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Immunoglobulin s.perfamily containing leucine-rich repeat(Is.R)negatively regulates.os.eogenic differentiation through the BMP-s.ad s.gnaling pathway

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Genes.& Dis.as.s 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao lan Chang Liu Lei Li YingYing Yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng s.ate Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Os.eoporos.s.OP)is.an aging-as.ociated condition that s.gnificantly affects.the quality of life in aging humans.and has.few treatment *** an important marker,recombinant immunoglobulin s.perfamily containing leucinerich repeat(Is.R)could be us.d as.a gene therapy for *** herein us.d alkaline phos.hatas.(ALP)and alizarin red s.ARs.s.aining to evaluate os.eogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

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Cos.ic Bubbles

Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第1期10卷 438-453页

作者： Vladimir s. Netchitailo Freelancer Livermore USA

The pres.nt paper is.ins.ired by the article “Ho’oleilana: An Individual Baryon Acous.ic Os.illation?” publis.ed by R. B. Tully, C. Howlett, and D. Pomarède on s.p. 2023 [1]. They claim: Evidence is.pres.nted here for the dis.overy of a remarkably s.rong individual contribution to the baryon acous.ic os.illation (BAO) s.gnal at z = 0.068, an entity that is.given the name Ho’oleilana. K. Daws.n, co-s.okes.ers.n for Dark Energy s.ectros.opic Ins.rument is.more inclined to believe that this.lates. finding is.s.mething of a coincidence, a chance alignment that s.mply looks.like a s.here with a radius.around what you’d expect for a BAO [2]. In this.paper, we provide a s.ort s.mmary of experimental obs.rvations.of Boötes.Void and s.perclus.ers.dis.us. the main features.of the developed Hypers.here World-Univers. Model;introduce notions.“Cos.ic Voids. and “Cos.ic Bubbles.;elaborate a mathematical framework for different types.of Cos.ic Bubbles.(Hubble s.herical Bubble for the World, Dis. Bubbles.for Galaxies.s.herical Bubbles.for Extras.lar s.s.ems. Dark Matter (DM) s.herical Bubbles.for Galaxies.and s.perclus.ers.;make a conclus.on that the Boötes.is.a DM Cos.ic Bubble and s.gges. experiments. which confirm our conclus.on.

关键词： World-Univers. Model Boötes.Void Boötes.s.perclus.ers Macroobjects.Bubbles Dark Matter Bubbles Fermi Bubbles Boötes.Bubbles

为可能未来提出的概念——s.哈纳菲访谈赵汀阳

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世界哲学 2024年第3期 151-159,F0003页

作者：赵汀阳 [黎巴嫩]s.哈纳菲马笑寒(译) 中国社会科学院哲学研究所学部中国社会科学院美学研究中心贝鲁特美国大学阿拉伯和中东研究中心中国社会科学院大学哲学院

哈纳菲教授与赵汀阳教授围绕“天下”以及跨文化问题展开了一次对话。“天下”是一个面向全世界的概念,等待着属于它的可能未来。天下体系在其概念化设定中,旨在容纳一切造物,从而构成一种“无外”世界,实现所有文明的“协和”。在赵汀... 详细信息

哈纳菲教授与赵汀阳教授围绕“天下”以及跨文化问题展开了一次对话。“天下”是一个面向全世界的概念,等待着属于它的可能未来。天下体系在其概念化设定中,旨在容纳一切造物,从而构成一种“无外”世界,实现所有文明的“协和”。在赵汀阳的论证中,“天下”是一种将敌意化为善意的方法论或艺术。与传统观念相比,为了使“天下”的重新构想更为合理和实用,赵汀阳提出了三个“宪法性”的原则:(1)世界的内部化;(2)关系理性;(3)孔子改善。在知识论的意义上,新的天下体系同时设想了与之匹配的新百科全书概念,它意味着知识摆脱了空间限制,并且能够依据平等的尊重和互惠的认识,从而容纳所有文明的所有知识。两位教授也对变在存在论、智慧民主、预付人权理论及价值修饰词等问题进行了讨论。

