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Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess:A case report

World Journal of Gastroenterology 2021年第5期27卷 442-448页

作者： heng yeh Chia-Jung Kuo Ren-Chin Wu Chien-Ming Chen Wen-Sy Tsai Ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le School of Medicine Chang Gung UniversityTaoyuan City 333323Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Taiwan Association of the Study of Small Intestine Disease Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Colon and Rectal Surgery Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Gastroenterology and Hepatology New Taipei City Municipal Tucheng HospitalNew Taipei City 236017Taiwan Liver Research Center Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan

BACKGROUND Fistula and intraabdominal abscess are common complications of Crohn’s disease(CD),but complex rectal fistula with abscess formation is *** necrosis factor antagonists combined with percutaneous drainage or surgical intervention is optimal treatment for fistulizing CD with intraabdominal *** is no study showing the efficacy of vedolizumab in such complicated *** SUMMARY A 47-year-old man has decompensated liver cirrhosis,Child *** suffered from abdominal pain,bloody diarrhea,fever,and body weight *** with rectoprostatic fistula,rectopresacral fistula,presacral abscess and cytomegalovirus(CMV)infection were *** received antibiotics,anti-viral therapy,transverse colostomy and vedolizumab *** months later,he had deep remission and complete fistula tracts *** Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.

关键词： Vedolizumab Crohn's disease Rectoprostatic fistula Rectal presacral fistula Presacral abscess Case report

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Relationship between use of selective serotonin reuptake inhibitors and irritable bowel syndrome: A populationbased cohort study

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World Journal of Gastroenterology 2017年第19期23卷 3513-3521页

作者： Wan-Tzu Lin Yi-Jun Liao Yen-Chun Peng Chung-Hsin Chang Ching-heng Lin Hong-Zen yeh Chi-Sen Chang Division of Gastroenterology and Hepatology Department of Internal MedicineTaichung Veterans General Hospital Division of Gastroenterology and Hepatology Department of Internal MedicinePuli Branch of Taichung Veterans General Hospital Faculty of Medicine College of MedicineNational Yang-Ming University Taichung Veteran General Hospital

AIM To investigate the relationship between selective serotonin reuptake inhibitor(SSRI)use and the subsequent development of irritable bowel syndrome(IBS).METHODS This retrospective,observational,population-based cohort study collected data from Taiwan’s National Health Insurance Research Database.A total of 19653patients newly using SSRIs and 78612 patients not using SSRIs,matched by age and sex at a ratio of 1:4, were enrolled in the study from January 1,2000 to December 31,*** patients were followed until IBS diagnosis,withdrawal from the National Health Insurance system,or the end of *** analyzed the effects of SSRIs on the risk of subsequent IBS using Cox proportional hazards regression *** A total of 236 patients in the SSRI cohort(incidence,2.17/1000 person-years)and 478 patients in the comparison cohort(incidence,1.04/1000 person-years)received a new diagnosis of *** mean follow-up period from SSRI exposure to IBS diagnosis was *** incidence of IBS increased with advancing *** with anxiety disorders had a significantly increased adjusted hazard ratio(a HR)of IBS(a HR=1.33,95%CI:1.11-1.59,P=0.002).After adjusting for sex,age,urbanization,family income,area of residence,occupation,the use of anti-psychotics and other comorbidities,the overall a HR in the SSRI cohort compared with that in the comparison cohort was1.74(95%CI:1.44-2.10;P<0.001).The cumulative incidence of IBS was higher in the SSRI cohort than in the non-SSRI cohort(log-rank test,P<0.001).CONCLUSION SSRI users show an increased risk of subsequent diagnosis of IBS in Taiwan.

关键词： Brain-gut axis Irritable bowel syndrome Selective serotonin reuptake inhibitor

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Effects of Gas Nitriding on the Mechanical and Corrosion Properties of SACM 645 Steel

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Engineering（科研） 2011年第9期3卷 942-948页

作者： Shu-Hung yeh Liu-Ho Chiu heng Chang 不详

The effects of the nitrided case produced by gas nitriding processes on the mechanical and corrosion resistance properties of the JIS SACM 645 steel were studied in this paper. JIS SACM 645 steel specimens with different substrate hardness were gas nitrided at 530?C for various nitriding durations. Nitrided specimens were characterized by means of optical and scanning electron microscopy, X-ray diffraction, glow discharge optical spectrometry, microhardness profiling, wear test, torsion mode fatigue test as well as electrochemical corrosion test in an aerated 3.5% NaCl solution. The surface hardness values of the nitrided specimens with Fe3N and Fe4N phases precipitated in the case layer were observed higher than 1000 HV0.1. Mass loss measurement of the wear test showed increases of wear resistance of the nitrided specimens, and the mass losses of the specimens were strongly influenced by nitriding durations. Electrochemical measurements showed that corrosion current density of the specimens was significantly decreased after nitriding and the corrosion potential was shifted to the noble direction as the increase of the nitriding durations. The fatigue limit of the specimen nitrided for 96 h rose 44% to 600 MPa in exceeding the untreated specimen in this study.

