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World Journal of Pediatrics 2024年第11期20卷 1115-1137页

作者： Ao-Jje Cai Kai Gao Fan zhangg Yu-Wu Jiang Department of Pediatrics Peking University First HospitalBeijingChina Department of Pediatrics The First Affiliated Hospital of Zhengzhou UniversityHenan ProvinceZhengzhou450052China Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background Epilepsy is a common neurological disorder with complex pathogenic mechanisms,and refractory epilepsy often lacks effective *** therapy is a promising therapeutic option,with various preclinical experiments achieving positive results,some of which have progressed to clinical *** sources This narrative review was conducted by searching for papers published in PubMed/MEDLINE with the following single and/or combination keywords:epilepsy,children,neurodevelopmental disorders,genetics,gene therapy,vectors,transgenes,receptors,ion channels,micro RNAs(miRNAs),clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)9(CRISPR/Cas9),expression regulation,optogenetics,chemical genetics,mitochondrial epilepsy,challenges,ethics,and disease *** Currently,gene therapy research in epilepsy primarily focuses on symptoms attenuation mediated by viral vectors such as adeno-associated virus and other *** in gene therapy technologies,such as CRISPR/Cas9,have provided a new direction for epilepsy ***,the clinical application still faces several challenges,including issues related to vectors,models,expression controllability,and ethical *** Here,we summarize the relevant research and clinical advances in gene therapy for epilepsy and outline the challenges facing its clinical *** addition to the shortcomings inherent in gene therapy components,the reconfiguration of excitatory and inhibitory properties in epilepsy treatment is a delicate ***-demand,cell-autonomous treatments and multidisciplinary collaborations may be crucial in addressing these *** gene therapy for epilepsy will help clinicians gain a clearer perception of the research progress and challenges,guiding the design of future clinical protocols and research decisions.

关键词： Challenges CRISPR Epilepsy Gene therapy Strategy

Surface-Condition-Dependent Deformation Mechanisms in Lead Nanocrystals

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Research 2022年第4期2022卷 589-595页

作者： Hongtao zhangg Wen Wang Jun Sun Li Zhong Longbing He Litao Sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China Center for Advanced Materials and Manufacture Southeast University-Monash University Joint Research InstituteSuzhou215123China

Serving as nanoelectrodes or frame units,small-volume metals may critically affect the performance and reliability of nanodevices,especially with feature sizes down to the nanometer ***-volume metals usually behave extraordinarily in comparison with their bulk counterparts,but the knowledge of how their sizes and surfaces give rise to their extraordinary properties is currently *** this study,we investigate the influence of surface conditions on mechanical behaviors in nanometer-sized Pb crystals by performing in situ mechanical deformation tests inside an aberration-corrected transmission electron microscope(TEM).Pseudoelastic deformation and plastic deformation processes were observed at atomic precision during deformation of pristine and surface-oxidized Pb particles,*** is found that in most of the pristine Pb particles,surface atom diffusion dominates and leads to a pseudoelastic deformation *** stark contrast,in surface-passivated Pb particles where surface atom diffusion is largely inhibited,deformation proceeds via displacive plasticity including dislocations,stacking faults,and twinning,leading to dominant plastic deformation without any *** research directly reveals the dramatic impact of surface conditions on the deformation mechanisms and mechanical behaviors of metallic nanocrystals,which provides significant implications for property tuning of the critical components in advanced nanodevices.

关键词： deformation sizes diffusion

我国开放型经济发展的空间生产及其新国家空间研究

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经济体制改革 2020年第6期 50-56页

作者：张晖海南大学经济学院海南海口570228

全面对外开放是我国建设现代化经济体系的必要要求。结合马克思主义空间生产理论和新国家空间理论,可以深入解析开放型经济发展的政治经济学机理。从改革开放之初的对外开放,到新时代背景下的构建全面开放新格局,开放型经济的生产方式... 详细信息

