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Advances in Reproductive Sciences 2015年第2期3卷 27-33页

作者： Olfa Kacem henda ben mustapha Amira Sallem Meriem Harzallah Ines Zidi Faten Hachani Salma Chachia Abdeljalil Khélifi Ali Saad Mounir Ajina Unit of Reproductive Medicine University Farhat Hached Hospital Sousse Tunisia Department of Obstetrics and Gynecology University Farhat Hached Hospital Sousse Tunisia Laboratories of Cytogenetic Molecular Biology and Human Biology of Reproduction Farhat Hached Hospital Sousse Tunisia

The role of oxidative stress in female reproduction is becoming increasingly important, as recent evidence suggests that it has been implicated in the pathology of infertility of both known and idiopathic origin. Although its efficacy has yet to be well established, supplementation with antioxidants is a new tool being developed in the therapeutic armamentarium for female-factor infertility. We present a case of a spontaneous viable pregnancy in a 37-year-old patient with a history of two consequent In Vitro Fertilization (IVF) failures, occurring after a 5-month antioxidant treatment. This report suggests that oral antioxidants supplementation in female patients may provide an alternative or adjunct to conventional fertility therapies and improve their chances of becoming pregnant.

关键词： Oxidative Stress Antioxidant Female Infertility Pregnancy IVF

Oxidative stress in male infertility and therapeutic approach: A mini-review

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Asian pacific Journal of Reproduction 2023年第6期12卷 249-255页

作者： Marwa Lahimer henda mustapha Véronique Bach Hafida Khorsi-Cauet Moncef benkhalifa Mounir Ajina Habib ben Ali Service of Reproductive Medicine University Hospital Farhat HachedSousseTunisia Exercise Physiology and Physiopathology:from Integrated to Molecular“Biology Medicine and Health”(Code:LR19ES09)SousseTunisia Péritox(UMR_I 01) UPJV/INERISUPJVCURSChemin de Thil 80025 AmiensFrance ART and Reproductive Biology Laboratory University Hospital and School of MedicinePicardie University Jules VerneCHU Sud80054AmiensFrance Laboratory Histology Embryology Faculty of Medicine SousseUniversity of SousseSousseTunisia

Growing evidence suggests that oxidative stress is a major cause of male *** are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant *** oxygen species(ROS)impact multiple signaling pathways involved in mitochondrial dysfunction,hormonal unbalance and semen quality *** origin of ROS is diverse,including generated normal cellular metabolism,environmental exposure,advanced paternal age and *** has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic ***,it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility *** current study highlights the deleterious effect of ROS and its impact on semen *** addition,it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility.

关键词： Oxidative stress Reactive oxygen species Mitochondria Antioxidant supplementation Spermatozoa

Exogenous approach to improve topic segmentation

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International Journal of Intelligent Computing and Cybernetics 2016年第2期9卷 165-178页

作者： Marwa Naili Anja Habacha Chaibi henda Hajjami ben Ghezala RIADI Laboratory National School of Computer ScienceUniversity of ManoubaTunisia

Purpose-Topic segmentation is one of the active research fields in natural language ***,many topic segmenters have been ***,the current challenge of researchers is the improvement of these segmenters by using external ***,the purpose of this paper is to integrate study and evaluate a new external semantic resource in topic ***/methodology/approach-New topic segmenters(TSS-Onto and TSB-Onto)are proposed based on the two well-known segmenters C99 and *** proposed segmenters integrate semantic knowledge to the segmentation process by using a domain ontology as an external ***,an evaluation is made to study the effect of this resource on the quality of topic segmentation along with a comparative study with related ***-Based on this study,the authors showed that adding semantic knowledge,which is extracted from a domain ontology,improves the quality of topic ***,TSS-Ont outperforms TSB-Ont in terms of quality of topic *** limitations/implications-The main limitation of this study is the used test corpus for the evaluation which is not a ***,we used a collection of scientific papers from well-known digital libraries(ArXiv and ACM).Practical implications-The proposed topic segmenters can be useful in different NLP applications such as information retrieval and text ***/value-The primary original contribution of this paper is the improvement of topic segmentation based on semantic *** knowledge is extracted from an ontological external resource.

