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Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain inj.ry and effects of miR-146a nanoparticle delivery

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Neural Regeneration Research 2021年第3期16卷 514-522页

作者： Wang-Xia Wang Paresh Praj.pati hemendra j.vekaria Malinda Spry Amber L.Cloud Patrick G.Sullivan j.e E.Springer Sanders Brown Center on Aging University of KentuckyLexingtonKYUSA Spinal Cord and Brain Inj.ry Research Center University of KentuckyLexingtonKYUSA Department of Pathology&Laboratory Medicine University of KentuckyLexingtonKYUSA Department of Neuroscience University of KentuckyLexingtonKYUSA

MicroRNAs(miRNAs)are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular *** previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation(i.e.,miR-142-3p,miR-142-5p,and miR-146a)are altered in the hippocampus at 3–12 hours following a severe traumatic brain *** the present study,we investigated the temporal expression profile of these inflammatory miRNAs in mitochondria and cytosol fractions at more chronic post-inj.ry times following severe controlled cortical impact inj.ry in *** addition,several inflammatory genes were analyzed in the cytosol *** analysis showed that while elevated levels were observed in cytoplasm,the mitochondria-enriched miRNAs,miR-142-3p and miR-142-5p continued to be significantly reduced in mitochondria from inj.red hippocampi for at least 3 days and returned to near normal levels at 7 days *** not statistically significant,miR-146a also remained at reduced levels for up to 3 days following controlled cortical impact inj.ry,and recovered by 7 *** contrast,miRNAs that are not enriched in mitochondria,including miR-124a,miR-150,miR-19b,miR-155,and miR-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 *** one exception was that miR-223 levels were reduced in mitochondria at 1 day following *** maj.r alterations were observed in sham operated *** temporal pattern was unique to mitochondria-enriched miRNAs and correlated with inj.ry-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory *** observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory miRNAs and may reflect an intracellular mechanism by which specific miRNAs regulate inj.ry-induced inflammatory *** test this,we utilized a novel peptide-based

关键词： cell permeable peptide-delivery controlled cortical impact inflammatory pathway mitochondria-associated microRNA nanoparticle nuclear factor-kappa B traumatic brain inj.ry

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Influence of thiol stress on oxidative phosphorylation and generation of ROS in Streptomyces coelicolor

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j.urnal of Biophysical Chemistry 2010年第3期1卷 172-176页

作者： hemendra j. vekaria Ratna Prabha Chivukula 不详

Thiols play very important role in the intracellular redox homeostasis. Imbalance in the redox status leads to changes in the intracellular metabolism including respiration. Thiol stress, a reductive type of stress can also cause redox imbalance. When Gram-positive bacterium Strep- tomyces coelicolor was exposed to thiol stress, catalaseA was induced. Induction of catalaseA is the consequence of elevation of ROS (reactive oxygen species). The two maj.r sources of reactive oxygen species are Fenton reaction and slippage of electrons from electron transport chain during respiration. Hence, the effect of thiol stress was checked on the rate of oxidative phosphorylation in S. coelicolor. We found correlation in the increase of oxidative phosphorylation rate and the generation of ROS, subsequently leading to induction of catalase. It was observed that thiol stress does not affect the functionality of the individual complexes of the ETC, but still there was an increase in the overall respiration, which may lead to generation of more ROS leading to induction of catalase.

关键词： Streptomyces coelicolor DTT Oxidative Phosphorylation CatalaseA ROS

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Influence of thiol stress on oxidative phosphorylation and generation of ROS in Streptomyces coelicolor

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j.urnal of Biophysical Chemistry（生物物理化学） 2010年第3期

作者： hemendra j. vekaria Ratna Prabha Chivukula

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Ultrathin tunable terahertz absorber based on MEMS-driven metamaterial

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Microsystems & Nanoengineering 2017年第1期3卷 169-174页

作者： Mingkai Liu Mohamad Susli Dilusha Silva Gino Putrino hemendra Kala Shuting Fan Michael Cole Lorenzo Faraone Vincent P.Wallace Willie j.Padilla David A.Powell Ilya V.Shadrivov Mariusz Martyniuk Nonlinear Physics Centre Research School of Physics and EngineeringAustralian National UniversityCanberraACT 2601Australia School of Electrical Electronic and Computer Engineeringthe University of Western AustraliaCrawleyWA 6009Australia School of Physics University of Western AustraliaCrawleyWA 6009Australia Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA

The realization of high-performance tunable absorbers for terahertz frequencies is crucial for advancing applications such as single-pixel imaging and *** on the strong position sensitivity of metamaterials’electromagnetic response,we combine meta-atoms that support strongly localized modes with suspended flat membranes that can be driven *** design maximizes the tunability range for small mechanical displacements of the *** employ a micro-electromechanical system technology and successfully fabricate the *** prototype devices are among the best-performing tunable THz absorbers demonstrated to date,with an ultrathin device thickness(~1/50 of the working wavelength),absorption varying between 60%and 80%in the initial state when the membranes remain suspended,and fast switching speed(~27μs).The absorption is tuned by an applied voltage,with the most marked results achieved when the structure reaches the snap-down *** this case,the resonance shifts by >200% of the linewidth(14% of the initial resonance frequency),and the absolute absorption modulation measured at the initial resonance can reach 65%.The demonstrated approach can be further optimized and extended to benefit numerous applications in THz technology.

关键词： absorber metamaterials micro-electro-mechanical system terahertz tunable device

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CT透视引导下颈段硬膜外类固醇注射液扩散程度的CT横断面评估

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国际医学放射学杂志 2019年第6期 732-732页

作者： T.j.Amrhein E.Bozdogan S.vekaria P.Patel R.Lerebours S.Luo 杨玉婷 Department of Radiology Duke University Medical Center

摘要以往研究使用平面透视法分析了颈椎硬膜外类固醇注射(CILESI)期间对比剂的扩散情况,发现注射液在腹侧硬膜外间隙(VES)的扩散率存在广泛差异。在体层CT上能

关键词：硬膜外神经孔注射液 CT 类固醇

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