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Portable multi-amplified temperature sensing for tumor exosomes based on MnO_(2)/IR780 nanozyme with high photothermal effect and oxidase-like activity

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Chinese Chemical Letters 2023年第3期34卷 226-230页

作者： Limin Yang heng guo Ting Hou Bin An Feng Li College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China

Efficient determination of tumor exosomes using portable devices is crucial for the establishment of facile and convenient early cancer diagnostic methods. However, it is still challenging to effectively amplify the detection signal to achieve tumor exosomes detection with high sensitivity by portable devices. To address this issue, we developed a portable multi-amplified temperature sensing strategy for highly sensitive detecting tumor exosomes based on multifunctional manganese dioxide/IR780 nanosheets(MnO_(2)/IR780 NSs) nanozyme with high oxidase-like activity and enhanced photothermal performance.Inspiringly, MnO_(2)/IR780 NSs were synthesized via a facile one-step method with mild experimental conditions, which not only exhibited a stronger photothermal effect than that of MnO_(2) but also showed excellent oxidase-like activity that can catalyze the oxidation of 3',3',5',5'-tetramethylbenzidine(TMB) to generate TMB oxide(oxTMB) with a robust photothermal property, thus conjoining with MnO_(2)/IR780 NSs to further enhance the temperature signal. The present assay enables highly sensitive determination of tumor exosomes with the detection limit down to 5.1×10~3 particles/mL, which was comparable or superior to those of the most previously reported sensors. Furthermore, detection of tumor exosomes spiked in biological samples was successfully realized. More importantly, our method showed the recommendable portability, robust applicability, and easy manipulation. By taking advantages of these features,this high-performance photothermal sensor offered a promising alternative means for nondestructive early cancer diagnosis and treatment efficacy evaluation.

关键词： Synergistic signal amplification MnO_(2)/IR780 nanozyme Tumor exosomes Photothermal effect Oxidase-like activity

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认罪认罚从宽制度下的辩护冲突

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东北大学学报（社会科学版） 2024年第1期26卷 117-125页

作者：郭恒太原理工大学文法学院山西太原030024

认罪认罚从宽制度下“检察主导模式”、“控审合作模式”、辩护律师职业伦理与被追诉人自身利益考量之间的矛盾,以及辩护律师与值班律师差别性法律帮助权是引发辩护冲突的主要原因。认罪认罚案件中辩护律师处理辩护冲突应当以辩护律师... 详细信息

认罪认罚从宽制度下“检察主导模式”、“控审合作模式”、辩护律师职业伦理与被追诉人自身利益考量之间的矛盾,以及辩护律师与值班律师差别性法律帮助权是引发辩护冲突的主要原因。认罪认罚案件中辩护律师处理辩护冲突应当以辩护律师的忠诚义务为出发点,坚持有限的独立辩护原则,强化辩护律师的协商义务,并在特定情形下履行对法庭的真实义务。审查起诉阶段认罪认罚案件的辩护冲突要区分“认罪”协商与“认罚”协商之辩护冲突分别处理,并确立审查起诉阶段控辩争议问题待处理的程序机制。审判阶段认罪认罚案件的辩护冲突要区分“定性”与“定量”存在争议的案件分别处理,并构建审判阶段辩方否定认罪认罚的程序规则。

关键词：认罪认罚控辩合意辩护冲突协商义务

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Scalability and efficiency challenges for the exascale supercomputing system:practice of a parallel supporting environment on the Sunway exascale prototype system

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Frontiers of Information Technology & Electronic Engineering 2023年第1期24卷 41-58页

作者： Xiaobin HE Xin CHEN heng guo Xin LIU Dexun CHEN Yuling YANG Jie GAO Yunlong FENG Longde CHEN Xiaona DIAO Zuoning CHEN National Research Center of Parallel Computer Engineering and Technology Beijing 100190China