全面对外开放是我国建设现代化经济体系的必要要求。结合马克思主义空间生产理论和新国家空间理论,可以深入解析开放型经济发展的政治经济学机理。从改革开放之初的对外开放,到新时代背景下的构建全面开放新格局,开放型经济的生产方式推动了我国空间生产的进行,也推动了国家空间的重构。从尺度维度看,国家空间项目主要表现为去中心化,国家空间战略主要表现为多样性;从领域维度看,国家空间项目主要表现为定制化,国家空间战略主要表现为集中化。全面对外开放的空间生产方式推动了新国家空间的重构,国家空间项目的去中心化程度将进一步增强,且会向统一性转变,国家空间战略则将向均等化转变。

关键词：对外开放空间生产新国家空间国家空间项目国家空间战略

在公共产品与地缘政治之间:西方安全援助的理论反思

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国际政治研究 2024年第3期45卷 9-32,5页

作者：张春杨琦云南大学国际关系研究院 650091

安全援助旨在通过作战支持、能力培养、装备与技术援助及后勤支助等手段提升伙伴国安全治理能力。西方安全援助主要通过两种操作来掩饰其地缘政治关切:一是将新兴的民事支助纳入安全援助,以此稀释地缘政治关切;二是对冲突管理、稳定化... 详细信息

安全援助旨在通过作战支持、能力培养、装备与技术援助及后勤支助等手段提升伙伴国安全治理能力。西方安全援助主要通过两种操作来掩饰其地缘政治关切:一是将新兴的民事支助纳入安全援助,以此稀释地缘政治关切;二是对冲突管理、稳定化与和平时期实现全覆盖,进而放大公共产品属性。但上述举措难以奏效:一方面,传统军事援助在西方安全援助中占据着主导地位;另一方面,西方安全援助往往强调垄断供应、拒绝分工合作。这意味着,西方安全援助的既有实践往往输出自由和平论,诱发供应竞争,并对伙伴国安全治理产生消极影响。中国提出的全球安全倡议坚持发展和平观,促进安全援助分工合作,推动伙伴国的持久和平,有助于安全援助公共产品属性的回归。

关键词：世界政治安全援助地缘政治公共产品全球安全倡议

Al-driven analysis establishes the single base substitution signatures as personalized prognostic predictors for five-year survival of gastric cancer

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Genes & Diseases 2024年第4期11卷 73-76页

作者： Zhenzhang Li Lingqing Xu Wen Luo Shaoan zhangg Chunyu Hou Xiaohong Xu ,Xubei Peng E.Shiju Janak L.Pathak Shizhen Zhang Jiawei Liu Linhai Li Yang Li School of Biomedical Engineering The Sixth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China College of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhouGuangdong 510665China The Second Affiliated Hospital Guangzhou Medical UniversityGuangzhouGuangdong 510260China Center for Learning Sciences and Technologies The Chinese University of Hong KongShatinNew Territories 999077China Affiliated Stomatology Hospital of Guangzhou Medical University Guangzhou Medical UniversityGuangzhouGuangdong 510182China International School of Photonics Cochin University of Science and TechnologyKochiKerala 682022India

Al-driven genetic engineering,as a burgeoning diagnostic tool,can offer predictive information on the five-year survival rate(FYSR)in the setup of a prognostic therapeutic *** approach provides the individuality and accuracy of prognosis for FYSR of gastric cancer(GC).Unlike traditional neoplasm staging criteria,our technique ensures accuracy and individuality without relying on statistical data and empirical study.

关键词： cancer gastric prognosis

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反向住房抵押贷款的可行性分析及对策研究

改革与战略 2011年第11期27卷 74-76页

作者：张鹏王慧丽武汉科技大学管理学院湖北武汉430081

随着社会的发展,我国的养老问题日益凸显,有关以房养老模式的研究,已经引起社会各界的重视。文章通过对我国养老现状及金融环境的系统地分析,论证了以房养老——反向住房抵押贷款在我国实行的可行性,并从加强法制建设、规范资信评级机... 详细信息

随着社会的发展,我国的养老问题日益凸显,有关以房养老模式的研究,已经引起社会各界的重视。文章通过对我国养老现状及金融环境的系统地分析,论证了以房养老——反向住房抵押贷款在我国实行的可行性,并从加强法制建设、规范资信评级机构、加快专业人才培养、强化规范化建设和加大政府扶持力度等方面给出了在我国如何实行以房养老的相关对策、建议及展望,为未来的市场参与者提供一个参考。