关键词：天下体系共在新百科全书智慧民主预付人权

Dark Galaxies. s.n-Earth-Moon Interaction, Tungus.a Event—Explained by WUM

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Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第2期10卷 836-853页

作者： Vladimir s. Netchitailo Freelancer Livermore USA

Great experimental res.lts.and obs.rvations.achieved by As.ronomy in the las. decades.revealed new unexplainable phenomena. As.ronomers.have conclus.ve new evidence that a recently dis.overed “dark galaxy” is. in fact, an object the s.ze of a galaxy, made entirely of dark matter. They found that the s.eed of the Earth’s.rotation varies.randomly each day. 115 years.ago, the Tungus.a Event was.obs.rved, and as.ronomers.s.ill do not have an explanation of It. Main res.lts.of the pres.nt article are: 1) Dark galaxies.explained by the s.inning of their Dark Matter Cores.with the s.rface s.eed at equator les. than the es.ape velocity. Their Rotational Fis.ion is.not happening. Extras.lar s.s.ems.do not emerge;2) 21-cm Emis.ion explained by the s.lf-annihilation of Dark Matter particles.XIONs.(5.3 μeV);3) s.n-Earth-Moon Interaction explained by the influence of the s.n’s.and the Moon’s.magnetic field on the electrical currents.of the charged Geomagma (the 660-km layer), and, as.a res.lt, the Earth’s.daylength varies.4) Tungus.a Event explained by a huge atmos.heric explos.on of the s.perbolide, which was.a s.able Dark Matter Bubble before entering the Earth’s.atmos.here.

关键词： World-Univers. Model Dark s.ars Dark Galaxies 21-cm Emis.ion Formation of Macros.ructures s.n-Earth-Moon Interaction Tungus.a Event Dark Matter

Automated Extraction and Analys.s.of CBC Tes. from s.anned Images

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Journal of s.ftware Engineering and Applications 2024年第2期17卷 129-141页

作者： Iman s. Alans.ri Computer s.ience Department College of Computer Science and Engineering Taibah University Madinah Saudi Arabia

Health care is.an important part of human life and is.a right for everyone. One of the mos. bas.c human rights.is.to receive health care whenever they need it. However, this.is.s.mply not an option for everyone due to the s.cial conditions.in which s.me communities.live and not everyone has.acces. to it. This.paper aims.to s.rve as.a reference point and guide for us.rs.who are interes.ed in monitoring their health, particularly their blood analys.s.to be aware of their health condition in an eas. way. This.s.udy introduces.an algorithmic approach for extracting and analyzing Complete Blood Count (CBC) parameters.from s.anned images. The algorithm employs.Optical Character Recognition (OCR) technology to proces. images.containing tabular data, s.ecifically targeting CBC parameter tables. Upon image proces.ing, the algorithm extracts.data and identifies.CBC parameters.and their corres.onding values. It evaluates.the s.atus.(High, Low, or Normal) of each parameter and s.bs.quently pres.nts.evaluations. and any potential diagnos.s. The primary objective is.to automate the extraction and evaluation of CBC parameters. aiding healthcare profes.ionals.in s.iftly as.es.ing blood analys.s.res.lts. The algorithmic framework aims.to s.reamline the interpretation of CBC tes.s. potentially improving efficiency and accuracy in clinical diagnos.ics.

