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Harrogate consensus agreement:Cycling-specific sport-related concussion

Sports Medicine and Health Science 2021年第2期3卷 110-114页

作者： Jeroen Swart Xavier Bigard Thomas Fladischer Roger Palfreeman helge riepenhof Nigel Jones Neil Heron Division of Exercise&Sports Medicine University of Cape TownFIMS Scientific CommissionUAE Tem EmiratesWorld Tour Professional Cycling TeamUnited Arab Emirates Medical Director International Cycling UnionAigleSwitzerland LKH Hochsteiermark Orthopedics&Traumatology Bruck/MurAustria Team Mitchelton Scott Australia Department of Sports and Rehabilitation Medicine BG Trauma Hospital of HamburgGermany Head of Medical British CyclingUK School of Medicine Dentistry and Biomedical Sciences Queen's UniversityBelfast.Team IneosWorld Tour Professional Cycling TeamUK

Sport-related concussion(SRC)is a common and increasingly recognised sport-related injury and accounts for between 1%and 9%of all cycling-specific *** has been drawn to the difficulty in managing suspected SRC in a fast-paced sport such as road cycling,particularly the lack of an effective and time-efficient assessment protocol.A meeting on cycling SRC was convened in Harrogate,United Kingdom,in an attempt to resolve this *** aim was to agree on standard terminology,definitions,diagnostic protocols and return to play protocols for the various differing codes of cycle *** experts in the field of cycling medicine were invited to participate by the International Cycling Union and are the authors of this *** panel recognised that the sport of cycling consists of varied disciplines,some of which provide a setting in which a sideline assessment is possible which is in line with the Berlin Consensus ***,other disciplines provide challenging circumstances where health care providers have limited access to participants and where participants are unable to discontinue participation and participate in sideline ***-based discipline-specific protocols and guidelines which recognise the limitations posed by these circumstances,but nevertheless,improve on the current situation specific to the sport of cycling are presented as a potential solution to the unique chal-lenges posed by these cycling disciplines.

关键词： Sport-related concussion Cycling

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国际自行车联合会哈罗盖特共识:自行车运动中的脑震荡

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成都体育学院学报 2021年第5期47卷 140-142页

作者： Jeroen Swart Xavier Bigard Thomas Fladischer Roger Palfreeman helge riepenhof Nigel Jones Neil Heron 开普敦大学运动医学部开普敦南非7725 国际自行车联盟艾格勒瑞士1860 霍赫施泰尔马克州立医院骨伤科穆尔河畔布鲁克奥地利8600 米切尔顿-斯科特车队澳大利亚 BG汉堡创伤医院运动与康复医学科汉堡德国21033 英国自行车协会英国贝尔法斯特女王大学医学牙医及生物医用科学学院贝尔法斯特英国BT97BL

运动相关脑震荡(Sport-related concussion,SRC)是一种常见且逐渐被大家重视的运动相关损伤,大约占自行车全部运动损伤的1%~9%。在快节奏的运动(如公路自行车项目)中如何管理SRC已经得到关注,特别是在缺少省时有效检测方案的情况下。近... 详细信息

运动相关脑震荡(Sport-related concussion,SRC)是一种常见且逐渐被大家重视的运动相关损伤,大约占自行车全部运动损伤的1%~9%。在快节奏的运动(如公路自行车项目)中如何管理SRC已经得到关注,特别是在缺少省时有效检测方案的情况下。近期在英国哈罗盖特召开的自行车运动SRC专家会议正努力解决该问题。该会议旨在将不同自行车项目下的标准术语、定义、诊断方案以及重返赛场标准达成一致。国际自行车联盟邀请了7位自行车医学专家(即本文作者)出席了本次会议。专家组认为,自行车运动涵盖了不同的项目,其中的一些项目具备场边评估的环境条件,符合柏林共识。然而,其他项目的场地环境受限于医疗保障人员与参赛者之间的接触困难,或参赛者不能够中止运动以进行场边评估,使得场边评估具有一定难度。基于共识的项目特异性方案和指南提出了现状的局限。尽管如此,此指南仍为当前不同自行车运动项目带来的独特挑战提供了潜在的解决方案,以改善自行车运动的现状。

关键词：运动相关脑震荡自行车运动国际自行车联合会

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Relative Impacts of Sea Ice Loss and Atmospheric Internal Variability on the Winter Arctic to East Asian Surface Air Temperature Based on Large-Ensemble Simulations with NorESM2

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Advances in Atmospheric Sciences 2024年第8期41卷 1511-1526页

