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A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1144-1155页

作者： Chikezie Grand Ihesiulor Khaled Alzahrani hema Rhadhakrishnan Division of Pharmacy&Optometry School of Health SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Ophthalmology King Fahad Armed Forces HospitalJeddah 23311Saudi Arabia

Various studies have suggested several environmental,pharmacological,medical,and optical interventions and some are in use but their efficacy in myopia control may be transient,and the cellular,molecular,and biochemical mechanisms involved *** exposure is currently regarded as an effective and enduring strategy in the control of myopia development and ***,the mechanism behind the effect of outdoor exposure and its association with genetic predisposition and other relatively more significant environmental factors on myopia is still a *** review focuses on survey-based and intervention-based studies carried out to propose a mechanism that accounts for myopia development and important for its control.

关键词： outdoor exposure daylight exposure myopia control myopia

MOALG: A Metaheuristic Hybrid of Multi-Objective Ant Lion Optimizer and Genetic Algorithm for Solving Design Problems

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Computers, Materials & Continua 2024年第3期78卷 3489-3510页

作者： Rashmi Sharma Ashok Pal Nitin mittal Lalit Kumar Sreypov Van Yunyoung Nam Mohamed Abouhawwash Department of Mathematics Chandigarh UniversityGharuanMohali140413India Deaprtment of Industry 4.0 Shri Vishwakarma Skill UniversityPalwal121102India Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Computational Mathematics Science and Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt

This study proposes a hybridization of two efficient algorithm’s Multi-objective Ant Lion Optimizer Algorithm(MOALO)which is a multi-objective enhanced version of the Ant Lion Optimizer Algorithm(ALO)and the Genetic Algorithm(GA).MOALO version has been employed to address those problems containing many objectives and an archive has been employed for retaining the non-dominated *** uniqueness of the hybrid is that the operators like mutation and crossover of GA are employed in the archive to update the solutions and later those solutions go through the process of MOALO.A first-time hybrid of these algorithms is employed to solve multi-objective *** hybrid algorithm overcomes the limitation of ALO of getting caught in the local optimum and the requirement of more computational effort to converge *** evaluate the hybridized algorithm’s performance,a set of constrained,unconstrained test problems and engineering design problems were employed and compared with five well-known computational algorithms-MOALO,Multi-objective Crystal Structure Algorithm(MOCryStAl),Multi-objective Particle Swarm Optimization(MOPSO),Multi-objective Multiverse Optimization Algorithm(MOMVO),Multi-objective Salp Swarm Algorithm(MSSA).The outcomes of five performance metrics are statistically analyzed and the most efficient Pareto fronts comparison has been *** proposed hybrid surpasses MOALO based on the results of hypervolume(HV),Spread,and *** primary objective of developing this hybrid approach has been achieved *** proposed approach demonstrates superior performance on the test functions,showcasing robust convergence and comprehensive coverage that surpasses other existing algorithms.

关键词： Multi-objective optimization genetic algorithm ant lion optimizer metaheuristic

Peer pressure and academic stress among junior high school students:a cross-sectional study

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Frontiers of Nursing 2024年第2期11卷 191-199页

作者： Rika Sarfika I Made MohYanuar Saifudin hema Malini Nursyirwan Effendi Bunga Permata Wenny Mental Health and Community Department Faculty of NursingUniversitas AndalasPadangWest Sumatra 25163Indonesia Department of Medicine and Health Faculty of MedicinePublic Healthand NursingUniversitas Gadjah MadaYogyakarta 55281Indonesia Department of Medical Surgical Faculty of NursingUniversitas AndalasPadangWest Sumatra 25163Indonesia Anthropology Department Faculty of Social and Political SciencesUniversitas AndalasPadangWest Sumatra 25163Indonesia

