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Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

中华医学杂志(英文版) 2024年第10期137卷 2024 Apr 1页

作者： zhang Chunlan Qin Yun Wu Yu Xu heng Shu Yang Department of Hematology West China Hospital Sichuan University Chengdu Sichuan China Department of Radiology West China Hospital Sichuan University Chengdu Sichuan China Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China Department of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan China Institute of General Surgery West China Hospital Sichuan University Chengdu Sichuan China Department of General Surgery Gastric Cancer Center and Laboratory of Gastric Cancer West China Hospital Sichuan University Chengdu Sichuan China

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome in solid cancers. Recently, a series of studies has highlighted its potential role in hematological malignancies in terms of these events. Similar to solid cancers,MALAT1 can regulate various target genes via sponging and epigenetic mechanisms, but the miRNAs sponged byMALAT1 differ from those identified in solid cancers. In this review, we systematically describe the role and underlying mechanisms ofMALAT1 in multiple types of hematological malignancies, including regulation of cell proliferation, metastasis, stress response, and glycolysis. Clinically,MALAT1 expression is related to poor treatment outcome and drug resistance, therefore exhibiting potential prognostic value in multiple myeloma, lymphoma, and leukemia. Finally, we discuss the evaluation ofMALAT1 as a novel therapeutic target against cancer in preclinical studies.

关键词： Long non-coding RNA MALAT1 Hematological malignancies Tumorigenesis Metastasis Drug resistance Prognostic biomarker

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Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

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World Journal of Gastroenterology 2023年第38期29卷 5374-5382页

作者： Dan Xu Song-Lin Ma Man-Lin Huang heng zhang Department of Gastroenterology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Key Laboratory for Molecular Diagnosis of Hubei Province The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina

BACKGROUND Many studies have shown that interstitial Cajal-like cell(ICLC)abnormalities are closely related to a variety of dynamic gastrointestinal disorders.ICLCs are pacemaker cells for gastrointestinal movement and are involved in the transmission of nerve impulses.AIM To elucidate the expression profile and significance of cholecystokinin-A(CCK-A)receptors in ICLCs in the common bile duct(CBD),as well as the role of CCK in regulating CBD motility through CCK-A receptors on CBD ICLCs.METHODS The levels of tyrosine kinase receptor(c-kit)and CCK-A receptors in CBD tissues and isolated CBD cells were quantified using the double immunofluorescence labeling technique.The CCK-mediated enhancement of the movement of CBD muscle strips through CBD ICLCs was observed by a muscle strip contraction test.RESULTS Immunofluorescence showed co-expression of c-kit and CCK-A receptors in the CBD muscularis layer.Observations of isolated CBD cells showed that c-kit was expressed on the surface of ICLCs,the cell body and synapse were colored and polygonal,and some cells presented protrusions and formed networks adjacent to the CBD while others formed filaments at the synaptic terminals of local cells.CCK-A receptors were also expressed on CBD ICLCs.At concentrations ranging from 10^(-6) mol/L to 10^(-10) mol/L,CCK promoted CBD smooth muscle contractility in a dose-dependent manner.In contrast,after ICLC removal,the contractility mediated by CCK in CBD smooth muscle decreased.CONCLUSION CCK-A receptors are highly expressed on CBD ICLCs,and CCK may regulate CBD motility through the CCK-A receptors on ICLCs.

