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The role of extracellular calcium in the effect of a snake venom Lys49-phospholipase A_(2) on water transport across epithelial membranes

Journal of Biophysical Chemistry（生物物理化学） 2011年第3期

作者： Renner de Souza Leite Wilson Franco heloísa sobreiro selistre-de-araujo

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Journal of Biophysical Chemistry 2011年第3期2卷 222-225页

作者： Renner de Souza Leite Wilson Franco heloisa sobreiro selistre-de-araujo Unidade Academica de saude do Centro de Educacao e saude Universidade Federal de Campina GrandeCuiteParaíbaBrazil departamento de Ciencias Fisiologicas Universidade Federal de Sao CarlosSao CarlosBrazil

ACLMT is a Lys49-phospholipase A2 myotoxin isolated from the venom of the Agkistrodon contortrix laticinctus snake. This study investigated the mechanisms involved in effect of ACLMT on membrane water permeability by examining the role of extracellular calcium and strontium in this effect. Water flow across the membrane was gravimetrically measured in bladder sac preparations. The decrease in extracellular calcium promoted a higher response of epithelium to ACLMT, suggesting that the extracellular calcium protects the membrane from the action of the toxin. No alteration in the effect of the toxin on water transport was observed when calcium was replaced by strontium, indicating that this effect is independent of its enzymatic activity. These findings may bring an important contribution towards the comprehension of the mechanisms involved in the effect of Lys49-phospholipase A2 myotoxins on water permeability of epithelial membranes, with implications for the understanding of renal toxicity.

关键词： Epithelial Tissue Membrane Permeability Myotoxin Lys49-Phospholipase A_(2) Toad Bladder Water Transport

Innovation and financial performance of companies doing business in Brazil

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International Journal of Innovation Studies 2018年第4期2卷 153-164页

作者： Juliana Albuquerquer saliba de Oliveira Leonardo Fernando Cruz Basso Herbert Kimura Vinicius Amorim sobreiro Mackenzie Presbyterian University Sao PauloSao Paulo01302-907Brazil department of Management Campus Darcy RibeiroUniversity of BrasiliaFederal DistrictBrasilia70910-900Brazil

In this paper,we analyze the relationships among innovation efforts,the impacts of these innovations,and the financial performance of Brazilian *** hypothesize that innovation efforts do not directly translate into financial *** to the inherent uncertainty of innovative projects,such efforts must first lead to effective innovation results or impacts before they are capable of contributing to a company's financial *** the Brazilian Institute of Geography and Statistics'(IBGE)comprehensive official databases on innovation and performance,we study 5,025 firms using exploratory factor analysis and structural equation *** results suggest that efforts in innovation possibly generate impacts;however,these impacts do not necessarily imply better financial ***,although firms'efforts may lead to new products,they will not contribute to financial gains in the short term,reflecting the risky and costly nature of *** study aims to contribute to the discussion on firm-level impacts of innovation from the context of a large developing country,since empirical results of the literature are mixed.

关键词： Innovation Efforts in innovation Impacts of innovation Financial performance PINTEC PIA

Examination of the profitability of technical analysis based on moving average strategies in BRICS

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Financial Innovation 2018年第1期4卷 44-61页

作者： Matheus JoséSilva de Souza Danilo Guimarães Franco Ramos Marina Garcia Pena Vinicius Amorim sobreiro Herbert Kimura department of Economics University of BrasíliaFederal DistrictBrazil department of Management University of BrasíliaFederal DistrictBrazil.

In this paper,we investigated the profitability of technical analysis as applied to the stock markets of the BRICS member *** addition,we searched for evidence that technical analysis and fundamental analysis can complement each other in these *** implement this research,we created a comprehensive portfolio containing the assets traded in the markets of each BRICS *** developed an automated trading system that simulated transactions in this portfolio using technical analysis *** assessment updated the findings of previous research by including more recent data and adding South Africa,the latest member included in *** results showed that the returns obtained by the automated system,on average,exceeded the value *** were groups of assets from each country that performed well above the portfolio average,surpassing the returns obtained using a buy and hold *** returns from the sample portfolio were very strong in Russia and *** also found that technical analysis can help fundamental analysis identify the most dynamic companies in the stock market.

关键词： Technical analysis Moving average strategies Automated trading systems Portfolio analysis BRICS

Assessing business incubation:A review on benchmarking

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International Journal of Innovation Studies 2018年第3期2卷 91-100页

作者： Mustafa Torun Laura Peconick Vinicius sobreiro Herbert Kimura Josep Pique department of Management Universidade de BrasiliaCampus Darcy RibeiroAsa NorteBrasiliaDF70910-900Brazil Universitat Ramon Llull La SalledUniversitat Ramon LlullBarcelonaCatalunya08022Spain

This paper studies benchmarking on Business Incubators(BIs),aggregating the state of knowledge about benchmarks for BI *** on 136 papers that evaluate BI performance,this study first investigates all Key Performance Indicators(KPIs)provided by 42 BI assessment studies and the relevant benchmarks for each *** final benchmark list is created by taking seven of the most prominent benchmarking studies as a *** this framework,this research contributes to the literature on BI assessment by providing comprehensive and aggregated benchmarks for these important innovation habitats.A final list of 33 benchmarks is provided so that BI assessment,for which no common framework exists,becomes *** study suggests that with the difficulty of creating a common assessment framework for BIs,it is more reasonable to create a common benchmarking framework that accounts for regional and industrial *** results could be subject to a multiple criteria decision *** paper is the first to aggregate the diverse information on benchmarking and provide researchers and BI managers with a base list of benchmarks.

关键词： Business incubation Performance evaluation Benchmarks