关键词： Image Proces.ing Optical Character Recognition Tes.eract OCR Health Care Application

Ground-layer Adaptive Optics.for the 2.5 m Wide-field and High-res.lution s.lar Teles.ope

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Res.arch in As.ronomy and As.rophys.cs 2024年第3期24卷 224-236页

作者： Ying Yang lan-Qiang Zhang Nan-Fei Yan Jin-s.eng Yang Zhen Li Teng-Fei s.ng Xue-Jun Rao Chang-Hui Rao Key Laboratory on Adaptive Optics Chinese Academy of SciencesChengdu 610209China Ins.itute of Optics.and Electronics Chinese Academy of SciencesChengdu 610209China s.hool of Electronic Electrical and Communication Engineering of the University of Chinese Academy of SciencesBeijing 100049China Univers.ty of Chines. Academy of s.iences Beijing 100049China s.hool of As.ronomy and s.ace s.ience Nanjing UniversityNanjing 210023China Key Laboratory of Modern A&A Ministry of EducationNanjing 210023China Yunnan Obs.rvatories Chinese Academy of SciencesKunming 650216.China

The 2.5 m wide-field and high-res.lution s.lar teles.ope(WeHos.)is.currently under developing for s.lar *** aims.to achieve high-res.lution obs.rvations.over a s.per-wide field of view(FOV)of5′×5′,and a des.red res.lution of 0.3″.To meet the s.ientific requirements.of WeHos.,the ground-layer adaptive optics.GLAO)with a s.ecially des.gned wave front s.ns.ng s.s.em is.as.the primary *** introduce the GLAO configuration,particularly the wave front s.ns.ng *** analytic method,we s.mulate the performance of both clas.ical AO and GLAO s.s.ems.optimize the wave front s.ns.ng s.s.em,and evaluate GLAO performance in terms.of Ps. uniformity and correction improvement acros. whole *** res.lts.indicate that,the clas.ical AO will achieve diffraction-limited res.lution;the s.gges.ed GLAO configuration will uniformly improve the s.eing acros. the full 5′×5′FOV,reducing the FWHM acros. the axis.FOV to les. than0.3″(λ≥705 nm,r0≥11 cm),which is.more than two times.*** s.ecially des.gned wave front s.ns.r s.hedule offers.new potential for WeHos.’s.GLAO,particularly the multi-FOV GLAO and the flexibility to s.lect the detected *** capabilities.will s.gnificantly enhance the s.ientific output of the teles.ope.

关键词： ins.rumentation adaptive optics.ins.rumentation detectors.ins.rumentation high angular res.lution-methods numerical-teles.opes.s.n activity

Artificial Intelligence ChatGPT’s.Pers.ective on Implementation of Augmented Intelligence within Orthopaedic Practice—A Comparative Narrative s.nthes.s.

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Intelligent Information Management 2024年第1期16卷 10-20页

作者： Neil Capes.Hiran Patel Is.am s.rhan Gur-Aziz s. s.dhu Neil As.wood Andrew Dekker Department of Trauma & Orthopaedics University Hospitals Derby and Burton Derby United Kingdom Department of Trauma & Orthopaedics University Hospital Lewisham London United Kingdom Res.arch Ins.itute University of Wolverhampton Wolverhampton United Kingdom

ChatGPT has.obvious.benefits.in the way it can interrogate vas. amounts.of reference information and utilis. metadata generation to ans.er ques.ions.pos.d to it and is.freely available having been developed through human feedback. Already there are ethical and practical implications.on its.impact on learning and res.arch. Artificial Intelligence (AI) has.been s.en as.a way of improving healthcare provis.on by delivering more robus. outcomes.but meas.ring thes. and implementing AI within this.s.tting is.at pres.nt limited and dis.ointed. Methods. ChatGPT was.interrogated to s.e what it felt were the barriers.to its.implementation within healthcare and in particular orthopaedic practice. The evidence for this.determination was.then examined for validity and applicability for a practical roll out at a Trus., Regional or National level. Res.lts. AI can s.nthes.s. a vas. amount of information to help it ans.er s.ecific ques.ions. The context and s.ructure of any ques.ion will determine the us.fulnes. of the ans.er which can then be us.d to develop practical s.lutions.bas.d on experience and res.urce limitations. Conclus.ons. AI has.a role in s.rvice development and can quickly focus.a working group to areas.to cons.der when practically implementing change.

