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Effects of protein restriction in utero on the metabolism of mink dams (<i>Neovison vison</i>) and on mink kit survival as well as on postnatal growth

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Open Journal of Animal Sciences 2012年第1期2卷 19-31页

作者： Kristine Vesterdorf Adrian Harrison Connie Frank Matthiesen Anne-helene Tauson 不详

Protein restriction in utero may give rise to restricted growth as well as induce metabolically related diseases. In order to determine the suitability of mink as an animal model for metabolism studies, the effects of protein restriction during gestation on dam and kit performance must first be determined. Mink dams were fed an adequate protein (AP;crude protein:fat:carbohydrate ratio of 31:55:14% of metabolizable energy, ME) or a low protein diet (LP;19%:49%: 32% of ME) during the last 21.2 ± 3.3 days of gestation, followed by an adequate diet during lactation. Respiration and balance experiments were performed during late gestation and twice during lactation. The dietary treatment only affected energy metabolism traits significantly during the treatment period in late gestation, such that LP dams oxidized less protein (12% vs 23% of heat production, HE, P = 0.001) but more carbohydrate (37% vs 26% of HE, P -***-1, P < 0.05) than AP dams. Reproductive performance and kit organ growth were not affected by diet. Kit losses up to weaning were higher in LP than AP dams (2.0 vs 1.4, P < 0.05). LP fetuses weighed less (8.3 vs 11.6 g, P < 0.001) and were shorter (6.2 vs 7.6 cm, P < 0.001) than AP fetuses, however, differences might have been due to different implantation times. LP kits weighed 8.5% less than AP kits at birth, and remained lighter until 21 days of age. The LP diet caused growth restriction and increased kit mortality indicating that the dietary protein supply during late gestation was suboptimal to re-quirements. The long-term consequences of protein restriction in utero in terms of permanent metabolic changes in adulthood now need to be investigated.

关键词： Intrauterine Metabolic Programming Nitrogen Metabolism Reproduction Performance Growth Rate Postnatal Development Organ Development

Family caregivers of demented elderly people and access to medical care: Who gets worn out, why and what for?

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Open Journal of Psychiatry 2013年第2期3卷 251-255页

作者： Cyril Hazif-Thomas Marie-helene Tritschler-LeMaitre Philippe Thomas Psychogeriatrics Department Hopital de BoharsBrestFrance Centre Jean-Marie Leger LimogesFrance

Demented persons in the process of slowly becoming dependent have to rely on the assistance of others. These others are health professionals (formal care), on the one hand and family carers (informal care) on the other hand. The latter, whether or not they have chosen to play a role which is hardly defined officially, have to face many difficult situations such as complicated access to care due to lack of equal opportunities under the health system, unable to support them efficiently. Taking care of a demented patient is a life challenge often leading to burn out, having impact on physical and mental health. Caregivers may thus even have no time or opportunity to take care of their own health. So, is it not high time for the decision-makers to think it over and take care of the carers by setting up programs and giving them the opportunity to learn, to work as a team with the professionals so as to protect themselves and their dignity as well as that of their patients. The difficulties/problems carers of demented patients may encounter should be a major issue for public health care because their role is a vital one and because the consequences which may have on their own health can be negative.

关键词： Dementia Family Caregiver Medical Care Access Dignity Health

当钟表遇到珠宝——透视2011年珠宝表流行风向标

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中国黄金珠宝 2011年第4期 106-111页

作者： helene

2011年在瑞士北部城市巴塞尔（Basel）举行的全球规模最大的世界钟表珠宝展览会上,珠宝表开始发力了。展览第一天,世界著名腕表宇舶表,携其亮眼的钟表——价值2百万欧元BIG BANG出现在大家的眼前,惊艳四座。说到珠宝表,历来也只不过是... 详细信息

2011年在瑞士北部城市巴塞尔（Basel）举行的全球规模最大的世界钟表珠宝展览会上,珠宝表开始发力了。展览第一天,世界著名腕表宇舶表,携其亮眼的钟表——价值2百万欧元BIG BANG出现在大家的眼前,惊艳四座。说到珠宝表,历来也只不过是正统男表中的小小配衬,好像只是为了迎合一下少数女士的需求,但在今年,珠宝表早已不肯再做默默无闻的绿叶,

关键词：珠宝钟表风向标展览会巴塞尔世界

Assessment of Lactational Performance in Dairy Cows Receiving a Rumen Protected B Vitamin Blend during Lactation: Part 2: A Regression Analysis of 50 Studies

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Open Journal of Animal Sciences 2021年第4期11卷 623-634页

