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Blockchain(Research and Applications) 2024年第3期5卷 53-66页

作者： Matthias Gottlieb Christina Deutsch Felix Hoops Hans Pongratz helmut Krcmar Bavarian Ministry of Digital Affairs 80333 MunichGermany Technical University of Munich 85478 Garching By MunichGermany TU Dortmund University 44139 DortmundGermany

In the education sector,blockchain is currently at the end of the peak of inflated expectations in Gartner’s Hype ***,it is crucial to understand whether this technology meets the expectations of Higher Education Institutions(HEIs).We go on an expedition to identify blockchain application scenarios and its potential for HEI administration-the universities are digitalized to just 23.3%.Current information systems research addresses classifications of blockchain-based projects(application level)rather than their technical realization(protocol level).Thus,when evaluating blockchain application scenarios in HEI administration,we intensively consider the technical side of blockchain-based *** perform a threestep approach:(1)systematic literature review,(2)qualitative exploratory semi-structured interviews to sup-plement information on market-ready solutions,and(3)an evaluation of the potential of the blockchain-based projects identified,based on HEI administration *** find that the leading blockchain application scenarios are credential verification and *** the protocol level,we obtain equivocal results regarding the technical realization of projects,e.g.,their underlying blockchain types and storage *** the application level,when discussing the potential of different projects,we find that most of them address adaptability,complexity decomposition,and cost reduction requirements between HEIs;interest diversity and stakeholder collaboration between HEIs and business actors;privacy and trust between HEIs and students.

关键词： Blockchain Higher education institution(HEI) Administration Protocol level Application level Application

Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra Khan Luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

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Genes & Diseases 2024年第1期11卷 413-429页

作者： Dongsheng Zhang Wenjuan Tang Haitao Niu William Tse Hai-Bin Ruan helmut Dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee Denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han Division of Hematology and Oncology Division of Cancer BiologyDepartment of MedicineMetroHealth Medical Center(MHMC)Case Western Reserve University(CWRU)School of MedicineClevelandOH 44109USA Cancer Genomics and Epigenomics Program Case Comprehensive Cancer CenterCase Western Reserve University(CWRU)ClevelandOH 44106USA Division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical Center(CCHMC)CincinnatiOH 45229USA Children’s Hospital of Fudan University Shanghai 201102China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Laboratory Animal Science(ILAS) Chinese Academy of Medical Science(CAMS)and Peking Union Medical College(PUMC)Beijing 100006China Department of Integrative Biology and Physiology University of Minnesota Medical SchoolMinneapolisMI 55455USA Institute of Medical Genetics Medical University of ViennaVienna 1040Austria Institute of Pathology Ludwig-Maximilians-University MunichMunich 80539Germany Institute of Biochemistry II University Hospital JenaJena 07743Germany Laboratory Animal Pathology University of Veterinary Medicine ViennaVienna 1210Austria Department of Pathology University of CincinnatiCincinnatiOH 45221USA Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266005China Department of Pathology Medical University of ViennaVienna 1040Austria Ludwig Boltzmann Institute for Cancer Research Vienna 1090Austria Medical University of Vienna Vienna 1040Austria Institute of Animal Breeding and Genetics University of Veterinary Medicine ViennaVienna 1210Austria Division of Experimental Hematology CCHMCCincinnatiOH 45229USA

CDC42 controls intestinal epithelial(IEC)stem cell(IESC)*** aberrant CDC42 initiates intestinal inflammation or neoplasia is *** utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and *** specimens were collected to determine the levels of CDC42 in IBD or colorectal ***42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient ***,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC *** studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD *** Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt *** Cdc42 depletion markedly enhanced irra-diation-or chemical-induced *** or inhibition of Cdc42 reduced colonic Lgr5+IESC *** conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal *** monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.

关键词： Cell divisioncycle 42(CDC42) Colitis Colorectal cancer(CRC) Inflammatory bowel diseases(IBD) Intestinal epithelial cell(IEC) Intestinal epithelial stem cell(IESC) Irradiation

进一步改善城市网-厂-水体系统升级改造和运行效率的四点看法

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给水排水 2024年

作者：曹业始 helmut Kroiss Markvan Loosdrecht Glen T.Daigger 中持新概念环境发展宜兴有限公司代尔夫特理工大学生物技术系维也纳工业大学水质和资源管理研究所密歇根大学土木和环境工程系

自2019年住建部等部委发布“城镇污水处理提质增效三年行动方案”以来，城市污水管网和污水处理厂在质量和运行效率方面都取得了显著的改善。去年住建部等部委进一步提出“深入打好城市黑臭水体治理攻坚战实施方案”，要求在以前工作... 详细信息

自2019年住建部等部委发布“城镇污水处理提质增效三年行动方案”以来，城市污水管网和污水处理厂在质量和运行效率方面都取得了显著的改善。去年住建部等部委进一步提出“深入打好城市黑臭水体治理攻坚战实施方案”，要求在以前工作的基础上，努力解决河流“雨后黑臭”和雨季河流断面水质下降问题，力争到2025年，进水BOD 浓度高于100毫克/升的城市生活污水处理厂规模占比达90%以上，城市生活污水集中收集率达到70%以上。水业界面临着防止雨后河流返黑和改善雨季河流水质等新任务。因此，结合近年来成绩?实践和欧美的经验教训，提出和讨论了与进一步改善网-厂-水体城市污水系统升级改造及运行效率相关的四个问题: 分流制管网有没有外(雨)水入侵和溢流? 污水厂的进水浓度应多高? 为什么部分污水厂需局部扩容?为什么污水管道中流速低于“自净流速”? 并在此基础上，对相关工作提出了建议。

