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Induction of apoptosis in leukemic cells by the alkaloid extract of garden cress(Lepidium sativum L.)

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Journal of Integrative Medicine 2019年第3期17卷 221-228页

作者： shriniwas s.Basaiyye sanjay kashyap Kannan Krishnamurthi saravanadevi sivanesan Environmental Health Division CSIR-National Environmental Engineering Research Institute Analytical Instrument Division CSIR-National Environmental Engineering Research Institute

Objective: Garden cress(Lepidium sativum L.) is an important herb in traditional medicine used to improve production of breast milk in women and semen in men. In the present research the authors evaluated its ability to destroy leukemic cancer(Jurkat E6-1) cells, using the alkaloid extract of this ***: Constituents of the alkaloid extract were analyzed by gas chromatography–mass spectrometry(GC–Ms) and their cytotoxicity in leukemic cancer cells and healthy peripheral blood mononuclear cells(PBMCs) was assessed. Cell death via apoptosis was confirmed by DNA laddering, caspase-3 activity,annexin V-fluorescein isothiocyanate and mitochondrial toxicity assays. The specific course of gene activation in treated cells was determined through quantitative polymerase chain reaction(qPCR).Results: GC–Ms analysis identified six alkaloids and proto-alkaloids, namely, benzyl isothiocyanate(1),2-ethoxy-4 H-3,1-benzoxazin-4-one(2),(4 R)-2-(2-aminophenyl)-4-phenyloxazoline(3), 5-acetyl-1,2-di hydro-6-methyl-2-oxo-4-phenyl-3-pyridinecarbonitrile(4), benzo[b][1,8]-naphthyridin-5(10 H)-on e,2,4,7-trimethyl(5) and 1,4-diaminoanthraquinone(6), in the alkaloid extract of L. sativum. Of these,compound 1 was previously identified in the seeds of L. sativum. Exposure to the alkaloid extract caused death of Jurkat E6-1 cells, with median lethal concentration(LC50) of 75.25 mg/mL. However, the alkaloid extract also showed a nontoxic and proliferative(1.6-fold) effect in healthy PBMCs. Further experiments performed with Jurkat cells at LC50 and sub-LC50 doses demonstrated DNA fragmentation, activation of caspase-3 and time-dependant phosphatidylserine translocation(apoptosis) from inner to outer cell membranes. Cell toxicity and assessment of adenosine triphosphate level, together with using qPCR to evaluate expression profile of major apoptosis genes, revealed that apoptosis may be induced by disruption in the mitochondrial outer membrane potential, through activation of extrinsic a

关键词： Lepidium sativum Benzyl isothiocyanate Apoptosis Peripheral blood mononuclear cell Mitochondrial toxicity

Microbial Biomass C,N and P in Disturbed Dry Tropical Forest soils,India

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Pedosphere 2010年第6期20卷 780-788页

作者： J.s.sINGH D.P.sINGH A.K.kashyap Department of Environmental science Babasaheb Bhimrao Ambedkar University Department of Botany Banaras Hindu University

Variations in microbial biomass C (MB-C),N (MB-N) and P (MB-P) along a gradient of different dominant vegeta- tion covers (natural forest,mixed deciduous forest,disturbed savanna and grassland ecosystems) in dry tropical soils of Vindhyan Plateau,India were studied from January 2005 to December *** water holding capacity,organic C,total N,total P and soil moisture content were comparatively higher in forest soils than in the savanna and grassland *** different study sites the mean annual MB-C,MB-N and MB-P at 0-15 cm soil depth varied from 312.05 ± 4.22 to 653.40 ± 3.17,32.16 ± 6.25 to 75.66 ± 7.21 and 18.94 ± 2.94 to 30.83 ± 23.08 μg g ?1 dry soil,*** all the investigated sites,the maximum MB-C,MB-N and MB-P occurred during the dry period (summer season) and the minimum in wet period (rainy season).In the present study,soil MB-C,MB-N and MB-P were higher at the forest sites compared to savanna and grassland *** differences in MB-C,MB-N and MB-P were significant (P sites and *** MB-C (P sitively correlated with organic C,while the relationship between soil moisture and MB-C,MB-N and MB-P (P spectively) was *** decreasing order of MB-C,MB-N and MB-P along study ecosystems was natural forest > mixed deciduous forest > savanna > *** results suggested that deforestation and land use practices (conversion of forest into savanna and grassland) caused the alterations in soil properties,which as a consequence,led to reduction in soil nutrients and MB-C,MB-N and MB-P in the soil of disturbed sites (grassland and savanna) compared to undisturbed forest ecosystems.

