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Design and performance test of a novel UAV air-assisted electrostatic centrifugal spraying system

International Journal of Agricultural and Biological Engineering 2022年第5期15卷 34-40页

作者： heming Hu Yutaka Kaizu Jingjing huang Kenichi Furuhashi Hongduo Zhang Xu Xiao Ming Li Kenji Imou Graduate School of Agricultural and Life Sciences the University of TokyoTokyo 113-0033Japan Hunan Agricultural Equipment Research Institute Changsha 410125China Hunan Advanced Engineering Technology Research Center for Agricultural Aviation Changsha 410125China Hunan Agricultural University Changsha 410128China

In order to improve the deposition and uniformity of the pesticide sprayed by the agricultural spraying drone,this study designed a novel spraying system,combining air-assisted spraying system with electrostatic ***,an air-assisted electrostatic centrifugal spray system was designed for agricultural spraying drones,including a shell,a diversion shell,and an electrostatic ***,experiments were conducted to optimize the setting of the main parameters that affect the charge-to-mass ratio,and outdoor spraying experiments were carried out on the spraying effect of the air-assisted electrostatic centrifugal spray *** results showed the optimum parameters were that the centrifugal rotation speed was 10000 r/min,the spray pressure was 0.3 MPa,the fan rotation speed was 14000 r/min,and the electrostatic generator voltage was 9 kV;The optimum charge-to-mass ratio of the spray system was 2.59 mC/*** average deposition density of droplets on the collecting platform was 366.1 particles/cm^(2) on the upper layer,345.1 particles/cm^(2) on the middle layer,and 322.5 particles/cm^(2) on the lower *** to the results of uncharged droplets on the upper,middle,and lower layers,the average deposition density was increased by 34.9%,30.4%,and 30.2%,respectively,and the uniformity of the distribution of the droplets at different collection points was better.

关键词： UAV spraying droplet drift centrifugal sprayer air-assisted spraying electrostatic spraying

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Research advances in peptide-drug conjugates

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药学学报:英文版 2023年第9期13卷 3659-3677页

作者： Liming Gong heming Zhao Yanhong Liu Hao Wu Chao Liu Shuangyan Chang Liqing Chen Mingji Jin Qiming Wang Zhonggao Gao Wei huang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations Department of PharmaceuticsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Yanbian UniversityYanji 133000China

Peptide-drug conjugates(PDCs)are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable *** an emerging prodrug strategy,PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the *** the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs,PDCs have already been extensively applied in drug ***,we review the types and mechanisms of peptides,linkers and drugs used to construct PDCs,and summarize the clinical applications and challenges of PDC drugs.

关键词： Peptide-drug conjugates Peptides Linkers Drug delivery systems Prodrug strategy

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Recognition and localization of strawberries from 3D binocular cameras for a strawberry picking robot using coupled YOLO/Mask R-CNN

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International Journal of Agricultural and Biological Engineering 2022年第6期15卷 175-179页

作者： heming Hu Yutaka Kaizu Hongduo Zhang Yongwei Xu Kenji Imou Ming Li Jingjing huang Sihui Dai Graduate School of Agricultural and Life Sciences the University of TokyoTokyo 113-0033Japan Hunan Agricultural Equipment Research Institute ChangshaHunan 410125China College of Horticulture Hunan Agricultural UniversityChangshaHunan 410128China

To solve the problem of high labour costs in the strawberry picking process,the approach of a strawberry picking robot to identify and find strawberries is suggested in this ***,1000 images including mature,immature,single,multiple,and occluded strawberries were collected,and a two-stage detection Mask R-CNN instance segmentation network and a one-stage detection YOLOv3 target detection network were used to train a strawberry identification model which classified strawberries into two categories:mature and *** accuracy ratings for YOLOv3 and Mask R-CNN were 93.4%and 94.5%,***,the ZED stereo camera,triangulation,and a neural network were used to locate the strawberry in three ***3 identification accuracy was 3.1 mm,compared to Mask R-CNN of 3.9 *** strawberry detection and positioning method proposed in this study may effectively be used to supply the picking robot with a precise location of the ripe strawberry.