关键词： Interstitial Cajal-like cells Tyrosine kinase receptor Common bile duct Cholecystokinin-A receptors

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Preliminary research and scheme design of deep underground in situ geo-information detection experiment for Geology in Time

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International Journal of Mining Science and Technology 2024年第1期34卷 1-13页

作者： Heping Xie Ru zhang Zetian zhang Yinshuang Ai Jianhui Deng Yun Chen Yong Zhou Mingchuan Li Liqiang Liu Mingzhong Gao Zeqian Yang Weiqiang Ling heng Gao Qijun Hao Kun Xiao Chendi Lou State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Sichuan UniversityChengdu 610065China College of Water Resource&Hydropower Sichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyShenzhen UniversityShenzhen 518060China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Yalong River Hydropower Development Company Limited Chengdu 610051China

The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the Long-Range Objectives Through the Year 2035.It is important to reveal the evolutionary process and mechanism of deep tectonics to understand the earth’s past,present and future.The academic con-notation of Geology in Time has been given for the first time,which refers to the multi-field evolution response process of geological bodies at different time and spatial scales caused by geological processes inside and outside the Earth.Based on the deep in situ detection space and the unique geological envi-ronment of China Jinping Underground Laboratory,the scientific issue of the correlation mechanism and law between deep internal time-varying and shallow geological response is given attention.Innovative research and frontier exploration on deep underground in situ geo-information detection experiments for Geology in Time are designed to be carried out,which will have the potential to explore the driving force of Geology in Time,reveal essential laws of deep earth science,and explore innovative technologies in deep underground engineering.

关键词： Deep underground Geology in Time China Jinping Underground Laboratory In situ detection

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Upper-Mantle Velocity Heterogeneity of Eastern Tibetan Plateau from Teleseismic P-Wave Tomography and Its Tectonic Implications

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Journal of Earth Science 2023年第1期34卷 280-290页

作者： Shahpara Sheikh Dola Junmeng Zhao heng zhang Shunping Pei State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Nuclear Safety Security&Safeguards Division(NSSSD)Bangladesh Atomic Energy Regulatory Authority(BAERA)Dhaka1207Bangladesh

An attempt has been made to reveal the upper mantle velocity structure of the eastern Tibetan Plateau using 628 teleseismic events recorded from 2003 to 2009 at 95 stations.A total of 8 532 Pwave arrival time residuals were inverted by using the FMTOMO(fast marching tomography) software package.Tomographic results show upper mantle velocity heterogeneity in many aspects.In the southern part visible high velocity anomaly is denoted as the Indian lithosphere.This part seems to be affected by slab tearing at 940E longitude as it is located on the eastern Himalayan syntaxis(EHS).The high velocity zone down to 500 km depth in the northern part could be the Asian lithosphere.At the central part some high velocity anomalies can be identified as detached patches of the lithosphere,surrounded by low velocity anomalies.These anomalies are the potential to create thermal convection and trigger plateau uplift or plateau growth.Sudden velocity change occurs on both sides of patches where low velocity anomaly is visible in between patches and Bangong-Nujiang suture even in between Songpan-Ganzi terrain and Asian Plate.In both cases intense low velocity zone spread down to 500 km.The depth range of low velocity anomalies in between two plates observed from 200 to-500 km.Hence the low velocity anomalies detected in our results may reflect either the hot asthenosphere upwelling or the mantle wedge due to the presence of the cold lithosphere.

关键词： upper mantle tomography eastern Tibetan Plateau FMTOMO velocity heterogeneity

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Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min Lai Qing-Hai Tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-heng Tan Jun zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&Research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information transduction.Here,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room temperature.An ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation energies.Using photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock state.We also develop a transition model to gain insight into the physical process behind the single defect state-phonon coupling.Our work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal

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Effect of heat treatment on mechanical properties and microstructure evolution of Mg-9.5Gd-4Y-2.2Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2022年第4期10卷 1124-1132页

作者： Jie Zheng Zhaoming Yan Jinsheng Ji Yusha Shi heng zhang Zhimin zhang Yong Xue School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

