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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 20-21页

作者： Chaoui R. heling k.- s. s.rioglu N. 高雪莲 Dept. of Obs.etrics.and Gynecology Char. Med. Sch. Humboldt University Schumannstr 20/21 D- 10098- Berlin Germany Dr.

The right s.bclavian artery aris.s.normally as.the firs. ves.el from the brachiocephalic artery of the aortic arch. An aberrant right s.bclavian artery aris.s.as.a s.parate ves.el from the aortic is.hmus.and cros.es.to the right, behind the trachea. This.variant is.pres.nt in s.bjects.with Down s.ndrome, an incidence between 19% and 36% was.reported. The purpos. of this.s.udy was.to as.es. the pos.ibility of the detection of an aberrant right s.bclavian artery in fetus.s.with Down s.ndrome. Fourteen cons.cutive fetus.s.with prenatally detected Down s.ndrome were examined between 18 and 33 week. of ges.ation. The pres.nce of an aberrant right s.bclavian artery was.determined by vis.alization of the trans.ers. 3- ves.el trachea view of the upper thorax with color Doppler ultras.nography. The right s.bclavian artery was.vis.alized in 100% of fetus.s.(14/14) with Down s.ndrome. An aberrant right s.bclavian artery was.identified in 35.7% of tris.my 21 fetus.s.(5/14). In 1 fetus. the aberrant right s.bclavian artery was.the only abnormal ultras.und finding. In 3 fetus.s. an aberrant right s.bclavian artery was.as.ociated with an intracardiac echogenic focus.plus.additional extracardiac mark.rs. In the fourth fetus. an aberrant right s.bclavian artery was.as.ociated with an atrioventricular s.ptal defect. All 9 fetus.s.with Down s.ndrome with a normal origin of the right s.bclavian artery had additional cardiac and/or extracardiac abnormalities. In 12 cas.s. pregnancy was.terminated; 2 fetus.s.were live born. This.preliminary s.udy s.gges.s.that the in utero identification of an aberrant right s.bclavian artery may be a new ultras.und mark.r to be found in fetus.s.with Down s.ndrome. Further s.udies.are required to as.es. the incidence of aberrant right s.bclavian artery in normal fetus.s.

关键词：唐氏综合征右锁骨下动脉影像学征象三体定期产前检查头臂动脉主动脉峡部超声学房室间隔缺损超声检查

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UNC13A Gene Brings.New Hope for ALs.Dis.as.-Modifying Drugs

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Neuros.ience Bulletin 2022年第11期38卷 1431-1434页

作者： Xi Chen heling Chu Yi Dong Department of Neurology National Center for Neurological DisordersHuashan HospitalFudan UniversityShanghai 200040China Department of Gerontology Shanghai Jiao Tong University Afliated Sixth People’s HospitalShanghai 200233China

Amyotrophic lateral s.leros.s.ALs.is.an idiopathic and fatal neurodegenerative dis.rder leading to progres.ive mus.le atrophy,dys.rthria,dys.hagia,and res.iratory failure[1].More than 80 different drugs.have been tes.... 详细信息

关键词： drugs res.iratory atrophy

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Holocene Mois.ure Variation Recorded by Aeolian s.nd-Palaeos.l s.quences.of the Gonghe Bas.n, Northeas.ern Qinghai-Tibetan Plateau, China

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Acta Geologica s.nica(Englis. Edition) 2020年第3期94卷 668-681页

作者： LIU Bing ZHAO Hui JIN heling CHEN Fahu k.y Laboratory of Des.rt and Des.rtification Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China k.y Laboratory of Wes.ern China's.Environmental s.s.ems Ministry of EducationLanzhou 73000China k.y Laboratory of Alpine Ecology Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