关键词： strawberry detection 3D point cloud mean-shift clustering method

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漫灌条件下增施腐殖酸对烤烟产质量的影响

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农学学报 2023年第5期13卷 28-34页

作者：孙兴权黄鹤鸣刘宏许山河刘羿男卢平袁修堂郑武王柱石云南瑞升烟草技术(集团)有限公司昆明650106 福建中烟工业有限责任公司福建厦门361012 云南省烟草公司楚雄州公司云南楚雄675500

为优化漫灌条件下的烤烟配套施肥措施,提高种烟收益,改善烟叶品质,以基肥的形式增施不同用量的水溶性腐殖酸,研究其对烤烟种植收益、常规化学成分、致香物质和感官质量的影响。与常规施肥相比,增施900 kg/hm^(2)腐殖酸,烤烟产量增加12.3... 详细信息

为优化漫灌条件下的烤烟配套施肥措施,提高种烟收益,改善烟叶品质,以基肥的形式增施不同用量的水溶性腐殖酸,研究其对烤烟种植收益、常规化学成分、致香物质和感官质量的影响。与常规施肥相比,增施900 kg/hm^(2)腐殖酸,烤烟产量增加12.35%,产值提高17.16%,净效益提高9.31%,综合经济性状表现最好。腐殖酸增施量与烤烟产量、产值和增施净效益符合二次相关关系,试验最高产量、产值和增施净效益对应的最优增施量分别为924.56、935.94、706.46 kg/hm^(2)。增施腐殖酸使烤烟烟碱含量显著提高21.53%~43.06%,氯离子含量显著降低24.80%~55.20%,显著改善化学成分的协调性。对酮、醇、酸和酯(内酯)类致香物质含量和致香物质总量有提高作用,使烟叶新植二烯与其他类别致香物质总量的比值不同程度降低。增施腐殖酸有利于提高单料烟香气量,增添焦香或干草香韵,但用量高于900 kg/hm^(2)会降低感官评吸质量。在漫灌栽培条件下,添加706~900 kg/hm^(2)的水溶性腐殖酸可兼顾种植收益和初烤烟叶品质,具有较好的推广应用价值。

关键词：腐殖酸漫灌烤烟经济效益品质

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低深度拷贝数变异测序在孕早中期流产物检测中的临床价值

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中国优生与遗传杂志 2021年第12期29卷 1773-1776页

作者：郭岩芸丛潇怡罗小金黄和明韦升市张豹韦深白江涛深圳市龙岗区人民医院广东深圳518172 深圳市龙岗区妇幼保健院广东深圳518172

目的通过对孕早中期流产物进行低深度全基因组拷贝数变异测序(CNV-seq),探讨该技术检测流产物染色体拷贝数变异的临床应用价值。方法对2018年2月至2021年1月因胚胎停育或自然流产来我院行终止妊娠术取样的828例流产物进行低深度全基因组... 详细信息

目的通过对孕早中期流产物进行低深度全基因组拷贝数变异测序(CNV-seq),探讨该技术检测流产物染色体拷贝数变异的临床应用价值。方法对2018年2月至2021年1月因胚胎停育或自然流产来我院行终止妊娠术取样的828例流产物进行低深度全基因组CNV-seq检测,STR进行母体污染鉴定。结果828例流产物中,CNV-seq共检出CNVs 482例,检出率为58.2%(482/828)。检出数目异常456例(55.1%,456/828),其中非整倍体异常434例。检出18例致病性CNVs,其中7例为>10 Mb的致病性CNVs,5例区域内含微缺失/微重复综合征;11例为<10 Mb的致病性CNVs,均与微缺失/微重复综合征相关。此外,检出8例临床意义不明CNVs(VOUS)。结论低深度CNV-seq除可检出流产物染色体数目异常和大片段CNVs外,还可以准确检出10 Mb以下的致病性CNVs和VOUS,为揭示自然流产的遗传病因提供更丰富的基因组学信息。

