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Journal of Advanced Ceramics 2014年第4期3卷 332-338页

作者： Pattem hemanth kumar Abhinav SRIVASTAVA Vijay kumar Nandini JAISWAL Pradeep kumar Vinay kumar SINGH Department of Ceramic Engineering Indian Institute of Technology(BHU)VaranasiIndia Department of Chemical Engineering Indian Institute of Technology(BHU)VaranasiIndia

Porcelain fused to metal(PFM)has received great attention over the last few years due to its importance in the ***(K_(2)O·Al_(2)O_(3)·SiO_(2))is a high thermal expansion porcelain,suitable for bonding to ***,kalsilite is a metastable phase which gets converted into crystalline leucite upon *** the current work feasibility of developing stable kalsilite phase,dispersion of MgF2 in it as an additive and using mechanochemical synthesis are *** fine dental material has been formulated by mixing prepared kalsilite with low temperature frit(LTF)in different *** crystalline phases evolved in fired powders are characterized by powder X-ray diffraction(XRD)*** with different ratio of LTF has been cold pressed and heat treated to examine its coefficient of thermal expansion(CTE),flexural strength,apparent porosity(AP),bulk density(BD)and *** indicate that MgF_(2) addition and high milling duration help in kalsilite *** also plays an important role in this stabilization,and at 1100℃single phase kalsilite formation is *** outcomes demonstrate that it is easily possible to synthesize a stable single phase kalsilite with desirable properties.

关键词： kalsilite porcelain fused to metal(PFM) dental ceramic mechanochemical synthesis thermal expansion X-ray diffraction(XRD)

Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： hemanth P.R.Vikram Tegginamath Pramod kumar Gunjan kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Biochemical and Metabolomics on Rice Cultivars

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Rice science 2019年第3期26卷 189-194,I0013,I0014-I0017页

作者： Hurugalavadi Puttaswamaiah RANJITHA Rame GOWDA Nagarajappa NETHRA Narayanappa AMRUTA hemanth kumar KANDIKATTU Department of Seed Science and Technology University of Agriculture Sciences Gandhi Krishi Vignana Kendra Biochemistry and Nanosciences Discipline Defence Food Research Laboratory

Plant metabolites are important for both plant life and human nutrition. However, the genetic control of plant metabolome remains largely unknown. Here, we performed a genetic analysis of the different rice metabolome and isozymes which are highly versatile and non-destructive as bio-markers. Five isozymes peroxidase, catalase, malate dehydrogenase, alcohol dehydrogenase(ADH), polyphenol oxidase were studied to characterize the thirty rice cultivars and two hybrids KRH-2 and KRH-4 along with their parental lines. Among the zymograms, ADH was found to be useful for the detection of cultivars, like CTH1, IR64, IR30864, with an Rm value of 0.549. The metabolomics of rice cultivars by using gas chromatography coupled with mass spectrometry instrument with selected reaction monitoring mode software identified the 66 metabolites in the rice samples, including amino, organic, fatty acids, alcohols and sugars(mono-/dis-accharides). All metabolites investigated varied significantly among rice samples. Jaya had the higher number of metabolites(15) with a peak for each metabolite, followed by Jyothi(13). This study demonstrated a powerful tool and provided a high-quality data for understanding the plant metabolome and isozymes, which may help bridge the gap between the genome and phenome.

关键词： gas chromatography mass spectrometry isozyme spectroscopy metabolomics rice

Airway management training program for nurses via online course in COVID-19 preparedness

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World Journal of Methodology 2022年第3期12卷 113-121页

作者： Bhavna Gupta Gaurav Jain Sharmishtha Pathak Priyanka Mishra hemanth kumar Shalinee Rao Department of Anesthesia All India Institute of Medical Sciences Rishikesh 249203 Uttarakhand India. Department of Anesthesia All India Institute of Medical Sciences Rishikesh 249203 Uttarakhand India. pmishra15390@***. Department of Advanced Centre of Continuous Professional Development All India Institute of Medical Sciences Rishikesh 249203 Uttarakhand India.

BACKGROUND Nursing officers are an integral component of any medical *** participate in taking care of basic airway management and assist in advanced airway management,specifically amidst the current coronavirus disease 2019(COVID-19)*** To assess the efficacy of a standardized web-based training module for nurses in preparedness to fight against *** The training was held in three sessions of 1 h each,consisting of live audio-visual lectures,case scenarios,and skill *** sequence of airway equipment,drug preparation,airway examination,and plans of airway management was demonstrated through mannequin-based *** Pre-and post-test scores as well as objective structured clinical examination scores were analyzed using Student’s t-test and the Likert scale was used for feedback *** was found that the mean score out of the total score of 20 was 8.47±4.2 in the pre-test,while in the post-test it was 17.4±1.8(P value<0.001).The participants also felt self-reliant in executing the roles of airway assistant(63.3%)and drug assistant(74.3%).Fear of self-infection with COVID-19 was also high,as 66%of participants feared working with the patient’s *** Amidst this COVID-19 emergency,when the health care systems are being persistently challenged,training of nursing staff in the safe conduct of airway management can ensure delivery of life-saving treatment.