The northeas.ern Qinghai-Tibetan Plateau(QTP) of China is.located at the triple junction of the As.an winter and s.mmer mons.ons.and the wes.erlies. where paleoclimatic evolution has.an important s.ientific s.gnificance for recognizing the s.atial-temporal pattern of As.an mons.ons.in the pas. and predicting environmental change in the future. Nevertheles., the framework.of the Holocene mois.ure variation and related mechanis.s.remain controvers.al, owing to complex hydroclimatic conditions.triggered by the landform of the large mountain-arid bas.n. Here, we employed geochemical proxies.from typical aeolian s.nd-palaeos.l s.quences.in the Gonghe Bas.n, northeas.ern QTP, together with Optically s.imulated Lumines.ence(Os.) dating, to recons.ruct the pattern of effective mois.ure variation and as.ociated mechanis.s.in this.region. Our res.lts.indicate that the regional effective mois.ure was.at its.lowes. until 9–8 k., and approached a maximum during 8–4/3 k. of the middle Holocene. Afterwards. the climate became relatively dry in general, but with a trans.ent humid interval around 2–1 k.. Our geochemical evidence indicates.that the dry early Holocene probably can be attributed to a s.rong winter mons.on forced by remnant ice s.eet, combined with the high evaporation caus.d by s.lar ins.lation. Als., s.ifts.of humid-dry are clos.ly link.d to the As.an s.mmer mons.onal s.rength and therefore the balance of evaporation-precipitation in the middle and late Holocene. Thus. the pattern of the Holocene effective mois.ure variation is.characterized as.the ‘mons.on model’ in a clos.d intermontane arid and s.mi-arid bas.n near the wes.ern As.an mons.onal limit.

关键词： effective mois.ure geochemical analys.s aeolian depos.ts Holocene Gonghe Bas.n

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Geochemical weathering of aeolian s.nd and its.palaeoclimatic implications.in the Mu Us.Des.rt,northern China,s.nce the Late Holocene

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Journal of Arid Land 2016年第5期8卷 647-659页

作者： LIU Bing JIN heling s.N Zhong ZHAO s.uang s.ate k.y Laboratory of Earth s.rface Proces.es.and Res.urce Ecology Beijing Normal University k.y Laboratory of Des.rt and Des.rtification Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences k.y Laboratory of Wes.ern China’s.Environmental s.s.em (Minis.ry of Education) Lanzhou University

In the s.mi-arid and arid regions.of northern China,geochemical behavior of the aeolian depos.t is.clos.ly related to climatic and environmental changes.which was.us.d to recons.ruct the pas. his.ory of environmental evolution and pos.ibly forcing ***,the related res.lt was.s.ill s.arce due to the lack.of detailed geochemical analys.s.res.lts.in the des.rt *** the pres.nt s.udy,we s.s.ematically analyzed the geochemical components.and parameters.of the paleo-aeolian s.nd dune and modern mobile s.nd depos.ts.in the Mu Us.Des.rt and dis.us. the climatic variation inferred from the paleo-aeolian s.nd dune during the pas. 4.2 k. *** res.lts.indicated that （1） geochemical compos.tion of the s.ndy depos.ts.were dominated by s.O_2,Al_2O_3 and Na_2O and the depos.ts.probably originated from the wides.read upper continental crus. （UCC） and were formed by long-term weathering,trans.ort and re-depos.tion;（2） thes. s.ndy depos.ts.were s.bjected to weak.r weathering or uneven weathering under cold and dry conditions.and had highly s.milar material s.urces.and degrees.of weathering and leaching in general;and （3） the direct Os. （Optically s.imulated Lumines.ence） dating ages.and geochemical parameters.from the palaeos.l-aeolian s.nd dune indicated that the regional climate change experienced s.veral typically cold and warm *** intervals.are 4.2,2.8 k. BP and Little Ice Age and Medieval Warm Period,which probably attributed to periodic variations.of the As.an s.mmer mons.onal s.rength and cold events.of the northern Atlantic Ocean in low and high latitudes.of the Northern *** res.lts.s.gges. that the development of the s.nd dune in the Mu Us.Des.rt provided a s.itable archive for unders.anding the pas. local climatic change,which is.link.d to the global climatic change.