关键词：全基因组拷贝数变异测序染色体异常流产物

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蚕豆秸秆添加腐熟剂还田对植烟土壤与烟叶品质的影响

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贵州农业科学 2023年第4期51卷 35-43页

作者：黄鹤鸣刘羿男孙兴权许山河龙伟林先塔卢平丁从凯刘宏陈国辉福建中烟工业有限责任公司福建厦门361012 云南省烟草公司楚雄州公司云南楚雄675500 云南瑞升烟草技术(集团)有限公司云南昆明650106

【目的】探明蚕豆秸秆添加腐熟剂还田对植烟土壤和烟叶品质的影响,为优化闲置生物质资源的循环利用技术、改良植烟土壤和改善烟叶品质提供参考。【方法】采用完全随机区组试验设计,以普通商品有机肥+化肥为对照(CK),研究蚕豆秸秆+化肥... 详细信息

【目的】探明蚕豆秸秆添加腐熟剂还田对植烟土壤和烟叶品质的影响,为优化闲置生物质资源的循环利用技术、改良植烟土壤和改善烟叶品质提供参考。【方法】采用完全随机区组试验设计,以普通商品有机肥+化肥为对照(CK),研究蚕豆秸秆+化肥、蚕豆秸秆+化肥+1号腐熟剂、蚕豆秸秆+化肥+2号腐熟剂、蚕豆秸秆+化肥+3号腐熟剂、蚕豆秸秆+化肥+4号腐熟剂和蚕豆秸秆+化肥+5号腐熟剂对植烟土壤及烟叶品质的影响。【结果】蚕豆秸秆添加不同腐熟剂还田对植烟土壤及烟叶品质的影响存在差异。蚕豆秸秆+化肥处理土壤速效钾含量、综合肥力值和蔗糖酶活性分别为184.10 mg/kg、0.71和14.05 mg/(g·d),显著高于CK;土壤真菌、细菌、放线菌数量和可培养微生物总量与CK差异均不显著,烤后烟叶化学成分协调性综合得分最低,为0.55分,烟叶品质下降。蚕豆秸秆+化肥+3号腐熟剂处理土壤速效氮和速效钾含量分别为138.05 mg/kg和207.13 mg/kg,显著高于CK;综合肥力值最高,达0.72;土壤真菌较CK显著降低31.97%,细菌和放线菌分别显著提高53.85%和35.19%,可培养微生物总量较高,为12.17×10^(6)CFU/g;除过氧化氢酶外,蔗糖酶、脲酶和纤维素酶活性均有所提高,且酶活性指数最大,达1.11;烤后烟叶化学成分协调性综合得分最高,为0.73分,能有效提升烤烟品质。【结论】烤烟生长以施用蚕豆秸秆+化肥+3号腐熟剂效果最佳,可加快秸秆自然腐解进程,有效提升植烟土壤肥力和烤烟品质。

关键词：烤烟蚕豆秸秆腐熟剂土壤微生物酶活性

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Molecular dynamics simulation of mechanical properties of TATB/fluorine-polymer PBXs along different surfaces

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Science China Chemistry 2005年第6期48卷 504-510页

作者： XIAO Jijun1, huang Yucheng1, HU Yingjie1,2 & XIAO heming1 1. Department of Chemistry, Nanjing University of Science and Technology, Nanjing 210094, China 2. Department of Chemistry, Nanjing Xiaozhuang College, Nanjing 210017, China Correspondence should be addressed to Xiao heming (email: xiao@***) Department of Chemistry Nanjing University of Science and Technology Nanjing China Department of Chemistry Nanjing Xiaozhuang College Nanjing China

The mechanical properties of PBXs composed of the well-known insensitive explo-sive TATB (1,3,5-Triamino-2,4,6-trinitrobenzene) crystal and four kinds of typical fluo-rine-polymers, i.e. poly (vinylidene difluoride) (PVDF), polychlorotrifluoroethylene (PCTFE), fluo-rine rubber (F2311) and fluorine resin (F2314) individually, have been simulated by molecular dy-namics (MD) method. The results show that the mechanical properties of TATB can be effectively improved by blending with a small amount of fluorine-polymers. Different mechanical properties of PBXs are obtained by putting fluorine-polymer binders parallel to different crystalline surfaces. The whole effect of improving mechanical properties is found to be (010)?(100)>(001).