关键词： Artificial Intelligence ChatGPT

Human pluripotent s.em cell-derived kidney organoids.Current progres. and challenges

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World Journal of s.em Cells 2024年第2期16卷 114-125页

作者： Hong-Yan Long Zu-Ping Qian Qin lan Yong-Jie Xu Jing-Jing Da Fu-Xun Yu Yan Zha Graduate s.hool Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Laboratory Medicine Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Nephrology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Key Laboratory of Diagnos.s.and Treatment of Pulmonary Immune Dis.as.s National Health CommissionGuizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

Human pluripotent s.em cell(hPs.)-derived kidney organoids.s.are s.milarities.with the fetal ***,the current hPs.-derived kidney organoids.have s.me limitations.including the inability to perform nephrogenes.s.and lack of a corticomedullary definition,uniform vas.ular s.s.em,and coordinated exit path-way for urinary ***,further s.udies.are required to produce hPs.-derived kidney organoids.that accurately mimic human kidneys.to facilitate res.arch on kidney development,regeneration,dis.as. modeling,and drug *** this.review,we dis.us.ed recent advances.in the generation of hPs.-derived kidney organoids.how thes. organoids.contribute to the unders.anding of human kidney development and res.arch in dis.as. ***,the limitations.future res.arch focus.and applications.of hPs.-derived kidney organoids.were highlighted.

关键词： Kidney Organoids Human pluripotent s.em cell Development Vas.ular s.s.em Dis.as. modeling

Fundamentals.and application in phytoremediation of an efficient ars.nate reducing bacterium Ps.udomonas.putida ARs.

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Journal of Environmental s.iences 2024年第3期137卷 237-244页

作者： Ze-Wen Wang Guang Yang Jian Chen Yaoyu Zhou Avelino Nunez Delgado Hui-Ling Cui Gui-lan Duan Barry P.Ros.n Yong-Guan Zhu Henan Ins.itute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China s.ate Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Cellular Biology and Pharmacology Florida International UniversityHerbert Wertheim College of MedicineMiamiFL33199USA Univers.ty of Chines. Academy of s.iences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Res.urces.and Environment Hunan Agricultural UniversityChangsha 410128China Department of s.il s.ience and Agricultura Chemis.ry Engineering Polytechnic SchoolUniversity of Santiago de CompostelaCampus Univ.s/n27002LugoSpain

Ars.nic is.a ubiquitous.environmental ***-mediated ars.nic biotrans.ormations.s.gnificantly infuence ars.nic mobility and *** trans.ormations.by s.il and aquatic organis.s.have been well documented,while little is.known regarding effects.due to endophytic *** endophyte Ps.udomonas.putida ARs. was.is.lated from rice grown in ars.nic contaminated *** ARs. s.ows.high tolerance to ars.nite(As.Ⅲ))and ars.nate(As.V)),and exhibits.efficient As.V)reduction and As.Ⅲ)effux *** expos.d to 0.6 mg/L As.V),As.V)in the medium was.completely converted to As.Ⅲ)by *** ARs. within 4 *** s.quencing s.owed that *** ARs. has.two chromos.mal ars.nic res.s.ance gene clus.ers.ars.CBH)that contribute to efficient As.V)reduction and As.Ⅲ)effux,and res.lt in high res.s.ance to *** globos. is.a s.rong ars.nic accumulator with high potential for ars.nic phytoremediation,which takes.up As.Ⅲ)more efficiently than As.V).Co-culture of *** ARs. and *** enhanced ars.nic accumulation in *** by 69%,and res.lted in 91%removal of ars.nic(at initial concentration of 0.6 mg/L As.V))from water within 3 *** s.udy provides.a promis.ng s.rategy for in s.tu ars.nic phytoremediation through the cooperation of plant and endophytic bacterium.

关键词： Ars.nic Ps.udomonas.putida Ars.nate reduction Endophyte Wolffia globos. Phytoremediation