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Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in southern China

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Journal of Traditional Chinese Medicine 2024年第3期44卷 586-594页

作者： YIN Lingjia sTALsBY LUNDBORG Cecilia WU Darong YANG Jinghua ALVEssON helle Molsted CAI Jianxiong LU Taoying XIE Qianwen MARRONE Gaetano Department of Global Public Health Karolinska InstitutetStockholm 17177Swede state Key Laboratory of Dampness syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Outcome Assessment Research Team in Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Health Construction Administration Centre Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine syndrome the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Pediatrics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

OBJECTIVE: To determine the effectiveness of pediatric Tuina(PT) in preventing recurrent acute respiratory tract infections(ARTIs) in children. METHODs: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. Children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes. REsULTs: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. Children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio(IRR): 0.59, 95% confidence interval(CI)(0.42-0.84)] and 2018 [IRR: 0.58, 95% CI(0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI(0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups. CONCLUsIONs: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

关键词： child massage pediatric Tuina respiratory tract infections

Phosphorus accumulation and leaching risk of greenhouse vegetable soils in southeast China

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Pedosphere 2021年第5期31卷 683-693页

作者： Yusef KIANPOOR KALKHAJEH Biao HUANG helle sORENsEN Peter EHOLM Hans Christian BHANsEN Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention School of Resources and EnvironmentAnhui Agricultural UniversityHefei 230036(China) Department of Plant and Environmental sciences University of CopenhagenThorvaldsensvej 40Frederiksberg DK-1871 C(Denmark) Key Laboratory of soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) sino-Danish Center for Education and Research(sDC) Beijing 101408(China) Data science Lab Department of Mathematical SciencesUniversity of CopenhagenUniversitetsparken 5DK-2100 Copenhagen East(Denmark)

Over-fertilization has caused significant phosphorus(P)accumulation in Chinese greenhouse vegetable production(GVP)*** study,for the first time,quantified profile P accumulation directly from soil P measurements,as well as subsoil P immobilization,in three alkaline coarse-textured GVP soil profiles with 5(s5),15(s15),and 30(s30)years of cultivation in Tongshan,southeast *** each profile,soil samples were collected at depths of 0-10(topsoil),10-20,20-40,40-60,60-80,and 80-100 *** accumulation was estimated from the difference in P contents between topsoil and parent material(60-100 cm subsoil).Phosphorus mobility was assessed from measurements of water-soluble P concentration(P_(sol)).Finally,P sorption isotherms were produced using a batch sorption experiment and fitted using a modified Langmuir *** total P contents of 1980(s5),3190(s15),and 2330(s30)mg kg^(-1) were measured in the topsoils versus lower total P content of approximately 600 mg kg^(-1) in the 80-100 cm ***,topsoil Psol values were very high,varying from 6.4 to 17.0 mg L^(-1).The estimated annual P accumulations in the topsoils were 397(s5),212(s15),and 78(s30)kg ha^(-1) year^(-1).sorption isotherms demonstrated the dominance of P desorption in highly P-saturated topsoils,whereas the amount of adsorbed P increased in the 80-100 cm subsoils with slightly larger P adsorption *** total P adsorption capacity of the 80-100 cm subsoils at a solution P concentration of0.5 mg L^(-1) was 15.7(s5),8.7(s15),and 6.5(s30)kg ha^(-1),demonstrating that subsoils were unable to secure P concentrations in leaching water below 0.5 mg L^(-1) because of their insufficient P-binding capacity.

关键词： greenhouse vegetable production Langmuir model P adsorption capacity P desorption P immobilization P mobility subsoil topsoil

Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4774-4782页

作者： Krisztina helle Anna ZsófiaÁrok Georgina Ollé Márk Antal András Rosztóczy Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Hungary Department of Operative and Esthetic Dentistry University of SzegedSzeged 6725Hungary