关键词： TATB, polymer bonded explosives, mechanical properties, molecular dynamics.

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全基因组拷贝数变异测序检测胎儿生长受限染色体异常的诊断价值

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临床检验杂志 2020年第12期38卷 886-890页

作者：罗小金郭岩芸黄和明韦升市刘金星陈婧曹宪振欧德标白江涛深圳市龙岗区妇幼保健院中心实验室广东深圳518172 深圳市龙岗区人民医院妇产科广东深圳518172

目的探讨低深度全基因组拷贝数变异测序(copy number variation sequencing,CNV-Seq)与核型分析技术在检测产前孕中晚期胎儿生长受限(fetal growth restriction,FGR)染色体异常中的临床诊断价值。方法对2018年4月至2020年10月因FGR行侵... 详细信息

目的探讨低深度全基因组拷贝数变异测序(copy number variation sequencing,CNV-Seq)与核型分析技术在检测产前孕中晚期胎儿生长受限(fetal growth restriction,FGR)染色体异常中的临床诊断价值。方法对2018年4月至2020年10月因FGR行侵入性产前诊断分析的138例胎儿同时进行G显带核型分析和全基因组CNV-Seq检测,结合短串联重复序列(STR)检测鉴别母体污染。结果138例FGR病例中,采用G显带核型分析检出>10 Mb染色体异常12例(8.7%,12/138),采用CNV-Seq检出9例(6.5%,12/138)>10 Mb染色体异常,2例平衡易位和1例低比例嵌合体。G显带核型分析检出10 Mb且涉及CNVs的染色体数目和结构异常外,还可额外检出核型正常FGR中<10 Mb的染色体CNV,可更系统全面地揭示产前FGR的遗传学病因,科学指导FGR胎儿妊娠选择。

关键词：全基因组测序核型分析胎儿生长受限染色体异常

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Integrating Polymorphic PDMs

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Computer Aided Drafting,Design and Manufacturing 1998年第2期8卷 50-56页

作者： Li Yinsheng Tong Bingshu Zhang heming huang Hongxing (Tsinghua University, Beijing, 100084)

Along with the explosive increase of product data management systems (PDMs),integrating polymorphic PDMs is becoming one of the focuses in the field. Aner brief describing several features of PDM, and market requirements and required performance for integrating the polymorphic PDMs, the paper specializes in discussing some key technologies involved in virtual enterprise oriented integrated development. Some implementing strategies and procedures are proposed.

关键词： Product Data Management (PDM) Virtual Enterprise (VE) Product Structure Model,Process Model Web Server

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Speech endpoint detection in low-SNRs environment based on perception spectrogram structure boundary parameter

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Chinese Journal of Acoustics 2014年第4期33卷 428-440页

作者： WU Di ZHAO heming huang Chengwei XIAO Zhongzhe ZHANG Xiaojun XU Yishen TAO Zhi College of Physics Optoelectronics and EnergySoochow University School of Electronic Information Soochow University

The Perception Spectrogram Structure Boundary（PSSB）parameter is proposed for speech endpoint detection as a preprocess of speech or speaker *** first a hearing perception speech enhancement is carried *** the two-dimensional enhancement is performed upon the sound spectrogram according to the difference between the determinacy distribution characteristic of speech and the random distribution characteristic of *** a decision for endpoint was made by the PSSB *** results show that,in a low SNR environment from-10 dB to 10 dB,the algorithm proposed in this paper may achieve higher accuracy than the extant endpoint detection *** detection accuracy of 75.2%can be reached even in the extremely low SNR at-10 *** it is suitable for speech endpoint detection in low-SNRs environment.

关键词： Speech endpoint detection in low-SNRs environment based on perception spectrogram structure boundary parameter

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