检索结果-南通市图书馆

Cancer stem cell subpopulations in metastatic melanoma to the brain express components of the renin-angiotensin system

引用

Journal of Cancer Metastasis and Treatment 2019年第8期4卷 12-20页

作者： Agadha C.Wickremesekera Helen D.Brasch Valerie M.Lee Paul F.Davis Andrew Parker helge Koeck Tinte Itinteang Swee T.Tan Gillies McIndoe Research Institute Wellington 6242New Zealand Department of Neurosurgery Wellington Regional HospitalWellington 6021New Zealand Wellington Regional Plastic Maxillofacial&Burns UnitHutt HospitalWellingtonLower Hutt 5010New Zealand.

Aim: There is increasing appreciation of the role of the renin-angiotensin system (RAS) in carcinogenesis with recent evidence showing expression of the RAS by cancer stem cells (CSCs) in different types of cancer. We have recently demonstrated the presence of three CSC subpopulations within metastatic melanoma (MM) to the brain: a Melan-A+ subpopulation and a Melan-A- subpopulation within the tumor that express OCT4, SALL4, SOX2 and NANOG;and a pSTAT3+ subpopulation localized to the CD34+ endothelium of microvessels within the tumor. In this study we investigated the expression and localization of components of the RAS in relation to these CSCs in MM to the brain. Methods: 3, 3-diaminobenzidine immunohistochemical (IHC) staining of components of the RAS: pro-renin receptor (PRR), angiotensin converting enzyme (ACE), angiotensin Ⅱ receptor 1 (ATIIR1) and angiotensin Ⅱ receptor 2 (ATIIR2) was performed on the same ten samples of MM to the brain included in our previous study. Immunofluorescence IHC staining of these components of the RAS was performed with embryonic stem cell markers OCT4 and NANOG, and endothelial marker CD34, on two of the samples of MM to the brain from the original cohort of ten patients. Western blotting (n = 5) and NanoString mRNA analysis (n = 4) were performed on samples of MM to the brain to confirm protein and mRNA expression of these components of the RAS, respectively. Results: DAB IHC staining showed the presence of PRR, ACE, ATIIR1 and ATIIR2 in all ten samples of MM to the brain. IF IHC staining showed that the CSC subpopulations in MM to the brain expressed PRR, ATIIR1 and ATIIR2;and a CSC subpopulation on the endothelium of the microvessels expressed ACE. Western blotting and NanoString mRNA analysis confirmed protein and mRNA expression of these components of the RAS, respectively. Conclusion: CSCs in MM to the brain expressed components of the RAS. Targeting the CSCs using modulators of the RAS may be a novel therapeutic approach f

关键词： Malignant melanoma metastatic cancer stem cells renin-angiotensin system cancer brain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水泥窑协同处置长江漂浮物过程的污染物排放与环境风险

引用

环境污染与防治 2023年第7期45卷 972-979页

作者：刘美佳崔长颢闫大海陈超李丽 Kare helge Karstensen 中国环境科学研究院国家环境保护危险废物鉴别与风险控制重点实验室北京100012 中国环境科学研究院固体废物污染控制技术研究所北京100012 Foundation for Scientific and Industrial Research Norway Oslo

长江水面聚集大量漂浮物,对发电和航运安全造成严重影响,也是影响库区环境的重要问题。在水泥窑协同处置长江漂浮物工程现场,分析了水泥窑协同处置长江漂浮物过程中窑尾烟气、水泥熟料和旁路放风粉尘中的污染物排放特征,评估了水泥窑协... 详细信息

长江水面聚集大量漂浮物,对发电和航运安全造成严重影响,也是影响库区环境的重要问题。在水泥窑协同处置长江漂浮物工程现场,分析了水泥窑协同处置长江漂浮物过程中窑尾烟气、水泥熟料和旁路放风粉尘中的污染物排放特征,评估了水泥窑协同处置长江漂浮物的环境风险,也研究了氯和5种典型重金属在水泥窑系统中的分配规律。结果表明,氯主要由入窑生料引入窑系统,由熟料带出,开启旁路放风时约20%的氯进到旁路放风粉尘中。Cr、Co、Ni、Cu和Sb主要来自于入窑生料,长江漂浮物也能引入一定量的重金属,最终超过90%的重金属经熟料带出窑系统,其余重金属主要进入窑灰。水泥窑协同处置长江漂浮物过程中,窑尾烟气、水泥熟料和旁路放风粉尘的大部分污染物均低于相应的标准限值,但需重点关注窑内燃烧状态,减少CO的产生以避免影响脱硝效率,旁路放风粉尘的Se浸出浓度超过《危险废物鉴别标准浸出毒性鉴别》(GB 5085.3—2007)规定的限值,具有一定环境风险。

