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Two-plane painting injection scheme for BRing of HIAF

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Nuclear Science and Techniques 2017年第8期28卷 47-53页

作者： Guo-Feng Qu Wei-Ping Chai Jia-Wen Xia Jian-Cheng Yang heng du Zhong-Shan Li Wen-Wen Ge Wen-heng Zheng Peng Shang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China University of Chinese Academy of Sciences Beijing 100046China

The high-intensity heavy-ion accelerator facility(HIAF)is under design at the Institute of Modern Physics(IMP)and will provide an intense ion beam for nuclear physics,atomic mass measurement research,and other *** the main ring of HIAF,the BRing accumulates beams to high intensity and accelerates them to high *** achieve high intensities up to 1×10^(11)(^(238)U^(34+)),the injection gain of the BRing must be as high as ***,multiple multiturn injection supported by the electron cooling system takes a long time,causing substantial beam loss under a strong space charge ***,a two-plane painting injection scheme is proposed for beam accumulation in the *** scheme uses a tilted injection septum and horizontal and vertical bump magnets to paint the beam into horizontal and vertical phase space *** this paper,the two-plane painting injection parameters are optimized,and the resulting injection process is simulated using the Objective Ring Beam Injection and Tracking(ORBIT)*** injection gain of up to 110.3 with a loss rate of 2:3%is achieved,meeting the requirements of BRing.

关键词：绘画平面近代物理研究所注射过程重离子加速器电子冷却系统束流损失纵向相空间

左旋紫草素基于调节NF-κB途径和NLRP3炎性体轴减轻急性胰腺炎动物模型胰腺组织损伤作用

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辽宁中医药大学学报 2024年第9期26卷 22-27页

作者：余洁杜恒秦清吴安定万里鹏黄冈市中心医院湖北黄冈438000

目的探究左旋紫草素对急性胰腺炎动物模型胰腺组织损伤的作用及其作用机制。方法选取SD大鼠48只,随机分为假手术组、模型组、左旋紫草素低剂量组和左旋紫草素高剂量组4组,每组12只。采用胆胰管逆行注射5%牛磺酸钠溶液构建急性胰腺炎模型... 详细信息

目的探究左旋紫草素对急性胰腺炎动物模型胰腺组织损伤的作用及其作用机制。方法选取SD大鼠48只,随机分为假手术组、模型组、左旋紫草素低剂量组和左旋紫草素高剂量组4组,每组12只。采用胆胰管逆行注射5%牛磺酸钠溶液构建急性胰腺炎模型,左旋紫草素低剂量组和高剂量组在造模前1 h及造模后分别腹腔注射左旋紫草素(10、20 mg/kg),模型组及假手术组给予等量0.9%氯化钠溶液。采用HE染色观察胰腺及心肌组织病理变化,免疫组织化学染色和蛋白免疫印迹(Western blot)分析NF-κB信号通路和NLRP3炎性体轴相关蛋白的表达情况,酶联免疫吸附法检测各组大鼠血清中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、肌酸激酶同工酶(CK-MB)水平。结果与假手术组相比,模型组大鼠的胰腺及心肌组织出现明显的病理损伤,NF-κB、NLRP3蛋白阳性率及相关蛋白NF-κB p65、p-p56、NLRP3、半胱氨酸蛋白酶1(Caspase-1)、ASC蛋白的相对表达水平显著升高(P<0.01),而IκBα的相对表达水平显著降低(P<0.01),且血清IL-1β、TNF-α、CK-MB水平显著升高(P<0.01)。与模型组相比,左旋紫草素低剂量组和高剂量组大鼠的胰腺及心肌组织损伤程度减轻,NF-κB、NLRP3蛋白阳性率及相关蛋白NF-κB p65、p-p56、NLRP3、Caspase-1、ASC蛋白的相对表达水平显著降低(P<0.01),IκBα的相对表达水平显著升高(P<0.01),血清IL-1β、TNF-α、CK-MB水平显著降低(P<0.01),且左旋紫草素高剂量组的效果优于低剂量组。结论左旋紫草素能够通过调节NF-κB信号通路和NLRP3炎性体轴减轻急性胰腺炎动物模型胰腺组织损伤,为左旋紫草素在急性胰腺炎的治疗提供重要的参考。