关键词： deciduous forest grassland savanna soil moisture vegetation

Review of Computational Techniques for the Analysis of Abnormal Patterns of ECG signal Provoked by Cardiac Disease

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Computer Modeling in Engineering & sciences 2021年第9期128卷 875-906页

作者： Revathi Jothiramalingam Anitha Jude Duraisamy Jude hemanth Kalaignarkarunanidhi Institute of Technology Coimbatore641402India Department of ECE Karunya Institute of Technology and SciencesCoimbatore641114India

The 12-lead ECG aids in the diagnosis of myocardial infarction and is helpful in the prediction of cardiovascular disease *** does,though,have certain *** other electrocardiographic anomalies such as Left Bundle Branch Block and Left Ventricular Hypertrophy syndrome,the ECG signal withMyocardial Infarction is difficult to *** diseases cause variations in the sT portion of the ECG *** reduces the clarity of ECG signals,making itmore difficult to diagnose these *** a result,the specialist is misled into making an erroneous diagnosis by using the incorrect therapeutic *** on these concepts,this article reviews the different procedures involved in ECG signal pre-processing,feature extraction,feature selection,and classification techniques to diagnose heart disorders such as LeftVentricularHypertrophy,Bundle Branch Block,andMyocardial *** reveals the flaws and benefits in each segment,as well as recommendations for developing more advanced and robustmethods for diagnosing these diseases,which will increase the system’s *** current issues and prospective research directions are also addressed.

关键词： Bundle branch block myocardial infarction left ventricular hypertrophy feature selection feature extraction classification

Measuring turbulence in a circulating fluidized bed using PIV techniques

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Particuology 2011年第6期9卷 572-588页

作者： Mayank kashyap Benjapon Chalermsinsuwan Dimitri Gidaspow Department of Chemical and Biological Engineering Illinois Institute of Technology Fuel Research Center Department of Chemical Technology Faculty of Science Chulalongkorn University Center of Excellence for Petroleum Petrochemicals and Advanced Materials Chulalongkorn University

This study utilized the particle image velocimetry （P1V） technique, non-invasively near the wall, in the developing region, for the measurements of laminar and turbulent properties during circulation of Geldart B type particles in the U.s. Department of Energy （DOE） National Energy Technology Laboratory （NETL） riser. A novel method was used to measure axial and radial laminar and turbulent solids dispersion coefficients using autocorrelation technique. The instantaneous and hydrodynamic velocities for the solid phase were measured simultaneously in the axial and radial directions using a CCD camera, with the help of a colored rotating transparency. The measured properties, such as laminar and Reynolds stresses, laminar and turbulent granular tempera- tures, laminar and turbulent dispersion coefficients and energy spectra exhibited anisotropy. The mixing in the riser was on the level of clusters. The total granular temperatures were in reasonable agreement with the literature values. However, the axial and radial solids dispersion coefficients measured near the wall were slightly lower than the radially averaged values in the literature.

关键词： Particle image velocimetry (PIV) Dispersion coefficient Autocorrelation Turbulence Anisotrnpy

Violence study of healthcare workers and systems in the Caribbean:VisHWas-Caribbean study

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World Journal of Methodology 2024年第3期14卷 106-118页