关键词： climatic change geochemical component weathering degree Late Holocene Mu Us.Des.rt

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Us.ng Healthcare Big Data Analytics.to Improve Women’s.Health:Benefits.Challenges.and Pers.ectives

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China CDC week.y 2024年第10期6卷 173-174页

作者： heling Bao Hui Liu Linhong Wang Ins.itute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina National Center for Chronic and Non-communicable Dis.as. Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Women’s.Health Care Branch Chinese Preventive Medicine AssociationBeijingCh

Women’s.health is.of paramount importance for the attainment of the s.s.ainable Development Goals.s.Gs.and Healthy China 2030,encompas.ing reproductive health and phys.cal and mental *** multifaceted concept of healt... 详细信息

关键词： s.s.ainable maternal Analytics

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Relations.ip Between Hematoma Expans.on Induced by Hypertens.on and Hyperglycemia and Blood-brain Barrier Dis.uption in Mice and Its.Pos.ible Mechanis.:Role of Aquaporin-4 and Connexin43

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Neuros.ience Bulletin 2020年第11期36卷 1369-1380页

作者： heling Chu Zidan Gao Chuyi Huang Jing Dong Yuping Tang Qiang Dong Department of Neurology Huashan HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200040China Department of Neurology North Huashan HospitalFudan UniversityShanghai 201907China Department of Neurology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Neurology Shanghai East HospitalTongji University School of MedicineShanghai 200120China

We aimed to s.lect an optimized hematoma expans.on(HE)model and inves.igate the pos.ible mechanis. of blood-brain barrier(BBB)damage in *** res.lts.s.owed that HE occurred in the group with hypertens.on combined with hyperglycemia(HH-HE)from3 to 72 h after intracerebral hemorrhage;this.was.accompanied by neurological deficits.and hardly influenced the s.rvival *** receiver operating characteris.ic curve s.gges.ed the criterion for this.model was.hematoma volume expans.on≥45.0%.Meanwhile,HH-HE aggravated BBB dis.uption.A protector of the BBB reduced HH-HE,while a BBB dis.uptor induced a further ***-4(AQP4)k.ock.out led to larger hematoma volume and more s.vere BBB ***,hematoma volume and BBB dis.uption were reduced by multiple connexin43(Cx43)inhibitors.in the wild-type group but not in the AQP4 k.ock.out *** conclus.on,the optimized HE model is.induced by hypertens.on and hyperglycemia with the criterion of hematoma volume expanding≥45.0%.HH-HE leads.to BBB dis.uption,which is.dependent on AQP4 and Cx43.

关键词： Intracerebral hemorrhage Hematoma expans.on Animal model Blood-brain barrier Aquaporin-4 Connexin43

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s.atiotemporal mapping of(ultra‐)mafic magmatic mine areas.Implications.of economic and political realities.in China

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Deep Underground s.ience and Engineering 2024年第1期3卷 91-102页

作者： heling Li Liang Tang Tim T.Werner Zhengmeng Hou Fan Meng Jingjing Li College of Earth s.iences Chengdu University of TechnologyChengduChina Ins.itute of s.bs.rface Energy s.s.ems Clausthal University of TechnologyClausthal ZellerfeldGermany s.hool of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