作者： Shengping HE helge DRANGE Tore FUREVIK Huijun WANG Ke FAN Lise Seland GRAFF Yvan J.ORSOLINI Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5020Norway Nansen Environmental and Remote Sensing Center Bergen 5007Norway Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 211544China Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 511458China School of Atmospheric Science Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Norwegian Meteorological Institute Oslo 0313Norway Norwegian Institute for Air Research Kjeller 2007Norway

To quantify the relative contributions of Arctic sea ice and unforced atmospheric internal variability to the “warm Arctic, cold East Asia”(WACE) teleconnection, this study analyses three sets of large-ensemble simulations carried out by the Norwegian Earth System Model with a coupled atmosphere–land surface model, forced by seasonal sea ice conditions from preindustrial, present-day, and future periods. Each ensemble member within the same set uses the same forcing but with small perturbations to the atmospheric initial state. Hence, the difference between the present-day(or future) ensemble mean and the preindustrial ensemble mean provides the ice-loss-induced response, while the difference of the individual members within the present-day(or future) set is the effect of atmospheric internal variability. Results indicate that both present-day and future sea ice loss can force a negative phase of the Arctic Oscillation with a WACE pattern in winter. The magnitude of ice-induced Arctic warming is over four(ten) times larger than the ice-induced East Asian cooling in the present-day(future) experiment;the latter having a magnitude that is about 30% of the observed cooling. Sea ice loss contributes about 60%(80%) to the Arctic winter warming in the present-day(future) experiment. Atmospheric internal variability can also induce a WACE pattern with comparable magnitudes between the Arctic and East Asia. Ice-lossinduced East Asian cooling can easily be masked by atmospheric internal variability effects because random atmospheric internal variability may induce a larger magnitude warming. The observed WACE pattern occurs as a result of both Arctic sea ice loss and atmospheric internal variability, with the former dominating Arctic warming and the latter dominating East Asian cooling.

关键词： Arctic sea ice loss warm Arctic–cold East Asia atmospheric internal variability large-ensemble simulation NorESM2 PAMIP

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Functional dissimilarity in mixed forests promotes stem radial growth by mitigating tree water deficit

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National Science Review 2024年第3期11卷 55-57页

作者：张宏图艾尤尔.亥热提白云旻郭焱培李珊 Bernhard Schmid helge Bruelheide 马克平唐志尧 Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of Ministry of EducationPeking University College of Geography and Tourism Xinjiang Normal University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences Department of Geography Remote Sensing LaboratoriesUniversity of Zurich Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-Wittenberg German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig

Tree growth is a key component of forest ecosystem functioning and is wellknown to be limited by water availability[1]. It is acknowledged that composition and diversity of co-occurring tree species can mitigate the influence of drought on tree growth through the resource complementarity for water use via niche partitioning and facilitation between different species [2,3].

关键词： RESILIENCE

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A Possible Feedback Mechanism Involving the Arctic Freshwater,the Arctic Sea Ice,and the North Atlantic Drift

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Advances in Atmospheric Sciences 2004年第5期21卷 784-801页

作者： Odd helge OTTER helge DRANGE Nansen Environmental and Remote Sensing Center Edv. Griegsvei 3A5059 Bergen Bjerknes Centre for Climate Research Allégt. 55 5007 BergenNansen Environmental and Remote Sensing Center Edv. Griegsvei 3A5059 Bergen Bjerknes Centre for Climate Research Allégt. 55 5007 BergenGeophysical Institute University of Bergen Allégt. 70 5007 Bergen Nansen-Zhu International Research Centre Beijing 100029

Model studies point to enhanced warming and to increased freshwater ?uxes to high northern latitudes in response to global warming. In order to address possible feedbacks in the ice-ocean system in response to such changes, the combined e?ect of increased freshwater input to the Arctic Ocean and Arctic warming—the latter manifested as a gradual melting of the Arctic sea ice—is examined using a 3-D isopycnic coordinate ocean general circulation model. A suite of three idealized experiments is carried out: one control integration, one integration with a doubling of the modern Arctic river runo?, and a third more extreme case, where the river runo? is ?ve times the modern value. In the two freshwater cases, the sea ice thickness is reduced by 1.5–2 m in the central Arctic Ocean over a 50-year period. The modelled ocean response is qualitatively the same for both perturbation experiments: freshwater propagates into the Atlantic Ocean and the Nordic Seas, leading to an initial weakening of the North Atlantic Drift. Furthermore, changes in the geostrophic currents in the central Arctic and melting of the Arctic sea ice lead to an intensi?ed Beaufort Gyre, which in turn increases the southward volume transport through the Canadian Archipelago. To compensate for this southward transport of mass, more warm and saline Atlantic water is carried northward with the North Atlantic Drift. It is found that the increased transport of salt into the northern North Atlantic and the Nordic Seas tends to counteract the impact of the increased freshwater originating from the Arctic, leading to a stabilization of the North Atlantic Drift.