关键词：急性胰腺炎左旋紫草素核因子κB信号通路 NLRP3炎性体轴

基于AutoForm的天地盖成型起皱仿真研究

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机械工程师 2024年第2期 4-7页

作者：王中盟朱仁胜柏强彭桠龙杜恒合肥工业大学机械工程学院合肥230009

为了解天地盖工件的成形起皱机理,以995铝合金为研究对象,通过有限元分析方法,利用Auto Form软件定量模拟坯料在不同形状、压边力、冲压速度、摩擦因数、圆角半径和凸模工艺面宽度下的成形起皱。结果表明:与长方形和圆角形坯料相比,采... 详细信息

为了解天地盖工件的成形起皱机理,以995铝合金为研究对象,通过有限元分析方法,利用Auto Form软件定量模拟坯料在不同形状、压边力、冲压速度、摩擦因数、圆角半径和凸模工艺面宽度下的成形起皱。结果表明:与长方形和圆角形坯料相比,采用切角的八边形坯料可以减轻工件的成形起皱;冲压速度对工件的成形起皱影响较小,几乎可以忽略不计,而压边力、摩擦因数和圆角半径的影响则相对较大,选用较大压边力、摩擦因数和圆角半径可以减轻工件的成形起皱;凸模工艺面宽度越小,工件成形起皱越小。该研究结果为实际生产提供了理论依据。

关键词：工艺参数几何参数数值模拟起皱

In-situ measurement on air-water flux of CH_(4),CO_(2) and their carbon stable isotope in lakes of northeast Tibetan Plateau

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Advances in Climate Change Research 2022年第2期13卷 279-289页

作者： Lei WANG Cun-De XIAO Zhi-heng du Damien T.MAHER Jing-Feng LIU Zhi-Qiang WEI State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Southern Cross Geoscience Southern Cross UniversityLismoreNSW 2480Australia College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Zhuhai Branch of State Key Laboratory of Earth Surface Process and Resource Ecology Beijing Normal UniversityZhuhai 519087China

Inland waters are important sources of greenhouse gases(GHGs)to the atmosphere that may partially offset the terrestrial carbon ***,GHG emissions from high altitude saline lakes on the Tibetan Plateau are currently poorly *** this study,we measured methane(CH_(4))and carbon dioxide(CO_(2))concentrations and their carbon stable isotope(δ13C),and calculated diffusive water-to-air fluxes from two saline high-altitude lakes,Qinghai Lake and Hala Lake,located in northeast Tibetan Plateau in October *** two lakes were mostly supersaturated in CH_(4)(89.8%-4623.9%sat)and acted as sources of CH_(4) to the ***,more than 96%investigated area of Qinghai Lake and all investigated area of Hala Lake was a sink of CO_(2).The average diffusive fluxes of CH_(4) and CO_(2) in the surface waters of Qinghai Lake were 34.51μmol m−2 d−1 and−1.29 mmol m−2 d−1,while diffusive fluxes of CH_(4) and CO_(2) in Hala Lake averaged 5.48μmol m−2 d−1 and−5.24 mmol m−2 d−1,***(Sal),fluorescent dissolved organic matter(fDOM),temperature(Temp)and dissolved oxygen(DO)are key factors for diffusive CH_(4) and CO_(2) flux in Qinghai Lake and Hala ***_(4) diffusive fluxes across water-air interface from Qinghai Lake and Hala Lake were found to be significantly lower than other freshwater lakes,likely due to their saline nature.A simple isotope mixing model(Miller-Tans plots)revealed a distinctly different isotopic source values of CO_(2) and CH_(4) in Qinghai Lake and Hala *** CH_(4) production pathway of Qinghai Lake was mainly by the acetate fermentation,while that of Hala Lake was mainly by the CO_(2) *** results show that the continuous measurement can help capture the spatial variability of GHGs fluxes in saline lakes.

关键词： Greenhouse gas Air-water flux Carbon stable isotope Tibetan Plateau Saline lakes

Effect of VIATORR stent in early ultrasound evaluation after transjugular intrahepatic portosystemic shunt(TIPS): A case report

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Journal of Interventional Medicine 2020年第2期3卷 106-108页

作者： heng du Yong Yao Suyu He Lei Feng Hang Wu Department of Gastroenterology Suining Central HospitalSuining629000China Department of Ultrasonography Suining Central HospitalSuining629000China

Shunt dysfunction is a major complication of transjugular intrahepatic portosystemic shunt(TIPS). Ultrasonography is a preferred method of shunt follow-up after TIPS, but some misjudgments can occur in cases of shunt dysfunction due to peculiarities of the VIATORR stent. Here we report one case and suggest that the first ultrasound evaluation for patients who received TIPS procedure with VIATORR stent should be performed one month after the procedure.