The s.atiotemporal extens.on/expans.on of mine areas.is.affected by multiple *** far,very little has.been done to examine the interaction between mine areas.and political or economic ***(ultra‐)mafic magmatic mines.in China played a s.ecific role in s.pporting national development and providing an ideal res.arch s.bject for monitoring their *** this.s.udy,remote s.ns.ng and mining‐related GIs.data were us.d to identify and analyze 1233(ultra‐)mafic magmatic mine area polygons.in China,which covered approximately 322.96 k.2 of land and included a V–Ti–Fe mine,a copper–nick.l mine,a chromite mine,an as.es.os.mine,and a diamond *** was.found that(1)the areal expans.on of mines.is.s.gnificantly related to the mine types.perimeter,topography,and population dens.ty.(2)The mine area variation als. reflects.mark.t and policy *** temporal expans.on of the mine area from 2010 to 2020 followed an s.s.aped pattern(with the turning point occurring in 2014),clos.ly related to iron overcapacity and tightened mining policies.(3)The complexity(D)of the mine area may reflect mine des.gn and excavation *** be s.ecific,lower D indicates.early‐s.age or artis.nal/s.all‐s.ale mining,whereas.higher D repres.nts.large‐s.ale *** s.udy demons.rates.that the detailed mapping of mine land can s.rve as.an indicator to implement miningrelated mark.t and policy ***(ultra‐)mafic mines.area data s.t can be acces.ed at https.//***/record/7636616#.Y-p0uXaZOa0.

关键词： complexity mine area mining and s.cioeconomic interaction s.atiotemporal dis.ribution (ultra‐)mafic magmatic mine

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Differences.in MITF gene expres.ion and his.ology between albino and normal s.a cucumbers.(Apos.ichopus.japonicus.s.lenk.)

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Chines. Journal of Oceanology and Limnology 2012年第1期30卷 80-91页

作者： ZHAO heling YANG Hongs.eng ZHAO Huan LIU s.ilin WANG Tianming Graduate Univers.ty of Chines. Academy of s.iences Beijing 100049China k.y Laboratory of Marine Ecology and Environmental s.iences Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Albino Apos.ichopus.japonicus.occur both in the wild and in captivity. The offs.ring of albino A. japonicus.als. s.ffer from albinis.. The formation of melanin in the melanocytes.is.dependant on microphthalmia-as.ociated trans.ription factor (MITF). To inves.igate the role of MITF in controlling albinis., we cloned the full-length MITF cDNA from A. japonicus.and compared MITF mRNA expres.ion in albino and normal A. japonicus. In addition, we us.d light and electron micros.opy to compare his.ological s.mples.of normal and albino A. japonicus. The body wall of albino adults.was.characterized by s.gnificantly lower levels.of MITF expres.ion and lower numbers.of epidermal melanocytes. which als. contained les. melanin. In albino juvenile offs.ring, MITF expres.ion levels.were s.gnificantly lower 32 d after fertilization and there were fewer, and les. developed, epidermal melanocytes. Thus. we conclude that albino A. japonicus.have fewer melanocytes.and a reduced ability to s.nthes.ze melanin, lik.ly becaus. of lower expres.ion of MITF.

关键词： microphthalmia-as.ociated trans.ription factor (MITF) melanocyte melanos.me melanin Apos.ichopus.japonicus

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s.rayable and rapidly bondable phenolic-metal coating for vers.tile oil/water s.paration

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Frontiers.of Materials.s.ience 2019年第2期13卷 193-205页

作者： heling GUO Xiaolin WANG Xie LI Xiulan ZHANG Xinghuan LIU Yu DAI Rongjie WANG Xuhong GUO Xin JIA s.hool of Chemis.ry and Chemical Engineering/k.y Laboratory for Green Proces.ing of Chemical Engineering of Xinjiang Bingtuan Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan Shihezi University Shihezi 832003 China s.ate k.y Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China

Phenolic-metal complexation coatings.have been dis.overed to be a univers.l route for the depos.tion of multifunctional coatings. However, mos. complexation coatings.have been prepared by the immers.on method, which limits.their practical large-s.ale application. Herein, we des.ribe a facile and green engineering s.rategy that involves.s.raying phenolic compound and metal ions.on s.bs.rate to form in-s.tu complexation coating with different coordination s.ates. The coating is.formed within minutes.and it can be achieved in large s.ale by the s.ray method. The pyrogallol-Fem complexation coating is.prepared at pH 7.5, which cons.s.s.predominantly of bis.oordination complexation with a s.all amount of tris.coordination complexation. It dis.lays.that the water contact angle is.near zero due to the generation of rough hierarchical s.ructures.and mas.ive hydroxyl groups. The s.perhydrophilic cotton res.lting from the depos.tion of the pyrogallol-Fe^Ⅲ complexation can s.parate oil/water mixtures.and s.rfactant-s.abilized oil-in-water emuls.ons.with high s.paration efficiency. The formation of the phenolic-metal complexation coating by us.ng s.ray technique cons.itutes.a cos.-effective and environmentally friendly, s.rategy with potential to be applied for large-s.ale s.rface engineering proces.es.and green oil/water s.paration.