BACKGROUND Heartburn is identically the key symptom of both,gastroesophageal reflux disease(GERD)and functional heartburn(FHB),making the differential diagnosis *** manifestations of GERD can be easily examined;therefore,their exploration might be a cheap,widely available,and useful tool in the differentiation of GERD and *** To evaluate the prevalence of dental erosions(DE)and periodontal diseases(PD)in patients with heartburn and their association with GERD and *** A total of 116[M/F:51/65,mean age:54(17-80)years]consecutive patients with heartburn were enrolled for detailed esophageal function and orodental *** Dental disorders were detected in 89%(103/116).Patients with PD+DE had significantly more often pathologic reflux(90.0%vs 27.8%;Psophagitis scores(1.8 vs 0.9;Psignificantly different mean impedance curve(P=0.04)than those without any dental *** opposite approach established that patients with GERD had significantly higher prevalence of DE and PD,especially if both were present(28.9%vs 2.0%;Psevere PD(1.5 vs 1.0;Pstory of heartburn(15 years vs 9 years;Pse with *** The dental evaluation of patients with heartburn seems to be useful in the differential diagnosis of GERD and *** the studied parameters,the co-appearance of DE and PD seems to be the best predictor of GERD,whereas the absence of dental disorders was mostly observed in FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence Risk factors Dental erosion Periodontal diseases

sequencing of 231 forensic genetic markers using the Miseq FGxTM forensic genomics system-an evaluation of the assay and software

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Forensic sciences Research 2018年第2期3卷 111-123页

作者： Christian Hussing Christina Huber Rajmonda Bytyci helle s.Mogensen Niels Morling Claus Bφrsting section of Forensic Genetics Department of Forensic MedicineFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

The Miseq FGx^(TM) Forensic Genomics system types 231 genetic markers in one multiplex polymerase chain reaction (PCR) *** markers include core forensic short tandem repeats (sTRs) as well as identity,ancestry and phenotype informative short nucleotide polymorphisms (sNPs).In this work,the Miseq FGx^(TM) Forensic Genomics system was evaluated by analysing reproducibility,sensitivity,mixture identification and forensic phenotyping capabilities of the ***,the genotype calling of the Forenseq^(TM) Universal Analysis software was verified by analysing *** files from the Miseq FGx^(TM) platform using the softwares sTRinNGs and ***,the performance of the Miseq FGx^(TM) Forensic Genomics system was ***,locus and allele drop-outs were relatively frequent at six loci (two sTRs and four human identification sNPs) due to low read depth or skewed heterozygote balances,and the stutter ratios were larger than those observed with conventional sTR genotyping *** risk of locus and allele drop-outs increased dramatically when the amount of DNA in the first PCR was lower than 250 ***-person 50∶1 mixtures were identified as mixtures,whereas 100∶1 and 1000∶1 mixtures were not.Y-chromosomal short tandem repeats (Y-sTRs) alleles were detected in the 100∶1 and 1000∶1 female/male *** Forenseq^(TM) Universal Analysis software provided the data analyst with useful alerts that simplified the analysis of the large number of *** of the alerts were due to user-defined,locus-specific *** results shown here indicated that the default settings should be altered for some ***,recommended changes to the assay and software are discussed.

关键词： Forensic science forensic genetics next generation sequencing short tandem repeats single nucleotide polymorphisms Forenseq^(TM)DNA signature Prep Kit Miseq FGx^(TM)Forensic Genomics system

Intercropping effect on root growth and nitrogen uptake at different nitrogen levels

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Journal of Plant Ecology 2015年第4期8卷 380-389页

作者： Javier Ramirez-Garcia helle J.Martens Miguel Quemada Kristian Thorup-Kristensen Dpto.Producción Vegetal:Fitotecnia ETSI AgrónomosAvd.Complutense s/nUniversidad Politécnica de Madrid28040 MadridSpain Department of Plant and Environmental sciences University of CopenhagenHøjbakkegaards Alle 13DK-2630TaastrupDenmark