Regarding the as-cast Mg-9.5Gd-4Y-2.2Zn-0.5Zr alloy,the effect of heat treatment on its properties at room temperature(RT),as well as the mechanical properties and microstructure evolution of various peak-aging samples at different tensile temperatures were discussed in this article.The results indicated that the optimal heat treatment process of the alloy was:520℃×24 h+200℃×112 h.Under this condition,the yield strength(YS),ultimate tensile strength(UTS)and elongation(EL)at RT were:238 MPa,327 MPa and 2.5%,respectively.As the tensile temperature increases,the strength increases firstly and then decreases,but the ductility increases monotonously.The microstructures evolution of 200℃ peak-aging(200PA)and 250℃ peak-aging(250PA)samples were different with the increasing tensile tenperature.When tensile test processed at 150℃,the denseβ’phase and rod-shaped basalγ’phase will be formed in the 200PA sample.However,at 300℃,theβ’phases disappeared.Theβ’and LPSO phases in the 250PA sample coarsened gradually as the tensile temperature increased,and 14H-LPSO phases were formed during tensile at 300℃.The 200PA sample reached the highest strength when tensile at 150℃,which was attributed to the hindrance of the basal dislocation and non-basal dislocation slip by the prismaticβ’phases and the newly formed basalγ’precipitates.

关键词： Mg-Gd-Y-Zn-Zr alloy Heat treatment Elevated temperature mechanical properties Microstructure evolution

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Trace nitrogen-doped hierarchical porous biochar nanospheres:Waste corn roots derived superior adsorbents for high concentration single and mixed organic dyes removal

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Nano Research 2023年第2期16卷 1846-1858页

作者： Lihua Wang Hongwei Li Mingyue Li Liyun zhang heng zhang Zi-Yu Liu Wancheng Zhu Department of Chemical Engineering Qufu Normal UniversityQufu 273165China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China

Seeking high performance adsorbents for highly efficient treatment of wastewater containing organic dyes has become increasingly imperative worldwide.Herein,with a specific surface area(SSA)of 2,745.4 m^(2)·g^(−1),trace N-doped porous biochar nanospheres(NPBs)are derived for the first time from affluent waste corn roots,via a hydrothermal conversion followed by a mild calcined activation by K2CO3(KC)in the presence of low virulent melamine.Melamine acts as N source and synergistic activator for significant promotion in SSA,pore volume,and surface defects.The obtained NPBs(CHC-0.5N-4KC-900)are confirmed as superior adsorbents for removal of organic dyes rhodamine B(RhB,qm=1,630.7 mg·g^(−1))and Congo red(CR,qm=1,766.2 mg·g^(−1))as well as their mixtures,within not only a low(50,esp.250–1500 mg·L^(−1))concentration range.The values for qm are far beyond commercially activated carbon(AC)as well as most reported biomass derived carbons,undoubtedly revealing the NPBs as great promising candidate adsorbents for disposal of real industrial wastewater.In addition,the adsorption of RhB is fitted by Langmuir,Freundlich,Temkin,and Dubinin–Radushkevich isotherm models.The kinetic analysis indicates that the adsorption before equilibrium conforms to the pseudo-second-order model,and the hydrogen bonding,electrostatic attraction,and esp.π–πinteraction have contributed to the superior adsorption performance of the NPBs.

关键词： biomass corn roots N-doped carbons biochar organic dyes adsorption

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Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie Liu Ming-Le Dou De-Feng Zhao Ao zhang heng-Kuan Li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian reproduction.Ruminant animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal development.The cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)cells.However,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and functionalization.To fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression profiles.Based on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell subpopulations.Cell communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental microenvironment.Differential analysis of cell trajectories identified a set of genes involved in regulation of trophoblast differentiation.Additionally,spatial modules and co-variant genes that help shape specific tissue structures were identified.Together,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

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Amorphous Sb/C composite with isotropic expansion property as an ultra-stable and high-rate anode for lithium-ion batteries

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Rare Metals 2024年第5期43卷 2039-2052页

作者： Ze-Zhou Yang Cheng-Yi zhang Yu-Qing Ou Zhi-Kang Su Yan Zhao heng-Jiang Cong Xin-Ping Ai Jiang-Feng Qian Hubei Key Laboratory of Electrochemical Power Sources College of Chemistry and Molecular Sciences Wuhan University Institute of Technological Sciences Wuhan University