关键词：以房养老反向年金抵押贷款金融机构

双唑泰栓联合乳酸杆菌治疗非特异性阴道炎的疗效比较

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中国实用医药 2013年第6期8卷 41-42页

作者：张莉四川省彭州市妇幼保健院妇科病区 611930

目的探讨双唑泰栓结合乳酸杆菌应用于非特异性阴道炎的效果。方法随机我院2010年5月至2012年5月非特异性阴道炎患者75名,分成A、B组,A组43名患者为治疗组,给予双唑泰栓结合乳酸杆菌医治;B组32名患者为对照组,给予单纯乳酸杆菌医治。结... 详细信息

目的探讨双唑泰栓结合乳酸杆菌应用于非特异性阴道炎的效果。方法随机我院2010年5月至2012年5月非特异性阴道炎患者75名,分成A、B组,A组43名患者为治疗组,给予双唑泰栓结合乳酸杆菌医治;B组32名患者为对照组,给予单纯乳酸杆菌医治。结果经医治,A组对象阴道疼痛、瘙痒、排尿痛等病症恢复优于B组,有效率高于B组,不良反应产生比例低于B组对象。结论双唑泰栓结合乳酸杆菌应用于非特异性阴道炎,具有较高的有效率。

关键词：双唑泰栓乳酸杆菌非特异性阴道炎

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关于中职学生良好职业态度的培养

职业教育研究 2011年第5期 72-73页

作者：张明中船澄西技工学校江苏江阴214432

职业教育是将人力资源转化为智力资源,将科学技术转化为现实生产力的重要桥梁。中职教育对于提高劳动者素质,促进经济和社会发展具有不可替代的作用。因此,应从认识职业特点,更新职业观念,激发职业热情;明确职业要求,注重职业训练,增强... 详细信息

职业教育是将人力资源转化为智力资源,将科学技术转化为现实生产力的重要桥梁。中职教育对于提高劳动者素质,促进经济和社会发展具有不可替代的作用。因此,应从认识职业特点,更新职业观念,激发职业热情;明确职业要求,注重职业训练,增强职业意识;进行职业实践,提高职业素质,培育职业精神等方面入手,培养中等职业学校学生良好的职业态度,使之成为企业欢迎的高素质技能人才。

关键词：中职学生职业态度培养

The non-canonical poly(A)polymerase FAM46C promotes erythropoiesis

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Journal of Genetics and Genomics 2024年第6期51卷 594-607页

作者： Ke Yang Tiangi Zhu Jiaying Yin Qiaoli zhangg Jing Li Hong Fan Gajing Han Weiyin Xu Nan Liu Xiang Lv Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Liangzhu Laboratory Zhejang UniversityHangzhouZhejang 311121China Institute of Hematology Zhejiang UniversityHangzhouZhejiang 311121China The State Key Laboratory for Complex Severeand Rare DiseasesHaihe Laboratory of Cell EcosystemDepartment of PathophysiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Medical Epigenetics Research Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

The post-transcriptional regulation of mRNA is a crucial component of gene *** disruption of this process has detrimental effects on the normal development and gives rise to various *** for novel post-transcriptional regulators and exploring their roles are essential for understanding development and *** a multimodal analysis of red blood cell trait genome-wide association studies(GWAS)and transcriptomes of erythropoiesis,we identify FAM46C,a non-canonical RNA poly(A)polymerase,as a necessary factor for proper red blood cell ***46C is highly expressed in the late stages of the erythroid lineage,and its developmental upregulation is controlled by an erythroidspecific *** demonstrate that FAM46C stabilizes mRNA and regulates erythroid differentiation in a polymerase activity-dependent ***,we identify transcripts of lysosome and mitochondria components as highly confident in vivo targets of FAM46C,which aligns with the need of maturing red blood cells for substantial clearance of organelles and maintenance of cellular redox *** conclusion,our study unveils a unique role of FAM46C in positively regulating lysosome and mitochondria components,thereby promoting erythropoiesis.

关键词： FAM46C TENT5C Poly(A)polymerase Erythroblasts Post-transcriptional regulation Erythroid-specific enhancer