关键词： Arctic Ocean freshwater seaice North Atlantic Drift

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The Effect of Diapycnal Mixing on the Ventilation and CFC-11 Uptake in the Southern Ocean

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Advances in Atmospheric Sciences 2004年第5期21卷 755-766页

作者： helge DRANGE Nansen Environmental and Remote Sensing Center Bergen Norway Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029Bjerknes Centre for Climate Research Bergen Norway Geophysical Institute University of Bergen Bergen Norway

The Miami Isopycnic Coordinate Ocean Model (MICOM) is used to investigate the effect of diapycnal mixing on the oceanic uptake of CFC-11 and the ventilation of the surface waters in the Southern Ocean (south of 45°S). Three model experiments are performed: one with a diapycnal mixing coefficientK d (m2 s?1) of 2 × 10?7/N (Expt. 1), one withK d = 0 (Expt. 2), and one withK d = 5 × 10?8/N (Expt. 3),N (s?1) is the Brunt-V?is?l? frequency. The model simulations indicate that the observed vertical distribution of CFC-11 along 88°W (prime meridian at 0°E) in the Southern Ocean is caused by local ventilation of the surface waters and westward-directed (eastward-directed) isopycnic transport and mixing from deeply ventilated waters in the Weddell Sea region. It is found that at the end of 1997, the simulated net ocean uptake of CFC-11 in Expt. 2 is 25% below that of Expt. 1. The decreased uptake of CFC-11 in the Southern Ocean accounts for 80% of this difference. Furthermore, Expts. 2 and 3 yield far more realistic vertical distributions of the ventilated CFC-waters than Expt. 1. The experiments clearly highlight the sensitivity of the Southern Ocean surface water ventilation to the distribution and thickness of the simulated mixed layer. It is argued that inclusion of CFCs in coupled climate models could be used as a test-bed for evaluating the decadal-scale ocean uptake of heat and CO2.

关键词： chlorofluorocarbons CFC-11 diapycnal mixing ocean modelling ocean ventilation Southern Ocean transient tracers

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Simulating the Effects of the 1991 Mount Pinatubo Volcanic Eruption Using the ARPEGE Atmosphere General Circulation Model

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Advances in Atmospheric Sciences 2008年第2期25卷 213-226页

作者： Odd helge OTTER Nansen Environmental and Remote Sensing Center Thorm0hlensgt. 47 5006 Bergen Norway Bjerknes Centre for Climate Research Allegt. 55 5007 Bergen Norway

The climate changes that occured following the volcanic eruption of Mount Pinatubo in the Phillippines on 15 June 1991 have been simulated using the ARPEGE atmosphere general circulation model （AGCM）. The model was forced by a reconstructed spatial-time distribution of stratospheric aerosols intended for use in long climate simulations. Four statistical ensembles of the AGCM simulations with and without volcanic aerosols over a period of 5 years following the eruption have been made, and the calculated fields have been compared to available observations. The model is able to reproduce some of the observed features after the eruption, such as the winter warming pattern that was observed over the Northern Hemisphere （NH） during the following winters. This pattern was caused by an enhanced Equator-to-pole temperature gradient in the stratosphere that developed due to aerosol heating of the tropics. This in turn led to a strengthening of the polar vortex, which tends to modulate the planetary wave field in such a way that an anomalously positive Arctic Oscillation pattern is produced in the troposphere and at the surface, favouring warm conditions over the NH. During the summer, the model produced a more uniform cooling over the NH.

关键词： volcanic aerosol climate Mount Pinatubo Arctic Oscillation

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A Preliminary Study on the Relationship Between Arctic Oscillation and Daily SLP Variance in the Northern Hemisphere During Wintertime

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Advances in Atmospheric Sciences 2005年第3期22卷 313-327页

作者：龚道溢 helge DRANGE Key Laboratory of Environmental Change and Natural DisasterCollege of Resources Science and Technology Beijing Normal University Beijing 100875 Bjerknes Centre for Climate Research/Nansen Environmental and Remote Sensing CenterUniversity of Bergen Norway