作者： Reshon Hadmon Daniella Myriam Pierre Akshat Banga Jacques W Clerville Hans Mautong Precious Akinsanya Rajat Das Gupta sama soliman Tolupe M Hunjah Bamidele A Hunjah Hafeez Hamza Ruman Khurshid Qasba Faisal A Nawaz salim surani Rahul kashyap Department of Medicine St.George University School of MedicineGrenada FZ818West Indies Department of Research Global Remote Research Scholar ProgramSt PaulMN 55101United States Department of Public Health Cuny Graduate School of Public Health and Health PolicyNew YorkNY 10027United States Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India school of Public Health Georgia State UniversityAtlantaGA 30302United States Department of sociology and Demography School of HealthUniversidad de Especialidades Espiritu SantoSamborondon 092301Ecuador Department of Medicine Holy Name Medical CenterTeaneckNJ 07666United States Department of Epidemiology and Biostatistics University of South CarolinaColumbiaSC 29208United States Department of Medicine Pavlov First State Medical University of St PetersburgSankt-Peterburg 197022Russia Department of Medicine University of SuffolkIpswich IP41QJUnited Kingdom Department of Medicine Unicaf University of ZambiaLusaka 20842Zambia Department of Pharmacy School of PharmacyGirne 99428Cyprus Department of Medicine Sher-i-KashmirInstitute of Medical ScienceSrinagar 190011India Department of Psychiatry Al Amal Psychiatric HospitalEmirates Health ServicesDubaiUnited Arab Emirates Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States Anesthesiology and Critical Care Mayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Violence against healthcare workers(HCWs)in the Caribbean continues to prevail yet remains *** aim is to determine the cause,traits,and consequences of violence on HCWs in the *** To determine the cause,traits,and consequences of violence on HCWs in the *** This research adopted an online cross-sectional survey approach,spanning over eight weeks(between June 6th and August 9th,2022).The survey was generated using Research Electronic Data Capture forms and followed a snowballing strategy to contact individuals using emails,social media,text messages,*** regression analysis was performed to evaluate the variables that influence violence,including gender,age,years of experience,institution type,and night shift *** The survey was completed by 225 *** comprised 61%.Over 51%of respondents belonged to the 21 to 35 age ***(n=61),Haiti(n=50),and Grenada(n=31)had the most *** HCWs(49%)worked for government academic institutions,followed by community hospitals(23%).Medical students(32%),followed by attending physicians(22%),and others(16%)comprised the most common cadre of *** 39%of the participants reported experiencing violence themselves,and 18%reported violence against colleague(s).Verbal violence(48%),emotional abuse(24%),and physical misconduct(14%)were the most common types of *** 63%of respondents identified patients or their relatives as the most frequent *** logistic regression analyses demonstrated that female gender(OR=2.08;95%CI:1.16-3.76,P=0.014)and higher frequency of night shifts(OR=2.22;95%CI:1.08-4.58,P=0.030)were associated with significantly higher odds of experiencing *** than 50%of HCWs felt less motivated and had decreased job satisfaction post-violent *** A large proportion of HCWs in the Caribbean are exposed to violence,yet the phenomenon remains *** a result,HCWs’job s

关键词： VisHWas Healthcare workers Violence survey Workplace violence Caribbean Cross-sectional study

Role of particle stimulated nucleation in recrystallization of hot extruded Al 6061/siC_p composites

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Transactions of Nonferrous Metals society of China 2013年第1期23卷 53-58页

作者： C.s.RAMEsH R.KEsHAVAMURTHY Praveennath G.KOPPAD K.T.kashyap Department of Mechanical Engineering PES Institute of TechnologyBangalore 560085India Visiting Professor School of DesignEngineering and ComputingBournemouth UniversityUnited Kingdom Central Manufacturing Technology Institute Tumkur RoadBangalore 560022India

studies on texture and microstructure evolution in hot extruded Al 6061 aluminium alloy reinforced with uncoated and nickel coated siC p were carried out by electron backscattered diffraction *** of both the alloy and its composite with nickel coated siC p do exhibit strong β fiber with its axis parallel to the direction of *** addition to the dominant cube texture（001） 100,fully recrystallized grains with partially equiaxed structure have been observed in the alloy reinforced with uncoated siC *** recrystallization texture of this composite can be attributed to the particle stimulated nucleation（PsN） due to the presence of siC p with size less than 5 μ*** these conditions,the low value of Zener-Hollomon,Z（～1012s-1） confirms that PsN is one of the dominant mechanisms for recrystallization and is governed by formation of deformation zone rather than stored energy.