Aims Intercropping legumes and non-legumes may affect the root growth of both components in the mixture,and the non-legume is known to be strongly favored by increasing nitrogen(N)*** knowledge of how root systems affect the growth of the individual species is useful for understanding the interactions in intercrops as well as for planning cover cropping *** aim of this work was(i)to determine if different levels of N in the topsoil influence root depth(rD)and intensity of barley and vetch as sole crops or as an inter-cropped mixture and(ii)to test if the choice of a mixture or the N availability in the topsoil will influence the N uptake by deep *** In this study,we combined rhizotron studies with root extraction and species identification by microscopy with studies of growth,N uptake and 15N uptake from deeper soil layers,for studying the root interactions of root growth and N foraging for barley(Hordeum vul-gare l.)and vetch(Vicia sativa l.),frequently grown in mixtures as cover crops.N was added at 0(N0),50(N1)and 150(N2)kg N ha−*** roots discrimination relying on the anatomical and morphologi-cal differences observed between dicots and monocots proved to be a reliable method providing valuable data for the *** Findingsthe intercrop and the barley attained slightly higher root intensity(rI)and rD than the vetch,with values around 150 crosses m−1 and 1.4 m,respectively,compared to 50 crosses m−1 and 0.9 m for the *** deep soil layers,intercropping showed slightly larger rI values compared to the sole-cropped *** barley and the intercropping had larger root length density(r D)values(200-600 m m−3)than the vetch(25-130)at 0.8-1.2 m *** topsoil N supply did not show a clear effect on the rI,rD or r D;however,increasing topsoil N favored the proliferation of vetch roots in the intercropping at deep soil layers,with the barley:vetch root ratio ranging from 25 at N0 to 5 at *** N uptake of the barley was

关键词： grasses legumes cover crops crop mixture root discrimination labeled N

First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities

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World Journal of Gastroenterology 2022年第20期28卷 2227-2242页

作者： Milán szalai Krisztina helle Barbara Dorottya Lovász Ádám Finta András Rosztóczy László Oczella László Madácsy Department of Gastroenterology Endo-Kapszula Health Centre and Endoscopy UnitSzékesfehérvár 8000Hungary Department of Internal Medicine University of SzegedSzeged 6725Hungar

BACKGROUND While capsule endoscopy(CE)is the gold standard diagnostic method of detecting small bowel(sB)diseases and disorders,a novel magnetically controlled capsule endoscopy(MCCE)system provides non-invasive evaluation of the gastric mucosal surface,which can be performed without sedation or *** standard sBCE,passive movement of the CE may cause areas of the complex anatomy of the gastric mucosa to remain unexplored,whereas the precision of MCCE capsule movements inside the stomach promises better visualization of the entire *** To evaluate the Ankon MCCE system’s feasibility,safety,and diagnostic yield in patients with gastric or sB *** Of outpatients who were referred for sBCE,284(male/female:149/135)were prospectively enrolled and evaluated by *** stomach was examined in the supine,left,and right lateral decubitus positions without ***,all patients underwent a complete sBCE study *** gastric mucosa was explored with the Ankon MCCE system with active magnetic control of the capsule endoscope in the stomach,applying three standardized pre-programmed computerized algorithms in combination with manual control of the magnetic *** The urea breath test revealed Helicobacter pylori positivity in 32.7%of *** mean gastric and sB transit times with MCCE were 0 h 47 min 40 s and 3 h 46 min 22 s,*** average total time of upper gastrointestinal MCCE examination was 5 h 48 min 35 *** magnetic movement of the Ankon capsule through the pylorus was successful in 41.9%of *** diagnostic yield for detecting abnormalities in the stomach and sB was 81.9%(68.6%minor;13.3%major pathologies);25.8%of abnormalities were in the sB;74.2%were in the *** diagnostic yield for stomach/sB was 55.9%/12.7%for minor and 4.9%/8.4%for major *** MCCE is a feasible,safe diagnostic method for evaluating gastric mucosal lesions and is a promising non-invasive scree

关键词： Bowel diseases Capsule endoscopy Diagnostic techniques Gastrointestinal diseases Gastric mucosa Helicobacter pylori

Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary

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World Journal of Gastroenterology 2019年第42期25卷 6365-6372页

作者： Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika szekeres Orsolya Inczefi Georgina Ollé Krisztina helle Richárd Róka András Rosztóczy Division of Gastroenterology First Department of MedicineUniversity of SzegedSzeged 6720Hungary Department of Physiology University of SzegedSzeged 6720Hungary of Clinical Microbiology University of SzegedSzeged 6725Hungary Hungarian National Blood Transfusion service Szeged 6722Hungary

BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(***)infection in Western *** To obtain data regarding the prevalence of *** in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive *** One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this *** were tested for *** IgG antibody positivity via enzyme-linked immunosorbent *** analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also *** The overall seropositivity of *** was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUsION Although the prevalence of *** infection decreased in recent decades in southeast Hungary,it remains high in middle-aged rural *** accepted risk factors for *** positivity appeared to be valid for the studied population.