关键词： Ultrasonography Doppler Color Portosystemic shunt Transjugular intrahepatic VIATORR stent Case report

Recent Advances in Fibrous Materials for Interfacial Solar Steam Generation

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Advanced Fiber Materials 2023年第3期5卷 791-818页

作者： Can Ge duo Xu heng du Ze Chen Jingyu Chen Zhuoer Shen Weilin Xu Qian Zhang Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

The scarcity of fresh water resources has become a serious issue hindering the sustainable development of modern *** interfacial solar steam generation(ISSG)system that produces heat on material surface through photothermal conversion for desalination has been demonstrated as a promising candidate for practical *** materials with unique flexibility,durability,processability,practicability,and multifunctionality have attracted considerable attention in the ISSG *** this review,the basics of fibrous materials,such as their classification,manufacturing methods and flexible fibrous structure,are firstly ***,the outstanding properties of fibrous materials on different dimensions are demonstrated,as well as the versatile morphologies and structures that allow fibrous materials to carry out different roles in ***,the practicability and multifunctionality of fibrous materials are illustrated in detail by combining specific cases to show their promising potential in practical ISSG ***,existing challenges and future opportunities of fibrous material-based ISSG systems are discussed.

关键词： Fibrous material Interfacial solar steam generation Desalination Photothermal conversion

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双线圈高速开关阀的水击特性验证

宇航总体技术 2024年第2期8卷 46-52页

作者：李雨铮陈福龙邓少贤杜恒生凯章福州大学机械工程及自动化学院福州350108 流体动力与电液智能控制福建省高校重点实验室福州350108 四川航天神坤科技有限公司成都610100

高速开关阀是航天领域动力系统的关键元件,需要具备高频响和高可靠性。然而,高速开关阀的开关特性会使系统产生水击现象,降低系统的可靠性,尤其是在高速开关阀高频切换过程中会产生更多的水击压力波,致使系统中的水击变得更加复杂。因此... 详细信息

高速开关阀是航天领域动力系统的关键元件,需要具备高频响和高可靠性。然而,高速开关阀的开关特性会使系统产生水击现象,降低系统的可靠性,尤其是在高速开关阀高频切换过程中会产生更多的水击压力波,致使系统中的水击变得更加复杂。因此,采用仿真和实验相结合的方法对不同频率下水击压力脉动的变化进行分析,最终通过对数据时域和频域的分析,发现了高速开关阀的水击压力脉动规律,研究结果可在航天动力系统中应用。

关键词：高速开关阀水击频率压力脉动

A novel triple responsive smart fluid for tight oil fracturing-oil expulsion integration

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Petroleum Science 2023年第2期20卷 982-992页

作者： Ming-Wei Gao Ming-Shan Zhang heng-Yi du Ming-Wei Zhao Cai-Li Dai Qing You Shun Liu Zhe-Hui Jin Shandong Key Laboratory of Oilfield Chemistry(China University of Petroleum(East China)) Qingdao266580ShandongPR China Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongPR China Department of Civil and Environmental Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil&Gas Reservoirs Engineering Research Center of Development and Management for Low to Ultra-low Permeability Oil&Gas Reservoirs in West China(Ministry of Education)Xi'an Shiyou UniversityXi'an710065ShaanxiPR China School of Energy Resources China University of GeosciencesBeijing100083PR China