关键词：长江漂浮物协同处置水泥窑环境风险

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用无线技术降低医疗费用

引用

电子产品世界 2009年第5期16卷 67-68,57页

作者： Alf helge More Nordic半导体

蓝牙低耗能规范保证会达到卫生机构关于在家中对病患者进行无线监控的严格要求,但是做到这点要战胜一些挑战,本文就是详细介绍如何利用无线技术提升医疗服务的范围和效率。

关键词：无线技术蓝牙医疗传感器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

铝的供需、经济和能源

引用

轻合金加工技术 1986年第6期 45-49页

作者： helge 梁平信

在1985年纽约美国矿冶石油工程师学会年会上,作为美国冶金学会轻金属委员会的一次特别会议,讨论了铝的供应,需求、经济和能源问题。会议精心地剖析了八十年代铝工业的形势。下面是有关专家对我们提出的五个问题的讨论。这些讨论记录没... 详细信息

在1985年纽约美国矿冶石油工程师学会年会上,作为美国冶金学会轻金属委员会的一次特别会议,讨论了铝的供应,需求、经济和能源问题。会议精心地剖析了八十年代铝工业的形势。下面是有关专家对我们提出的五个问题的讨论。这些讨论记录没有发表在《1985年轻金属》(Light MetaMs 1985)一书内,而刊登于冶金学会特刊上。以下是讨论记录梗概。

关键词：工程师学会能源问题八十年代轻金属材料轻合金加工铝消费铝罐塑料制造金属膜原铝

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

无线监控方案精确掌握储罐液位

引用

世界电子元器件 2021年第8期 17-18页

作者： Alf helge More Nordic Semiconductor公司

现今,燃料耗尽仍然会带来生活不便生活甚至危及生命。无线液位传感器可以帮助人们保障燃料箱中燃料不被耗尽。蜂窝物联网和低功耗蓝牙在远程监控储箱液位方面发挥着重大作用,帮助防止燃料或工农业生产中、运输中所必需的任何液体被耗尽。

关键词：液位传感器无线监控远程监控低功耗蓝牙蜂窝物联网储罐液位耗尽工农业生产

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods

引用

Plant Phenomics 2020年第1期2卷 243-254页

作者： Etienne David Simon Madec Pouria Sadeghi-Tehran helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan

The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of *** studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning ***,these methods have generally been calibrated and validated on limited *** variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer ***,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more *** a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)*** contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of *** for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection *** GWHD dataset is publicly available at http://***/and aimed at developing and benchmarking methods for wheat head detection.

关键词： Wheat wheat maturity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regeneration of Nothofagus dombeyi(Mirb.)?*** little to moderately disturbed southern beech forests in the Andes of Patagonia(Argentina)

引用

Forest Ecosystems 2023年第4期10卷 472-482页

作者： Stefan Zerbe Stefanie T.Storz Georg Leitinger Natalia Zoe Joelson José Bava Steffi Heinrichs Christoph Leuschner Gabriel Loguercio Alois Simon María F.Urretavizcaya helge Walentowski Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Department of Ecology University of Innsbruck Faculty of Resource Management HAWK University of Applied Sciences and Arts Department of Plant Ecology and Ecosystem Research Albrecht-von-Haller-Institute for Plant SciencesUniversity of G?ttingen Centro de Investigación y Extensión Forestal Andino Patagónico(CIEFAP) Department of Forest Planning Tyrol Forest Administration Office of the Tyrolean Government

Natural forests and stands subj ected to little to moderate human impact are continuously declining worldwide and with these,their biodiversity and ecosystem *** Nothofagus forests in the south of the South American continent are in a pristine state or only moderately impacted by *** grazing by livestock,in the past and still today often practiced in a non-sustainable way is,however,increasingly under discussion to meet current environmental and socio-economic ***,we investigate the regeneration of Nothofagus dombeyi,a keystone species of the Patagonian Andes,in secondary forests in Argentinian northern Patagonia,particularly addressing the role of disturbance through grazing by livestock at various *** test the hypothesis that the regeneration of this tree species is favored by grazing impact and,thus,disturbance of the herb layer and soil *** support of our hypothesis,Nothofagus dombeyi regeneration was significantly higher in terms of individuals and height classes in moderately grazed *** analysis shows significant positive effects of moderate grazing pressure,herb layer cover,and the occurrence of bare soil on the regeneration of Nothofagus *** results show that an integration of livestock grazing and forest regeneration is possible and that agroforestry systems can be an adequate management option for stakeholders in the region.A grazing management can also be part of a forest fire prevention ***,the regeneration success and grazing pressure should be continuously monitored.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际自行车联合会哈罗盖特共识:自行车运动中的脑震荡