关键词： Nitriding Steel Wear Fatigue

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Ultrasonic Spray Coating for Proton Exchange Membrane Fuel Cell

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Open Journal of Acoustics 2013年第3期3卷 33-37页

作者： Ting-Chu Jao Guo-Bin Jung heng-Li Shen Chia-Chen yeh Yi-Ju Su Department of Mechanical Engineering Fuel cell center Yuan Ze University Taoyuan Taiwan

Ultrasound is now a widely used method for catalyst synthesis, catalyst support treatment, catalyst layer fabrication, membrane electrode assembly (MEA) fabrication, and humidifier etc. for fuel cell applications. Among the abovementioned uses, ultrasonic technology has been utilised mainly for MEA fabrication—especially since it has demonstrated the capability to produce ultralow platinum loadings. This paper reports the power density and cathode mass power density at peak power and 500 mA/cm2 conditions for ultrasonically spray coated MEAs. These MEAs were also produced with various Nafion content ratios and platinum loadings. The results indicate varying optimum values for different conditions.

关键词： Fuel Cell Proton Exchange Membrane Fuel Cell (PEMFC) Ultrasonic Spray Coating Ultrasound

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Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2014年第32期20卷 11384-11393页

作者： Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee Hong-Zen yeh Ming-Chih Ho Sheng-Shun Yang Mei-Due Yang Ming-Chin Yu Rey-heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen Graduate Institute of Clinical Medicine Hepatitis Research Center and Department of Internal Medicine National Taiwan University College of Medicine and National Taiwan University Hospital Chang Gung Memorial Hospital-Linkou Medical Center and Chang Gung University Taichung Veterans General Hospital China Medical University Hospital National Cheng Kung University Hospital Kaohsiung Veterans General Hospital Medigen Biotechnology Corporation

AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma (HCC) recurrence for up to 3 year following curative resection.

关键词： Antiangiogenesis Antimetastasis Adjuvant therapy Disease-free survival Heparanase inhibitor Hepatocellular carcinoma PI-88 Tumor recurrence

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2010年台湾心脏病学会高血压管理指南

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中华高血压杂志 2011年第1期19卷 9-23页

作者： Chern-En Chiang Tzung-Dau Wang Yi-heng Li Tsung-Hsien Lin Kuo-Liong Chien Hung-I yeh Kou-Gi Shyu Wei-Chuen Tsai Ting-Hsing Chao Juey-Jen Hwang Fu-Tien Chiang Jyh-Hong Chen Unknown unit

高血压是心血管疾病和心血管死亡的重要危险因素。从2003年美国高血压预防、检测、评价和治疗全国联合委员会第7次报告（the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of hig... 详细信息

关键词：欧洲心脏病学会高血压协会管理指南 prevention 心血管疾病台湾地区联合委员会危险因素

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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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Antineutrino energy spectrum unfolding based on the Daya Bay measurement and its applications

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Chinese Physics C 2021年第7期45卷 1-19页

作者： F.P.An A.B.Balantekin M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal D.Dolzhikov J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong M.Grassi W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans a M.He K.M.Heeger Y.K.heng Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang J.H.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettel S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li H.L.Li J.J.Li Q.J.Li R.H.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link26 L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu J.X.Liu C.Lu H.Q.Lu K.B.Luk B.Z.Ma X.B.Ma X.Y.Ma Y.Q.Ma R.C.Mandujano C.Marshall K.T.McDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova T.M.T.Nguyen J.P.Ochoa-Ricoux A.Olshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej1 K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing H.K.Xu J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue V.Zavadskyi S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang S.Q.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao R.Z.Zhao L.Zhou H.L.Zhuang J.H.Zou Institute of Modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 Brookhaven National Laboratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of Hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague Joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse beta decay reactions observed by the Daya Bay experiment,in combination with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can be used to produce a precise,data-based prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to obtain the antineutrino energy spectra by removing the contribution from detector response with the Wiener-SVD unfolding *** results are obtained with other unfolding methods.A technique to construct a data-based prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison between the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model bias of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya Bay application

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