检索结果-南通市图书馆

Induction chemotherapy followed by weekly paclitaxel and carboplatin with concurrent radiotherapy in inoperable stage Ⅲ non-small cell lung cancers: results of a phase Ⅱ trial

引用

The Chinese-German Journal of Clinical Oncology 2013年第2期12卷 56-60页

作者： hend ahm.d el-hadaad Hanan ahm.d Wahba Eman Toson Clinical Oncology and Nuclear Medicine department Faculty of MedicineMansoura University

Objective： several trials have suggested the superiority of concurrent chemoradiotherapy. It has been hypothesized that the addition of systemic dose sequential chemotherapy to concurrent chemoradiotherapy, as induction or as consolidation, might further improve survival rates. So we sought to evaluate the safety and efficacy of induction paclitaxel and carboplatin followed by weekly paclitaxel and carboplatin with concurrent radiotherapy in inoperable stage III non-small cell lung cancer （NSCLC）. Methods： Fifty-six patients with stage III inoperable NSCLC received induction chemotherapy with 2 cycles of paclitaxel 200 mg/m2 and carboplatin AUC-6 every 3 weeks then patients were assigned to concurrent chemoradiotherapy with paclitaxel 45 mg/m2 and carboplatin AUC-2 weekly along with concurrent radiotherapy at dose of 60 Gy （1.8 Gy/d x 5 d/week）. Results： Median age of the 56 eligible patients was 61 years, most of them were males （87.5%）. Squamous cell carcinoma was the most common pathological type （55.4%） and 85.7% had a performance status of 1. The majority of patients were presented with stage IIIB （62.5%）. Neutropenia was the most common toxicity during induction therapy （12.5% expressed grade 3） whereas esophagitis was the most common non hematologic adverse reaction during concurrent chemoradiotherapy （14.3% of grade 3）. The overall response rate was 71.6% with complete response in 19.6%. After median follow up of 20 months, the median survival time was 13 months （95% CI： 10.917-15.083） and 1 year overall survival rate was 53.6%. Conclusion： This regimen has demonstrated an acceptable toxicity profile and encouraging response to treatment. Evaluation of this regimen in larger number and a phase III trial are recommended.

关键词： induction chemotherapy non-small cell lung cancer (NSCLC) carboplatin paclitaxel concurrent radiotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis

引用

World Journal of Gastroenterology 2012年第17期18卷 2026-2034页

作者： Sahar K Hegazy Mohamed el-Bedewy Akira Yagi department of Clinical Pharmacy Faculty of PharmacyTanta UniversityTanta 8130Egypt department of Internal Medicine Faculty of MedicineTanta UniversityTanta 8130Egypt Placenta/Aloe Research Institute Japan Bio-Products Co.Ltd.1488-4Aikawa-machiKurume-shiFukuoka Bio Factory 204Fukuoka 839-0861Japan

AIM:To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver ***:Aloe vera high molecular weight fractions(ahm) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray *** healthy volunteers as the control group and 40 patients were *** patients were randomly subdivided into two equal groups:the conventional group was treated with placebo(starch),and ahm group was treated with 0.15 gm/d ahm,both for 12 consecutive *** patients were investigated before and after *** activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),hyaluronic acid(HA),transforming growth factor-β(TGF-β) and matrixmetalloproteinase-2(MMP-2) were *** reduced glutathione(GSH) and malondialdehyde(MdA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin(α-SMA) was identified by ***:At the start of the study,the hematoxylin and eosin staining revealed fibro-proliferated bile ductules,thick fibrous septa and dense inflammatory cellular infiltration in the patients before *** use of ahm for 12 wk significantly ameliorated the fibrosis,inhibited the inflammation,and resulted in minimal infiltration and minimal fibrosis compared to the conventional *** enzyme activities of the liver(ALT,AST and ALP) were attenuated after treatment in both groups,and the decrease in the ahm group was more significant as compared with the conventional *** to the AST,the MdA levels were significantly higher before treatment,and were attenuated after treatment in both *** contrast,the hepatic glutathione content in the patients were decreased significantly in the ahm group compared to the *** serum levels of the fibrosis markers(HA,TGF-β and MMP-2) were also reduced significantly after *** expression of α-SMA was m

关键词： Hepatic fine periportal fibrosis Aloe vera α-smooth muscle actin Transforming growth factor-β Hyaluronic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：