关键词：城市污水系统污水管网外水入侵雨水溢流污水浓度污水厂扩容水环境容量

Unveiling the correlation between structural alterations and enhanced high-voltage cyclability in Na-deficient P3-type layered cathode materials via Li incorporation

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Electron 2024年第1期2卷 164-176页

作者： Xiaoxia Yang Suning Wang Hang Li Jochi Tseng Zhonghua Wu Sylvio Indris helmut Ehrenberg Xiaodong Guo Weibo Hua School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina School of Chemical Engineering Sichuan UniversityChengduChina Institute for Applied Materials(IAM) Karlsruhe Institute of Technology(KIT)Eggenstein‐LeopoldshafenGermany Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)KoutoSayo‐choSayo‐gunHyogoJapan Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina

With exceptional capacity during high-voltage cycling,P3-type Nadeficient layered oxide cathodes have captured substantial ***,they are plagued by severe capacity degradation over *** this study,tuning and optimizing the phase composition in layered oxides through Li incorporation are proposed to enhance the high-voltage *** structural dependence of layered Na_(2/3)LixNi_(0.25)Mn_(0.75)O_(2)þδoxides on the lithium content(0.0≤x≤1.0)offered during synthesis is investigated systematically on an atomic ***,increasing the Li content triggers the formation of mixed P2/O3-type or P3/P2/O3-type layered *** the voltage window is 1.5-4.5 V,P3-type Na2/3Ni_(0.25)Mn_(0.75)O_(2)(NL0.0NMO,R3m)material exhibits a sequence of phase transformations throughout the process of(de)sodiation,that is,O3⇌P3⇌O30⇌O3″.Such complicated phase transitions can be effectively suppressed in the Na2/3Li_(0.7)Ni_(0.25)Mn_(0.75)O_(2.4)(NL_(0.7)NMO)oxide with P2/P3/O3-type mixed ***,cathodes made of NL0.7NMO exhibit a substantially enhanced cyclic performance at high voltages compared to that of the P3-type layered NL0.0NMO ***,NL0.7NMO demonstrates an outstanding capacity retention of 98%after 10 cycles at 1 C within 1.5-4.5 V,much higher than that of NL0.0NMO(83%).This work delves into the intricate realm of bolstering the high-voltage durability of layered oxide cathodes,paving the way for advanced sodium-ion battery technologies.

关键词： high-voltage cycling Li incorporation phase transition sodium ion batteries triphasic composites

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A Stellar Life

Research in Astronomy and Astrophysics 2022年第11期22卷 1-13页

作者： helmut A.Abt Kitt Peak National Observatory Box 26732TucsonAZUnited States of America

In this autobiography of 70+yr of publishing astronomical papers,I summarize some of my major fields of research,such as(1)hfs in the solar spectrum,(2)the atmospheres of supergiants,(3)shock waves in Cepheids,(4)the Crab Nebula,(5)frequencies of binaries,(6)exoplanets,(7)starting Kitt Peak National Observatory,(8)catalogs,(9)China,(10)editing the Astrophysical Journal,(11)blue stragglers,(12)the Local Interstellar Bubble,and(13)publication studies.

关键词： biographies stars:general ISM:supernova remnants

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Bivalve hinge reveals the structural design of fatigue-resistant deformable ceramic materials

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中国科学:材料科学(英文版) 2023年第10期66卷 4141-4142页

作者： helmut Colfen Physical Chemistry University of KonstanzUniversitätsstraße 10Box 714 D-78457 KonstanzGermany

Sophisticated principles of design and material integration of biomaterials have long been a major source of inspiration for the development of artificial materials[1,2].In recent years,inspired by the multi-level architecture of biomineral materials such as shell nacre[3,4],tooth enamel[5],and bone[6],several strong and tough bioinspired structural materials like advanced ceramic composites and metallic alloys have been reported.

关键词： composites ceramic structural

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Charmonium spectroscopy and decay at CLEO-c

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Chinese Physics C 2010年第6期34卷 621-625页

作者： helmut Vogel Department of Physics Carnegie Mellon University

We report recent results on charmonium spectroscopy and decay from the CLEO-c experiment at the Cornell electrompositron storage ring accelerator, CESR. Most of the results are based on the analysis of 54 pb-1 of luminosity collected at the ψ（2S） resonance, corresponding to 27 M ψ（2S） decays. We concentrate on radiative decays of ψ（2S） and J/ψ, on two-body mesonic decay of XcJ, on hadronic decay of the he, and on higher multipoles in the two-photon cascade ψ（2S）→γχcJ, XcJ→γJ/ψ.

关键词： charmonium radiative decay two-body decay photon transitions higher multipoles

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Mimicking nature at multiple scales

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Nano Research 2022年第7期15卷 6447-6448页

作者： helmut Cölfen Physical Chemistry Department of ChemistryUniversity of KonstanzUniversitätsstraße 10Box 714D-78457 KonstanzGermany

Nacre-like ceramics have received an intense focus from the structural material community because the inherently low damage resistance of ceramics,which is a fatal deficiency of ceramics as reliable load-bearing *** can be improved through nacreinspired structural designs,i.e.,the“brick-and-mortar”structure with alternating soft and hard layers on the *** technologies have been developed to produce nacre-like ceramics,including freeze casting[1],magnetically assisted slip casting[2],laminating[3]and biomimetic mineralization[4].The obtained artificial ceramics can exhibit extraordinary anti-fracture behavior without introducing a high volume fraction of ductile nonceramic components causing a drastic strength decrease of the ***.

关键词： ceramics material. ceramic