作者： Essi Evans helene Leclerc Emilie Fontaine Ousama Al Zahal Elizabeth Santin E + E Technical Advisory Services Bowmanville Ontario Canada Jefo Nutrition Inc. St. Hyacinthe Quebec Canada AlZahal Innovation and Nutrition Kitchener Ontario Canada

A previous series of meta-analyses demonstrated that a protected blend of B vitamins (RPBV: folic acid, B12, pyridoxine, pantothenic acid, and biotin;Jefo, St. Hyacinthe, QC, Canada) improved milk fat and protein yield, with variation in the extent of the response. These results represent additional analyses of the same dataset to determine if the degree of response to RPVB on milk, fat and protein yield might be related to the level of production, lactation number, or days in milk (DIM). Results from 50 on-farm switchback trials conducted in 7 countries between 2005 and 2015 were included in the analysis. All herds participated in monthly milk recording services, and all were Holstein herds. A total of 6483 cows, averaging 163 DIM on the first test date, participated in the studies. Data were analyzed using regression models that accounted for the effects of trial, period, days in milk (DIM) and lactation number on milk and component yield. Milk yield and fat yield increased with B vitamin inclusion, and the extent of change was determined to increase with lactation number (P -protected B vitamin blend = 4.05 + [0.917 ×

关键词： Meta-Regression Dairy Nutrition Rumen Protection B Vitamins

Cardiac Malformations in Congenital Hypothyroidism: A Case Report

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Open Journal of Pediatrics 2024年第2期14卷 279-284页

作者： Suzanne Sap Gaelle Ntsoli Jocelyn Tony Ritha Mbono helene Kamo David Chelo Mother and Child Center of Chantal Biya Foundation Yaounde Cameroon University of Yaounde I Yaounde Cameroon Laquintinie Hospital University of Douala Douala Cameroon General Hospital of Garoua University of Garoua Garoua Cameroon

Introduction: Congenital hypothyroidism is the most common causes of preventable mental retardation. It is associated with other births defects like cardiac malformations. Descriptions in Sub Saharan Africa are rare, justifying the present report. Case Report: We reported the cases of 3 female patients, diagnosed with hypothyroidism, presenting in addition pulmonary stenosis. The diagnosis was late in all the patients and we noticed clinical improvement under levothyroxine. Conclusion: Association congenital hypothyroidism and cardiac defect is not rare. Our patients are female with no history of consanguinity, presenting congenital hypothyroidism with a gland in situ associated with pulmonary stenosis. Systematic screening of other births defects is thus recommended in affected patients.

关键词： Congenital Hypothyroidism Cardiac Malformations Children

The impact of out-of-pocket expenditures on missed appointments at HIV r care and treatment centers in Northern Tanzania

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Global Health Journal 2021年第2期5卷 90-96页

作者： Carl Mhina Hayden Bosworth John A.Bartlett helene Vilme Joyce H.Mosha Deborah F.Shoo Tom J.Kakumbi Glory Jacob Charles Muiruri Department of Population Health Sciences School of MedicineDuke University215 Morris StreetDurhamNC 27701USA Kilimanjaro Christian Medical University College Box 2240Moshi KilimanjaroTanzania Health Economics Unit School of Public Health and Family MedicineFaculty of Health SciencesUniversity of Cape TownOBSERVATORY 7925South Africa Duke Global Health Institute Duke UniversityDurhamNC 27708USA Durham Center of Innovation to Accelerate Discovery and Practice Transformation Durham Veterans Affairs Health Care System508 Fulton StreetHSRD 152DurhamNC 27705USA Muhimbili University of Health and Allied Sciences P.0.Box 65001Dar-es-SalaamTanzania

Background:Missed clinic appointments negatively impact clinic patient flow and health outcomes of people living with HIV(PLHIV).PLHIV likelihood of missing clinic appointments is associated with direct and indirect expenditures made while accessing HIV *** objective of this study was to examine the relationship between out-of-pocket(OOP)health expenditures and the likelihood of missing ***:Totally 618 PLHIV older than 18 years attending two HIV care and treatment centres(CTC)in Northern Tanzania were enrolled in the *** attendance and clinical characteristics were abstracted from medical *** on OOP health expenditures,demographics,and socio-economic factors were self-reported by the *** used a hurdle *** first part of the hurdle model assessed the marginal effect of a one Tanzanian Shillings(TZS)increase in OOP health expenditure on the probability of having a missed appointment and the second part assessed the probability of having missed appointments for those who had missed an appointment over the study ***:Among these 618 participants,242(39%)had at least one missed clinic appointment in the past *** expenditure was not significantly associated with the number of missed clinic *** median amount of OOP paid was 5100 TZS per visit,about 7%of the median monthly *** who were separated from their partners(adjusted odds ratio[AOR]=1.83,95%confidence interval[CZ]:1.11-8.03)and those aged above 50 years(AOR=2.85,95%CI:1.01-8.03)were significantly associated with missing an *** those who had at least one missed appointment over the study period,the probability of missing a clinic appointment was significantly associated with seeking care in a public CTC(P=0.49,95%CI:0.88-0.09)and aged between>25-35 years(P=0.90,95%CI:0.11-1.69).Conclusion:Interventions focused on improving compliance to clinic appointments should target public CTCs,PLHIV aged between>