Objective:The objective of the study was to explore the connection between peer pressure and academic stress among junior high school ***:This descriptive correlational study was conducted to investigate the link between perceived peer pressure and academic *** study involved a total of 525 adolescents,aged 14-19 years,drawn from 6 public junior high schools(PJHS)in Padang,Indonesia,using purposive *** stress and perceived peer pressure were assessed using the Educational Stress Scale for Adolescents(ESSA)and the Perceived Peer Pressure Scale(PPPS).Results:The findings indicated significant variations in stress levels among students in different grade levels(7th,8th,and 9th grades)(P0.05).Additionally,there was a positive correlation observed between perceived peer pressure and academic stress(r=0.14,P<0.05).Furthermore,multiple regression analyses,incorporating demographic variables and perceived peer pressure as independent factors,yielded statistically significant results(adjusted R^(2)=0.082,F=4.33,P<0.001).Notably,peer pressure had a direct impact on academic stress among adolescents,with class level and parents’educational background mediating the relationship between academic stress and adolescent behavioral ***:These findings underscore the importance of addressing both external and internal factors at the individual,family,school,and societal levels to enhance adolescents’psychological resilience and mitigate problem behaviors.

关键词： academic stress adolescents behavioral problem Indonesia peer pressure students

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Honeymoon phase in type 1 diabetes mellitus: A window of opportunity for diabetes reversal?

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World Journal of Clinical Cases 2024年第1期12卷 9-14页

作者： Madhukar mittal Pradakshna Porchezhian Nitin Kapoor Department of Endocrinology and Metabolism All India Institute of Medical Sciences JodhpurJodhpur 342005India Department of Endocrinology Diabetes and MetabolismChristian Medical College and HospitalVellore 632004Tamil NaduIndia

The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly *** natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic *** all individuals of T1DM progress in that specific *** hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of *** now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being *** third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its *** honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in *** this phase is therefore the key,with a lot of varying criteria having been proposed.

关键词： Diabetes reversal Diabetes remission Type 1 diabetes Honeymoon phase Immunomodulation

Sclerosing Mucoepidermoid Cancer: A Unique Entity

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Open Journal of Endocrine and Metabolic Diseases 2024年第5期14卷 107-114页

作者： Ashima mittal Christina Dimech Farhad Hasan Gayatri Jaiswal Division of Endocrinology Allegheny Health Network Pittsburgh Pennsylvania USA

Sclerosing mucoepidermoid thyroid cancer (SMECE) is a rare entity with less than 100 cases reported in the literature. Previously considered to have an indolent course, however, recent evidence has reported an aggressive nature ranging from local invasion to distant metastasis. We present a 66-year-old Caucasian female with SMECE who initially presented neck compressive symptoms. A thyroid ultrasound (US) revealed a solid hypoechoic mass replacing the left thyroid lobe. Fine needle aspiration cytology (FNAC) of the nodule resulted in suspicion of Papillary Thyroid Cancer, Bethesda category 5. The patient underwent total thyroidectomy and surgical pathology showed SMECE. Post-therapy whole-body scan following treatment with 150 mCi I-131 showed no residual or metastatic disease. SMECE is more common in females, between the third to eighth decade of life. Preoperative diagnosis may not be accurate given variable cytopathologic features. Differential diagnoses include primary squamous cell carcinoma of the thyroid, squamous differentiation of other thyroid malignancies, anaplastic thyroid cancer and nodular sclerosing variety of Hodgkin’s lymphoma. Due to its rarity, treatment of SMECE has ranged from thyroid surgery without or with radioactive iodine therapy, to surgery and external beam radiation and even chemotherapy.

关键词： Sclerosing Mucoepidermoid Cancer Papillary Thyroid Cancer Thyroid Cancer

Deep Learning-Based Mask Identification System Using ResNet Transfer Learning Architecture

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Computer Systems Science & Engineering 2024年第2期48卷 341-362页

作者： Arpit Jain Nageswara Rao Moparthi A.Swathi Yogesh Kumar Sharma Nitin mittal Ahmed Alhussen Zamil S.Alzamil MohdAnul Haq Department of Computer Science and Engineering KoneruLakshmaiah Education FoundationVaddeswaram522302India Department of Computer Science and Engineering Sreyas Institute of Engineering and TechnologyHyderabad500068India University Centre for Research and Development Chandigarh UniversityMohali140413India Department of Computer Engineering College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Recently,the coronavirus disease 2019 has shown excellent attention in the global community regarding health and the *** Health Organization(WHO)and many others advised controlling Corona Virus Disease in *** limited treatment resources,medical resources,and unawareness of immunity is an essential horizon to *** all resources,wearing a mask is the primary non-pharmaceutical intervention to stop the spreading of the virus caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)*** countries made masks mandatory to prevent *** such enforcement,automatic and effective face detection systems are *** study presents a face mask identification approach for static photos and real-time movies that distinguishes between images with and without *** contribute to society,we worked on mask detection of an individual to adhere to the rule and provide awareness to the public or *** paper aims to get detection accuracy using transfer learning from Residual Neural Network 50(ResNet-50)architecture and works on detection *** experiment is tested with other popular pre-trained models such as Deep Convolutional Neural Networks(AlexNet),Residual Neural Networks(ResNet),and Visual Geometry Group Networks(VGG-Net)advanced *** proposed system generates an accuracy of 98.4%when modeled using Residual Neural Network 50(ResNet-50).Also,the precision and recall values are proved as better when compared to the existing *** outstanding work also can be used in video surveillance applications.

