function in UC mice,but the precise mechanism remains *** this study,we aimed to delve into whether paeoniflorin may promote intestinal mucosal repair in chronic colitis by inhibiting DR3 signaling in ILC3s.C57BL/6 mice were subjected to random allocation into 7 distinct groups,namely the control group,the 2%dextran sodium sulfate(DSS)group,the paeoniflorin groups(25,50,and 100 mg/kg),the anti-tumor necrosis factor-like ligand 1A(anti-TL1A)antibody group,and the IgG *** detected the expression of DR3 signaling pathway proteins and the proportion of ILC3s in the mouse colon using Western blot and flow cytometry,***,DR3-overexpressing MNK-3 cells and 2%DSS-induced Rag1^(-/-)mice were used for *** results showed that paeoniflorin alleviated DSS-induced chronic colitis and repaired the intestinal mucosal ***,paeoniflorin inhibited the DR3 signaling pathway in ILC3s and regulated the content of cytokines(interleukin-17A,granulocyte-macrophage colony stimulating factor,and interleukin-22).Alternatively,paeoniflorin directly inhibited the DR3 signaling pathway in ILC3s to repair mucosal damage independently of the adaptive immune *** additionally confirmed that paeoniflorin-conditioned medium(CM)restored the expression of tight junctions in Caco-2 cells via *** conclusion,paeoniflorin ameliorates chronic colitis by enhancing the intestinal barrier in an ILC3-dependent manner,and its mechanism is associated with the inhibition of the DR3 signaling pathway.

关键词： Paeoniflorin Ulcerative colitis Intestinal mucosal barrier DR3 signaling pathway Group 3 innate lymphoid cells

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SapBase:A central portal for functional and comparative genomics of Sapindaceae species

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Journal of Integrative Plant Biology 2024年第8期66卷 1561-1570页

作者： Jiawei Li Chengjie Chen Zaohai Zeng Fengqi Wu Junting Feng bo Liu Yingxiao Mai Xinyi Chu Wanchun Wei Xin Li Yanyang Liang YuanLong Liu Jing Xu Rui xia State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of HorticultureSouth China Agricultural UniversityGuangzhou 510640China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510640China Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in South China at the Ministry of Agriculture and Rural Affairs South China Agricultural UniversityCollege of HorticultureGuangzhou 510640China

The Sapindaceae family,encompassing a wide range of plant forms such as herbs,vines,shrubs,and trees,is widely distributed across tropical and subtropical *** family includes economically important crops like litchi,longan,rambutan,and *** the wide application of genomic technologies in recent years,several Sapindaceae plant genomes have been decoded,leading to an accumulation of substantial omics data in this *** surge in data highlights the pressing need for a unified genomic data center capable of storing,sharing,and analyzing these ***,we introduced SapBase,that is,the Sapindaceae Genome *** houses seven published plant genomes alongside their corresponding gene structure and functional annotations,small RNA annotations,gene expression profiles,gene pathways,and synteny block *** offers user-friendly features for gene information mining,co-expression analysis,and interspecies comparative genomic ***,we showcased SapBase's extensive capacities through a detailed bioinformatic analysis of a MYB gene in ***,Sap Base could serve as an integrative genomic resource and analysis platform for the scientific exploration of Sapinaceae species and their comparative studies with other plants.

关键词： functional crops unified

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Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening

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Virologica Sinica 2024年第2期39卷 301-308页

作者： Qiu-Yan Zhang Jia-Qi Li Qi Li Yang Zhang Zhe-Rui Zhang xiao-Dan Li Hong-Qing Zhang Cheng-Lin Deng Feng-xia Yang Yi Xu bo Zhang The Joint Center of Translational Precision Medicine Department of Infections and DiseasesGuangzhou Institute of PediatricsGuangzhou Women and Children's Medical CenterGuangzhou510623China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Science and Technology of China Department of Life Sciences and MedicineHefei230026China Hunan Normal University School of MedicineChangsha410081China