With the continuous improvement of supercomputer performance and the integration of artificial intelligence with traditional scientific computing,the scale of applications is gradually increasing,from millions to tens of millions of computing cores,which raises great challenges to achieve high scalability and efficiency of parallel applications on super-large-scale systems.Taking the Sunway exascale prototype system as an example,in this paper we first analyze the challenges of high scalability and high efficiency for parallel applications in the exascale era.To overcome these challenges,the optimization technologies used in the parallel supporting environment software on the Sunway exascale prototype system are highlighted,including the parallel operating system,input/output(I/O)optimization technology,ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method.Parallel operating systems and I/O optimization technology mainly support largescale system scaling,while the ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method mainly enhance the efficiency of large-scale applications.Finally,the contributions to various applications running on the Sunway exascale prototype system are introduced,verifying the effectiveness of the parallel supporting environment design.

关键词： Parallel computing Sunway Ultra-large-scale Supercomputer

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Nanoscale multi-beam lithography of photonic crystals with ultrafast laser

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光:科学与应用(英文版) 2023年第8期12卷 1604-1615页

作者： Jiaqun Li Jianfeng Yan Lan Jiang Jiachen Yu heng guo Liangti Qu State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Chemistry Tsinghua UniversityBeijing 100084China

Photonic crystals are utilized in many noteworthy applications like optical communications,light flow control,and quantum optics.Photonic crystal with nanoscale structure is important for the manipulation of light propagation in visible and near-infrared range.Herein,we propose a novel multi beam lithography method to fabricate photonic crystal with nanoscale structure without cracking.Using multi-beam ultrafast laser processing and etching,parallel channels with subwavelength gap are obtained in yttrium aluminum garnet crystal.Combining optical simulation based on Debye diffraction,we experimentally show the gap width of parallel channels can be controlled at nanoscale by changing phase holograms.With the superimposed phase hologram designing,functional structures of complicated channel arrays distribution can be created in crystal.Optical gratings of different periods are fabricated,which can diffract incident light in particular ways.This approach can efficiently manufacture nanostructures with controllable gap,and offer an alternative to the fabrication of complex photonic crystal for integrated photonics applications.

关键词： lithography beam optics

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High-performance self-powered ultraviolet to near-infrared photodetector based on WS_(2)/InSe van der Waals heterostructure

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Nano Research 2023年第5期16卷 7851-7857页

作者： Jinping Chen Zhen Zhang Yi Ma Jiying Feng Xiaoyu Xie Xiaoxuan Wang Aoqun Jian Yuanzheng Li Zhuxin Li heng guo Yizhi Zhu Qiannan Cui Zengliang Shi Chunxiang Xu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Micro Nano System Research Center Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education&College of Information Engineering and ComputerTaiyuan University of TechnologyTaiyuan 030024China Key Laboratory of UV-Emitting Materials and Technology of Ministry of Education Northeast Normal UniversityChangchun 130024China

van der Waals heterostructures(vdWHs)based on two-dimensional(2D)materials without the crystal lattice matching constraint have great potential for high-performance optoelectronic devices.Herein,a WS_(2)/InSe vdWH photodiode is proposed and fabricated by precisely stacking InSe and WS_(2)flakes through an all-dry transfer method.The WS_(2)/InSe vdWH forms an n–n heterojunction with strong built-in electric field due to their intrinsic n-type semiconductor characteristics and energy-band alignments with a large Fermi level offset between WS_(2)and InSe.As a result,the device displays excellent photovoltaic behavior with a large open voltage of 0.47 V and a short-circuit current of 11.7 nA under 520 nm light illumination.Significantly,a fast rising/decay time of 63/76μs,a large light on/off ratio of 105,a responsivity of 61 mA/W,a high detectivity of 2.5×10^(11) Jones,and a broadband photoresponse ranging from ultraviolet to near-infrared(325–980 nm)are achieved at zero bias.This study provides a strategy for developing high-performance self-powered broadband photodetectors based on 2D materials.