关键词： Helicobacter pylori Epidemiology Prevalence Central Europe Healthy volunteers Enzyme-linked immunosorbent assay Differences in urban and rural population

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评价性语用预设与话语主客体权力再分配机制

解放军外国语学院学报 2012年第5期35卷 13-17,127页

作者：叶惠珍 H.J.helle 华侨大学外语学院福建泉州362021 华侨大学哲学与社会发展学院福建厦门361021 德国慕尼黑大学社会学研究院巴伐利亚州慕尼黑80801

Martin&White的英语评价系统在词汇层对内嵌评价性预设的语篇进行了分析。支永碧等人则从句法和语篇层剖析了评价性预设与意识形态的关联性。不容忽视的是,在收缩性和扩展性两种话语路径以及现实生活的合力下,客体在"态度"倾向与"级差"... 详细信息

Martin&White的英语评价系统在词汇层对内嵌评价性预设的语篇进行了分析。支永碧等人则从句法和语篇层剖析了评价性预设与意识形态的关联性。不容忽视的是,在收缩性和扩展性两种话语路径以及现实生活的合力下,客体在"态度"倾向与"级差"等级上与主体产生程度不一的交互作用,导致双方评价体系融合或分离,并进一步引起话语权的二次分配,包括话语霸权的阶段性凝固和话语权均分趋势。由此可构建创新性的评价性语用预设与话语主客体权力再分配机制。

关键词：英语评价系统语用预设话语主体话语客体话语权话语霸权

Effectiveness of Grassed Buffer in Reducing spinosad Runoff: Real Data and FOCUs Output

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Journal of Environmental Protection 2020年第3期11卷 169-195页

作者： stefan Otto simone Gottardi Massimiliano Pasini Luca Menaballi Rita Bradascio Olivier de Cirugeda helle National Research Council Institute for Sustainable Plant Protection (IPSP-CNR) Agripolis Viale dell’Università 16 Legnaro (PD) Italy AGREA s.r.l. Centro studi Via Garibaldi 5/16 San Giovanni Lupatoto (VR) Italy International Centre for Pesticides and Health Risk Prevention Via G.B. Grassi Milano Italy Dow Agrosciences Italia srl Viale F. Albani Milano Italy Dow Agrosciences LLC Indianapolis IN USA

In Italy high-quality vines are grown on sloping fields where pesticide runoff to surface water is possible and vegetated buffers are suggested as mitigation measure. spinosad is an insecticide used to control pests in vineyards. For regulatory purposes, FOCUs modelling is used to calculate pesticides runoff reduction provided by a vegetated buffer, but there is an urgent need for field-based results. A field trial with artificial runoff was performed in september 2017 in Northern Italy to evaluate the efficiency of a grassed buffer to reduce spinosad runoff. Trial conditions were based on FOCUs scenarios but made worse to draw prudent conclusions. For the first time in Italy, the trial was conducted according to Good Laboratory Practices to increase reliability of results and reproducibility of the study for regulatory purposes. Five plots were tested, each simulating a grassed buffer of 12 m length on a slope of 10% - 13%. The artificial runoff was 200 mm in 3 hours and rainfall pre- and during runoff was 45 mm. Results show that the 12 m buffer completely retained runoff and effectively mitigated runoff concentration, and mean reduction of spinosad concentration was 59%. A width effect exists, and every 6.5 m of buffer reduces concentration by 50%. Comparison of field results with FOCUs modelling shows that both VFsMod and LM models provide acceptable estimation of runoff reduction for a 5 m buffer, while LM seems more precise. For a 10 m buffer the VFsMod is very accurate, while LM underestimates reduction observed in the field.

关键词： FOCUs Modeling Good Laboratory Practices Mitigation Runoff Vegetated Buffer Vineyards