Hand,foot,and mouth disease(HFMD)is a common pediatric illness mainly caused by enteroviruses,which are important human ***,there are no available antiviral agents for the therapy of enterovirus *** this study,an excellent high-content antiviral screening system utilizing the EV-A71-eGFP reporter virus was *** this screening system,we screened a drug library containing 1042 natural compounds to identify potential EV-A71 ***(FAN),a bis-benzylisoquinoline alkaloid,exhibits potential inhibitory effects against various enteroviruses that cause HFMD,such as EV-A71,CV-A10,CV-B3 and *** investigations revealed that FAN targets the early stage of the enterovirus life *** the selection of FAN-resistant EV-A71 viruses,we demonstrated that the VP1 protein could be a potential target of FAN,as two mutations in VP1(E145G and V258I)resulted in viral resistance to *** research suggests that FAN is an efficient inhibitor of EV-A71 and has the potential to be a broad-spectrum antiviral drug against human enteroviruses.

关键词： Hand,foot,and mouth disease(HFMD) Enterovirus EV-A71 High-content screening Fangchinoline(FAN)

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Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

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China Geology 2024年第3期7卷 382-408页

作者： bo Han Zhen Ma Liang-jun Lin Hong-wei Liu Yi-hang Gao Yu-bo xia Hai-tao Li Xu Guo Feng Ma Yu-shan Wang Ya-long Zhou Hong-qiang Li Tianjin Center China Geological Survey(North China Center of Geoscience Innovation)Ministry of Natural ResourcesTianjin 300170China Xiong’an Urban Geological Research Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China China Institute of Geo-Environment Monitoring Beijing 100081China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Center for Hydrogeology and Environmental Geology China Geological SurveyMinistry of Natural ResourcesBaoding 071051China Institute of Geophysical&Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Chinese Academy of Geological Sciences Beijing 10037China

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei *** 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this *** achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally ***’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and *** future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

关键词： Low Carbon New City Planning and construction Land Geothermal resources Groundwater Wetland Underground space Geologic disasters Site stability Natural resource Ecosystem Geological safety Transparent Xiong’an Resilient city Xiong’an New Area

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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-Ya Zhang xia Wu Fa-Ming Zhang bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

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关于“戏剧与影视学”学科建设的几个问题

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四川戏剧 2024年第7期 4-9页

作者：夏波中央戏剧学院

学科是人类对世界(或宇宙)事物及人类自身行为,根据其所具有的某些相对独立性的共性特点与领域而进行科学性划分的知识体系,其具有相对独立性与科学性特点。“戏剧与影视学”学科首先应该从建设好应有的师资队伍抓起,真正下大功夫深入... 详细信息

学科是人类对世界(或宇宙)事物及人类自身行为,根据其所具有的某些相对独立性的共性特点与领域而进行科学性划分的知识体系,其具有相对独立性与科学性特点。“戏剧与影视学”学科首先应该从建设好应有的师资队伍抓起,真正下大功夫深入探索和建构真正具有原创性和能够自洽的现代戏剧影视学“学科、学术、话语”体系。学科发展规划的制定与学科评价原则方法的设定,应当符合人才成长道路及其规律特点要求,同时符合高水平作品和成果的孕育要素构成及成长发展的本质规律性要求。

关键词：戏剧与影视学师资人才发展规划评价

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Impact of gradient microstructure on strain hardening via activation of multiple deformation mechanisms in CoCrNi medium entropy alloy

Materials Futures

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Materials Futures 2024年第4期3卷 11-21页

作者： Jiaqi Meng Yonghao Zhao Yi Liu Zongyao Li bo Gao Mengning Xu Weiheng xia Xuefei Chen Hao Zhou Yuntian Zhu Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094People’s Republic of China School of Materials Science and Engineering Hohai UniversityChanazhou 213200People’s Republic of China Liaoning Academy of Materials Shenyang 110167People’s Republic of China Department of Materials Science and Engineering City University of Hong KongHong Kong Special Administrative Region of China 999077People’s Republic of China

Face centered cubic(FCC)structural medium/high entropy alloys(MEAs),characterized by excellent strength and ductility,have attracted significant attention by the research *** incorporation of gradient structures(GSs)further can enhance their mechanical *** the present research,we employ the rotation acceleration shot peening technique to introduce a GS within the CoCrNi FCC MEA to investigate underlying mechanisms governing the physical deformation processes during the generation of GSs through processing,which the primary goal is mitigating the intrinsic trade-off between strength and *** the microstructures analysis along the depth direction,both pre and post uniaxial tensile plastic deformation,we unveiled that the low stacking fault(SF)energy characteristic of the CoCrNi MEA triggered the emergence of diverse defects in the core *** presence of nanoscale deformation twins,SFs,Lomer–Cottrell dislocation locks and phase transformation from FCC to hexagonal close-packed at twin boundaries synergistically enhanced the strain hardening capacity of the material.