关键词： two-dimensional materials van der Waals heterostructure self-powered photodetector photocurrent

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Factors influencing the continuity of evidence-based practice in perioperative airway management for elderly patients with fractures:A qualitative study

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World Journal of Clinical Cases 2024年第22期12卷 5032-5041页

作者： Jia Zeng Jia Zhang Rui Li Zhi-heng guo Fang Wu Si-Meng Wang Hai-Yue Zhang Fei-Hu Qian Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Nursing Shanghai Tongren HospitalShanghai 200335China Department of Emergency Shanghai Tongren HospitalShanghai 200335China Department of Orthopedics Shanghai Tongren HospitalShanghai 200335China

BACKGROUND More and more evidence-based practices are emerging,but researchers mostly focus on short-term effects,resulting in evidence-based practices not being applied in the clinic in the long term.In this study,we took the evidence-based practice of perioperative airway management in elderly fracture patients as an example and adopted a descriptive phenomenological approach to understand the influencing factors of its sustainability to provide a reference basis for promoting the continuity of evidence-based practice in the clinic.AIM To explore factors influencing the persistence of evidence-based practice in perioperative airway management in elderly patients with fractures.METHODS This study was qualitative research.Nine nurses who implemented evidencebased practice in the orthopedic ward of a tertiary comprehensive hospital in Shanghai from September 2023 to October 2023 were selected using purposive sampling as research subjects.Semi-structured interviews were conducted with them,and the data were analyzed using the Colaizzi phenomenological analysis method based on the three dimensions and ten factors of the NHS sustainability model.RESULTS Three main themes and ten subthemes were identified:Process aspects(benefits to patients,benefits to nurses,lack of follow-up,complex processes);staff aspects(insufficient human resources,inadequate training and education,lack of leadership support);and organizational environment aspects(inadequate infrastructure,poor patient compliance,poor doctor cooperation).CONCLUSION Human resources,training and education,leadership support,infrastructure,and patient-physician collaboration are important factors influencing the sustainability of evidence-based practice for perioperative airway management in older patients with fractures.

关键词： Elderly Fracture Airway management Evidence-based practice Sustainability Sustainability model

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Co-registered photoacoustic and ultrasound imaging for tongue cancer detection

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Journal of Innovative Optical Health Sciences 2018年第3期11卷 20-27页

作者： heng guo Weizhi Qi Ming He Jian Rong Lei Xi School of Physical Electronics University of Electronic Science and Technology of China ChengduSichuanP.R.China Center for Information in Biomedicine University of Electronic Science and Technology of China SichuanP.R.China

Tongue cancer is an increasingly common disease with high morbidity,Besides clinical obser-vation,biomedical imaging techniques have been investigated for early detection of tonguecancer.In this paper,we proposed a co-registered dual-modality photoacoustic(PA)and ul.trasound imaging technique to simultaneously map the functional and structural information ofhuman tongue,which has the potential to detect and diagnose tongue cancer in early stage,Theimaging probe comprises a 20-MHz side-view focused transducer for ultrasound imaging and PAdetection,a light path constructed by a multimode optical fiber,and a prism for PA illumination.Phantom experiments were conducted to evaluate the performance of the system includingpenetration depth,spatial resolution and signal-to-noise ratio.In vivo imaging of animaltumor and human tongue was carried out to show the feasibility of the proposed technique todetect tumor lesions in human tongue.The results of phantom and in vivo experiments suggestthat the proposed technique has the potential to detect the early-stage cancer lesions in humantongue.

关键词： Tongue cancer photoacoustic imaging multimodal imaging.