Antimony （Sb） is an intriguing anode material for Li-ion batteries （LIBs） owing to its high theoretical capacity of 660 m Ah·g-1and appropriate working potential of～0.8 V （vs.Li+/Li）.However,just like all alloying materials,the Sb anode suffers from huge volume expansion （230%） during repeated insertion/extraction of Li+ions,resulting in structural deterioration and rapid capacity decay.In this work,a novel amorphous Sb/C composite with atomically dispersed Sb particles in carbon matrix is prepared via a straightforward high-energy ball milling approach.The intimate intermixing of amorphous Sb with C provides homogeneous element distribution and isotropic volume expansion during cycling,resulting in persistent structural stability.Meanwhile,the disordered structure of amorphous material shortens the diffusion distance of lithium ions/electrons,promoting fast reaction kinetics and rate capability.Benefiting from the aforementioned effects,the amorphous Sb/C exhibits a high reversible capacity of537.4 m Ah·g-1at 0.1 A·g-1and retains 201.0 m Ah·g-1at an ultrahigh current rate of 10.0 A·g-1.Even after 1500deep cycles at 2.0 A·g-1,the amorphous Sb/C electrode still maintains 86.3%of its initial capacity,which outperforms all existing Sb-based anodes reported so far.Postmortem analysis further reveals a greatly reduced volume variation of merely 34.6%for the amorphous Sb/C electrode,much lower than that of 223.1%for crystalline Sb materials.This study presents a new approach to stabilizing Sb-based alloy anodes and contributes to the construction of high-performance amorphous anode materials for LIBs,enabling advanced energy storage.

关键词： Amorphous Sb/C anode Homogeneous element distribution Isotropic volume expansion Ultra-long cycle stability High-rate capability Lithium-ion battery

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Novel Au nanoparticles-inlaid titanium paper for PEM water electrolysis with enhanced interfacial electrical conductivity

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International Journal of Minerals,Metallurgy and Materials 2022年第5期29卷 1090-1098页

作者： Yue Liu Shaobo Huang Shanlong Peng heng zhang Lifan Wang Xindong Wang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Energy Storage Science and Engineering School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China School of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023China

Proton-exchange membrane water electrolysis(PEM WE)is a particularly promising technology for renewable hydrogen produc-tion.However,the excessive passivation of the gas diffusion layer(GDL)will seriously affect the high surface-contact resistance and result in energy losses.Thus,a mechanism for improving the conductivity and interface stability of the GDL is an urgent issue.In this work,we have prepared a hydrophilic and corrosion resistant conductive composite protective coating.The polydopamine(PDA)film on the Ti surface,which was obtained via the solution oxidation method,ensured that neither micropores nor pinholes existed in the final hybrid coatings.In-situ reduced gold nanoparticles(AuNPs)improved the conductivity to achieve the desired interfacial contact resistance and further enhanced the corrosion resistance.The surface composition of the treated samples was investigated using scanning electron microscopy(SEM),transmis-sion electron microscopy(TEM),X-ray diffraction(XRD),and Fourier transform infrared spectroscopy(FTIR).The results indicated that the optimized reaction conditions included a pH value of 3 of HAuCl_(4) solution with PDA deposition(48 h)on papers and revealed the lowest con-tact resistance(0.5 mΩ·cm^(2))and corrosion resistance(0.001μA·cm^(−2))in a 0.5 M H_(2)SO_(4)+2 ppm F−solution(1.7 V vs.RHE)among all the modified specimens,where RHE represents reversible hydrogen electrode.These findings indicated that the Au-PDA coating is very appropriate for the modification of Ti GDLs in PEM WE systems.

关键词： water electrolysis proton-exchange membrane hydrogen energy titanium paper diffusion layer Au nanoparticles inlaid titanium gold–polydopamine nanocomposite

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