关键词： s.ray coating in-s.tu complexation s.perhydrophilicity oil/water s.paration s.rface engineering Contents 1 Introduction

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The correlation of miRNA expres.ion and tumor mutational burden in uterine corpus.endometrial carcinoma

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BIOCELL 2023年第6期47卷 1353-1364页

作者： YANYA CHEN HONGYUAN WU RUIs. ZHOU heling DONG XUEFANG ZHANG XUEWEI WU WENs.AN CHEN YANTING YOU YIFEN WU Department of Gynaecology Affiliated Dongguan People’s HospitalSouthern Medical UniversityDongguan523009China Department of Radiation Oncology Affiliated Dongguan People’s HospitalSouthern Medical UniversityDongguan523009China Department of Oncology Affiliated Dongguan People’s HospitalSouthern Medical UniversityDongguan523009China s.hool of s.orts.Education Jinan UniversityGuangzhou510632China s.ndrome Laboratory of Integrated Chines. and Wes.ern Medicine School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou510515China

Back.round:The relations.ip between microRNA(miRNA)expres.ion patterns.and tumor mutation burden(TMB)in uterine corpus.endometrial carcinoma(UCEC)was.inves.igated in this.***:The UCEC datas.t from The Cancer Genome Atlas.TCGA)databas. was.us.d to identify the miRNAs.that differ in expres.ion between high TMB and low TMB s.mple *** total s.mple s.ts.were divided into a training s.t and a tes. *** levels.were predicted us.ng miRNA-bas.d s.gnature clas.ifiers.developed by Las.o Cox *** s.ts.were us.d to validate the *** s.udy inves.igated the relations.ip between a miRNA-bas.d s.gnature clas.ifier and three immune check.oint molecules.programmed cell death protein 1[PD-1],programmed cell death ligand 1[PD-L1],cytotoxic T lymphocyte-as.ociated antigen 4[CTLA-4]).For the miRNA-bas.d s.gnature clas.ifier,functional enrichment analys.s.was.performed on the *** analys.s.of the relations.ip between PD-1,PD-L1,and CTLA-4 immune check.oint genes.was.carried out us.ng the miRNA-bas.d s.gnature ***:We identified 27 differentially expres.ed miRNAs.in miRNA-bas. *** predicting the TMB level,27-miRNA-bas.d s.gnature clas.ifiers.had accuracies.of 0.8689 in the training cohort,0.8276 in the tes. cohort,and 0.8524 in the total *** correlation between the miRNA-bas.d s.gnature clas.ifier and PD-1 was.negative,while the correlation between PD-L1 and CTLA4 was.*** on the miRNA profiling des.ribed above,we validated the expres.ion levels.of 9 miRNAs.in clinical s.mples.by quantitative revers. trans.ription PCR(qRT-PCR).Four of them were highly expres.ed and many cancer-related and immune-as.ociated biological proces.es.were link.d to thes. 27 ***,the developed miRNA-bas.d s.gnature clas.ifier was.correlated with TMB levels.that could als. predict TMB levels.in UCEC ***:In this.s.udy,we inves.igated the relations.ip between a miRNAbas.d s.gnature clas.ifier and TMB levels.in

关键词： Tumor mutation burden Uterine corpus.endometrial carcinoma miRNA-bas.d s.gnature clas.ifiers Immune check.oints

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