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Antihyperglycemic effect of Juniperus phoenicea *** alloxan-induced diabetic rats and diterpenoids isolated from the fruits

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Journal of Coastal Life Medicine 2015年第11期 906-909页

作者： Salma Ahmed El-Sawi hemaia mohamed motawae Abdel-Rahman Omar El-Shabrawy mohamed Aboul-Fotouh Sleem Amani Ameen Sleem Maii Abdel Naby Ismail Maamoun Pharmacognosy Department National Research CentreCairoEgypt Pharmacognosy Department Faculty of PharmacyCairo UniversityCairoEgypt Pharmacology Department National Research CentreCairoEgypt

Objective:To explore the traditional use of Juniperus phoenicea L.(***)growing in Egypt as antidiabetic ***:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture *** a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer ***:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(P<0.01).The highest antihyperglycemic activity was exhibited by the crude extracts of fruits and leaves of which the potency was 83.6%and 81.9%,respectively,after 8 weeks,comparing to metformin drug(100%potency).Chloroform fractions of leaves and fruits were the most potent fractions(potencies were 70.3%,71.4%),respectively,along with ethyl acetate fraction of fruits(71.4%).Phytochemical investigating of the chloroform fraction of fruits resulted in the isolation and identification of 5 abietane ***,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of *** growing in *** identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the ***:It has become clear that leaves and fruits of the Egyptian *** provide effective antihyperglycemic action in diabetic rats as was reported in folk *** high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.

关键词： Juniperus phoenicea Antihyperglycemic Abietane Labdane Diterpenoid

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