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Cross and joint ordinal partition transition networks for multivariate time series analysis

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Frontiers of physics 2018年第5期13卷 203-212页

作者： heng guo Jia-Yang Zhang Yong Zou Shu-Guang Guan Department of Physics East China Normal University Shanghai 200062 China

We propose the construction of cross and joint ordinal pattern transition networks from multivariate time series for two coupled systems, where synchronizations are often present. In particular, we focus on phase synchronization, which is a prototypical scenario in dynamical systems. We systematically show that cross and joint ordinal pattern transition networks are sensitive to phase synchronization. Furthermore, we find that some particular missing ordinal patterns play crucial roles in forming the detailed structures in the parameter space, whereas the calculations of permutation entropy measures often do not. We conclude that cross and joint ordinal partition transition network approaches provide complementary insights into the traditional symbolic analysis of synchronization transitions.

关键词： nonlinear time series analysis complex networks ordinal pattern partition transitionnetwork phase synchronization

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Biosynthesis of the Central Piperidine Nitrogen Heterocycle in Series a Thiopeptides

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Chinese Journal of Chemistry 2019年第1期37卷 35-41页

作者： Jingyu Liu Zhi Lin Hua Chen heng guo Jiang Tao Wen Liu State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence on Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of Sciences345 Lingling RoadShanghai 200032China Department of General Dentistry Ninth People s HospitalShanghai Jiao Tong Umversity School of MedicineShanghai Key Laboratory of 5tomatologyShanghai 200011China State Key Laboratory of Microbial Metabolism School of Life Science & BiotechnologyShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Huzhou Center of Bio-Synthetic Innovation 1366 Hongfeng RoadHuzhouZhejiang 313000China

Summary of main observation and conclusion Thiopeptides,arising from complex posttranslational modifications of a genetically encoded precursor peptide,are of great interest due to their structural complexity and important biological activities.All of these antibiotics share a macrocyclic peptidyl core that contains a central,six-membered nitrogen heterocycle and are classified into five series a-e based on the oxidation state of the central nitrogenous ring.Here,we report that the biosynthesis of the central piperidine heterocycle of series a thiopeptides relies on the activity of homologues of an F420H2-dependent reductase TppX4 by exploiting and characterizing the piperidine-containing thiopeptin biosynthetic gene (tpp)cluster in Streptomyces tateyamensis.In vitro reconstruction of TppX4 activity demonstrated that the piperidine heterocycle of thiopeptins was transformed from a dehydropiperidine heterocycle,and TppX4 tolerated the changes in the C-termini and macrocyclic peptidyl core of substrate and also tolerated dehyropiperidine-containing monocyclic or bicyclic thiopeptides.The identification of TppX4 and its substrate tolerance enriches the biosynthetic toolbox for development of additional thiopeptide analogs for clinical drug screening.

关键词： complexity important report

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Spatiotemporal sectioning of two-photon fluorescence ellipsoid with a CsPbBr_(3) nanosheet

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Nano Research 2021年第11期14卷 4288-4293页

作者： Yizhi Zhu Jinping Chen Qiannan Cui heng guo Zhuxin Li Zengliang Shi Chunxiang Xu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

Two-photon fluorescence (TPF) ellipsoid formed by a focused femtosecond laser into luminescent media serves as a fundamental pixel for TPF spatiotemporal imaging. Visualizing spatiotemporal evolution of the TPF ellipsoid itself in a selected luminescent medium is important for correctly reconstructing and interpreting spatiotemporal information of imaged targets. Here, we report a new spatiotemporal sectioning technique with a luminescent CsPbBr_(3) nanosheet and visualize the spatiotemporal evolution of TPF ellipsoid along the axial direction. Time-resolved axial lengths of TPF ellipsoids turn out to broaden nonlinearly with a turning point at about 600 ps. By comparison experiments, observed phenomena are attributed to photocarrier trapping and TPF photon recycling processes within CsPbBr_(3) nanosheets. The spatiotemporal sectioning technique is expected to be widely applicable, which will ignite a plethora of investigations and applications utilizing TPF ellipsoid.

关键词： spatiotemporal sectioning two-photon fluorescence ellipsoid CsPbBr_(3)nanosheet photocarrier trapping photon recycling

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