关键词： Missed clinic appointments Out-of-pocket expenditure HIV Tanzania

CdSe/CdS纳米晶在壳层形成和生长过程中的形貌调控:表面配体对晶体结构的决定性作用

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Science China Materials 2023年第9期66卷 3621-3628页

作者：郝俊杰刘皓宸段西健周子明赵冰心张文达徐冰孙小卫 Marie-helene Delville Centre national de la recherche scientifique University of BordeauxBordeaux INPICMCBUMR 5026PessacF-33608France Institute of Nanoscience and Applications and Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China College of Integrated Circuits and Optoelectronic Chips Shenzhen Technology UniversityShenzhen 518118China Department of Materials Science and Engineering and Centre for Functional Photonics(CFP)City University of Hong KongHong Kong SAR 999077China Key Laboratory of Energy Conversion and Storage Technologies(Southern University of Science and Technology) Ministry of EducationShenzhen 518055China Shenzhen Planck Innovation Technologies Co. Ltd.Shenzhen 518173China Hainan Provincial Key Laboratory of Fine Chemicals Hainan UniversityHaikou 570228China

CdSe/CdS纳米晶是研究最多的半导体纳米晶之一,然而,仍有许多方面有待研究.本文中,我们揭示了核-壳纳米晶的形貌主要由表面配体和核心浓度控制,而非核心的晶体结构.其中,羧酸镉促进各向同性结构的生长,而相反地,长链膦酸镉有利于各向异... 详细信息

CdSe/CdS纳米晶是研究最多的半导体纳米晶之一,然而,仍有许多方面有待研究.本文中,我们揭示了核-壳纳米晶的形貌主要由表面配体和核心浓度控制,而非核心的晶体结构.其中,羧酸镉促进各向同性结构的生长,而相反地,长链膦酸镉有利于各向异性结构的制备.对于蝌蚪形貌纳米晶,羧酸镉对于头部壳层影响较大,而膦酸镉在各向异性尾部生长中起主要作用.与预期相反, CdSe核心的晶体结构(闪锌矿或纤锌矿)在决定最终的晶体形貌方面几乎没有作用,这可能是由于CdS壳层两个阶段的生长,并导致了蝌蚪形貌的生成.通过选择恰当的表面配体,可以在CdSe/CdS核壳结构形成和生长过程中精确地调控其形貌.在本工作中,蝌蚪、纳米花、点-棒结构、多足结构均可以通过调控表面配体的比率而获得.这种独特的晶体生长机制可以应用于其他基于种子生长的工艺以构筑各向异性纳米结构.

关键词：半导体纳米晶纳米花晶体结构形貌调控晶体形貌各向异性壳层浓度控制

What lessons can be learned from y T cell-based cancer immunotherapy trials？

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Cellular & Molecular Immunology 2013年第1期10卷 35-41页

作者： Jean-Jacques Fournie helene Sicard Mary Poupot Christine Bezombes Amandine Blanc Franqois-Romagne Loic Ysebaert Guy Laurent INSERM UMR1037-Cancer ResearchCenter of Toulouse Toulouse France University of Toulouse Toulouse France ERL 5294 CNRS BP3028 Hospital Purpan ToulouseFrAnce lnnate Pharma Marseilles France and Department of Hematology Hospital Purpan Toulouse France

During the last several years, research has produced a significant amount of knowledge concerning the characteristics of human 76 T lymphocytes. Findings regarding the immune functions of these cells, particularly their natural killer cell-like lyric activity against tumor cells, have raised expectations for the therapeutic applications of these cells for cancer. Pharmaceutical companies have produced selective agonists for these lymphocytes, and several teams have launched clinical trials of y8 T cell-based cancer therapies. The findings from these studies include hematological malignancies （follicular lymphoma, multiple myeloma, acute and chronic myeloid leukemia）, as well as solid tumors （renal cell, breast and prostate carcinomas）, consisting of samples from more than 250 patients from Europe, Japan and the United States. The results of these pioneering studies are now available, and this short review summarizes the lessons learned and the role of y6 T cell-based strategies in the current landscape of cancer immunotherapies.

关键词： cancer cell therapy gamma-delta lymphocytes immunotherapy lymphoma trials

Building the sequence map of the human pan-genome

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Building the sequence map of the human pan-genome