关键词： COVID-19 Nursing Airway management Online Training Preparedness

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

A Survey on Effect of Agro Waste Ash as Reinforcement on Aluminium Base Metal Matrix Composites

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Open Journal of Composite Materials 2019年第3期9卷 312-326页

作者： Prasanna P. Kulkarni B. Siddeswarappa Kariyappla Shivashankar hemanth kumar Department of Mechanical Engineering STJ Institute of Technology Ranibennur India Department of Studies in Industrial Production Engineering University BDT College of Engineering Davanagere India

In the present day availability of agricultural waste products is very huge quantity. Most of the industries prefer Metal matrix composite (MMC) due to their density, high strength to weight ratio, hardness, corrosion resistance, fatigue and creep resistance. Hence they are widely used in structural applications along with aerospace and automobile industry, marine, sports, electronic and automation industries. In the present paper a study is focused on the mechanical, tribological and corrosion behavior of the metal matrix composite using different agro waste ash which is easily available. Agro waste ash like Rice Husk, groundnut shell, bamboo leaf, coconut shell can be used as reinforcement and applicable for various applications like automotive, structural components. From this current study, it’s clearly identified that addition of agro waste ash as reinforcement with Aluminium improves the properties of metal matrix composite. Aluminium metal with such reinforcement materials has shown a high specific strength, yield strength and ultimate tensile strength, also it will increase hardness, satisfactory levels of corrosion resistance.

关键词： Metal Matrix Composite Agro Waste Ash Reinforcement Mechanical Behavior Tribological Behavior Corrosion Properties

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肠造口的自行闭合

Gastroenterology Report 2016年第4期4卷 325-327,I0003页

作者： Narendra Pandit Harjeet Singh hemanth kumar Rajesh Gupta G.R.Verma Division of Surgical Gastroenterology Department of General Surgery Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems,but it rarely undergoes spontaneous closure,without surgical *** male patients presented to our emergency surgical department with acute abdominal *** of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the *** other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy;the patient underwent second loop ileostomy,this time for complicated intestinal *** our surprise,both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks,respectively,without any *** stoma closure is a rare and interesting *** exact etiology for spontaneous closure remains unknown,but it may be hypothesized to result from slow retraction of the stoma,added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

关键词： ileostomy colostomy spontaneous closure of stoma

Angiosarcoma of Maxillary Sinus: A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 85-87页

作者： D. S. Deenadayal B. Naveen kumar B. hemanth kumar Department of Otorhinolaryngology Yashoda Hospital Secunderabad India

Purpose: To describe a rare malignancy involving the sinonasal cavities. To discuss the clinical, diagnostic, and treatment modalities. Study Design: A case report including histopathological, radiological analysis and review of literature. Method: A case report is described from a tertiary care centre. Histopathological and radiological details are reviewed. Results: This case report presents a 29 year old male with 3 days history of bleeding from the left nostril, blood stained saliva with post nasal discharge and head ache. Biopsy demonstrated poorly differentiated Angiosarcoma. On immune stains the tumor cells showed diffuse strong cytoplasmic membrane positivity with CD 31 and few cells are positive for CD34. FLI-1 is also positive. Conclusion: Angiosarcoma is a rare malignancy involving the sinonasal cavities. Multidisciplinary approach is essential to obtain clear diagnoses and appropriate treatment plans.

关键词： Angiosarcoma of Maxilla Sarcoma

一处罕见的感染性胰腺坏死的肝外液体积聚区:腹股沟阴囊区

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Gastroenterology Report 2016年第3期4卷 246-250,I0003页

作者： Saurabh Kalia Rahul Gupta Sunil DShenvi hemanth kumar Rajesh Gupta Mandeep Kang Surinder Singh Rana Deepak kumar Bhasin Rajinder Singh Surgical Gastroenterology Division Department of General SurgeryPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Radiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Severe acute pancreatitis often leads to pancreatic and peripancreatic collections but,rarely,it can lead to collections at sites remote from the *** male patients presented with abdominal pain and inguinoscrotal *** were initially misdiagnosed with obstructed inguinal hernia,epididymo-orchitis and hydrocele,***,their diagnosis of acute pancreatitis was revealed on laparotomy in one patient and on computed tomography(CT)in the remaining two *** these cases had extensive peripancreatic necrosis and paracolic collections tracking along the psoas muscle,downwards towards the *** collections were initially managed by percutaneous drainage and saline irrigation as a part of the‘step-up’*** of these patients required open necrosectomy,while all required incision and drainage of inguinoscrotal *** the patients were discharged in satisfactory *** swelling is unusual as a first presentation of acute pancreatitis.A high index of suspicion,with careful study of patient’s history and examination along with CT,may provide an accurate *** drainage may be required to control sepsis and also provide an egress route for intra-abdominal collections.

关键词： acute pancreatitis inguinoscrotal collections step-up approach necrosectomy

Five “Ds” of plastic surgery

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Plastic and Aesthetic Research 2017年第1期4卷 13-14页

作者： Preethitha Babu Ravi kumar Chittoria Sudhanva hemanth kumar Senthil kumaran Marimuthu Elan kumar Subbarayan Konda Sireesha Reddy Vinayak Chavan Devi Prasad Mohapatra Meethale Thiruvoth Friji Dinesh kumar Sivakumar Department of Plastic Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

Although there are a variety of definitions that describe plastic surgery,confusion persists in the minds of both the lay public and doctors.A common lay misconception is that actual pieces of plastic are used to repair injured tissues or placed over defects to make them appear *** the other hand,resident doctors from specialities such as ear-nose-throat and general surgery fail to appreciate the vast scope that plastic surgery specialty *** recognition of this,trainee plastic surgeons are often asked to briefly define our specialty in their final exams,so that subsequent misconceptions are minimized.

关键词： Definitions Plastic surgery Confusion persists