关键词： Transfer learning depth analysis convolutional neural networks(CNN) COVID-19

Optimisation of Thermal Comfort of Building in a Hot and Dry Tropical Climate: A Comparative Approach between Compressed Earth/Concrete Block Envelopes

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Journal of Minerals and Materials Characterization and Engineering 2024年第1期12卷 1-16页

作者： Arnaud Louis Sountong-Noma Ouedraogo Césaire hema Sjoerd Moustapha N’guiro Philbert Nshimiyimana Adamah Messan Laboratoire Eco-Matériaux et Habitat Durable (LEMHaD) Institut International de l’Ingénierie de l’eau et de l’environnement (Institut 2iE) Rue de la science 01 BP 594 Ouagadougou Burkina Faso

Compressed earth blocks (CEB) are an alternative to cement blocks in the construction of wall masonry. However, the optimal architectural construction methods for adequate thermal comfort for occupants in hot and arid environments are not mastered. This article evaluates the influence of architectural and constructive modes of buildings made of CEB walls and concrete block walls, to optimize and compare their thermal comfort in the hot and dry tropical climate of Ouagadougou, Burkina Faso. Two identical pilot buildings whose envelopes are made of CEB and concrete blocks were monitored for this study. The thermal models of the pilot buildings were implemented in the SketchUp software using an extension of EnergyPlus. The models were empirically validated after calibration against measured thermal data from the buildings. The models were used to do a parametric analysis for optimization of the thermal performances by simulating plaster coatings on the exterior of walls, airtight openings and natural ventilation depending on external weather conditions. The results show that the CEB building displays 7016 hours of discomfort, equivalent to 80.1% of the time, and the concrete building displays 6948 hours of discomfort, equivalent to 79.3% of the time. The optimization by modifications reduced the discomfort to 2918 and 3125 hours respectively;i.e. equivalent to only 33.3% for the CEB building and 35.7% for the concrete building. More study should evaluate thermal optimizations in buildings in real time of usage such as residential buildings commonly used by the local middle class. The use of CEB as a construction material and passive means of improving thermal comfort is a suitable ecological and economical option to replace cementitious material.

关键词： Compressed Earth Blocks Hot and Dry Climate Thermal Comfort Architectural Optimization of Thermal Models Cement Blocks Empirical Validation

Barriers in early detection of colorectal cancer and exploring potential solutions

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World Journal of Clinical Oncology 2024年第7期15卷 811-817页

作者： Maryam Aleissa Ernesto Raul Drelichman Vijay K mittal Jasneet Singh Bhullar Department of Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States College of Medicine Princess Norah University HospitalRiyadh 11564Saudi Arabia

This editorial discusses the literature review article by Tonini and Zanni,the paper was published in January 2024,and the authors provided very interesting conclusions regarding existing barriers to the early diagnosis of colon *** cancers do not have identifiable precursors,or there are currently no screening tests to find ***,these cancers do not have preventive screening *** detection is crucial for reducing mortality rates by identifying cancer at an earlier stage through screening,as opposed to no *** cancer develops from precancerous lesions,which can be detected early and potentially prevented and *** detection leads to improved survival rates,decreased complications,and reduced healthcare *** editorial provides a brief description of the biology of colon cancer,emphasizing the contrast in outcomes between early detection and late *** also describe screening programs around the globe and examine the barriers in each ***,we explore potential future solutions to enhance inclusion in screening programs and improve patient compliance.

关键词： Colon cancer Rectal cancer Early detection