引用

成都体育学院学报 2021年第5期47卷 140-142页

作者： Jeroen Swart Xavier Bigard Thomas Fladischer Roger Palfreeman helge Riepenhof Nigel Jones Neil Heron 开普敦大学运动医学部开普敦南非7725 国际自行车联盟艾格勒瑞士1860 霍赫施泰尔马克州立医院骨伤科穆尔河畔布鲁克奥地利8600 米切尔顿-斯科特车队澳大利亚 BG汉堡创伤医院运动与康复医学科汉堡德国21033 英国自行车协会英国贝尔法斯特女王大学医学牙医及生物医用科学学院贝尔法斯特英国BT97BL

运动相关脑震荡(Sport-related concussion,SRC)是一种常见且逐渐被大家重视的运动相关损伤,大约占自行车全部运动损伤的1%~9%。在快节奏的运动(如公路自行车项目)中如何管理SRC已经得到关注,特别是在缺少省时有效检测方案的情况下。近... 详细信息

运动相关脑震荡(Sport-related concussion,SRC)是一种常见且逐渐被大家重视的运动相关损伤,大约占自行车全部运动损伤的1%~9%。在快节奏的运动(如公路自行车项目)中如何管理SRC已经得到关注,特别是在缺少省时有效检测方案的情况下。近期在英国哈罗盖特召开的自行车运动SRC专家会议正努力解决该问题。该会议旨在将不同自行车项目下的标准术语、定义、诊断方案以及重返赛场标准达成一致。国际自行车联盟邀请了7位自行车医学专家(即本文作者)出席了本次会议。专家组认为,自行车运动涵盖了不同的项目,其中的一些项目具备场边评估的环境条件,符合柏林共识。然而,其他项目的场地环境受限于医疗保障人员与参赛者之间的接触困难,或参赛者不能够中止运动以进行场边评估,使得场边评估具有一定难度。基于共识的项目特异性方案和指南提出了现状的局限。尽管如此,此指南仍为当前不同自行车运动项目带来的独特挑战提供了潜在的解决方案,以改善自行车运动的现状。

关键词：运动相关脑震荡自行车运动国际自行车联合会

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alkyl Thiophene Vinylene Electropolimerization in C<sub>8</sub>mimPF<sub>6</sub>, Potential Use in Solar Cells

引用

Materials Sciences and Applications 2017年第5期8卷 405-417页

作者： Vania Rojas Francisco Martínez Jean Christian Bernède Linda Cattin Guenadez Alexander Efimov helge Lemmetyinen Departamento de Ciencia de los Materiales Facultad de Ciencias Físicas y Matemáticas Universidad de Chile Santiago Chile Lamp Facultè de Sciences et des Tecniques Université de Nantes Nantes France Department of Chemistry and Bioengineering Tampere University of Technology Hervanta Finland

We report the electrosynthesis of a novel semiconductor polymer based on alkyl vinylthiophene derivative in the presence of an ionic liquid (IL). The polymerization was performed under galvanostatic conditions and the polymer was studied as potential donor component of a multilayer heterojunction organic solar cell (OSC). The monomer used was (E)-1,2-di-(3-octyl-2-thienyl) vinylene (OTV) and the IL used for the electropolymerization was 1-octyl-3-methylimidazole hexafluorophosphate C8mimPF6. Optical properties, stability and morphology of the polymer were analyzed using FT-IR, UV-vis, Raman and XPS spectroscopy. Voltammetry analysis and scanning electron microscopy (SEM-EDX) were also performed on the polymer. The OSC assembled with the polymer of OTV was used as electro donor and C60 as acceptor. Molybdenum trioxide (MoO3) and bathocuproine (BCP) were used as buffer layer between anode and cathode respectively. I-V curves, in the dark and under AM 1.5 solar simulator were performed to measure its efficiency.

关键词： Conducting Polymer Vinylene Thiophene Ionic Liquids Organic Solar Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

2022年中国地球科学联合学术年会

作者： Qi Zhang Erwin Appel Shouyun Hu Nathani Basavaiah helge Stanjek James Byrne Southern University of Science and Technology University of Tuebingen Nanjing Institute of Geography and Limnology Indian Institute of Geomagnetism Navi RWTH Aachen University University of Bristol

Maghemitization of magnetite is an important topic in rock magnetism. It happens as low-temperature oxidation (LTO) under normal atmospheric conditions, causing gradual transformation of magnetite to maghemite, and potentially culminating in transformation to hematite. Better understanding of how humidity and temperature affect LTO is of great interest for paleoclimate studies, which use magnetic properties as proxies.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：