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Sevoflurane induced Malignant Hyperthermia-a case report

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Sevoflurane Induced Malignant Hyperthermia-a case report

尿线粒体DNA拷贝数可识别高血压患者慢性肾损伤

2008年中华医学会全国麻醉学术年会

作者： Ching-Chung Shu Hung-jr Chiou To-Hang Or Ching-Hsiung Lin i-Wen Yin Department of Anesthesiology lo Tung poh Ai Hospital Lo TungI Lan

Malignant hyperthermia(MH)is a myopathy that features acute loss of control of intracellular calcium *** is an anesthesia associated disease of increased metabolism of skeletal muscle,and involving the use of volatile...

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中华高血压杂志 2016年第7期24卷 699-699页

作者： Eirin A Saad A Tang H Herrmann SM Woollard jr Lerman A Textor SC Lerman lo 赵狄练桂丽

在几种肾脏病模型中线粒体损伤会导致肾功能异常，但线粒体损伤是否与人类高血压相关仍不明确。死亡细胞释放的线粒体基因片段被认为是线粒体损伤的标志。该研究假设高血压与尿线粒体DNA拷贝数增加有关。研究人员在原发性高血压（n=25）、

关键词：线粒体损伤 DNA拷贝数高血压患者肾损伤慢性识别原发性高血压尿

肥胖合并高血压的非洲裔美国患者的肾小球高滤过与升高的尿线粒体DNA拷贝数相关

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中华高血压杂志 2018年第7期26卷 698-698页

作者： Eirin A Saad A Woollard jr Juncos LA Calhoun DA Tang H Lerman A Textor SC Lerman lo 陈云叶鹏

肾小球高滤过可能引起肥胖的非洲裔美国原发性高血压（obese African Americans essential hypertension,ObAAEH）患者肾脏疾病发病率高,但具体是如何造成肾脏损伤的机制尚未阐明。线粒体是高血压性肾脏损伤的重要决定因素,尿液中增加... 详细信息

肾小球高滤过可能引起肥胖的非洲裔美国原发性高血压（obese African Americans essential hypertension,ObAAEH）患者肾脏疾病发病率高,但具体是如何造成肾脏损伤的机制尚未阐明。线粒体是高血压性肾脏损伤的重要决定因素,尿液中增加的线粒体DNA（mitochondrial DNA,mtDNA）水平可能预示肾性线粒体损伤。

关键词：线粒体损伤 DNA拷贝数肾小球高滤过原发性高血压 hypertension 高血压性肾脏损伤患者美国

Advances and New Applications Using the Acousto-Optic Effect in Optical Fibers

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photonic Sensors 2013年第1期3卷 1-25页

作者： Alexandre A. p. pOHL Roberson A. OLiVEiRA Ricardo E. DA SiLVA Carlos A. F. MARQUES paulo de Tarso NEVES jr. Kevin COOK John CANNiNG Rogério N. NOGUEiRA3 Advanced Telecommunications Laboratory Federal University of Technology - Paraná Curitiba Brazil Volvo GTT Advanced Technology & Research Curitiba Brazil instituto de Telecomunicagōes P6lo de Aveiro 3810-193 Aveiro Portugal interdisciplinary photonics Labs School of Chemistry University of Sydney New South Wales 2006 Australia

This work presents a short review of the current research on the acousto-optic mechanism applied to optical fibers. The role of the piezoelectric element and the acousto-optic modulator in the excitation of flexural and longitudinal acoustic modes in the frequency range up to 1.2 MHz is highlighted. A combination of the finite elements and the transfer matrix methods is used to simulate the interaction of the waves with Bragg and long period gratings. Results show a very good agreement with experimental data. Recent applications such as the writing of gratings under the acoustic excitation and a novel viscometer sensor based on the acousto-optic mechanism are discussed.

关键词： Acousto-optics fiber gratings optical fibers optical sensors

Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

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Bone Research 2022年第3期10卷 548-564页

作者： Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-preiser Kerem Ben-Meir ivan Mikula jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash The Concern Foundation Laboratories at The Lautenberg Center for immunology and Cancer Research Israel-Canada Medical Research InstituteFaculty of MedicineThe Hebrew UniversityJerusalemIsrael Department of physiology and Cell Biology Ben-Gurion University of the NegevBeer-ShevaIsrael Division of proteomics of Stem Cells and Cancer German Cancer Research Center(DKFZ)HeidelbergGermany institute for Drug Research Faculty of MedicineThe Hebrew UniversityJerusalemIsrael Hebrew University-Hadassah School of Dental Medicine JerusalemIsrael Heidelberg University Medical FacultyHeidelbergGermany

Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(iBL)during chronic inflammatory ***,the specific OC precursors(OCps)responding to inflammatory cues and the underlying mechanisms leading to iBL are poorly *** identified two distinct OCp subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCps(iOCps)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCps(hOCps)which remained *** and proteomic characterization revealed that while iOCps were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced *** contrast,hOCps were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory *** derived from iOCps expressed higher levels of resorptive and metabolic proteins than those generated from hOCps,highlighting that different osteoclast populations are formed by distinct *** further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCp response during chronic ***,we demonstrated that the response of iOCps but not that of hOCps was abrogated in tnf-α^(-/-)mice,in correlation with attenuated *** findings suggest a central role for iOCps in iBL *** can serve as potential biomarkers for iBL detection and possibly as new therapeutic targets to combat iBL in a wide range of inflammatory conditions.

关键词： inflammation inflammatory osteoclast

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眼睑粘着综合征

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 28-29页

作者： Kortvelesy J.S. Buerger jr. G.F. 张自峰

To report on patients seen with an unusual condition affecting the eyelids. Th e syndrome manifests as a temporary adhesion which forms between the upper and l ower eyelid associated with laxity of the lower lid retractors. This results in a peculiar closure of the lids. Retrospective case reports. Charts of affected p atients were reviewed for their clinical histories, examination findings, external photographs, and the results of trea tment. Ten consecutive patients with the associated findings were reviewed. All cases were unilateral. Seven patients were Asian and three were Caucasian. Nine patients were symptomatic; of these, all were treated conservatively except for one who requested surgery. Two cases are described and photographs are shown. lo wer eyelid retractor laxity combined with a temporary adhesion between the upper and lower lid results in the clinical findings of Sticky Eyelid Syndrome.

关键词：下睑肌松弛高加索人亚洲人

impact of high dose vitamin C on platelet function

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World Journal of Critical Care Medicine 2017年第1期6卷 37-47页

作者： Bassem M Mohammed Kimberly W Sanford Bernard J Fisher Erika J Martin Daniel Contaifer jr Urszula Osinska Warncke Dayanjan S Wijesinghe Charles E Chalfant Donald F Brophy Alpha A Fowler Ⅲ Ramesh Natarajan Department of Clinical pharmacy Faculty of Pharmacy Cairo University Department of pharmacotherapy and Outcomes Science Virginia Commonwealth University Department of pathology Virginia Commonwealth University Division of pulmonary Disease and Critical Care Medicine De-partment of Internal Medicine Virginia Commonwealth University Research and Development Hunter Holmes Mc Guire Veterans Administration Medical Center the Department of Biochemistry and Molecular Biology the VCU Massey Cancer Center the VCU Institute of Molecular Medicine and the VCU Johnson Center for Critical Care and Pulmonary Research Virginia Commonwealth University

AiM To examine the effect of high doses of vitamin C(VitC) on ex vivo human platelets(pLTs).METHODS platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to:(1) normal saline(control);(2) 0.3 mmol/L VitC(lo VitC); or(3) 3 mmol/L VitC(Hi VitC, final concentrations) and stored appropriately. The Vit C additive was preservative-free buffered ascorbic acid in water, pH 5.5 to 7.0, adjusted with sodium bicarbonate and sodium hydroxide. The doses of Vit C used here correspond to plasma Vit C levels reported in recently completed clinical trials. prior to supplementation, a baseline sample was collected for analysis. pLTs were sampled again on days 2, 5 and 8 and assayed for changes in pLT function by: Thromboelastography(TEG), for changes in viscoelastic properties; aggregometry, for pLT aggregation and adenosine triphosphate(ATp) secretion in response to collagen or adenosine diphosphate(ADp); and flow cytometry, for changes in expression of CD-31, CD41 a, CD62 p and CD63. in addition, pLT intracellular Vit C content was measured using a fluorimetric assay for ascorbic acid and pLT poor plasma was used for plasma coagulation tests [prothrombin time(pT), partial thrombplastin time(pTT), functional fibrinogen] and Lipidomics analysis(UpLC ESi-MS/MS).RESULTS VitC supplementation significantly increased pLTs intracellular ascorbic acid levels from 1.2 mmol/L at baseline to 3.2 mmol/L(lo VitC) and 15.7 mmol/L(Hi VitC, p itC supplementation did not significantly change pT and pTT values, or functional fibrinogen levels over the 8 d exposure period(p > 0.05). pLT function assayed by TEG, aggregometry and flow cytometry was not significantly altered by lo or Hi VitC for up to 5 d. However, pLTs exposed to 3 mmol/L VitC for 8 d demonstrated significantly increased R and K times by TEG and a decrease in the α-angle(p in maximum amplitude associated with the Hi VitC compared to both baseline and d