The traditional multi-process to enhance tight oil recovery based on fracturing and huff-n-puff has obvious deficiencies,such as low recovery efficiency,rapid production decline,high cost,and complexity,***,a new technology,the so-called fracturing-oil expulsion integration,which does not need flowback after fracturing while making full use of the fracturing energy and gel breaking fluids,are needed to enable efficient exploitation of tight oil.A novel triple-responsive smart fluid based on“pseudo-Gemini”zwitterionic viscoelastic surfactant(VES)consisting of N-erucylamidopropyl-N,N-dimethyl-3-ammonio-2-hydroxy-1-propane-sulfonate(EHSB),N,N,N′,N′-tetramethyl-1,3-propanediamine(TMEDA)and sodium p-toluenesulfonate(NaPts),is ***,the rheology of smart fluid is systematically studied at varying conditions(CO_(2),temperature and pressure).Moreover,the mechanism of triple-response is discussed in ***,a series of fracturing and spontaneous imbibition performances are systematically *** smart fluid shows excellent CO_(2)-,thermal-,and pressure-triple responsive *** can meet the technical requirement of tight oil fracturing construction at 140°C in the presence of 3.5 MPa CO_(2).The gel breaking fluid shows excellent spontaneous imbibition oil expulsion(∼40%),salt resistance(1.2×104 mg/L Na+),temperature resistance(140°C)and aging stability(30 days).

关键词： Fracturing-oil expulsion integration Tight oil Triple responsive smart fluid "Pseudo-gemini"zwitterionic surfactant Fracturing fluid Spontaneous imbibition

地榆皂苷Ⅱ抑制结肠癌细胞增殖、迁移、侵袭和诱导凋亡的体外实验研究

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实用临床医药杂志 2024年第1期28卷 7-12页

作者：钟新强陈康杜恒肖海鹏陆艳军吴安定湖北省黄冈市中心医院胃肠外科湖北黄冈438000 湖北省黄冈市中心医院药剂科湖北黄冈438000

目的探讨地榆皂苷Ⅱ对结肠癌细胞HT-29增殖、迁移、侵袭和凋亡的作用并探讨其作用机制。方法采用CCK-8法检测地榆皂苷Ⅱ对细胞增殖的影响,采用划痕试验检测地榆皂苷Ⅱ对细胞迁移能力的影响,采用Transwell小室实验检测地榆皂苷Ⅱ对细胞... 详细信息

目的探讨地榆皂苷Ⅱ对结肠癌细胞HT-29增殖、迁移、侵袭和凋亡的作用并探讨其作用机制。方法采用CCK-8法检测地榆皂苷Ⅱ对细胞增殖的影响,采用划痕试验检测地榆皂苷Ⅱ对细胞迁移能力的影响,采用Transwell小室实验检测地榆皂苷Ⅱ对细胞侵袭能力的影响,采用流式细胞术测定地榆皂苷Ⅱ对细胞凋亡的影响,分别采用实时定量反转录聚合酶链反应(qRT-PCR)和Western blot法测定地榆皂苷Ⅱ对细胞中蛋白激酶B(AKT)/磷脂酰肌醇-3-激酶(PI3K)信号通路mRNA和蛋白表达的影响。结果地榆皂苷Ⅱ(0、1、5、10、20、40、60和80μmol/mL)可剂量依赖性抑制结肠癌细胞HT-29的增殖;地榆皂苷Ⅱ(5、10和20μmol/mL)可剂量依赖性抑制结肠癌细胞HT-29的迁移能力;地榆皂苷Ⅱ(5、10和20μmol/mL)可剂量依赖性抑制结肠癌细胞HT-29的侵袭能力;地榆皂苷Ⅱ(5、10和20μmol/mL)可剂量依赖性促进结肠癌细胞HT-29的凋亡;地榆皂苷Ⅱ(5、10和20μmol/mL)可剂量依赖性降低结肠癌细胞HT-29中AKT和PI3K mRNA的表达,增加Caspase-3和Caspase-9 mRNA的表达;地榆皂苷Ⅱ(5、10和20μmol/mL)可剂量依赖性地降低结肠癌细胞HT-29中磷酸化蛋白激酶B(p-AKT)和磷酸化磷脂酰肌醇-3-激酶(p-PI3K)蛋白的表达,增加Cleaved-Caspase-3和Cleaved-Caspase-9蛋白的表达,差异有统计学意义(P<0.05)。结论地榆皂苷Ⅱ具有抑制结肠癌细胞HT-29的增殖、迁移、侵袭,促进细胞凋亡作用,可能与其促进AKT和PI3K蛋白磷酸化、Caspase-3和Caspase-9蛋白活化而调节AKT/PI3K信号通路有关。

关键词：地榆皂苷Ⅱ 结肠癌细胞增殖细胞迁移细胞侵袭细胞凋亡 AKT/PI3K信号通路