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Application of machine learning and artificial intelligence in oil and gas industry

Petroleum Research 2021年第4期6卷 379-391页

作者： Anirbid Sircar Kriti Yadav Kamakshi Rayavarapu Namrata Bist hemangi oza Centre of Excellence for Geothermal Energy Pandit Deendayal Petroleum UniversityGandhinagarGujaratIndia

Oil and gas industries are facing several challenges and issues in data processing and *** amount of data bank is generated with various techniques and *** proper technical analysis of this database is to be carried out to improve performance of oil and gas *** paper provides a comprehensive state-of-art review in the field of machine learning and artificial intelligence to solve oil and gas industry *** also narrates the various types of machine learning and artificial intelligence techniques which can be used for data processing and interpretation in different sectors of upstream oil and gas *** achievements and developments promise the benefits of machine learning and artificial intelligence techniques towards large data storage capabilities and high efficiency of numerical *** this paper a summary of various researchers work on machine learning and artificial intelligence applications and limitations is showcased for upstream and sectors of oil and gas *** existence of this extensive intelligent system could really eliminate the risk factor and cost of *** development and progress using this emerging technologies have become smart and makes the judgement procedure easy and *** study is useful to access intelligence of different machine learning methods to declare its application for distinct task in oil and gas sector.

关键词： Artificial intelligence Machine learning Upstream Oil and gas industry Petroleum exploration

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绿原酸载药类脂囊泡和前体泡囊:体外抗氧化和抗菌活性与伤口愈合疗效

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Digital Chinese Medicine 2023年第2期6卷 170-188页

作者： hemangi Ramesh Trivedi Prashant Keshao Puranik Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpurMaharashtra 440033India

目的开发和优化天然多酚绿原酸(CGA)的类脂囊泡和前体泡囊递送系统,以提高其理化性质和渗透性,从而可能增强其药理活性。方法已配制的CGA类脂囊泡(CGANs)和CGA前体泡囊(CGAPNs)用薄膜水化法和阶段分离凝聚法进行准备,对其粒子尺寸、形... 详细信息

目的开发和优化天然多酚绿原酸(CGA)的类脂囊泡和前体泡囊递送系统,以提高其理化性质和渗透性,从而可能增强其药理活性。方法已配制的CGA类脂囊泡(CGANs)和CGA前体泡囊(CGAPNs)用薄膜水化法和阶段分离凝聚法进行准备,对其粒子尺寸、形态学、包封率、Z电位、变形能力、体外扩散、离体渗透性和长期稳定性等不同属性进行描述。并使用体外抗氧化测定、抗菌测定和大鼠切除创面愈合模型进一步评价其效率。结果优化后的CGANs和CGAPNs呈球形囊泡状,粒径分别为(490.1±43.0)和(280.0±22.0)nm,多分散指数(PDI)值分别为0.526和0.173,稳定Z电位值分别为(−29.3±6.4)和(−33.2±6.5)mV。与普通CGA相比,CGANs和CGAPNs囊泡具有较高的包封率(98.27%±0.46%&97.27%±0.25%)和良好的变形性(8.77±0.22&6.87±0.17),更高的体外扩散率(97.96%±1.67%&91.00%±1.32%)和渗透系数值(67×10^(−3)±1.72&52×10^(−3)±1.09),具有长期的稳定性。二者均表现出增强的DPPH自由基清除和Fe2+螯合能力,且CGAPNs优于CGANs。与普通CGA相比,它们还表现出对不同革兰氏阳性和革兰氏阴性菌株的致死杀菌活性,最小抑菌浓度(MIC)值较低(低8倍和16倍)。与市售CGANs(92.89%)和CGA水凝胶(88.89%)相比,CGANPs(99.56%)和CGANs(98.44%)在第9天观察到收缩百分比较高的伤口面积显著减小(P<0.05)。结论这些结果显示CGANs和CGAPNs在局部伤口愈合应用中的巨大潜力。这是CGA在类脂囊泡和前体泡囊局部给药系统中的首个研究。

关键词：绿原酸类脂囊泡前体泡囊抗氧化剂抗菌伤口愈合

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Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury-a clinical study

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Cell Regeneration 2020年第1期9卷 6-16页

作者： Alok K.Sharma hemangi M.Sane Pooja P.Kulkarni Nandini Gokulchandran Hema Biju Prerna B.Badhe Department of Medical Services NeuroGen Brain&Spine InstitutePlot 19Sector 40Next to Seawood Grand Central Station(W)Off Palm Beach RoadNerulNavi Mumbai 400706India Off Palm Beach RoadNerulNavi Mumbai 400706India Off Palm Beach RoadNerulNavi Mumbai 400706India Off Palm Beach RoadNerulNavi Mumbai 400706India

Background:Chronic Traumatic Brain Injury(TBI)is one of the common causes of longterm disability *** transplantation has gained attention as a prospective therapeutic option for neurotraumatic disorders like *** postulated mechanism of cell transplantation which includes angiogenesis,axonal regeneration,neurogenesis and synaptic remodeling,may tackle the pathology of chronic TBI and improve overall ***:To study the effects of cell transplantation,50 patients with chronic TBI were enrolled in an open label nonrandomized *** intervention included intrathecal transplantation of autologous bone marrow mononuclear cells and *** follow up duration was 22 *** patients underwent second dose of cell transplantation,6 months after their first *** analysis was performed to analyze the symptomatic improvements in the *** independence measure(FIM)was used as an outcome measure to evaluate the functional changes in the *** tests were applied on the pre-intervention and post-intervention scores for determining the *** Positron Emission Tomography-computed tomography(PET CT)scans were performed in 10 patients to monitor the effect of intervention on brain *** such as age,multiple doses,time since injury and severity of injury were also analyzed to determine their effect on the outcome of cell *** events were monitored throughout the follow up ***:Overall 92%patients showed improvements in symptoms such as sitting and standing balance,voluntary control,memory,oromotor skills lower limb activities,ambulation,trunk&upper limb activity,speech,posture,communication,psychological status,cognition,attention and concentration,muscle tone,coordination,activities of daily living.A statistically significant(at p≤0.05 with p-value 0)improvement was observed in the scores of FIM after intervention on the Wilcox

关键词： Autologous Bone marrow Mononuclear cells Chronic Traumatic brain injury PET CT scan Neurorehabilitation

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