关键词： platelet function Thromboelastography Flow cytometry platelet lipidomics Vitamin C

Fe2O3/pVDF光催化膜的制备及降解苯酚研究

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水处理技术 2020年第5期46卷 36-40页

作者：刘全諹齐明亮吕国琴马啸宙土鹏政周海祎甘肃省生态环境科学设计研究院 730020 甘肃省环境科学学会 730020 兰州森新环境科技有限公司甘肃兰州730000

采用具有压电效应的聚偏氟乙烯(pVDF)为基底,以窄带系的Fe2O3为吸光主体,制备出了Fe2O3/pVDF光催化膜,采用X射线衍射仪(XRD)、电化学测试等对其进行结构表征和光电性能测试,并用于光催化降解苯酚。结果表明,与单一的Fe2O3相比,复合薄膜... 详细信息

采用具有压电效应的聚偏氟乙烯(pVDF)为基底,以窄带系的Fe2O3为吸光主体,制备出了Fe2O3/pVDF光催化膜,采用X射线衍射仪(XRD)、电化学测试等对其进行结构表征和光电性能测试,并用于光催化降解苯酚。结果表明,与单一的Fe2O3相比,复合薄膜的光生电荷分离效率显著提高。这与pVDF受力情况下能够产生一定的负电压,进而诱导空穴向催化剂表面迁移有关。Fe2O3/pVDF表现出显著改善的光催化降解苯酚性能,在搅拌条件下,Fe2O3/pVDF薄膜样品的1 h内对苯酚去除率可达到59.8%,最高约为单一Fe2O3的2倍。所制备的光催化膜在5次循环使用后性能没有明显衰减,说明其在重复使用上具有优势。

关键词： Fe2O3 聚偏氟乙烯光催化膜光生电荷分离苯酚降解

大脑MRi检查结果和认知功能的关系:动脉粥样硬化风险的社区研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 49-50页

作者： Mosley jr. T.H. Knopman D.S. Catellier D.J. 张殿增 Department of Medicine (Geriatrics) University of Mississippi Medical Center 2500 North State Street Jackson MS 39216-4505 United States Dr.

Objective: To examine the association between prevalent cerebral abnormalitie s identified on MRi and cognitive functioning in a predominantly middle- aged, population- based study cohort. Methods: Cerebral MRi was performed on 1,538 in dividuals (aged 55 to 72) from the Atherosclerosis Risk in Communities (ARiC) co hort, with no history of stroke or TiA, at study sites in Forsyth County, NC, an d Jackson, MS. White matter hyperintensities (WMHs)- , ventricular size, and su lcal size were graded by trained neuroradiologists on a semiquantitative, 10- p oint scale. Cognitive functioning was assessed using the Delayed Word Recall Tes t (DWRT), Digit Symbol Substitution Test (DSST), and Word Fluency Test (WFT). Re sults: High ventricular grade was independently associated with significantly lo wer scores on the DWRT and DSST and greater risk (odds ratio [OR] 2.32, 95% co nfidence interval [Ci] 1.51 to 3.56) of impaired scores (i.e., percentile ) on the DWRT. High sulcal grade was associated with a modest decrement in score s on the DWRT. The presence of coexisting high grade WMHs and silent infarcts wa s independently associated with lower scores on all cognitive tests and greater risk of impaired functioning on the DSST (OR 2.91, 95% Ci: 1.23 to 6.89) and W FT (OR 2.28, 95% Ci 1.03 to 5.08). The presence of two or more high- grade ab normalities was as sociated with increased risk of impaired functioning on all cognitive tests ( DWRT: OR 2.23, 95% Ci 1.40 to 3.55; DSST: OR 2.06, 95% Ci 1.13 to 3.76; WFT: OR 2.07, 95% Ci 1.23 to 3.49) independent of multiple covariates and silent i nfarcts. Conclusion: Common changes in brain morphology are associated with dimi nished cognitive functioning in middle- aged and young- elderly individuals.

关键词：认知功能 MRi检查结果社区研究队列研究异常发生率中央沟放射科医师流畅度无症状点量表