关键词： Semantics Domain ontology External resources Topic segmentation

Fragrant Microcapsules Based onβ-Cyclodextrin for Cosmetotextile Application

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Journal of Renewable Materials 2019年第12期7卷 1347-1362页

作者： Maroua ben Abdelkader Nedra Azizi Ayda Baffoun Yves Chevalier mustapha Majdoub Laboratoire des Interfaces et Matériaux Avancés(LIMA) Facultédes SciencesUniversitéde Monastirbd de l’Environnement5019 MonastirTunisia Laboratoire d’Automatique de Génie des Procédés et de Génie Pharmaceutique(LAGEPP)UniversitéClaude Bernard Lyon 1UMR CNRS 500743 bd du 11 Novembre 191869622 Villeurbanne CedexFrance Unitéde Recherche Matériaux et Procédés Textiles Universitéde MonastirÉcole Nationale d’Ingénieurs de Monastirav.Ibn Eljazzar5019 MonastirTunisia

Microencapsulation of neroline inside microcapsules having a polyurethane shell based onβ-cyclodextrin(β-CD)and hexane diisocyanate was performed by interfacial *** polyol nature ofβ-CD caused tight crosslinking of microcapsules *** of neroline were characterized for their chemical composition and structure of the polyurethane shell by FTIR spectroscopy,thermogravimetric analysis,optical and electron microscopy,light scattering and electrophoresis *** content and encapsulation yield were 15%and 60%,*** microcapsules of mean diameter 29μm were slightly cationic with an isoelectric point of ***-loaded microcapsules were fixed on cotton fabric using an impregnation *** functionalized fabric showed improved resistance to washing cycles in comparison with previously reported diol-based *** microcapsules display great potential for the long-lasting release of fragrance in the framework of cosmetotextile.

关键词： Microcapsules interfacial polycondensation β-cyclodextrin neroline cosmetotextile

Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 154-158页

作者： Rim Aouni Mossadok ben Attia Mohamed Habib Jaafoura Amina Bibi-Derbel mustapha Haouari Faculty of Sciences of Bizerte Department of life Sciences7021 JarzounaUniversity of Carthage INNTA SURVEN Research Laboratory(Monitoring and nutritional epidemiology in Tunisia) Laboratoire Biomonitoring of the Environment Faculty of Sciences of Bizerte.7021 JarzounaUniversity of Carthage Orthopedic InstituteMohamed Kassab Laboratory of Cyto-Morphology and Anatomy Pathologic National Institute of Nutrition and Food technology Clinical laboratory of biochemistry Ecole Superior of Science and Technology of Health of Tunis University of Tunis El Manar

Objective:To evaluate the effects of ethanol–water(80:20) extract of Marrubium vulgare(***) on the hematological parameters,macroscopic and histological aspects of the uterus and fetus in non-pregnant and pregnant ***:Female rats were divided into 4 equal groups(n = 9),group N(normal rats) and group G(pregnant rats) considered as control groups,group NE(normal rats treated with the ethanol–water(80:20,v/v) extract of ***) and group GE(pregnant rats treated with the extract).The ethanol–water(80:20) plant extract was administered in a single daily dose 1 g/kg at the morning,during 19 *** the 19 day of the experiment,animals were sacrificed,the uterus and fetuses were removed for the morphological and histological studies and the blood was collected in EDTA tubes for the measurement of hematological parameters with the use of an automate ‘HORIBA ABX Micros 60 Hematology Analyzer'.Results:Our results showed,in group NE and GE,a significant decrease on hematological parameters:red blood cells(NE:18.6%;GE:38.4%),hematocrit(NE:13.8%;GE:20.4%),hemoglobin(NE:12.1%;GE:8.3%) and mean corpuscular volume(NE:6.4%;GE:2%) with P more less a ***,the extract of *** caused a significant decrease on the mean implantations of fetuses(82.5%,P<0.001) and their size(47.2%,P< 0.01).As for the macroscopic and histological appearance of uterus,our data showed no change in normal treated *** contrast,the treated pregnant rats showed a severe histological change characterized by the existence of location of stopped ***,it was also found in the uterus of these rat lyses placental and embryo ***:All these results support the hypothesis of an abortifacient effect of ***.

关键词： Vegetal extract Abortificiant effect Hematological parameters Fetuses Uterus Histology

Free Convection of a Viscous Electrically Conducting Fluid Past a Stretching Surface

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Fluid Dynamics & Materials Processing 2022年第2期18卷 205-222页

作者： Abdulmajeed D.Aldabesh P.K.Pattnaik S.Jena S.R.Mishra Mouna ben henda Iskander Tlili Department of Mechanical Engineering Faculty of EngineeringAlbaha UniversityAl Bahah65527Saudi Arabia Department of Mathematics College of Engineering and TechnologyBhubaneswarOdisha751029India Department of Mathematics Centurion University of Technology and ManagementBhubaneswarOdisha751009India Department of Mathematics Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswarOdisha751030India Physics Department College of ScienceAl-ZulfiMajmaah UniversityAL-Majmaah11952Saudi Arabia

Free convection of a viscous electrically conducting liquid past a vertical stretching surface is investigated in the presence of a transverse magnetic *** convection is driven by both thermal and solutal *** original partial differential equations governing the problem are turned into a set of ordinary differential equations through a similar variables *** alternate set of equations is solved through a Differential Transform Method(DTM)and the Pade *** response of the considered physical system to the non-dimensional parameters accounting for the relative importance of different effects is assessed considering different situations.