关键词： metal matrix composites 6061/siC p composite extrusion particle stimulated nucleation recrystallization stored energy

Microstructure and dry sliding wear behavior of Cu-sn alloy reinforced with multiwalled carbon nanotubes

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Transactions of Nonferrous Metals society of China 2016年第7期26卷 1755-1764页

作者： H.M.MALLIKARJUNA K.T.kashyap P.G.KOPPAD C.s.RAMEsH R.KEsHAVAMURTHY Advanced Composites Research Centre (ACRC) P E S Institute of Technology Department of Mechanical Engineering GEC Department of Mechanical Engineering Atria Institute of Technology Research and Development Rapsri Engineering Products Company Ltd. Department of Mechanical Engineering Alliance College of Engineering and Design Alliance University Department of Mechanical Engineering Dayananda Sagar College of Engineering

Multiwalled carbon nanotubes （MWCNTs） reinforced Cu-sn alloy based nanocomposite was developed by powder metallurgy route. The mass fraction of CNTs was varied from 0 to 2% in a step of 0.5%. The developed nanocomposites were subjected to density, hardness, electrical conductivity, and friction and wear tests. The results reveal that the density of nanocomposite decreases with the increase of the mass fraction of CNTs. A significant improvement in the hardness is noticed in the nanocomposite with the addition of CNTs. The developed nanocomposites show low coefficient of friction and improved wear resistance when compared with unreinforced alloy. At an applied load of 5 N, the coefficient of friction and wear loss of 2%CNTs reinforced Cu-sn alloy nanocomposite decrease by 72% and 68%, respectively, compared with those of Cu-sn alloy. The wear mechanisms of worn surfaces of the composites are reported. In addition, the electrical conductivity reduces with the increase of the content of CNTs.

关键词： Cu-sn alloy carbon nanotube nanocomposites powder metallurgy microstructure sliding wear

Effect of carbon nanotube and silicon carbide on microstructure and dry sliding wear behavior of copper hybrid nanocomposites

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Transactions of Nonferrous Metals society of China 2016年第12期26卷 3170-3182页

作者： H.M.MALLIKARJUNA C.s.RAMEsH P.G.KOPPAD R.KEsHAVAMURTHY K.T.kashyap Advanced Composites Research Centre P E S Institute of Technology Department of Mechanical Engineering Government Engineering College Department of Mechanical Engineering Alliance College of Engineering & DesignAlliance University Department of Mechanical Engineering CMR Institute of Technology Department of Mechanical Engineering Dayananda Sagar College of Engineering Department of Mechanical Engineering School of Engineering and TechnologyJain University

Microstructure and tribological properties of copper-based hybrid nanocomposites reinforced with copper coatedmultiwalled carbon nanotubes (MWCNTs) and silicon carbide (siC) were studied. Carbon nanotube was varied from 1% to 4% withsilicon carbide content being fixed at 4%. The synthesis of copper hybrid nanocomposites involves ball milling, cold pressing andsintering followed by hot pressing. The developed hybrid nanocomposites were subjected to density, grain size, and hardness *** tribological performances of the nanocomposites were assessed by carrying out dry sliding wear tests using pin-on-steel disctribometer at different loads. A significant decrease in grain size was observed for the developed hybrid composites when comparedwith pure copper. An improvement of 80% in the micro-hardness of the hybrid nanocomposite has been recorded for 4% carbonnanotubes reinforced hybrid composites when compared with pure copper. An increase in content of CNTs in the hybridnanocomposites results in lowering of the friction coefficient and wear rates of hybrid nanocomposites.

关键词： copper carbon nanotubes (CNTs) siC microhardness wear mechanisms nanocomposite

Intraocular fine needle aspiration cytology as a diagnostic modality for retinoblastoma

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1233-1235页

作者： Bhavna Chawla Anand Tomar seema sen Mandeep s.Bajaj seema kashyap Ocular Oncology & Paediatric Ophthalmology service Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences Ocular Pathology service Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences

INTRODUCTION The diagnosis of retinoblastoma(RB)is usually made by clinical examination and imaging modalities such as B-scan ultrasonography of the eye,CT scan and MRI of the *** role of fine needle aspiration cytology(FNAC)as a diagnostic modality for RB has been controversial,mainly due to concerns of tumor dissemination and extra-ocular spread[1-2].Although the majority of RB cases can be diagnosed without the need for any invasive procedure,in

关键词： FNAC RB