关键词： CoCrNi MEA heterogeneous structure twinning phase transformation strain hardening

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Network Pharmacology of xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-xia Zhao Cheng-Lin Song Qin-Chang Zhang Hao-Jie Du Shu-Qiong Zhang Yu-xian Shen Yang Sun Hai-bo Cheng Wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the xian-Lian-Jie-Du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology xian-Lian-Jie-Du decoction

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Mechanism of Pediococcuspentosaceus PP04 in Alleviating High-fat Diet Caused Hyperlipidemiavia Modulation of Intestinal Flora and It′s Metabolites

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Food Science and Human Wellness 2024年

作者： Yu Wang Xinyue Xing Yamei He Yue Zhang Yuxuan Ma bo Nan xia Li Yuhua Wang Jingsheng Liu College of Food Science and Engineering， Jilin Agricultural University Jilin Province Innovation Center for Food Biological Manufacture， Jilin Agricultural University National Processing Laboratory for Soybean Industry and Technology National Engineering Research Center for Wheat and Corn Deep Processing

The gut microbiota and it′s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia， which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota and it′s metabolites directly， the rebalanced intestinal flora mediated by PP04 could facilitate the secretion of short chain fatty acids to control body weight gain， PP04 intervention also changed bile acids (BAs) profiles and enhanced the ileal concentrations of antagonists including tauro-α/β-muricholic acid sodium salt and ursodeoxycholic acid to inhibit intestinal farnesoid X receptor/fibroblast growth factor 15 (FXR/FGF15) signaling coupled with the activation of hepatic FXR/small heterodimer partners signaling (SHP)， which accelerated the hepatic BAs de novo synthesis and excretion with feces to eliminate HFD caused hyperlipemia effectively. This study provided important evidence regarding PP04 as dietary supplement to relieve hyperlipidemia by influencing BAs enterohepatic circulation.

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Lactobacillus plantarum 104 Cell-freesupernatant improved bile acid metabolism by regulating gut microbiota of high-fat diet mice

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Food Science and Human Wellness 2024年

作者： xia Li Shanshan Wei Ruixue Zhao Yue Zhang Zixin Gao Zhanpeng Wang Yu Wang bo Nan Yuhua Wang College of Food Science and Engineering and Jilin Province Innovation Center for Food Biological Manufacture， Jilin Agricultural University

Lactiplantibacillusplantarum 104， which was previously screened in the laboratory， has been confirmed to have the effect of lowering lipids and regulating intestinal microbial homeostasis. However， the mechanism of action of its fermentation supernatant in alleviating metabolic disorders is ***104 cell-freesupernatant (LP104s) was fed to high-fat C57BL/6N mice for 8 weeks. The intervention of LP104s increased the concentration of conjugated bile acids in the ileum， especially taur-α/β-muricholic acid sodium salt (T-α-MCA or T-β-MCA)， inhibited intestinal farnesoid X receptor (FXR)-related signaling pathways. LP104s reduced cholesterol levels by increasing the synthesis of hepatic cholic acid (CA)， chenodeoxycholic acid (CDCA)， and the excretion of bile acids in feces. Moreover， western blotting results showed that TLR2/NF-?B signaling pathway expression was inhibited. In addition， 16S rDNA sequencing results showed that LP104s regulated the relative abundance of bacteria associated with inflammatory response and obesity (Prevotella， Ruminococcus， and Clostridium). Therefore， this paper further elaborates the role of gut microbiology and bile acids in improving metabolism from the perspective of secondary bile acids and intestinal chronic inflammation and also lays a theoretical foundation for the next step in the development of fermentation products of this strain.

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