In the present study, the authors investigated the relationship between the Arctic Oscillation (AO) and the high-frequency variability of daily sea level pressures in the Northern Hemisphere in winter (November through March), using NCEP/NCAR reanalysis datasets for the time period of 1948/49-2000/01. High-frequency signals are defined as those with timescales shorter than three weeks and measured in terms of variance, for each winter for each grid. The correlations between monthly mean AO index and high-frequency variance are conducted. A predominant feature is that several regional centers with high correlation show up in the middle to high latitudes. Significant areas include mid- to high-latitude Asia centered at Siberia, northern Europe and the middle-latitude North Atlantic east of northern Africa. Their strong correlations can also be confirmed by the singular value decomposition analysis of covariance between mean SLP and high-frequency variance. This indicates that the relationship of AO with daily Sea Level Pressure (SLP) is confined to some specific regions in association with the inherent atmospheric dynamics. In middle-latitude Asia, there is a significant (at the 95% level) trend of variance of-2.26% (10 yr)-1. Another region that displays a strong trend is the northwestern Pacific with a significant rate of change of 0.80% (10 yr)-1. If the winter of 1948/49, an apparent outlier, is excluded, a steady linear trend of +1.51% (10 yr)-1 shows up in northern Europe. The variance probability density functions (PDFs) are found to change in association with different AO phases. The changes corresponding to high and low AO phases, however, are asymmetric in these regions. Some regions such as northern Europe display much stronger changes in high AO years, whereas some other regions such as Siberia show a stronger connection to low AO conditions. These features are supported by ECMWF reanalysis data. However, the dynamical mechanisms involved in the AO-high fr

关键词： Arctic Oscillation sea level pressure (SLP) Northern Hemisphere synoptic variance

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The CLE40 and CRN/CLV2 Signaling Pathways Antagonistically Control Root Meristem Growth in Arabidopsis

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Molecular Plant 2014年第11期7卷 1619-1636页

作者： helge Pallakies Rudiger Simon Institute for Developmental Genetics and Cluster of Excellence on Plant Sciences (CEPLAS) Universitatsstr. 1 Heinrich-Heine University40225 D~sseldorf Germany

Differentiation processes in the primary root meristem are controlled by several signaling pathways that are regulated by phytohormones or by secreted peptides. Long-term maintenance of an active root meristem requires that the generation of new stem cells and the loss of these from the meristem due to differentiation are precisely coordinated. Via phenotypic and large-scale transcriptome analyses of mutants, we show that the signaling peptide CLE40 and the recep- tor proteins CLV2 and CRN act in two genetically separable pathways that antagonistically regulate cell differentiation in the proximal root meristem. CLE40 inhibits cell differentiation throughout the primary root meristem by controlling genes with roles in abscisic acid, auxin, and cytokinin signaling. CRN and CLV2 jointly control target genes that promote cell differentiation specifically in the transition zone of the proximal root meristem. While CRN and CLV2 are not acting in the CLE40 signaling pathway under normal growth conditions, both proteins are required when the levels of CLE40 or related CLE peptides increase. We show here that two antagonistically acting pathways controlling root meristem differentiation can be activated by the same peptide in a dosage-dependent manner.

关键词： root meristem transcriptomics CLE40 CRN/CLV2 signaling peptides phytohormones.

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Contrast-enhanced and targeted ultrasound

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World Journal of Gastroenterology 2011年第1期17卷 28-41页

作者： Michiel Postema Odd helge Gilja Emmy Noether Research Group Institute of Medical EngineeringDepartment of Electrical Engineering and Information SciencesRuhr-Universit t Bochum44780 BochumGermany Department of Physics and Technology Un versity of Bergen5007 BergenNorway Department of Engineering The University of HullKingston upon Hull HU6 7RXUnited Kingdom Centre de Biophysique Moléculaire UPR 4301 CNRS affiliated to the University of Orléans45071 OrléansFrance National Center for Ultrasound in Gastroenterology Department of MedicineHaukeland University Hospital5021 BergenNorway Institute of Medicine University of Bergen 5007 BergenNorway

Ultrasonic imaging is becoming the most popular medical imaging modality,owing to the low price per examination and its ***,blood is a poor scatterer of ultrasound waves at clinical diagnostic transmit *** perfusion imaging,markers have been designed to enhance the contrast in B-mode *** so-called ultrasound contrast agents consist of microscopically small gas bubbles encapsulated in biodegradable *** this review,the physical principles of ultrasound contrast agent microbubble behavior and their adjustment for drug delivery including sonoporation are ***,an outline of clinical imaging applications of contrast-enhanced ultrasound is *** is a challenging task to quantify and predict which bubble phenomenon occurs under which acoustic condition,and how these phenomena may be utilized in ultrasonic *** by high-speed photography,our improved understanding of encapsulated microbubble behavior will lead to more sophisticated detection and delivery *** sophisticated methods use quantitative approaches to measure the amount and the time course of bolus or reperfusion curves,and have shown great promise in revealing effective tumor responses to anti-angiogenic drugs in humans before tumor shrinkage *** are beginning to be accepted into clinical *** the long term,targeted microbubbles for molecular imaging and eventually for directed anti-tumor therapy are expected to be tested.

关键词：对比度增强超声波超声造影剂抗肿瘤治疗成像方式声波成像可生物降解抗血管生成

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