关键词： Viscous fluid magnetohydrodynamic(MHD) thermal and mass buoyancy differential transform method and pade approximant

Synergistic Effect of Halloyosite Nanotube and Nanocellulose on Thermal and Mechanical Properties of Poly(Ethylmethacrylate-co-Acrylonitrile)Bionanocomposites

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Journal of Renewable Materials 2020年第3期8卷 301-317页

作者： Karima ben Hamou Amal Kadimi Remo Merijs Meri Sergei Gaidukov Hamid Kaddami mustapha Raihane Mouhamed Lahcini Fouad Erchiqui Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials Faculty of Sciences and Technology of MarrakechCadi Ayyad UniversityGuélizAv.A.El KhattabiMarrakechBP 618Morocco Engineering School University of Québec in Abitibi-Témiscamingue445 Boulevard de l'UniversitéRouyn-NorandaJ9X 5E4QuébecCanada Institute of Polymer Materials Riga Technical UniversityKaļķu iela 1Centra rajonsRīgaLV-1658Latvia

This work reports a comprehensive study on poly(Ethylmethacrylateco-Acrylonitrile)Poly(EMA-AN)nanocomposites reinforced with a hybrid mixture of nanoreiforcements based on nanocrystals of cellulose(NCC)(1 or 5%wt)and halloysite nanotubes(HNTs)(1 or 5%wt).The morphology,thermal and mechanical properties of these nanocomposites were *** dispersion of the nanofillers has been shown by scanning electron microscopy.A significant increase of the rubbery modulus and glass transition temperature were obtained upon filler addition,due to the reduction of mobility of the matrix macromolecular *** the other hand,compared with the neat Poly(EMAAN),the storage modulus of the nanocomposites increased by a factor 38 when adding 5 wt%NCC and by 17 for the same concentration of *** properties of ternary nanocomposites were furthers increased resulting from a synergistic effect of these two nanofillers.

关键词： Poly(Ethylmethacrylate-co-Acrylonitrile) nanocrystals cellulose halloysite nanotubes nanocomposites hybrid mechanical properties

Wind Energy Conversion Systems Adapted to the Tunisian Sites

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Smart Grid and Renewable Energy 2013年第1期4卷 57-68页

作者： Fathi ben Amar mustapha Elamouri Department of Technology Preparatory Institute for Engineering Studies of Sfax (IPEIS) Sfax Tunisia

The choice of a wind turbine for a given site is a very significant operation. It is advised to make an in-depth study on the characteristics of the aerogenerator and the implantation site before any installation of a wind farm for choosing well the system best adapted to the energy needs. The objective of this study is to sensitize the users of the wind energy on the various problems involved in the aerogenerator installation on any site and to provide a decision-making aid to the judicious choice of the wind system best adapted. The idea is to estimate, for a selected implantation site, the energy production and the operating time of several wind systems. We can thus select the aerogenerator best adapted by making a compromise between a maximum recovery of energy and a high time of production. The influence height of the aerogenerator on energy profitability is also studied. We apply this step to the twenty six Tunisian synoptic sites by implantation scenarios of seven wind systems of various nominal speeds in function of the height.

关键词： Tunisia Wind Energy Wind Turbine Meteorological Method

Densification and Microstructure of Fluorapatite Sintered with Alkaline and Alkaline-Earth Additives

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Journal of Materials Science and Chemical Engineering 2018年第1期6卷 52-67页

作者： mustapha Hidouri Faycal ben Tahar Khaled Bouzouita Higher Institute of Applied Sciences Gabes University Gabes Tunisia RU Catalysis and Materials for Environment and Process Engineering School Gabes University Gabes Tunisia

A study was performed to investigate the effect of some selected sintering additives on the densification and microstructure of fluorapatite (FAp, Ca10(PO4)6F2). The sintering aids, used for improving the material densification at lower than 1080℃ temperature, were classified according to their cations as alkaline such as Li2CO3, NaF, Na2CO3, Na3PO4, KCl, K2CO3, and alkaline-earth such as CaF2, CaCl2 and MgCl2. Amounts of 0.1;1 and 3 wt% were vigorously homogenized with FAp powders then the solid mixture was pressurelessly sintered under argon flow with 10℃ .?min-1 heating and cooling speed. The density of each sintered material was determined by calculation of the pellet dimension and weight, the crystalline phases were identified using X-ray diffraction (XRD) and the phase morphology was examined by scanning electron microscopy (SEM). The dependence of densification and microstructure on sintering temperature range 900℃ - 1000℃ and amount of sintering aids was studied. It was found that all sintering additives were able to ameliorate the sintrability of the material at temperatures 900℃ and 1000℃. Maximums of about 96% were reached with adequate amounts and sintering temperatures. An exception was found with KCl which had no effect on the density. The microstructures of sintered specimens strictly follow the densification ratios and the sintering mechanism depended on the melting point of the additive.

关键词： Fluorapatite Sintering Additive Densification Microstructure

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin