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Fatal graft versus host hemolytic reaction from Rhesus compatible mismatched liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 186-188页

作者： hemant sharma Vivian McAlister Department of Multiorgan Transplant Surgery Ochsner Medical CenterNew OrleansLAUSA Department of Surgery University of Western OntarioLondonONCanada

Matching for Rhesus(Rh)blood group is not part of organ allocation *** principle concern expressed in the literature is that Rh-negative recipients might become sensitized and produce anti-D antibody which would have consequences for them if transfusion with Rh-positive blood or a pregnancy were to occur *** Rh allosensitization is thought to occur in over 80%of Rh-negative recipients of Rh-positive blood,Starzl reported that it is less much less common in organ(liver,heart,lung)recipients even if they received Rh-positive blood during the operation(1).A more recent review of pediatric liver transplantation confirms the very low rate of allosensitization of Rh recipients of grafts from Rh-positive donors(2).In theory,there should be no risk of rejection if the combination is reversed—Rh-negative donor to a Rh-positive ***,it does not appear to be necessary to consider Rh status when allocating organs for transplantation.

关键词： organs transfusion liver

MOE-Analysis for Oversaturated Flow with Interrupted Facility and Heterogeneous Traffic for Urban Roads

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International Journal of Transportation Science and Technology 2012年第3期1卷 287-296页

作者： hemant Kumar sharma B.L.Swami Malviya National Institute of Technology Jaipur-302017India Rajasthan Urban Infrastructure Development Project(A.D.B.assisted Project) Jaipur-302017India

Speed–flow functions have been developed by several transportation experts to predict accurately the speed of urban road *** Speed-Flow Curve,BPR Curve,MTC Speed-Flow Curve,Akçelik Speed-Flow Curve are some extraordinary efforts to define the shape of speedflow ***,the complexity of driver’s behaviour,interactions among different type of vehicles,lateral clearance,co-relation of driver’s psychology with vehicular characteristics and interdependence of various variables of traffic has led to continuous development and refinement of speed-flow *** problem gets more difficult in the case of urban roads with heterogeneous traffic,oversaturated flow and signalized network(which includes some unsignalized intersections as well).This paper presents analysis for various measures of effectiveness(MOE)for urban roads with interrupted flow comprising heterogeneous *** has been developed for heterogeneous traffic under constraints of roadway geometry,vehicle characteristics,driving behaviour and traffic *** model developed in this paper predicts speed,delay,average queue and maximum queue estimates for urban roads and quantifies congestion for oversaturated *** investigation details the oversaturated portion of flow in particular.

关键词： saturated Flow behaviour

Bidirectional graft-host hematological traffic in liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 253-257页

作者： hemant sharma Mauro E.Tun-Abraham Vivian McAlister Department of Multiorgan Transplant Surgery Ochsner Medical CenterNew OrleansLAUSA Department of Surgery University of Western OntarioLondonONCanada

The highly complex immuno-hematological system of the recipient has to rebalance itself when the liver is replaced with a graft that has its own *** gives us an opportunity for *** we consider the graft-to-recipient direction with passenger lymphocyte syndrome(PLS)as well as the recipient-to-graft direction with Factor VIII(FVIII)inhibitors,paroxysmal nocturnal hemoglobinuria(PNH)and graft endothelial replacement with liver *** extends beyond the ABO blood groups to any situation where the donor has been sensitized to a recipient *** directed against ABO or minor blood group antigens is usually self limiting whereas Rhesus(Rh)PLS persists with life threatening immune *** platelet antigen(HPA)1A PLS results in life threatening immune *** of severe PLS may include reduction in immunosuppression,anti-B-cell therapy,plasmapheresis and *** transplantation into recipients with FVIII inhibitors has been *** with acquired hemophilia may transmit the capacity to make FVIII inhibitors by PLS and should be *** with PNH have been transplanted successfully but a considerable cost in the continued use of high dose *** speculate that combined bone marrow and liver transplantation would be a better option for recipients with FVIII inhibitors or *** of liver graft endothelium with recipient cells is common and may explain relative transplant tolerance that is believed to occur with liver transplantation.

关键词： Liver transplantation passenger lymphocyte syndrome(PLS) human platelet antigen(HPA) paroxysmal nocturnal hemoglobinuria(PNH) endothelium

Optimizing Performance of atgrade Intersection with Bus Rapid Transit Corridor and Heterogeneous Traffic

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International Journal of Transportation Science and Technology 2012年第2期1卷 131-145页

作者： hemant Kumar sharma Mansha Swami B.L.Swami Malviya National Institute of Technology Jaipur-302017India Rajasthan Urban Infrastructure Development Project(Asian Development Bank assisted Project) Jaipur-302017India Sardar Vallabhbhai National Institute of Technology Surat-395007India

Bus Rapid Transit(BRT)has emerged as a preferred mode of public transport in various countries all over the world for its cost effectiveness in construction as well as in operation and *** rapid transit feature of BRT is seen as a solution to many traffic problems in these ***,in developing countries like India,the right–of-way for most of the roads is restricted and traffic is heterogeneous in *** of BRT in existing right–ofway reduces the capacity available for other motorized *** the buses travel with a certain frequency on dedicated bus-ways,the dedicated corridor remains unused for most of the period when other traffic on motorized vehicle(MV)lanes suffers from *** problem gets severe at ***,if buses are operated in mixed traffic it is no more rapid ***,a solution is required to address this problem and optimize the performance of traffic as a *** paper presents the effect if dedicated bus-ways end at a reasonable distance before the stop line at a busy signalized at-grade intersection,and bus lanes(beyond that)are made available to all the motorized vehicular traffic(heterogeneous traffic)at *** performance evaluation is done in terms of average queue length,maximum queue length,average delay time per vehicle,vehicle throughput,average speed in network and emission of Carbon monoxide CO,mono-nitrogen oxides NOx and Volatile organic compounds(VOC).It is observed that availability of bus lanes to other motorized traffic for a reasonable distance before intersection considerably reduces the average queue length,maximum queue length,average delay time per vehicle and emission per vehicle,while there is an increase in vehicle throughput and average speed of all the vehicles in the *** it results in reduction of congestion and performance enhancement of at-grade intersections and *** of investigation are relevant in international ***

关键词： Bus Rapid Transit(BRT) Performance Optimization Microscopic Simulation

Multimodality Medical Image Fusion Based on Pixel Significance with Edge-Preserving Processing for Clinical Applications

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Computers, Materials & Continua 2024年第3期78卷 4317-4342页

作者： Bhawna Goyal Ayush Dogra Dawa Chyophel Lepcha Rajesh Singh hemant sharma Ahmed Alkhayyat Manob Jyoti Saikia Department of ECE and UCRD Chandigarh UniversityMohaliPunjab140413India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjab140401India Department of ECE Uttaranchal Institute of TechnologyUttaranchal UniversityDehradun248007India IES College of Technology IES UniversityBhopal462044India College of Technical Engineering The Islamic UniversityNajaf54001Iraq Department of Electrical Engineering University of North FloridaJacksonvilleFL32224USA

Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical *** fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many ***,recent image fusion techniques have encountered several challenges,including fusion artifacts,algorithm complexity,and high computing *** solve these problems,this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion ***,the method employs a cross-bilateral filter(CBF)that utilizes one image to determine the kernel and the other for filtering,and vice versa,by considering both geometric closeness and the gray-level similarities of neighboring pixels of the images without smoothing *** outputs of CBF are then subtracted from the original images to obtain detailed *** further proposes to use edge-preserving processing that combines linear lowpass filtering with a non-linear technique that enables the selection of relevant regions in detailed images while maintaining structural *** regions are selected using morphologically processed linear filter residuals to identify the significant regions with high-amplitude edges and adequate *** outputs of low-pass filtering are fused with meaningfully restored regions to reconstruct the original shape of the *** addition,weight computations are performed using these reconstructed images,and these weights are then fused with the original input images to produce a final fusion result by estimating the strength of horizontal and vertical *** standard quality evaluation metrics with complementary properties are used for comparison with existing,well-known algorithms objectively to validate the fusion *** results from th

关键词： Image fusion fractal data analysis biomedical diseases research multiresolution analysis numerical analysis

Actinomycetes from Soil of Lachung, a Pristine High Altitude Region of Sikkim Himalaya, Their Antimicrobial Potentiality and Production of Industrially Important Enzymes

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Advances in Microbiology 2019年第8期9卷 750-773页

作者： Laishram Shantikumar Singh hemant sharma Dinabandhu Sahoo Institute of Bioresources and Sustainable Development Sikkim Centre DBT Gangtok India Institute of Bioresources and Sustainable Development DBT Imphal India

Investigations on actinomycetes are profoundly significant area of research since they form major resource for bioactive compounds, antimicrobials, anticancer agents, immunosuppressants, and biological control agents. A total of 59 actinomycetes were isolated from the soil sample collected from Domang, Lachung, North Sikkim, Sikkim, India. Out of the total isolates, 26 isolates with unique and distinct characteristic features were selected and analysed for antimicrobial activity as well as extracellular enzyme production. Out of 26 isolates, 17 (66%) isolates exhibited different level of growth inhibition against the test microorganism. 12 (47%) isolates showed antifungal activity and six (23%) isolates showed antibacterial activity. Most of the isolates showed antifungal activity. Isolate RCS260 was found to exhibit maximum growth inhibition (60%) against Colletotrichum gloeosporioides MTCC 8021. Isolate RCS252 showed maximum growth inhibition (67%) against Bacillus subtilis MTCC 441. Out of 26 isolates, 14 (54%) isolates exhibited chitinase activity, 25 (96%) isolates showed cellulase production, 20 (77%) isolates produced amylase enzyme and 17 (65%) isolates showed positive for protease activity. Potential isolate RCS260 has been characterized and identified as Streptomyces vinaceus strain RCS260 while isolate RCS252 was identified as Kitasatospora aburavienis strain RCS252. The antagonistic profile of strain RCS260 highlights its potential as antifungal agent against phytopathogens.

关键词： Actinomycetes Antimicrobial Activity Extracellular Enzyme Production

A Hybrid WSVM-Levy Approach for Energy-Efficient Manufacturing Using Big Data and IoT

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Computers, Materials & Continua 2024年第12期81卷 4895-4914页

作者： Surbhi Bhatia Khan Mohammad Alojail Mahesh Thyluru Ramakrishna hemant sharma School of Science Engineering and EnvironmentUniversity of SalfordManchesterM68HDUK University Centre for Research and Development Chandigarh UniversityMohali140307India Management Information System Department College of Business AdministrationKing Saud UniversityRiyadh11495Saudi Arabia Department of Computer Science and Engineering JAIN(Deemed-to-be University)Bangalore560030India Department of Computer Science and Engineering IES College of TechnologyBhopal462044India

In Intelligent Manufacturing,Big Data and industrial information enable enterprises to closely monitor and respond to precise changes in both internal processes and external environmental factors,ensuring more informed decision-making and adaptive system *** also promotes decision making and provides scientific analysis to enhance the efficiency of the operation,cost reduction,maximizing the process of production and so *** methods are employed to enhance productivity,yet achieving sustainable manufacturing remains a complex challenge that requires careful *** study aims to develop a methodology for effective manufacturing sustainability by proposing a novel Hybrid Weighted Support Vector-based Lévy flight(HWS-LF)*** objective of the HWS-LF method is to improve the environmental,economic,and social aspects of manufacturing *** this approach,Support Vector Machines(SVM)are used to classify data points by identifying the optimal hyperplane to separate different classes,thereby supporting predictive maintenance and quality control in *** Forest is applied to boost efficiency,resource allocation,and production optimization.A Weighted Average Ensemble technique is employed to combine predictions from multiple models,assigning different weights to ensure an accurate system for evaluating manufacturing ***,Lévy flight Optimization is incorporated to enhance the performance of the HWS-LF method *** method’s effectiveness is assessed using various evaluation metrics,including accuracy,precision,recall,F1-score,and *** show that the proposed HWS-LF method outperforms other state-of-the-art techniques,demonstrating superior productivity and system performance.

关键词： Sustainable manufacturing support vector machine random forest levy flight optimization weighted average ensemble

Quantification of Structurally Alert Mutagenic Impurities in Meropenem Trihydrate Drug Substance by Liquid Chromatography with High Resolution Mass Spectrometer (LC-HRMS)

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American Journal of Analytical Chemistry 2024年第3期15卷 119-133页

作者： Anwar Sulaiman K. Ramakrishna Reddy Vundavilli Jagadeesh Kumar hemant Kumar sharma REVA University Bangalore India Quality Division Aurobindo Pharma Limited Hyderabad India APL Research Centre-II Analytical Research Department Aurobindo Pharma Limited Hyderabad India

Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic method using High Resolution Mass Spectrometer (LC-HRMS) technique is proved to be suitable for simultaneous quantification of all ten identified impurities with required specificity, sensitivity, resolution, precision, accuracy, and other method characteristics as per ICH Guidelines. The acceptable limit of less than 2.9 μg/g was considered for evaluations, based on drug substance dosage and duration of treatment. The method stands most sensitive with a Limit of Detection of 0.35 μg/g, considering the challenge full acceptance criteria as per current regulatory standards.

关键词： Mutagenic Impurities LC-HRMS Meropenem Trihydrate Method Validation

Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study

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World Journal of Hepatology 2019年第9期11卷 689-700页

作者： Pablo Lozano Lominchar Maitane Igone Orue-Echebarria Lorena Martín Cristina Julia Lisbona María Magdalena Salcedo Luis Olmedilla hemant sharma Jose Manuel Asencio JoséAngel López-Baena General Surgery Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Anesthesiology Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Hepatology Department Liver Transplant UnitHospital General Universitario Gregorio MaranonMadrid 28007Spain Department of Transplant Surgery Oschner Medical CenterNew OrleansLA 70816United States

BACKGROUND Early allograft dysfunction(EAD)after liver transplantation(LT)is an important cause of morbidity and *** ensure adequate graft function,a critical hepatocellular mass is required in addition to an appropriate blood *** hypothesized that intraoperative measurement of portal venous and hepatic arterial flow may serve as a predictor in the diagnosis of *** To study whether hepatic flow is an independent predictor of EAD following *** This is an observational cohort study in a single *** arterial blood flow and portal venous blood flow were measured intraoperatively by transit *** was defined using the Olthoff *** and multivariate analyses were used to determine the intraoperative predictors of *** analysis and prognostic factor analysis were performed using the Kaplan-Meier and Cox regression *** A total of 195 liver transplant procedures were performed between January 2008 and December 2014 in 188 patients.A total of 54(27.7%)patients developed *** median follow-up was 39 *** venous flow,hepatic arterial flow(HAF)and total hepatic arterial flow were associated with EAD in both the univariate and multivariate *** is an independent prognostic factor for 30-d patient *** Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD;Moreover,HAF should be considered a predictor of 30-d patient mortality.

关键词： Hepatic flow Early allograft dysfunction Liver transplant